JP2006515611A - ピリミド［５，４−ｅ］［１，２，４］トリアジン−５，７−ジオン、その製造方法及び使用 - Google Patents
ピリミド［５，４−ｅ］［１，２，４］トリアジン−５，７−ジオン、その製造方法及び使用 Download PDFInfo
- Publication number
- JP2006515611A JP2006515611A JP2006500522A JP2006500522A JP2006515611A JP 2006515611 A JP2006515611 A JP 2006515611A JP 2006500522 A JP2006500522 A JP 2006500522A JP 2006500522 A JP2006500522 A JP 2006500522A JP 2006515611 A JP2006515611 A JP 2006515611A
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- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- compound
- aryl
- agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000000034 method Methods 0.000 title claims description 8
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- IDJLTUNWTSUIHO-UHFFFAOYSA-N 1,6-didemethyltoxoflavin Chemical compound N1=CN=C2C(=O)NC(=O)NC2=N1 IDJLTUNWTSUIHO-UHFFFAOYSA-N 0.000 title abstract description 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
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- 125000003118 aryl group Chemical group 0.000 claims description 13
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- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 4
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- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Rheumatology (AREA)
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- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
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- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10301788A DE10301788B4 (de) | 2003-01-20 | 2003-01-20 | Pharmazeutische Verwendung von Pyrimido[5,4-e][1,2,4]triazin-5,7-dionen |
| PCT/EP2004/000040 WO2004065387A1 (de) | 2003-01-20 | 2004-01-07 | PYRIMIDO[5,4-e][1,2,4]TRIAZIN-5,7-DIONE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006515611A true JP2006515611A (ja) | 2006-06-01 |
| JP2006515611A5 JP2006515611A5 (https=) | 2007-02-22 |
Family
ID=32602696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500522A Abandoned JP2006515611A (ja) | 2003-01-20 | 2004-01-07 | ピリミド［５，４−ｅ］［１，２，４］トリアジン−５，７−ジオン、その製造方法及び使用 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1587806B1 (https=) |
| JP (1) | JP2006515611A (https=) |
| AT (1) | ATE414086T1 (https=) |
| AU (1) | AU2004205351A1 (https=) |
| BR (1) | BRPI0406828A (https=) |
| CA (1) | CA2513285A1 (https=) |
| DE (2) | DE10301788B4 (https=) |
| MX (1) | MXPA05007201A (https=) |
| WO (1) | WO2004065387A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| BRPI0923373B8 (pt) * | 2008-12-12 | 2021-05-25 | Merck Patent Gmbh | composições farmacêuticas compreendendo uma combinação de insulina com derivados de triazina, e uso da dita combinação |
| WO2010072807A2 (en) | 2008-12-23 | 2010-07-01 | Fondation Jerome Lejeune | Inhibitors of cystathionine beta synthase to reduce the neurotoxic overproduction of endogenous hydrogen sulfide |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| BR112013021236B1 (pt) | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
| US9527875B2 (en) | 2012-08-02 | 2016-12-27 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| EP4613274A1 (en) | 2024-03-06 | 2025-09-10 | Freie Universität Berlin | Senolytic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09255681A (ja) * | 1996-03-25 | 1997-09-30 | Taisho Pharmaceut Co Ltd | 抗腫瘍剤 |
| GB0022079D0 (en) * | 2000-09-08 | 2000-10-25 | Inst Of Molecul & Cell Biology | Novel protein tyrosine phosphatase inhibitor |
-
2003
- 2003-01-20 DE DE10301788A patent/DE10301788B4/de not_active Expired - Fee Related
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2004
- 2004-01-07 AT AT04700447T patent/ATE414086T1/de not_active IP Right Cessation
- 2004-01-07 MX MXPA05007201A patent/MXPA05007201A/es active IP Right Grant
- 2004-01-07 BR BR0406828-9A patent/BRPI0406828A/pt not_active IP Right Cessation
- 2004-01-07 WO PCT/EP2004/000040 patent/WO2004065387A1/de not_active Ceased
- 2004-01-07 EP EP04700447A patent/EP1587806B1/de not_active Expired - Lifetime
- 2004-01-07 JP JP2006500522A patent/JP2006515611A/ja not_active Abandoned
- 2004-01-07 AU AU2004205351A patent/AU2004205351A1/en not_active Abandoned
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- 2004-01-07 DE DE502004008447T patent/DE502004008447D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004065387A1 (de) | 2004-08-05 |
| CA2513285A1 (en) | 2004-08-05 |
| AU2004205351A1 (en) | 2004-08-05 |
| BRPI0406828A (pt) | 2005-12-27 |
| DE10301788B4 (de) | 2005-08-25 |
| DE502004008447D1 (de) | 2008-12-24 |
| MXPA05007201A (es) | 2005-09-12 |
| EP1587806A1 (de) | 2005-10-26 |
| DE10301788A1 (de) | 2004-07-29 |
| EP1587806B1 (de) | 2008-11-12 |
| ATE414086T1 (de) | 2008-11-15 |
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