JP2006514925A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006514925A5 JP2006514925A5 JP2004551393A JP2004551393A JP2006514925A5 JP 2006514925 A5 JP2006514925 A5 JP 2006514925A5 JP 2004551393 A JP2004551393 A JP 2004551393A JP 2004551393 A JP2004551393 A JP 2004551393A JP 2006514925 A5 JP2006514925 A5 JP 2006514925A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- amino
- propoxy
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36842702P | 2002-03-27 | 2002-03-27 | |
| PCT/US2003/009461 WO2004043939A1 (en) | 2002-03-27 | 2003-03-26 | Amide compounds and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514925A JP2006514925A (ja) | 2006-05-18 |
| JP2006514925A5 true JP2006514925A5 (https=) | 2006-06-29 |
| JP4471842B2 JP4471842B2 (ja) | 2010-06-02 |
Family
ID=32312375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004551393A Expired - Lifetime JP4471842B2 (ja) | 2002-03-27 | 2003-03-26 | アミド化合物および該化合物を用いる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7247748B2 (https=) |
| EP (1) | EP1497270A4 (https=) |
| JP (1) | JP4471842B2 (https=) |
| AU (1) | AU2003220558A1 (https=) |
| WO (1) | WO2004043939A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002024632A2 (en) * | 2000-09-18 | 2002-03-28 | Glaxo Group Limited | Substituted aminopropoxyaryl derivatives useful as agonists for lxr |
| EP1490047B1 (en) | 2002-03-27 | 2009-12-30 | SmithKline Beecham Corporation | Certain pharmaceutically useful substituted aminoalkyl heterocycles |
| EP1575495A4 (en) * | 2002-03-27 | 2009-12-02 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| AU2003220558A1 (en) | 2002-03-27 | 2004-06-03 | Smithkline Beecham Corporation | Amide compounds and methods of using the same |
| US7560586B2 (en) * | 2002-03-27 | 2009-07-14 | Smithkline Beecham Corporation | Acid and ester compounds and methods of using the same |
| US7989179B2 (en) * | 2005-06-28 | 2011-08-02 | Daiichi Sankyo Company, Limited | LXR ligand testing method |
| CA2656057C (en) * | 2006-06-16 | 2012-10-02 | H. Lundbeck A/S | Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
| MX2011011800A (es) * | 2009-05-07 | 2012-01-27 | Gruenenthal Gmbh | Derivados de carboxamida y urea aromaticas sustituidas como ligandos del receptor de vanilloides. |
| AU2013302861A1 (en) | 2012-08-13 | 2015-03-05 | The Rockefeller University | Treatment and diagnosis of melanoma |
| WO2015106164A1 (en) | 2014-01-10 | 2015-07-16 | Rgenix, Inc. | Lxr agonists and uses thereof |
| TWI735416B (zh) | 2014-10-06 | 2021-08-11 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
| EP3402477A4 (en) | 2016-01-11 | 2019-08-21 | The Rockefeller University | METHOD FOR THE TREATMENT OF DISEASES RELATED TO MYELOID-DERIVED SUPPRESSOR CELLS |
| ES2946970T3 (es) | 2016-03-31 | 2023-07-28 | Vertex Pharma | Regulador de conductancia transmembrana de moduladores de fibrosis quística |
| SI3519401T1 (sl) | 2016-09-30 | 2022-01-31 | Vertex Pharmaceuticals Incorporated | Modulator regulatorja transmembranske prevodnosti pri cistični fibrozi, farmacevtski sestavki, postopki zdravljenja in proces za izdelavo modulatorja |
| CN110267948B (zh) | 2016-12-09 | 2023-12-08 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控剂的调节剂、药物组合物、治疗方法和制备所述调节剂的方法 |
| EP3589280B1 (en) | 2017-03-03 | 2024-02-07 | Inspirna, Inc. | Formulations with improved stability |
| AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| MA49631A (fr) | 2017-07-17 | 2020-05-27 | Vertex Pharma | Méthodes de traitement de la fibrose kystique |
| TWI799435B (zh) | 2017-08-02 | 2023-04-21 | 美商維泰克斯製藥公司 | 製備化合物之製程 |
| US10654829B2 (en) | 2017-10-19 | 2020-05-19 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
| CA3078981A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
| KR102716244B1 (ko) | 2017-12-08 | 2024-10-14 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| US11613517B2 (en) | 2018-03-02 | 2023-03-28 | Oregon Health & Science University | Amide prodrugs of small molecule nuclear receptor modulators |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| AU2019397067A1 (en) | 2018-12-12 | 2021-07-22 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| WO2020180624A1 (en) | 2019-03-01 | 2020-09-10 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| CA3150729A1 (en) * | 2019-09-11 | 2021-03-18 | Inspirna, Inc. | Methods of treating cancer |
