JP2006517230A5 - - Google Patents
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- Publication number
- JP2006517230A5 JP2006517230A5 JP2006503348A JP2006503348A JP2006517230A5 JP 2006517230 A5 JP2006517230 A5 JP 2006517230A5 JP 2006503348 A JP2006503348 A JP 2006503348A JP 2006503348 A JP2006503348 A JP 2006503348A JP 2006517230 A5 JP2006517230 A5 JP 2006517230A5
- Authority
- JP
- Japan
- Prior art keywords
- lys
- benzyl
- dtpa
- tyr
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 26
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 230000008685 targeting Effects 0.000 claims 9
- 239000003957 anion exchange resin Substances 0.000 claims 6
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 3
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 claims 3
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical compound [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 3
- 229960001479 tosylchloramide sodium Drugs 0.000 claims 3
- -1 N-hydroxysulfosuccinimide ester Chemical class 0.000 claims 2
- 125000002228 disulfide group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 239000011347 resin Substances 0.000 claims 2
- 229920005989 resin Polymers 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- FJQZXCPWAGYPSD-UHFFFAOYSA-N 1,3,4,6-tetrachloro-3a,6a-diphenylimidazo[4,5-d]imidazole-2,5-dione Chemical compound ClN1C(=O)N(Cl)C2(C=3C=CC=CC=3)N(Cl)C(=O)N(Cl)C12C1=CC=CC=C1 FJQZXCPWAGYPSD-UHFFFAOYSA-N 0.000 claims 1
- RAEOEMDZDMCHJA-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl]amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O RAEOEMDZDMCHJA-UHFFFAOYSA-N 0.000 claims 1
- JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims 1
- DTRVZAALOQTDSF-UHFFFAOYSA-N 2-[[2-[bis(carboxymethyl)amino]-3-phenylpropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(N(CC(O)=O)CC(O)=O)CC1=CC=CC=C1 DTRVZAALOQTDSF-UHFFFAOYSA-N 0.000 claims 1
- JUIKUQOUMZUFQT-UHFFFAOYSA-N 2-bromoacetamide Chemical compound NC(=O)CBr JUIKUQOUMZUFQT-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 208000037259 Amyloid Plaque Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- RUSUZAGBORAKPY-UHFFFAOYSA-N acetic acid;n'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCNCCN RUSUZAGBORAKPY-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 229940059260 amidate Drugs 0.000 claims 1
- 230000002494 anti-cea effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 231100001011 cardiovascular lesion Toxicity 0.000 claims 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 235000009518 sodium iodide Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/359,276 US7521531B2 (en) | 1996-08-28 | 2003-02-06 | Methods for the purification of stable radioiodine conjugates |
| US10/359,276 | 2003-02-06 | ||
| PCT/US2004/003305 WO2004071571A1 (en) | 2003-02-06 | 2004-02-04 | Methods for the purification of stable radioiodine conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006517230A JP2006517230A (ja) | 2006-07-20 |
| JP2006517230A5 true JP2006517230A5 (https=) | 2007-01-18 |
| JP4732331B2 JP4732331B2 (ja) | 2011-07-27 |
Family
ID=32867920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503348A Expired - Fee Related JP4732331B2 (ja) | 2003-02-06 | 2004-02-04 | 安定な放射性ヨウ素複合体の精製方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7521531B2 (https=) |
| EP (1) | EP1592476B1 (https=) |
| JP (1) | JP4732331B2 (https=) |
| KR (1) | KR101022145B1 (https=) |
| CN (1) | CN1768266A (https=) |
| AT (1) | ATE359511T1 (https=) |
| CA (1) | CA2515088C (https=) |
| DE (1) | DE602004005826T2 (https=) |
| IL (1) | IL170030A (https=) |
| MX (1) | MXPA05008352A (https=) |
| WO (1) | WO2004071571A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312318B2 (en) * | 2002-03-01 | 2007-12-25 | Immunomedics, Inc. | Internalizing anti-CD74 antibodies and methods of use |
| US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7172751B2 (en) * | 2003-06-13 | 2007-02-06 | Immunomedics, Inc. | D-amino acid peptides |
| EP1638989B1 (en) * | 2003-06-25 | 2008-07-30 | Peregrine Pharmaceuticals, Inc. | Method and apparatus for continuous large-scale radiolabeling of proteins |
