JP2006512090A5 - - Google Patents
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- Publication number
- JP2006512090A5 JP2006512090A5 JP2005507928A JP2005507928A JP2006512090A5 JP 2006512090 A5 JP2006512090 A5 JP 2006512090A5 JP 2005507928 A JP2005507928 A JP 2005507928A JP 2005507928 A JP2005507928 A JP 2005507928A JP 2006512090 A5 JP2006512090 A5 JP 2006512090A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- acid sequence
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 136
- 108090000765 processed proteins & peptides Proteins 0.000 claims 55
- 125000003275 alpha amino acid group Chemical group 0.000 claims 50
- 229920001184 polypeptide Polymers 0.000 claims 49
- 102000004196 processed proteins & peptides Human genes 0.000 claims 49
- 108030001720 Bontoxilysin Proteins 0.000 claims 36
- 102000040430 polynucleotide Human genes 0.000 claims 33
- 108091033319 polynucleotide Proteins 0.000 claims 33
- 239000002157 polynucleotide Substances 0.000 claims 33
- 239000003795 chemical substances by application Substances 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 17
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 101000714466 Mus musculus Synaptotagmin-1 Proteins 0.000 claims 10
- 101000891892 Mus musculus Synaptotagmin-2 Proteins 0.000 claims 10
- 108010055170 Synaptotagmin I Proteins 0.000 claims 8
- 102100036417 Synaptotagmin-1 Human genes 0.000 claims 8
- -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 7
- 150000002270 gangliosides Chemical class 0.000 claims 7
- 108010055445 Synaptotagmin II Proteins 0.000 claims 6
- 102100036151 Synaptotagmin-2 Human genes 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 102000003137 synaptotagmin Human genes 0.000 claims 6
- 108060008004 synaptotagmin Proteins 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 241000193155 Clostridium botulinum Species 0.000 claims 2
- 229940053031 botulinum toxin Drugs 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108010074523 rimabotulinumtoxinB Proteins 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 125000002421 ganglioside group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42295102P | 2002-10-31 | 2002-10-31 | |
| US49812803P | 2003-08-27 | 2003-08-27 | |
| PCT/US2003/034348 WO2005016233A2 (en) | 2002-10-31 | 2003-10-28 | Botulinum neurotoxin b receptors and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009229744A Division JP2010006833A (ja) | 2002-10-31 | 2009-10-01 | ボツリヌス神経毒ｂ受容体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512090A JP2006512090A (ja) | 2006-04-13 |
| JP2006512090A5 true JP2006512090A5 (https=) | 2006-06-01 |
Family
ID=34197667
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005507928A Pending JP2006512090A (ja) | 2002-10-31 | 2003-10-28 | ボツリヌス神経毒ｂ受容体およびその使用 |
| JP2009229744A Pending JP2010006833A (ja) | 2002-10-31 | 2009-10-01 | ボツリヌス神経毒ｂ受容体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009229744A Pending JP2010006833A (ja) | 2002-10-31 | 2009-10-01 | ボツリヌス神経毒ｂ受容体およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040191887A1 (https=) |
| EP (1) | EP1578382B1 (https=) |
| JP (2) | JP2006512090A (https=) |
| AT (1) | ATE442161T1 (https=) |
| AU (1) | AU2003304419A1 (https=) |
| CA (1) | CA2504532C (https=) |
| DE (1) | DE60329225D1 (https=) |
| ES (1) | ES2333319T3 (https=) |
| IL (1) | IL167943A (https=) |
| WO (1) | WO2005016233A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005016233A2 (en) * | 2002-10-31 | 2005-02-24 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin b receptors and use thereof |
