JP2006513185A5 - - Google Patents
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- Publication number
- JP2006513185A5 JP2006513185A5 JP2004561284A JP2004561284A JP2006513185A5 JP 2006513185 A5 JP2006513185 A5 JP 2006513185A5 JP 2004561284 A JP2004561284 A JP 2004561284A JP 2004561284 A JP2004561284 A JP 2004561284A JP 2006513185 A5 JP2006513185 A5 JP 2006513185A5
- Authority
- JP
- Japan
- Prior art keywords
- polymorph
- crude
- ethanol
- pure
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 13
- 238000000034 method Methods 0.000 claims 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- -1 2-morpholin-4-yl-ethoxy Chemical group 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- ZGGDOFNPCAHTKI-UHFFFAOYSA-N 3-tert-butyl-1-(4-methylphenyl)pyrazol-4-amine Chemical compound C1=CC(C)=CC=C1N1N=C(C(C)(C)C)C(N)=C1 ZGGDOFNPCAHTKI-UHFFFAOYSA-N 0.000 claims 1
- MROVYGBBVOSFPE-UHFFFAOYSA-N 4-(2-morpholin-4-ylethoxy)naphthalen-1-amine Chemical compound C12=CC=CC=C2C(N)=CC=C1OCCN1CCOCC1 MROVYGBBVOSFPE-UHFFFAOYSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43613602P | 2002-12-23 | 2002-12-23 | |
| PCT/EP2003/014128 WO2004056783A1 (en) | 2002-12-23 | 2003-12-12 | Process for the preparation of an essentially pure polymorph of an n-pyrazolyl-n'-naphthyl-urea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006513185A JP2006513185A (ja) | 2006-04-20 |
| JP2006513185A5 true JP2006513185A5 (enExample) | 2007-02-08 |
Family
ID=32682346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004561284A Pending JP2006513185A (ja) | 2002-12-23 | 2003-12-12 | Ｎ−ピラゾリル−ｎ’−ナフチル−尿素の実質的に純粋な多形体の調製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040138216A1 (enExample) |
| EP (1) | EP1581502A1 (enExample) |
| JP (1) | JP2006513185A (enExample) |
| AU (1) | AU2003298178A1 (enExample) |
| CA (1) | CA2511325A1 (enExample) |
| WO (1) | WO2004056783A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| EP1716121A1 (en) * | 2003-12-18 | 2006-11-02 | Boehringer Ingelheim Pharmaceuticals Inc. | Polymorph of birb 796, a p38map kinase inhibitor |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| CA2684950A1 (en) | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CN111818915B (zh) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| AU2019216351B2 (en) | 2018-01-31 | 2024-07-25 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of mastocytosis |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| NZ784949A (en) | 2019-08-12 | 2025-09-26 | Deciphera Pharmaceuticals Llc | Ripretinib for treating gastrointestinal stromal tumors |
| KR20250057151A (ko) | 2019-12-30 | 2025-04-28 | 데시페라 파마슈티칼스, 엘엘씨 | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의조성물 |
| AU2020419197B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| DE60024830T2 (de) * | 1999-07-09 | 2006-06-14 | Boehringer Ingelheim Pharma | Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen |
| JP4263336B2 (ja) * | 2000-04-12 | 2009-05-13 | パイオニア株式会社 | プラズマディスプレイパネルの隔壁構造 |
| MXPA03006749A (es) * | 2001-02-15 | 2004-05-31 | Boehringer Ingelheim Pharma | Proceso para la sintesis de compuestos de urea sustituidos con heteroarilo, utiles como agentes antiinflamatorios. |
-
2003
- 2003-12-03 US US10/727,214 patent/US20040138216A1/en not_active Abandoned
- 2003-12-12 CA CA002511325A patent/CA2511325A1/en not_active Abandoned
- 2003-12-12 AU AU2003298178A patent/AU2003298178A1/en not_active Abandoned
- 2003-12-12 WO PCT/EP2003/014128 patent/WO2004056783A1/en not_active Ceased
- 2003-12-12 JP JP2004561284A patent/JP2006513185A/ja active Pending
- 2003-12-12 EP EP03795888A patent/EP1581502A1/en not_active Withdrawn
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