JP2006514546A - Ｂｃｌ−２を標的とする抑制性オリゴヌクレオチド - Google Patents
Ｂｃｌ−２を標的とする抑制性オリゴヌクレオチド Download PDFInfo
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- JP2006514546A JP2006514546A JP2004553781A JP2004553781A JP2006514546A JP 2006514546 A JP2006514546 A JP 2006514546A JP 2004553781 A JP2004553781 A JP 2004553781A JP 2004553781 A JP2004553781 A JP 2004553781A JP 2006514546 A JP2006514546 A JP 2006514546A
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- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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| US42626902P | 2002-11-14 | 2002-11-14 | |
| PCT/US2003/036614 WO2004046327A2 (en) | 2002-11-14 | 2003-11-14 | Inhibitory oliogonucleotides targeted to bcl-2 |
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| JP2006514546A true JP2006514546A (ja) | 2006-05-11 |
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| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US20060229267A1 (en) * | 2004-06-01 | 2006-10-12 | Reza Sheikhnejad | Methods and compositions for the inhibition of gene expression |
| CA2631677C (en) * | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| WO2009071681A2 (en) * | 2007-12-07 | 2009-06-11 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of bcl-2 |
| TW201019969A (en) * | 2008-11-17 | 2010-06-01 | Enzon Pharmaceuticals Inc | Branched cationic lipids for nucleic acids delivery system |
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| US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US5734033A (en) * | 1988-12-22 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Antisense oligonucleotides inhibiting human bcl-2 gene expression |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5912147A (en) * | 1996-10-22 | 1999-06-15 | Health Research, Inc. | Rapid means of quantitating genomic instability |
| US6041181A (en) * | 1997-07-23 | 2000-03-21 | International Business Machines Corporation | Method of, system for, and computer program product for providing quick fusion in WHERE constructs |
| US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
| DE69938128D1 (de) | 1998-03-28 | 2008-03-27 | Univ Utah Res Found | Zielgerichtete antisense-bibliotheken |
| CA2365984A1 (en) | 1999-04-08 | 2000-10-19 | Oasis Biosciences, Inc. | Antisense oligonucleotides comprising universal and/or degenerate bases |
| US6310047B1 (en) | 1999-08-24 | 2001-10-30 | Virginia Commonwealth University | High affinity DNA binding compounds as adjuvants in antisense technology |
| US7056653B2 (en) | 2000-02-10 | 2006-06-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Detection of binding of charged species using PH- or potential-sensitive probes |
| US7795232B1 (en) * | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| US7060690B2 (en) * | 2001-01-22 | 2006-06-13 | Genta Incorporated | Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof |
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