| US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| CN1838968A (zh) | 2003-08-08 | 2006-09-27 | 艾伯吉尼斯公司 | 针对甲状旁腺激素(pth)之抗体和其用途 |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| GB0520529D0 (en) | 2005-10-10 | 2005-11-16 | Ge Healthcare Ltd | Automated radiolabelling method |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US8524239B2 (en) | 2010-07-09 | 2013-09-03 | The United States of America as represented by the Secrectary, Department of Health and Human Services | Photosensitizing antibody-fluorophore conjugates |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| CA2841120C (en) * | 2011-07-11 | 2020-10-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody-ir700 conjugates for photodynamic therapy |
| US8927732B2 (en) | 2012-03-30 | 2015-01-06 | General Electric Company | Biotin stannane for HPLC-free radioiodination |
| KR101426422B1 (ko) | 2012-05-10 | 2014-08-06 | 한국원자력연구원 | 안질환 또는 암 치료용 아이오딘 씨드의 제조방법 및 이에 의하여 제조되는 아이오딘 씨드 |
| AU2014225381B2 (en) | 2013-03-08 | 2018-05-17 | University Of Southern California Usc Stevens | Vinylsulfone-based 18f-labeling compositions and methods and uses thereof |
| US10830678B2 (en) | 2014-08-08 | 2020-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Photo-controlled removal of targets in vitro and in vivo |
| CN121270700A (zh) | 2015-08-07 | 2026-01-06 | 美国政府(由卫生和人类服务部的部长所代表) | 用于治疗癌症的针对抑制细胞的近红外光免疫疗法(nir-pit) |
| ES2889904T3 (es) | 2015-08-18 | 2022-01-14 | Rakuten Medical Inc | Conjugados de colorante de ftalocianina y su almacenamiento |
| US11154620B2 (en) | 2015-08-18 | 2021-10-26 | Rakuten Medical, Inc. | Compositions, combinations and related methods for photoimmunotherapy |
| US10799597B2 (en) | 2017-04-03 | 2020-10-13 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169947C (no) | 1981-10-27 | 1992-08-26 | Hybritech Inc | Fremgangsmaate for fremstilling av et monoklonalt antistoff til et tumorassosiert antigen |
| SE466403B (sv) * | 1988-03-24 | 1992-02-10 | Kurt G I Nilsson | Saett att syntetisera oligosackarider |
| FR2652004B1 (fr) | 1989-09-21 | 1994-10-28 | Immunotech Partners | Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques. |
| US5273738A (en) | 1990-03-03 | 1993-12-28 | Fred Hutchinson Cancer Research Center | Radiation delivery to lymphoid and marrow tissues |
| ATE125270T1 (de) | 1990-12-21 | 1995-08-15 | Pliva Pharm & Chem Works | Tert-butyloxycarbonyl-l-tyrosyl- peptidoglycanmonomer und deren 125 i-markiertes derivat, deren herstellung und verwendung. |
| US5554745A (en) | 1992-05-14 | 1996-09-10 | National Starch And Chemical Investment Holding Corporation | Aldehyde cationic derivatives of galactose containing polysaccharides used as paper strength additives |
| CA2189051C (en) | 1994-04-29 | 2008-06-17 | M. Jules Mattes | Composition for delivery of toxic radioisotopes to the cell nucleus and use |
| US5672335A (en) | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| ATE194143T1 (de) | 1996-08-28 | 2000-07-15 | Immunomedics Inc | Stabile radioiodium-konjugate und verfahren zu deren herstellung |
| US6558669B1 (en) | 1996-08-28 | 2003-05-06 | Immunomedics, Inc. | Stable radioiodine conjugates and methods for their synthesis |
| US6663866B1 (en) | 1996-08-28 | 2003-12-16 | Immunomedics, Inc. | Stable radioiodine conjugates and methods for their synthesis |
| EP1507562B1 (en) * | 2002-05-29 | 2010-03-24 | Immunomedics, Inc. | Compositions for radioimmunotherapy of brain |
-
2003
- 2003-02-06 US US10/359,276 patent/US7521531B2/en not_active Expired - Fee Related
-
2004
- 2004-02-04 JP JP2006503348A patent/JP4732331B2/ja not_active Expired - Fee Related
- 2004-02-04 KR KR1020057014399A patent/KR101022145B1/ko not_active Expired - Fee Related
- 2004-02-04 MX MXPA05008352A patent/MXPA05008352A/es not_active Application Discontinuation
- 2004-02-04 WO PCT/US2004/003305 patent/WO2004071571A1/en not_active Ceased
- 2004-02-04 DE DE602004005826T patent/DE602004005826T2/de not_active Expired - Lifetime
- 2004-02-04 EP EP04708243A patent/EP1592476B1/en not_active Expired - Lifetime
- 2004-02-04 CA CA2515088A patent/CA2515088C/en not_active Expired - Fee Related
- 2004-02-04 CN CNA2004800091734A patent/CN1768266A/zh active Pending
- 2004-02-04 AT AT04708243T patent/ATE359511T1/de active
-
2005
- 2005-08-02 IL IL170030A patent/IL170030A/en not_active IP Right Cessation
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