JP2006513199A - 口内乾燥の治療に使用できる、過酸化脂質に基づく油性組成物 - Google Patents
口内乾燥の治療に使用できる、過酸化脂質に基づく油性組成物 Download PDFInfo
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- JP2006513199A JP2006513199A JP2004563301A JP2004563301A JP2006513199A JP 2006513199 A JP2006513199 A JP 2006513199A JP 2004563301 A JP2004563301 A JP 2004563301A JP 2004563301 A JP2004563301 A JP 2004563301A JP 2006513199 A JP2006513199 A JP 2006513199A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Emergency Medicine (AREA)
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- Nutrition Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Edible Oils And Fats (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
Description
−口腔内に使用できる抗菌剤(例えば、クロルヘキシジン)
−口腔内に使用できる任意の局所用抗真菌剤であってもよい抗真菌剤(例えば、イミジアゾール(imidiazole)を含む誘導体、接触性抗真菌性抗生物質(contact antifungal antibiotic agent))
−口腔内における上記組成物の許容性を改善するための薬剤(例えば許容因子又は緩和因子として知られる任意の成分)
−製剤の安定化剤(例えば、バッファー、増粘剤若しくは流体化剤、又は、pH中和剤)
−抗菌効果のある薬剤等の製剤の保護剤、又は、防腐剤(例えば、p−ヒドロキシ安息香酸のエステル(例えば、パラヒドロキシ安息香酸メチル、パラヒドロキシ安息香酸プロピル)又はイソチアゾリノン)
−芳香性組成物(例えば、食用香料、精油、植物又は果物の抽出物)
等の、口腔内に使用できる他の要素を更に含むことも可能であろう。
a.組成
・過酸化度50〜150ミリ等量/kgの過酸化トウモロコシ油:94.4%
・ナトリウム二酸化物(AEROSIL300(R)、デグサ社):1.5%
・ミント食用香料:1.0%
・オレンジ−グレープフルーツ食用香料:3.0%
・アスパルテーム:0.1%
a.試験の目的
この試験は、口内乾燥症状のある使用者について、トリグリセリド酸化物の効果を評価することからなる。
試験物質を、使用者の口腔内に、一押しで100μL分散するポンプ及びチューブを備えた装置を使用して微細な霧状でスプレーし、投与頻度は必要なだけとする。毎食後、かつ、必要となる度に、一回又は二回スプレーし、患者は、投与の度に事前に口を十分にすすぐ。
c1.使用者が実施した評価
使用者がD0において10cmのアナロジースケール(analogical scale)を使用して評価した不自由さの強度は、平均6.34である。
実験者が臨床的に観察することによって、使用者が報告した有益な効果を確認する。
Claims (13)
- 過酸化脂質及びシリカに基づく油性の医薬組成物であって、
過酸化度が5〜600ミリ等量/kgである過酸化脂質、及び、0.5重量%以上かつ4重量%未満の含量で前記過酸化脂質中に分散しているシリカを必須成分として含む
ことを特徴とする医薬組成物。 - シリカを0.5〜3.5重量%含む
ことを特徴とする請求項1に記載の医薬組成物。 - シリカを0.5〜2重量%含む
ことを特徴とする請求項1又は2に記載の医薬組成物。 - スプレー使用可能な形態である
ことを特徴とする請求項1〜3のいずれか1項に記載の医薬組成物。 - シリカはコロイダルシリカの形態である
ことを特徴とする請求項1〜4のいずれか1項に記載の医薬組成物。 - 組成物調製時に、毛細管粘度計を使用して測定した20℃における動的粘度が26.6〜44.4mm2/sである
ことを特徴とする請求項1〜5のいずれか1項に記載の医薬組成物。 - 密度が0.95±10%である
ことを特徴とする請求項1〜6のいずれか1項に記載の組成物。 - 過酸化脂質の過酸化度が5〜600ミリ等量/kg、好ましくは30〜500ミリ等量/kg、より好ましくは50〜300ミリ等量/kg、より好ましくは50〜150ミリ等量/kgである
ことを特徴とする請求項1〜7のいずれか1項に記載の組成物。 - 過酸化脂質は、天然の脂質又は脂肪を、好ましくは天然植物油に由来する脂質を過酸化することによって得られる
ことを特徴とする請求項1〜9のいずれか1項に記載の医薬組成物。 - 天然油は、スイートアーモンド油、ヘーゼルナッツ油、ピーナッツ油、トウモロコシ油、グレープシード油、ゴマ油及びベニバナ油、並びに、これらの混合物からなる群より選択される
ことを特徴とする請求項10に記載の医薬組成物。 - 口内乾燥治療用の医薬組成物を調製するための、請求項1又は8〜11のいずれか1項に記載の過酸化脂質の使用。
- 前記組成物は、少なくとも0.5重量%かつ4重量%未満の、好ましくは0.5〜3.5重量%の、より好ましくは0.5〜2重量%のコロイダルシリカを含む、
ことを特徴とする請求項12に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR02/16517 | 2002-12-23 | ||
FR0216517A FR2848852B1 (fr) | 2002-12-23 | 2002-12-23 | Composition huileuse a base de lipides peroxydes utilisable dans le traitement de la xerostomie |
PCT/FR2003/003861 WO2004058138A2 (fr) | 2002-12-23 | 2003-12-22 | Composition huileuse a base de lipides peroxydes utilisable dans le traitement de la xerostomie |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006513199A true JP2006513199A (ja) | 2006-04-20 |
JP4712393B2 JP4712393B2 (ja) | 2011-06-29 |
Family
ID=32406398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004563301A Expired - Lifetime JP4712393B2 (ja) | 2002-12-23 | 2003-12-22 | 口内乾燥の治療に使用できる、過酸化脂質に基づく油性組成物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8367650B2 (ja) |
EP (1) | EP1575670B1 (ja) |
JP (1) | JP4712393B2 (ja) |
AT (1) | ATE482746T1 (ja) |
AU (1) | AU2003303330A1 (ja) |
BR (1) | BRPI0317196B1 (ja) |
DE (1) | DE60334403D1 (ja) |
ES (1) | ES2358073T3 (ja) |
FR (1) | FR2848852B1 (ja) |
WO (1) | WO2004058138A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012508772A (ja) * | 2008-11-13 | 2012-04-12 | ヴイディーエフ・フューチャーシューティカルズ,インコーポレーテッド | 唾液分泌減退を緩和し口腔の快適性を提供するための組成物および方法 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1902753A1 (de) * | 2006-09-19 | 2008-03-26 | Thomas Dr. Tenspolde | Spülung für den Mundinnenraum |
