JP2006512090A5 - - Google Patents
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- Publication number
- JP2006512090A5 JP2006512090A5 JP2005507928A JP2005507928A JP2006512090A5 JP 2006512090 A5 JP2006512090 A5 JP 2006512090A5 JP 2005507928 A JP2005507928 A JP 2005507928A JP 2005507928 A JP2005507928 A JP 2005507928A JP 2006512090 A5 JP2006512090 A5 JP 2006512090A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- acid sequence
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 136
- 108090000765 processed proteins & peptides Proteins 0.000 claims 55
- 125000003275 alpha amino acid group Chemical group 0.000 claims 50
- 229920001184 polypeptide Polymers 0.000 claims 49
- 102000004196 processed proteins & peptides Human genes 0.000 claims 49
- 108030001720 Bontoxilysin Proteins 0.000 claims 36
- 102000040430 polynucleotide Human genes 0.000 claims 33
- 108091033319 polynucleotide Proteins 0.000 claims 33
- 239000002157 polynucleotide Substances 0.000 claims 33
- 239000003795 chemical substances by application Substances 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 17
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 101000714466 Mus musculus Synaptotagmin-1 Proteins 0.000 claims 10
- 101000891892 Mus musculus Synaptotagmin-2 Proteins 0.000 claims 10
- 108010055170 Synaptotagmin I Proteins 0.000 claims 8
- 102100036417 Synaptotagmin-1 Human genes 0.000 claims 8
- -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 7
- 150000002270 gangliosides Chemical class 0.000 claims 7
- 108010055445 Synaptotagmin II Proteins 0.000 claims 6
- 102100036151 Synaptotagmin-2 Human genes 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 102000003137 synaptotagmin Human genes 0.000 claims 6
- 108060008004 synaptotagmin Proteins 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 241000193155 Clostridium botulinum Species 0.000 claims 2
- 229940053031 botulinum toxin Drugs 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108010074523 rimabotulinumtoxinB Proteins 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 125000002421 ganglioside group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42295102P | 2002-10-31 | 2002-10-31 | |
| US49812803P | 2003-08-27 | 2003-08-27 | |
| PCT/US2003/034348 WO2005016233A2 (en) | 2002-10-31 | 2003-10-28 | Botulinum neurotoxin b receptors and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009229744A Division JP2010006833A (ja) | 2002-10-31 | 2009-10-01 | ボツリヌス神経毒ｂ受容体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512090A JP2006512090A (ja) | 2006-04-13 |
| JP2006512090A5 true JP2006512090A5 (https=) | 2006-06-01 |
Family
ID=34197667
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005507928A Pending JP2006512090A (ja) | 2002-10-31 | 2003-10-28 | ボツリヌス神経毒ｂ受容体およびその使用 |
| JP2009229744A Pending JP2010006833A (ja) | 2002-10-31 | 2009-10-01 | ボツリヌス神経毒ｂ受容体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009229744A Pending JP2010006833A (ja) | 2002-10-31 | 2009-10-01 | ボツリヌス神経毒ｂ受容体およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040191887A1 (https=) |
| EP (1) | EP1578382B1 (https=) |
| JP (2) | JP2006512090A (https=) |
| AT (1) | ATE442161T1 (https=) |
| AU (1) | AU2003304419A1 (https=) |
| CA (1) | CA2504532C (https=) |
| DE (1) | DE60329225D1 (https=) |
| ES (1) | ES2333319T3 (https=) |
| IL (1) | IL167943A (https=) |
| WO (1) | WO2005016233A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2504532C (en) * | 2002-10-31 | 2014-09-16 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin b receptors and use thereof |
| US7341843B2 (en) * | 2003-04-11 | 2008-03-11 | Allergan, Inc. | Botulinum toxin A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy |
