CA2505680A1 - Inhibitory oliogonucleotides targeted to bcl-2 - Google Patents
Inhibitory oliogonucleotides targeted to bcl-2 Download PDFInfo
- Publication number
- CA2505680A1 CA2505680A1 CA002505680A CA2505680A CA2505680A1 CA 2505680 A1 CA2505680 A1 CA 2505680A1 CA 002505680 A CA002505680 A CA 002505680A CA 2505680 A CA2505680 A CA 2505680A CA 2505680 A1 CA2505680 A1 CA 2505680A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- oligonucleotide
- oligonucleotides
- bcl
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
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- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Landscapes
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- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
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- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
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- Oncology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42626902P | 2002-11-14 | 2002-11-14 | |
| US60/426,269 | 2002-11-14 | ||
| PCT/US2003/036614 WO2004046327A2 (en) | 2002-11-14 | 2003-11-14 | Inhibitory oliogonucleotides targeted to bcl-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2505680A1 true CA2505680A1 (en) | 2004-06-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002505680A Abandoned CA2505680A1 (en) | 2002-11-14 | 2003-11-14 | Inhibitory oliogonucleotides targeted to bcl-2 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7256284B2 (enExample) |
| EP (1) | EP1572970A4 (enExample) |
| JP (1) | JP2006514546A (enExample) |
| AU (1) | AU2003295561A1 (enExample) |
| CA (1) | CA2505680A1 (enExample) |
| WO (1) | WO2004046327A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US20080152700A1 (en) * | 2004-06-01 | 2008-06-26 | Reza Sheikhnejad | Methods and compositions for the inhibition of gene expression |
| US8367628B2 (en) | 2005-12-01 | 2013-02-05 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| WO2009071681A2 (en) * | 2007-12-07 | 2009-06-11 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of bcl-2 |
| JP2012509258A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための分岐カチオン性脂質 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5734033A (en) * | 1988-12-22 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Antisense oligonucleotides inhibiting human bcl-2 gene expression |
| US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5912147A (en) * | 1996-10-22 | 1999-06-15 | Health Research, Inc. | Rapid means of quantitating genomic instability |
| US6041181A (en) * | 1997-07-23 | 2000-03-21 | International Business Machines Corporation | Method of, system for, and computer program product for providing quick fusion in WHERE constructs |
| US7704962B1 (en) * | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
| EP1068350B1 (en) | 1998-03-28 | 2008-02-13 | University Of Utah Research Foundation | Directed antisense libraries |
| CA2365984A1 (en) | 1999-04-08 | 2000-10-19 | Oasis Biosciences, Inc. | Antisense oligonucleotides comprising universal and/or degenerate bases |
| US6310047B1 (en) | 1999-08-24 | 2001-10-30 | Virginia Commonwealth University | High affinity DNA binding compounds as adjuvants in antisense technology |
| US7056653B2 (en) | 2000-02-10 | 2006-06-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Detection of binding of charged species using PH- or potential-sensitive probes |
| US7795232B1 (en) * | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| AU2002241952A1 (en) * | 2001-01-22 | 2002-07-30 | Genta Incorporated | Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers |
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2003
- 2003-11-14 JP JP2004553781A patent/JP2006514546A/ja active Pending
- 2003-11-14 WO PCT/US2003/036614 patent/WO2004046327A2/en not_active Ceased
- 2003-11-14 EP EP03786757A patent/EP1572970A4/en not_active Withdrawn
- 2003-11-14 CA CA002505680A patent/CA2505680A1/en not_active Abandoned
- 2003-11-14 AU AU2003295561A patent/AU2003295561A1/en not_active Abandoned
- 2003-11-14 US US10/714,310 patent/US7256284B2/en not_active Expired - Fee Related
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2007
- 2007-07-12 US US11/827,995 patent/US20080096835A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080096835A1 (en) | 2008-04-24 |
| AU2003295561A1 (en) | 2004-06-15 |
| EP1572970A2 (en) | 2005-09-14 |
| US7256284B2 (en) | 2007-08-14 |
| WO2004046327A3 (en) | 2005-12-29 |
| EP1572970A4 (en) | 2006-11-15 |
| WO2004046327A2 (en) | 2004-06-03 |
| JP2006514546A (ja) | 2006-05-11 |
| US20040152654A1 (en) | 2004-08-05 |
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