| US12466781B2 (en) | 2019-11-29 | 2025-11-11 | Autobahn Therapeutics, Inc. | Thyromimetics |
| TWI888447B (zh) | 2019-12-13 | 2025-07-01 | 美商因思博納公司 | 金屬鹽及其用途 |
| US12590072B2 (en) | 2020-06-17 | 2026-03-31 | Autobahn Therapeutics, Inc. | Thyromimetics |
| WO2021257851A1 (en) | 2020-06-17 | 2021-12-23 | Autobahn Therapeutics, Inc. | Thyromimetics |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139623A (en) | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| DE3889545T2 (de) | 1987-10-20 | 1994-10-13 | Otsuka Pharma Co Ltd | Phenylcarbonsäure-abkömmlinge. |
| US20030153541A1 (en) | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| AU2000235960A1 (en) * | 2000-02-14 | 2001-08-27 | Tularik, Inc. | Lxr modulators |
| WO2002024632A2 (en) | 2000-09-18 | 2002-03-28 | Glaxo Group Limited | Substituted aminopropoxyaryl derivatives useful as agonists for lxr |
| US7470659B2 (en) | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| US20030229062A1 (en) | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| WO2003049685A2 (en) | 2001-12-07 | 2003-06-19 | The Regents Of The University Of California | Treatment for age-related macular degeneration |
| EP1490047B1 (en) | 2002-03-27 | 2009-12-30 | SmithKline Beecham Corporation | Certain pharmaceutically useful substituted aminoalkyl heterocycles |
| US7560586B2 (en) | 2002-03-27 | 2009-07-14 | Smithkline Beecham Corporation | Acid and ester compounds and methods of using the same |
| AU2003220558A1 (en) | 2002-03-27 | 2004-06-03 | Smithkline Beecham Corporation | Amide compounds and methods of using the same |
| EP1575495A4 (en) | 2002-03-27 | 2009-12-02 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| US20050171084A1 (en) | 2002-03-27 | 2005-08-04 | Cairns William J. | Methods of treatment with lxr modulators |
| WO2004058175A2 (en) | 2002-12-23 | 2004-07-15 | Irm Llc | Novel use of liver x receptor agonists |
| GB0230177D0 (en) | 2002-12-24 | 2003-02-05 | Karobio Ab | LXR beta crystal |
| EP1635773A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. (a New Jersey corp.) | Combination therapy for the treatment of hypertension |
| EP1635832A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
| US20060189693A1 (en) | 2003-07-22 | 2006-08-24 | Barone Frank C | Methods of treatment with lxr agonists |
| JP2007500158A (ja) | 2003-07-28 | 2007-01-11 | グラクソ グループ リミテッド | Ｌｘｒアゴニストを用いる炎症性腸疾患の治療方法 |
| WO2005055998A1 (en) | 2003-12-04 | 2005-06-23 | Smithkline Beecham Corporation | Methods of treatment with lxr agonists |
| AU2004298486A1 (en) | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
| US20060020036A1 (en) | 2004-06-24 | 2006-01-26 | Luc Van Rompaey | Methods and compositions to promote bone homestasis |
| WO2006004030A1 (ja) | 2004-07-02 | 2006-01-12 | Sankyo Company, Limited | 組織因子産生抑制剤 |
-
2003
- 2003-03-26 AU AU2003220558A patent/AU2003220558A1/en not_active Abandoned
- 2003-03-26 US US10/508,791 patent/US7247748B2/en not_active Expired - Lifetime
- 2003-03-26 WO PCT/US2003/009461 patent/WO2004043939A1/en not_active Ceased
- 2003-03-26 EP EP03716872A patent/EP1497270A4/en not_active Withdrawn
- 2003-03-26 JP JP2004551393A patent/JP4471842B2/ja not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006514925A5 (https=) | ||
| RU2361868C2 (ru) | Новые производные тиазола | |
| JP2022506445A5 (https=) | ||
| JP2006077019A5 (https=) | ||
| JP2010527984A5 (https=) | ||
| JP2013519680A5 (https=) | ||
| JP2013523636A5 (https=) | ||
| JP2011529037A5 (https=) | ||
| JP2008540574A5 (https=) | ||
| JP2015536306A5 (https=) | ||
| JP2010527985A5 (https=) | ||
| HRP20170352T1 (hr) | Spojevi bis(fluroalkil)-1,4-benzodiazepinona kao notch inhibitori | |
| JP2013525318A5 (https=) | ||
| JP2005519024A5 (https=) | ||
| JP2011503199A5 (https=) | ||
| JP2016503786A5 (https=) | ||
| JP2013510122A5 (https=) | ||
| JP2006151984A5 (https=) | ||
| HRP20151405T1 (hr) | Novi supstituirani kinolinski spojevi kao inhibitori reduktaze s-nitrosoglutationa | |
| JP2009528296A5 (https=) | ||
| JP2005532331A5 (https=) | ||
| JP2013525293A5 (https=) | ||
| JP2023517944A5 (https=) | ||
| JP2004509857A5 (https=) | ||
| JP2023511616A5 (https=) |