US9597278B2 (en) | 2008-11-13 | 2017-03-21 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
US9884082B2 (en) | 2008-11-13 | 2018-02-06 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
MX338801B (es) | 2011-05-16 | 2016-05-02 | Colgate Palmolive Co | Composiciones de cuidado oral. |
CN104208564A (zh) * | 2014-09-25 | 2014-12-17 | 周红玲 | 一种治疗反复性口腔溃疡的中药 |
FR3053252B1 (fr) * | 2016-06-29 | 2020-04-24 | Laboratoires Carilene | Produit, ou agent actif, ou composition pour le soin des seins en periode pre-mensuelle ou menstruelle ou pour le soin de la symptomatologie des mastodynies |
AU2018392886B2 (en) | 2017-12-20 | 2021-12-23 | Solventum Intellectual Properties Company | Oral compositions and methods of use |
AU2019381843A1 (en) | 2018-11-16 | 2021-07-01 | Decima Diagnostics, LLC. | Oral wash for oral fluid collection and analysis and methods of use thereof |
AU2021353503A1 (en) | 2020-09-29 | 2023-05-11 | Decima Diagnostics, LLC | Compositions, kits and methods for collecting analyte in a saliva sample |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1077061A2 (fr) * | 1999-08-16 | 2001-02-21 | Stéphane Desjonqueres | Utilisation de lipides peroxydés dans le traitement ou la prévention des plaies et inflammations des muqueuses de la cavité buccale |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2591110B1 (fr) * | 1985-12-06 | 1989-02-24 | Desjonqueres Stephane | Composition medicamenteuse a base d'huile naturelle d'origine vegetale destinee a etre utilisee pour le traitement des hemorroides. |
FR2649011A1 (fr) * | 1989-07-03 | 1991-01-04 | Carilene Laboratoires | Produit medicamenteux pour la revascularisation des tissus |
FR2705568B1 (fr) * | 1993-05-27 | 1995-08-18 | Carilene Laboratoires | Utilisation de lipides peroxydés pour la préparation d'une composition pharmaceutique destinées au traitement par application locale des télangiectasies. |
-
2002
- 2002-12-23 FR FR0216517A patent/FR2848852B1/fr not_active Expired - Fee Related
-
2003
- 2003-12-22 US US10/538,835 patent/US8367650B2/en active Active
- 2003-12-22 DE DE60334403T patent/DE60334403D1/de not_active Expired - Lifetime
- 2003-12-22 AU AU2003303330A patent/AU2003303330A1/en not_active Abandoned
- 2003-12-22 ES ES03813932T patent/ES2358073T3/es not_active Expired - Lifetime
- 2003-12-22 AT AT03813932T patent/ATE482746T1/de not_active IP Right Cessation
- 2003-12-22 BR BRPI0317196A patent/BRPI0317196B1/pt not_active IP Right Cessation
- 2003-12-22 JP JP2004563301A patent/JP4712393B2/ja not_active Expired - Lifetime
- 2003-12-22 WO PCT/FR2003/003861 patent/WO2004058138A2/fr active Application Filing
- 2003-12-22 EP EP03813932A patent/EP1575670B1/fr not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1077061A2 (fr) * | 1999-08-16 | 2001-02-21 | Stéphane Desjonqueres | Utilisation de lipides peroxydés dans le traitement ou la prévention des plaies et inflammations des muqueuses de la cavité buccale |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012508772A (ja) * | 2008-11-13 | 2012-04-12 | ヴイディーエフ・フューチャーシューティカルズ,インコーポレーテッド | 唾液分泌減退を緩和し口腔の快適性を提供するための組成物および方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1575670A2 (fr) | 2005-09-21 |
ATE482746T1 (de) | 2010-10-15 |
EP1575670B1 (fr) | 2010-09-29 |
US20060078620A1 (en) | 2006-04-13 |
WO2004058138A2 (fr) | 2004-07-15 |
JP4712393B2 (ja) | 2011-06-29 |
FR2848852A1 (fr) | 2004-06-25 |
AU2003303330A8 (en) | 2004-07-22 |
FR2848852B1 (fr) | 2007-03-16 |
AU2003303330A1 (en) | 2004-07-22 |
US8367650B2 (en) | 2013-02-05 |
BRPI0317196B1 (pt) | 2016-09-27 |
DE60334403D1 (de) | 2010-11-11 |
WO2004058138A3 (fr) | 2004-09-30 |
BR0317196A (pt) | 2005-11-01 |
ES2358073T3 (es) | 2011-05-05 |
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