JP2006512292A5 - - Google Patents
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- Publication number
- JP2006512292A5 JP2006512292A5 JP2004536597A JP2004536597A JP2006512292A5 JP 2006512292 A5 JP2006512292 A5 JP 2006512292A5 JP 2004536597 A JP2004536597 A JP 2004536597A JP 2004536597 A JP2004536597 A JP 2004536597A JP 2006512292 A5 JP2006512292 A5 JP 2006512292A5
- Authority
- JP
- Japan
- Prior art keywords
- nell
- probe
- antibody
- seq
- hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000523 sample Substances 0.000 description 4
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 238000002105 Southern blotting Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- OXEUETBFKVCRNP-UHFFFAOYSA-N 9-ethyl-3-carbazolamine Chemical compound NC1=CC=C2N(CC)C3=CC=CC=C3C2=C1 OXEUETBFKVCRNP-UHFFFAOYSA-N 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 108010032337 diaminobenzidine peroxidase Proteins 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41084602P | 2002-09-13 | 2002-09-13 | |
| PCT/US2003/029281 WO2004024893A2 (en) | 2002-09-13 | 2003-09-15 | Nell-1 enhanced bone mineralization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512292A JP2006512292A (ja) | 2006-04-13 |
| JP2006512292A5 true JP2006512292A5 (enExample) | 2009-10-08 |
Family
ID=31994216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536597A Pending JP2006512292A (ja) | 2002-09-13 | 2003-09-15 | Ｎｅｌｌ−１による骨石灰化の増進 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060111313A1 (enExample) |
| EP (1) | EP1551978A4 (enExample) |
| JP (1) | JP2006512292A (enExample) |
| KR (1) | KR20050084550A (enExample) |
| CN (1) | CN1867673A (enExample) |
| AU (1) | AU2003270736A1 (enExample) |
| CA (1) | CA2498751A1 (enExample) |
| WO (1) | WO2004024893A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7052856B2 (en) | 1999-10-05 | 2006-05-30 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| US7687462B2 (en) | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
| US20090060988A1 (en) * | 1999-10-05 | 2009-03-05 | Kang Ting | Nell-1 enhanced bone mineralization |
| US7884066B2 (en) | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| CN101018562A (zh) | 2003-02-07 | 2007-08-15 | 加州大学董事会 | Nell肽表达系统和nell肽的骨形成活性 |
| US7691607B2 (en) | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
| US20060053503A1 (en) * | 2004-07-30 | 2006-03-09 | Ut-Battelle, Llc | Cranial and vertebral defects associated with loss-of-function of Nell |
| CA2597605A1 (en) | 2005-02-16 | 2006-08-24 | The Regents Of The University Of California | Pharmaceutical compositions for treating or preventing bone conditions |
| WO2009045800A1 (en) * | 2007-09-28 | 2009-04-09 | Culiat Cymbeline T | Treatment of cardiovascular disorders using the cell differentiation signaling protein nell1 |
| JP2010540557A (ja) * | 2007-09-28 | 2010-12-24 | ユーティー−バッテル・エルエルシー | 細胞シグナル伝達タンパク質ｎｅｌｌ１を用いた、創傷治癒及び筋再生の促進方法 |
| WO2010016469A1 (ja) | 2008-08-04 | 2010-02-11 | 片山化学工業株式会社 | Ｎｅｌｌ－１による組織・臓器異所再生制御技術 |
| ES2595364T3 (es) | 2008-10-07 | 2016-12-29 | The Regents Of The University Of California | Producción de proteínas NELL recombinantes |
| WO2010062738A1 (en) * | 2008-11-03 | 2010-06-03 | Ut-Battelle, Llc | Diagnosis and treatment of congenital heart defects using nell 1 |
| CA2756168A1 (en) | 2009-03-25 | 2010-09-30 | Kang Ting | Isoform nell-1 peptide |
| CA2932787A1 (en) * | 2013-12-06 | 2015-06-11 | Novimmune S.A. | Anti-tlr4 antibodies and methods of use thereof |
| US10752663B2 (en) | 2016-08-29 | 2020-08-25 | NellOne Therapeutics, Inc. | Methods and compositions for regenerating tissues |
| CN116763987B (zh) * | 2023-05-05 | 2025-08-22 | 吉林大学 | 一种侧枝改性的Gelma水凝胶的制备方法及其应用 |
| CN116768996B (zh) * | 2023-05-30 | 2024-09-06 | 华南农业大学 | 一种形成素蛋白基因OsFH2在植物育种调控中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4409332A (en) * | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5674725A (en) * | 1991-07-11 | 1997-10-07 | British Technology Group Limited | Implant materials having a phosphatase and an organophosphorus compound for in vivo mineralization of bone |
| US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| US5763416A (en) * | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
| US5942496A (en) * | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US6083690A (en) * | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
| US6352972B1 (en) * | 1995-06-06 | 2002-03-05 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
| US6008208A (en) * | 1995-10-23 | 1999-12-28 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
| US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US6005088A (en) * | 1996-03-19 | 1999-12-21 | Otsuka Pharmaceutical Co., Ltd. | Human NPIK gene |
| US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
| US6462019B1 (en) * | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
| US7052856B2 (en) * | 1999-10-05 | 2006-05-30 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| GB0011356D0 (en) * | 2000-05-12 | 2000-06-28 | Univ Nottingham Trent | Medical implant materials |
-
2003
- 2003-09-15 WO PCT/US2003/029281 patent/WO2004024893A2/en not_active Ceased
- 2003-09-15 EP EP03752446A patent/EP1551978A4/en not_active Ceased
- 2003-09-15 AU AU2003270736A patent/AU2003270736A1/en not_active Abandoned
- 2003-09-15 US US10/527,786 patent/US20060111313A1/en not_active Abandoned
- 2003-09-15 KR KR1020057004382A patent/KR20050084550A/ko not_active Ceased
- 2003-09-15 CN CNA038249758A patent/CN1867673A/zh active Pending
- 2003-09-15 CA CA002498751A patent/CA2498751A1/en not_active Abandoned
- 2003-09-15 JP JP2004536597A patent/JP2006512292A/ja active Pending
-
2007
- 2007-10-09 US US11/973,831 patent/US20090047275A1/en not_active Abandoned
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