JP2006514066A5 - - Google Patents
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- Publication number
- JP2006514066A5 JP2006514066A5 JP2004566575A JP2004566575A JP2006514066A5 JP 2006514066 A5 JP2006514066 A5 JP 2006514066A5 JP 2004566575 A JP2004566575 A JP 2004566575A JP 2004566575 A JP2004566575 A JP 2004566575A JP 2006514066 A5 JP2006514066 A5 JP 2006514066A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- dimethylphenyl
- hydrogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- -1 2,6-dimethylphenyl Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 6
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 3
- 239000005977 Ethylene Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000029549 Muscle injury Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- VXPLXMJHHKHSOA-UHFFFAOYSA-N propham Chemical compound CC(C)OC(=O)NC1=CC=CC=C1 VXPLXMJHHKHSOA-UHFFFAOYSA-N 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43786003P | 2003-01-03 | 2003-01-03 | |
| PCT/US2003/040607 WO2004063180A1 (en) | 2003-01-03 | 2003-12-19 | Substituted heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514066A JP2006514066A (ja) | 2006-04-27 |
| JP2006514066A5 true JP2006514066A5 (https=) | 2006-12-07 |
Family
ID=32713240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004566575A Pending JP2006514066A (ja) | 2003-01-03 | 2003-12-19 | 置換ヘテロ環化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7205303B2 (https=) |
| EP (1) | EP1578737B1 (https=) |
| JP (1) | JP2006514066A (https=) |
| KR (1) | KR20050086956A (https=) |
| AT (1) | ATE443058T1 (https=) |
| AU (1) | AU2003303676A1 (https=) |
| CA (1) | CA2512261A1 (https=) |
| DE (1) | DE60329323D1 (https=) |
| ES (1) | ES2329997T3 (https=) |
| NZ (1) | NZ541069A (https=) |
| WO (1) | WO2004063180A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ541069A (en) * | 2003-01-03 | 2008-09-26 | Cv Therapeutics Inc | Piperazine derivatives as fatty acid oxidation inhibitors |
| BRPI1009800A2 (pt) * | 2009-04-02 | 2016-03-15 | Merck Patent Gmbh | compostos heterocíclicos como inibidores de autotaxina |
| WO2011026241A1 (en) * | 2009-09-04 | 2011-03-10 | Zalicus Pharmaceuticals Ltd. | Substituted heterocyclic derivatives for the treatment of pain and epilepsy |
| EP2961403A4 (en) | 2013-03-01 | 2016-11-30 | Zalicus Pharmaceuticals Ltd | HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US181352A (en) * | 1876-08-22 | Improvement in cotton-cleaners | ||
| US729499A (en) * | 1901-08-12 | 1903-05-26 | John Machaffie | Igniter for gas-engines. |
| US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
| JPS584774A (ja) * | 1981-06-23 | 1983-01-11 | ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ | Ｎ−アリ−ル−ピペラジンアルカンアミド類 |
| US4558129A (en) | 1983-05-18 | 1985-12-10 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade |
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| US4588129A (en) * | 1983-09-06 | 1986-05-13 | Hudson Oxygen Therapy Sales Company | Nebulizer |
| ATE142497T1 (de) | 1989-06-23 | 1996-09-15 | Syntex Inc | Ranolazin und verwandte piperazine zur behandlung von geweben, von physischen oder chemischen schäden betroffen |
| JPH03141258A (ja) | 1989-10-25 | 1991-06-17 | Kowa Co | 新規なピペラジン誘導体 |
| HU209723B (en) | 1990-10-31 | 1994-10-28 | Richter Gedeon Vegyeszet | Process for producing of piperazine derivatives |
| US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
| AU2001238590A1 (en) * | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| US6677336B2 (en) * | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| US6552023B2 (en) * | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
| IL151178A0 (en) * | 2000-02-22 | 2003-04-10 | Cv Therapeutics Inc | Substituted piperazine compounds |
| US6451798B2 (en) * | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
| AU2001239827A1 (en) * | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted alkylene diamine compounds |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| SE0003795D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
| US6573264B1 (en) * | 2000-10-23 | 2003-06-03 | Cv Therapeutics, Inc. | Heteroaryl alkyl piperazine derivatives |
| WO2003008411A1 (en) | 2001-07-19 | 2003-01-30 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
| CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
| AU2003300827B2 (en) * | 2002-12-05 | 2009-08-13 | Gilead Palo Alto, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
| NZ541069A (en) * | 2003-01-03 | 2008-09-26 | Cv Therapeutics Inc | Piperazine derivatives as fatty acid oxidation inhibitors |
-
2003
- 2003-12-19 NZ NZ541069A patent/NZ541069A/en unknown
- 2003-12-19 EP EP03808498A patent/EP1578737B1/en not_active Expired - Lifetime
- 2003-12-19 AT AT03808498T patent/ATE443058T1/de not_active IP Right Cessation
- 2003-12-19 CA CA002512261A patent/CA2512261A1/en not_active Abandoned
- 2003-12-19 WO PCT/US2003/040607 patent/WO2004063180A1/en not_active Ceased
- 2003-12-19 US US10/745,224 patent/US7205303B2/en not_active Expired - Lifetime
- 2003-12-19 ES ES03808498T patent/ES2329997T3/es not_active Expired - Lifetime
- 2003-12-19 KR KR1020057012518A patent/KR20050086956A/ko not_active Ceased
- 2003-12-19 AU AU2003303676A patent/AU2003303676A1/en not_active Abandoned
- 2003-12-19 DE DE60329323T patent/DE60329323D1/de not_active Expired - Lifetime
- 2003-12-19 JP JP2004566575A patent/JP2006514066A/ja active Pending
-
2007
- 2007-03-08 US US11/683,917 patent/US20070155728A1/en not_active Abandoned
-
2008
- 2008-07-09 US US12/170,199 patent/US7566717B2/en not_active Expired - Lifetime
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