JP2006514925A5 - - Google Patents
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- Publication number
- JP2006514925A5 JP2006514925A5 JP2004551393A JP2004551393A JP2006514925A5 JP 2006514925 A5 JP2006514925 A5 JP 2006514925A5 JP 2004551393 A JP2004551393 A JP 2004551393A JP 2004551393 A JP2004551393 A JP 2004551393A JP 2006514925 A5 JP2006514925 A5 JP 2006514925A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- amino
- propoxy
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36842702P | 2002-03-27 | 2002-03-27 | |
| PCT/US2003/009461 WO2004043939A1 (en) | 2002-03-27 | 2003-03-26 | Amide compounds and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514925A JP2006514925A (ja) | 2006-05-18 |
| JP2006514925A5 true JP2006514925A5 (https=) | 2006-06-29 |
| JP4471842B2 JP4471842B2 (ja) | 2010-06-02 |
Family
ID=32312375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004551393A Expired - Lifetime JP4471842B2 (ja) | 2002-03-27 | 2003-03-26 | アミド化合物および該化合物を用いる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7247748B2 (https=) |
| EP (1) | EP1497270A4 (https=) |
| JP (1) | JP4471842B2 (https=) |
| AU (1) | AU2003220558A1 (https=) |
| WO (1) | WO2004043939A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509161A (ja) * | 2000-09-18 | 2004-03-25 | グラクソ グループ リミテッド | Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体 |
| EP1487776A4 (en) | 2002-03-27 | 2005-05-25 | Smithkline Beecham Corp | ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF |
| US7247748B2 (en) | 2002-03-27 | 2007-07-24 | Smithkline Corporation | Amide compounds and methods of using the same |
| AU2003226094A1 (en) | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Compounds and methods |
| ATE453389T1 (de) | 2002-03-27 | 2010-01-15 | Smithkline Beecham Corp | Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen |
| US7989179B2 (en) * | 2005-06-28 | 2011-08-02 | Daiichi Sankyo Company, Limited | LXR ligand testing method |
| AU2007260356B2 (en) * | 2006-06-16 | 2013-01-24 | H. Lundbeck A/S | Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
| BRPI1011192A2 (pt) | 2009-05-07 | 2016-03-15 | Gruenenthal Gmbh | derivados de carboxamida e ureia aromáticas substituídas como ligantes de receptor de vaniloide, composição farmacêutica, uso e processo para preparação dos referidos derivados |
| EP3626309B1 (en) | 2012-08-13 | 2023-03-08 | The Rockefeller University | Lxrbeta agonist for the treatment of cancer |
| US10669296B2 (en) | 2014-01-10 | 2020-06-02 | Rgenix, Inc. | LXR agonists and uses thereof |
| MA41051B1 (fr) | 2014-10-06 | 2020-11-30 | Vertex Pharma | Modulateurs du régulateur de conductance transmembranaire de la mucoviscidose |
| CA3010883A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| CA3019380A1 (en) | 2016-03-31 | 2017-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN109803962B (zh) | 2016-09-30 | 2022-04-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控蛋白的调节剂、以及药物组合物 |
| MD3551622T2 (ro) | 2016-12-09 | 2021-03-31 | Vertex Pharma | Modulator al regulatorului conductanței transmembranare în fibroză chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului |
| CN110494415A (zh) | 2017-03-03 | 2019-11-22 | 睿治尼斯公司 | 具有改善的稳定性的制剂 |
| US11253509B2 (en) | 2017-06-08 | 2022-02-22 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| MA49631A (fr) | 2017-07-17 | 2020-05-27 | Vertex Pharma | Méthodes de traitement de la fibrose kystique |
| JP7121794B2 (ja) | 2017-08-02 | 2022-08-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | ピロリジン化合物を調製するためのプロセス |
