JP2006511482A5 - - Google Patents
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- Publication number
- JP2006511482A5 JP2006511482A5 JP2004542034A JP2004542034A JP2006511482A5 JP 2006511482 A5 JP2006511482 A5 JP 2006511482A5 JP 2004542034 A JP2004542034 A JP 2004542034A JP 2004542034 A JP2004542034 A JP 2004542034A JP 2006511482 A5 JP2006511482 A5 JP 2006511482A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- penten
- isopropoxy
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 150000003222 pyridines Chemical class 0.000 claims 2
- 150000003333 secondary alcohols Chemical group 0.000 claims 2
- QMWXIPKDLIFJCI-GQCTYLIASA-N (e)-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine Chemical compound CC(C)OC1=CN=CC(\C=C\CC(C)N)=C1 QMWXIPKDLIFJCI-GQCTYLIASA-N 0.000 claims 1
- QMWXIPKDLIFJCI-MALLOTDXSA-N (e,2s)-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine Chemical compound CC(C)OC1=CN=CC(\C=C\C[C@H](C)N)=C1 QMWXIPKDLIFJCI-MALLOTDXSA-N 0.000 claims 1
- XVZDZUKYMUYZRS-FNORWQNLSA-N 3-[(e)-4-(methylamino)pent-1-enyl]-5-propan-2-yloxy-1h-pyridin-4-one Chemical compound CNC(C)C\C=C\C1=CN=CC(OC(C)C)=C1O XVZDZUKYMUYZRS-FNORWQNLSA-N 0.000 claims 1
- XVZDZUKYMUYZRS-ZRQQLDRUSA-N 3-[(e,4s)-4-(methylamino)pent-1-enyl]-5-propan-2-yloxy-1h-pyridin-4-one Chemical compound CN[C@@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1O XVZDZUKYMUYZRS-ZRQQLDRUSA-N 0.000 claims 1
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 claims 1
- FSZRSTNRZUIEMA-UHFFFAOYSA-N 5-bromo-2-propan-2-yloxypyridine Chemical group CC(C)OC1=CC=C(Br)C=N1 FSZRSTNRZUIEMA-UHFFFAOYSA-N 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N p-toluenesulfonic acid Substances CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- -1 p-toluenesulfonic acid ester Chemical class 0.000 claims 1
- ZHZCYWWNFQUZOR-UHFFFAOYSA-N pent-4-en-2-ol Chemical group CC(O)CC=C ZHZCYWWNFQUZOR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/263,083 US6979695B2 (en) | 1996-04-23 | 2002-10-02 | Compounds capable of activating cholinergic receptors |
| PCT/US2003/031188 WO2004031151A1 (en) | 2002-10-02 | 2003-10-01 | Compounds capable of activating cholinergic receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011051171A Division JP2011144192A (ja) | 2002-10-02 | 2011-03-09 | コリン作動性受容体を活性化できる化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006511482A JP2006511482A (ja) | 2006-04-06 |
| JP2006511482A5 true JP2006511482A5 (https=) | 2009-10-22 |
Family
ID=32068267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542034A Pending JP2006511482A (ja) | 2002-10-02 | 2003-10-01 | コリン作動性受容体を活性化できる化合物 |
| JP2011051171A Pending JP2011144192A (ja) | 2002-10-02 | 2011-03-09 | コリン作動性受容体を活性化できる化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011051171A Pending JP2011144192A (ja) | 2002-10-02 | 2011-03-09 | コリン作動性受容体を活性化できる化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US6979695B2 (https=) |
| EP (2) | EP2253616A1 (https=) |
| JP (2) | JP2006511482A (https=) |
| AU (1) | AU2003282908B2 (https=) |
| CA (1) | CA2501335C (https=) |
| WO (1) | WO2004031151A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| US7790757B2 (en) * | 1998-06-16 | 2010-09-07 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| ES2330849T3 (es) * | 2004-04-02 | 2009-12-16 | Arterial Remodelling Technologies Inc. | Ensamblaje de stent basado en polimero. |
| US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| ATE548363T1 (de) | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| JP5112317B2 (ja) | 2005-08-29 | 2013-01-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン |
| EP1919906B1 (en) | 2005-08-29 | 2011-10-12 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| US8017785B2 (en) | 2006-05-09 | 2011-09-13 | Astrazeneca Ab | Salt forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)y1]-4-penten 2-amine |
| TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| WO2008091588A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| WO2009018367A2 (en) * | 2007-07-31 | 2009-02-05 | Targacept, Inc. | Novel salt forms of (2s)-(4e)-n-methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine |
| JP2010535237A (ja) * | 2007-07-31 | 2010-11-18 | ターガセプト・インコーポレイテッド | （２ｓ）−（４ｅ）−ｎ−メチル−５−（３−（５−イソプロポキシピリジン）イル）−４−ペンテン−２−アミンの経皮投与 |
