JP2006512897A5 - - Google Patents
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- Publication number
- JP2006512897A5 JP2006512897A5 JP2004524880A JP2004524880A JP2006512897A5 JP 2006512897 A5 JP2006512897 A5 JP 2006512897A5 JP 2004524880 A JP2004524880 A JP 2004524880A JP 2004524880 A JP2004524880 A JP 2004524880A JP 2006512897 A5 JP2006512897 A5 JP 2006512897A5
- Authority
- JP
- Japan
- Prior art keywords
- pth
- composition
- pthrp receptor
- individual
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 39
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims 30
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims 30
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 16
- 239000000126 substance Substances 0.000 claims 14
- 210000000963 osteoblast Anatomy 0.000 claims 6
- 230000001737 promoting effect Effects 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 5
- 238000012423 maintenance Methods 0.000 claims 5
- 239000000018 receptor agonist Substances 0.000 claims 5
- 229940044601 receptor agonist Drugs 0.000 claims 5
- 210000002536 stromal cell Anatomy 0.000 claims 5
- 210000001185 bone marrow Anatomy 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 210000002751 lymph Anatomy 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 2
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000006353 environmental stress Effects 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39880102P | 2002-07-25 | 2002-07-25 | |
| US60/398,801 | 2002-07-25 | ||
| PCT/US2003/023425 WO2004011484A2 (en) | 2002-07-25 | 2003-07-25 | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006512897A JP2006512897A (ja) | 2006-04-20 |
| JP2006512897A5 true JP2006512897A5 (enExample) | 2007-10-04 |
| JP4750416B2 JP4750416B2 (ja) | 2011-08-17 |
Family
ID=31188487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004524880A Expired - Fee Related JP4750416B2 (ja) | 2002-07-25 | 2003-07-25 | 副甲状腺ホルモン受容体の活性化と造血前駆細胞の増殖 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7429383B2 (enExample) |
| EP (1) | EP1545603B1 (enExample) |
| JP (1) | JP4750416B2 (enExample) |
| AU (1) | AU2003256839B2 (enExample) |
| CA (1) | CA2492295C (enExample) |
| WO (1) | WO2004011484A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2492295C (en) | 2002-07-25 | 2014-01-28 | The General Hospital Corporation | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
| US7635477B2 (en) | 2002-07-25 | 2009-12-22 | The General Hospital Corporation | Parathyroid hormone receptor activation and stem and progenitor cell expansion |
| AU2005304687B2 (en) * | 2004-11-11 | 2012-01-19 | The General Hosptial Corporation | Parathyroid hormone receptor activation and stem and progenitor cell expansion |
| EP2094839B1 (en) | 2006-12-08 | 2020-02-05 | University of Rochester | Expansion of hematopoietic stem cells |
| ES2583002T3 (es) * | 2007-04-09 | 2016-09-16 | The Board Of Trustees Of The University Of Arkansas | Proteínas de fusión de un dominio de enlazamiento a colágeno y hormona paratiroidea |
| WO2011011675A1 (en) * | 2009-07-23 | 2011-01-27 | Zelos Therapeutics, Inc. | Pharmaceutically acceptable formulations/compositions for peptidyl drugs |
| WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
| US9579273B2 (en) | 2011-12-14 | 2017-02-28 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| AU2017281631B2 (en) * | 2016-06-23 | 2023-06-15 | Tithon Biotech, Inc. | Cells expressing parathyroid hormone 1 receptor and uses thereof |
| US11624060B2 (en) | 2017-02-10 | 2023-04-11 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5747456A (en) * | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| US6342477B1 (en) * | 1996-02-01 | 2002-01-29 | Chugai Seiyaku Kabushiki Kaisha | Remedies for thrombocytopenia |
| JP4053107B2 (ja) * | 1996-02-01 | 2008-02-27 | 中外製薬株式会社 | 血小板減少症の予防剤および治療剤 |
| AU5268600A (en) * | 1999-05-14 | 2000-12-05 | City Of Hope | (ex vivo) expansion of mammalian hematopoietic stem cells |
| WO2001012785A1 (en) | 1999-08-13 | 2001-02-22 | University Of Rochester | Ex vivo generation of functional osteoclasts from bone marrow in a three-dimensional bioreactor |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| CA2492295C (en) | 2002-07-25 | 2014-01-28 | The General Hospital Corporation | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
-
2003
- 2003-07-25 CA CA2492295A patent/CA2492295C/en not_active Expired - Fee Related
- 2003-07-25 JP JP2004524880A patent/JP4750416B2/ja not_active Expired - Fee Related
- 2003-07-25 US US10/521,971 patent/US7429383B2/en not_active Expired - Lifetime
- 2003-07-25 EP EP03771904.4A patent/EP1545603B1/en not_active Expired - Lifetime
- 2003-07-25 WO PCT/US2003/023425 patent/WO2004011484A2/en not_active Ceased
- 2003-07-25 AU AU2003256839A patent/AU2003256839B2/en not_active Ceased
-
2008
- 2008-08-28 US US12/200,419 patent/US7776334B2/en not_active Expired - Fee Related
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