| WO2019079760A1 (en) | 2017-10-19 | 2019-04-25 | Vertex Pharmaceuticals Incorporated | CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| EP3720849A2 (en) | 2017-12-08 | 2020-10-14 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| WO2019168842A1 (en) | 2018-03-02 | 2019-09-06 | Oregon Health & Science University | Amide prodrugs of small molecule nuclear receptor modulators |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EP3894383A1 (en) | 2018-12-12 | 2021-10-20 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| CA3130371A1 (en) | 2019-03-01 | 2020-09-10 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| AU2020345791A1 (en) * | 2019-09-11 | 2022-03-31 | Inspirna, Inc. | Methods of treating cancer |
| KR20220121239A (ko) | 2019-11-29 | 2022-08-31 | 아우토반 쎄라퓨틱스, 인크. | 신규한 갑상선 호르몬 모방제 |
| HUE067466T2 (hu) | 2019-12-13 | 2024-10-28 | Inspirna Inc | Fémsók és alkalmazásuk |
| WO2021257851A1 (en) | 2020-06-17 | 2021-12-23 | Autobahn Therapeutics, Inc. | Thyromimetics |
| JP7813730B2 (ja) | 2020-06-17 | 2026-02-13 | オートバーン セラピューティクス，インク． | 甲状腺様作用剤 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139623A (en) | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| DE3889545T2 (de) | 1987-10-20 | 1994-10-13 | Otsuka Pharma Co Ltd | Phenylcarbonsäure-abkömmlinge. |
| US20030153541A1 (en) | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| AU2000235960A1 (en) * | 2000-02-14 | 2001-08-27 | Tularik, Inc. | Lxr modulators |
| JP2004509161A (ja) | 2000-09-18 | 2004-03-25 | グラクソ グループ リミテッド | Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体 |
| US7470659B2 (en) | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| US20030229062A1 (en) | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| JP2005511713A (ja) | 2001-12-07 | 2005-04-28 | ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア | 加齢性黄斑変性についての処置 |
| EP1487776A4 (en) | 2002-03-27 | 2005-05-25 | Smithkline Beecham Corp | ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF |
| US20050171084A1 (en) | 2002-03-27 | 2005-08-04 | Cairns William J. | Methods of treatment with lxr modulators |
| ATE453389T1 (de) | 2002-03-27 | 2010-01-15 | Smithkline Beecham Corp | Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen |
| US7247748B2 (en) | 2002-03-27 | 2007-07-24 | Smithkline Corporation | Amide compounds and methods of using the same |
| AU2003226094A1 (en) | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Compounds and methods |
| WO2004058175A2 (en) | 2002-12-23 | 2004-07-15 | Irm Llc | Novel use of liver x receptor agonists |
| GB0230177D0 (en) | 2002-12-24 | 2003-02-05 | Karobio Ab | LXR beta crystal |
| WO2004110368A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Combination therapy for the treatment of hypertension |
| EP1635832A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
| US20060189693A1 (en) | 2003-07-22 | 2006-08-24 | Barone Frank C | Methods of treatment with lxr agonists |
| EP1653938A2 (en) | 2003-07-28 | 2006-05-10 | Glaxo Group Limited | Methods of treatment of inflammatory bowel disease with lxr agonists |
| WO2005055998A1 (en) | 2003-12-04 | 2005-06-23 | Smithkline Beecham Corporation | Methods of treatment with lxr agonists |
| RU2006124843A (ru) | 2003-12-12 | 2008-01-20 | Уайт (Us) | Хинолины, пригодные для лечения сердечно-сосудистого заболевания |
| EP1758651A2 (en) | 2004-06-24 | 2007-03-07 | Galapagos N.V. | Lxr agonists to promote bone homeostasis |
| US20080255111A1 (en) | 2004-07-02 | 2008-10-16 | Sankyo Company Limited | Tissue Factor Production Inhibitor |
-
2003
- 2003-03-26 US US10/508,791 patent/US7247748B2/en not_active Expired - Lifetime
- 2003-03-26 JP JP2004551393A patent/JP4471842B2/ja not_active Expired - Lifetime
- 2003-03-26 AU AU2003220558A patent/AU2003220558A1/en not_active Abandoned
- 2003-03-26 EP EP03716872A patent/EP1497270A4/en not_active Withdrawn
- 2003-03-26 WO PCT/US2003/009461 patent/WO2004043939A1/en not_active Ceased
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