| WO2005030119A2 (en) * | 2003-04-11 | 2005-04-07 | Allergan, Inc. | Botulinum toxin a peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy |
| US8748106B2 (en) * | 2005-04-18 | 2014-06-10 | Bal Ram Singh | Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II |
| DE102005019302A1 (de) | 2005-04-26 | 2006-11-16 | Toxogen Gmbh | Carrier zum Targeting von Nervenzellen |
| US7985554B2 (en) | 2005-10-14 | 2011-07-26 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin A receptor and the use thereof |
| DE102005051789B4 (de) | 2005-10-28 | 2014-08-07 | Toxogen Gmbh | Der Botulinus Neurotoxin A Proteinrezeptor und seine Anwendungen |
| WO2009035476A1 (en) | 2007-09-14 | 2009-03-19 | Biosentinel, Llc | Resonance energy transfer assay with cleavage sequence and spacer |
| US11325954B2 (en) | 2011-06-01 | 2022-05-10 | Biomadison, Inc. | Compositions and methods for stability testing of botulinum toxin |
| US9303285B2 (en) | 2012-01-04 | 2016-04-05 | Biomadison, Inc. | Methods and compounds for increasing sensitivity of botulinum assays |
| US12422428B2 (en) | 2011-06-01 | 2025-09-23 | Biomadison, Inc. | Compositions and methods for cell-based assays |
| US10908146B2 (en) | 2011-06-01 | 2021-02-02 | Biomadison, Inc. | Compositions and methods for improving sensitivity in cell based assays |
| KR101853103B1 (ko) | 2011-06-01 | 2018-04-27 | 바이오메디슨, 인코퍼레이티드 | 비-ｆｒｅｔ 보툴리눔 검정법 |
| LT3030905T (lt) | 2013-08-09 | 2018-01-25 | Biomadison, Inc. | Padidinto jautrumo botulino toksino tyrimas |
| WO2023210585A1 (ja) * | 2022-04-25 | 2023-11-02 | 株式会社Jiksak Bioengineering | 標的化剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6994995B1 (en) * | 2001-03-16 | 2006-02-07 | Lexicon Genetics Incorporated | Human synaptotagmin and polynucleotides encoding the same |
| US8022172B2 (en) * | 2001-08-28 | 2011-09-20 | Allergan, Inc. | Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| WO2005016233A2 (en) * | 2002-10-31 | 2005-02-24 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin b receptors and use thereof |
| WO2005076785A2 (en) * | 2003-12-19 | 2005-08-25 | Wisconsin Alumni Research Foundation | Method and compositions for detecting botulinum neurotoxin |
| CA2605160A1 (en) * | 2005-04-05 | 2006-10-05 | Allergan, Inc. | Clostridial toxin activity assays |
| JP2009502205A (ja) * | 2005-08-02 | 2009-01-29 | プラネット・バイオテクノロジー・インコーポレイテッド | 炭疽菌の処置および予防のための改良されたキメラ毒素受容体タンパクおよびキメラ毒素受容体タンパク質 |
| US7985554B2 (en) * | 2005-10-14 | 2011-07-26 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin A receptor and the use thereof |
| WO2013011055A1 (en) * | 2011-07-19 | 2013-01-24 | ETH Zürich | Means and methods for determining clostridial neurotoxins |
-
2003
- 2003-10-28 WO PCT/US2003/034348 patent/WO2005016233A2/en not_active Ceased
- 2003-10-28 ES ES03816739T patent/ES2333319T3/es not_active Expired - Lifetime
- 2003-10-28 EP EP03816739A patent/EP1578382B1/en not_active Expired - Lifetime
- 2003-10-28 AU AU2003304419A patent/AU2003304419A1/en not_active Abandoned
- 2003-10-28 JP JP2005507928A patent/JP2006512090A/ja active Pending
- 2003-10-28 AT AT03816739T patent/ATE442161T1/de not_active IP Right Cessation
- 2003-10-28 DE DE60329225T patent/DE60329225D1/de not_active Expired - Lifetime
- 2003-10-28 US US10/695,577 patent/US20040191887A1/en not_active Abandoned
- 2003-10-28 CA CA2504532A patent/CA2504532C/en not_active Expired - Fee Related
-
2005
- 2005-04-10 IL IL167943A patent/IL167943A/en unknown
-
2009
- 2009-10-01 JP JP2009229744A patent/JP2010006833A/ja active Pending
-
2011
- 2011-10-26 US US13/281,501 patent/US8617573B2/en not_active Expired - Fee Related
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