CA2515644A1 - Oligomeric compounds for the modulation of ras expression - Google Patents

Oligomeric compounds for the modulation of ras expression Download PDF

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Publication number
CA2515644A1
CA2515644A1 CA002515644A CA2515644A CA2515644A1 CA 2515644 A1 CA2515644 A1 CA 2515644A1 CA 002515644 A CA002515644 A CA 002515644A CA 2515644 A CA2515644 A CA 2515644A CA 2515644 A1 CA2515644 A1 CA 2515644A1
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CA
Canada
Prior art keywords
compound
ras
lna
carcinoma
seq
Prior art date
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Abandoned
Application number
CA002515644A
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English (en)
French (fr)
Inventor
Bo Hansen
Charlotte Albaek Thrue
Kamille Dumong Petersen
Majken Westergaard
Margit Wissenbach
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Roche Innovation Center Copenhagen AS
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Individual
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Publication of CA2515644A1 publication Critical patent/CA2515644A1/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
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  • Microbiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
CA002515644A 2003-02-10 2004-02-10 Oligomeric compounds for the modulation of ras expression Abandoned CA2515644A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200300184 2003-02-10
DKPA200300184 2003-02-10
DKPA200301539 2003-10-20
DKPA200301539 2003-10-20
PCT/DK2004/000097 WO2004069992A2 (en) 2003-02-10 2004-02-10 Oligomeric compounds for the modulation of ras expression

Publications (1)

Publication Number Publication Date
CA2515644A1 true CA2515644A1 (en) 2004-08-19

Family

ID=32852146

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002515644A Abandoned CA2515644A1 (en) 2003-02-10 2004-02-10 Oligomeric compounds for the modulation of ras expression

Country Status (6)

Country Link
US (2) US20040248840A1 (https=)
EP (1) EP1592795A2 (https=)
JP (1) JP2006518197A (https=)
AU (1) AU2004209599A1 (https=)
CA (1) CA2515644A1 (https=)
WO (1) WO2004069992A2 (https=)

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JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
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US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
BR112014028634A2 (pt) 2012-05-16 2017-06-27 Rana Therapeutics Inc composições e métodos para modulação da expressão de utrn
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Also Published As

Publication number Publication date
EP1592795A2 (en) 2005-11-09
AU2004209599A1 (en) 2004-08-19
US20040248840A1 (en) 2004-12-09
JP2006518197A (ja) 2006-08-10
WO2004069992A2 (en) 2004-08-19
US20080188432A1 (en) 2008-08-07
WO2004069992A3 (en) 2005-04-21

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