| WO2006113648A2 (en) * | 2005-04-18 | 2006-10-26 | University Of Massachusetts | Hn-33 compositions and methods |
| DE102005019302A1 (de) * | 2005-04-26 | 2006-11-16 | Toxogen Gmbh | Carrier zum Targeting von Nervenzellen |
| US7985554B2 (en) | 2005-10-14 | 2011-07-26 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin A receptor and the use thereof |
| DE102005051789B4 (de) | 2005-10-28 | 2014-08-07 | Toxogen Gmbh | Der Botulinus Neurotoxin A Proteinrezeptor und seine Anwendungen |
| KR101226604B1 (ko) | 2007-09-14 | 2013-01-28 | 바이오센티넬, 인코포레이티드 | 절단 서열 및 스페이서를 이용한 공명 에너지 전달 분석 |
| US10908146B2 (en) | 2011-06-01 | 2021-02-02 | Biomadison, Inc. | Compositions and methods for improving sensitivity in cell based assays |
| US12422428B2 (en) | 2011-06-01 | 2025-09-23 | Biomadison, Inc. | Compositions and methods for cell-based assays |
| US9303285B2 (en) | 2012-01-04 | 2016-04-05 | Biomadison, Inc. | Methods and compounds for increasing sensitivity of botulinum assays |
| KR101910490B1 (ko) | 2011-06-01 | 2018-10-22 | 바이오메디슨, 인코퍼레이티드 | 비-ｆｒｅｔ 보툴리눔 검정법 |
| US11325954B2 (en) | 2011-06-01 | 2022-05-10 | Biomadison, Inc. | Compositions and methods for stability testing of botulinum toxin |
| LT3030905T (lt) * | 2013-08-09 | 2018-01-25 | Biomadison, Inc. | Padidinto jautrumo botulino toksino tyrimas |
| EP4516316A4 (en) * | 2022-04-25 | 2026-04-22 | Jiksak Bioengineering Inc | TARGETING AGENT |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6994995B1 (en) * | 2001-03-16 | 2006-02-07 | Lexicon Genetics Incorporated | Human synaptotagmin and polynucleotides encoding the same |
| US8022172B2 (en) * | 2001-08-28 | 2011-09-20 | Allergan, Inc. | Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity |
| US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| CA2504532C (en) * | 2002-10-31 | 2014-09-16 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin b receptors and use thereof |
| US8137924B2 (en) * | 2003-12-19 | 2012-03-20 | Wisconsin Alumni Research Foundation | Method and compositions for detecting botulinum neurotoxin |
| ES2351942T3 (es) * | 2005-04-05 | 2011-02-14 | Allergan Inc | Analisis de la actividad de una toxina clostridial. |
| CA2617877A1 (en) * | 2005-08-02 | 2007-04-19 | Planet Biotechnology, Inc. | Improved chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax |
| US7985554B2 (en) * | 2005-10-14 | 2011-07-26 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin A receptor and the use thereof |
| EP2734635A1 (en) * | 2011-07-19 | 2014-05-28 | ETH Zürich | Means and methods for determining clostridial neurotoxins |
-
2003
- 2003-10-28 CA CA2504532A patent/CA2504532C/en not_active Expired - Fee Related
- 2003-10-28 ES ES03816739T patent/ES2333319T3/es not_active Expired - Lifetime
- 2003-10-28 DE DE60329225T patent/DE60329225D1/de not_active Expired - Lifetime
- 2003-10-28 WO PCT/US2003/034348 patent/WO2005016233A2/en not_active Ceased
- 2003-10-28 AU AU2003304419A patent/AU2003304419A1/en not_active Abandoned
- 2003-10-28 US US10/695,577 patent/US20040191887A1/en not_active Abandoned
- 2003-10-28 EP EP03816739A patent/EP1578382B1/en not_active Expired - Lifetime
- 2003-10-28 JP JP2005507928A patent/JP2006512090A/ja active Pending
- 2003-10-28 AT AT03816739T patent/ATE442161T1/de not_active IP Right Cessation
-
2005
- 2005-04-10 IL IL167943A patent/IL167943A/en unknown
-
2009
- 2009-10-01 JP JP2009229744A patent/JP2010006833A/ja active Pending
-
2011
- 2011-10-26 US US13/281,501 patent/US8617573B2/en not_active Expired - Fee Related
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