| WO2009146031A1 (en) | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| CN103180277A (zh) * | 2010-05-20 | 2013-06-26 | 塔格塞普特股份有限公司 | 制备芳基取代的烯属胺的新方法 |
| US9488490B2 (en) | 2014-04-02 | 2016-11-08 | Here Global B.V. | Storing and accessing traffic data images in a limited bandwidth environment |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4927838A (en) | 1987-07-10 | 1990-05-22 | Hoffman-La Roche Inc. | Pyridine compounds which are useful in treating a disease state characterized by an excess of platelet activating factors |
| US4922901A (en) | 1988-09-08 | 1990-05-08 | R. J. Reynolds Tobacco Company | Drug delivery articles utilizing electrical energy |
| US5356906A (en) | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
| DE4102289A1 (de) | 1991-01-26 | 1992-07-30 | Bayer Ag | Verfahren zur herstellung von (hetero)arylalk(en/in)-ylaminen und neue (hetero)arylkinylamine |
| US5212188A (en) | 1992-03-02 | 1993-05-18 | R. J. Reynolds Tabacco Company | Method for treatment of neurodegenerative diseases |
| US5242935A (en) | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| US5723477A (en) | 1994-11-10 | 1998-03-03 | Sibia Neurosciences, Inc. | Modulators of acetylcholine receptors |
| US5731314A (en) | 1995-01-06 | 1998-03-24 | Bencherif; Merouane | Pharamceutical compositions for prevention and treatment of tourette's syndrome |
| US5824692A (en) | 1995-01-06 | 1998-10-20 | Lippiello; Patrick Michael | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| WO1996020600A1 (en) | 1995-01-06 | 1996-07-11 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5616707A (en) | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| US5604231A (en) | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
| US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5585388A (en) | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| WO1996036637A1 (en) | 1995-05-17 | 1996-11-21 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| US5616716A (en) | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| US20020052497A1 (en) * | 2000-03-09 | 2002-05-02 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| US6166048A (en) * | 1999-04-20 | 2000-12-26 | Targacept, Inc. | Pharmaceutical compositions for inhibition of cytokine production and secretion |
| US5663356A (en) | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| JP4357001B2 (ja) | 1996-04-23 | 2009-11-04 | ターガセプト，インコーポレイテッド | 中枢神経系障害の予防及び治療のための医薬組成物 |
| US5629325A (en) | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US5861423A (en) | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| DE69825879T2 (de) * | 1997-02-21 | 2005-09-01 | Targacept, Inc. | Pharmazeutische zusammensetzungen welche aryl-substituierte olefinische amin-verbindungen enthalten |
| US6531606B1 (en) * | 1997-02-21 | 2003-03-11 | Targacept, Inc. | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| US5811442A (en) | 1997-02-21 | 1998-09-22 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow |
| CA2709735A1 (en) * | 1998-06-16 | 1999-12-23 | Targacept, Inc. | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
| US6232316B1 (en) | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
| US20050131034A1 (en) * | 1998-06-16 | 2005-06-16 | Caldwell William S. | Compounds capable of activating cholinergic receptors |
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| US6337351B1 (en) * | 1998-10-22 | 2002-01-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6262124B1 (en) | 1998-10-22 | 2001-07-17 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
| US6455554B1 (en) * | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
| EP1185514A1 (en) * | 1999-06-07 | 2002-03-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6743812B1 (en) * | 2000-07-14 | 2004-06-01 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6432954B1 (en) * | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
-
2002
- 2002-10-02 US US10/263,083 patent/US6979695B2/en not_active Expired - Fee Related
-
2003
- 2003-10-01 CA CA2501335A patent/CA2501335C/en not_active Expired - Fee Related
- 2003-10-01 EP EP10075370A patent/EP2253616A1/en not_active Withdrawn
- 2003-10-01 AU AU2003282908A patent/AU2003282908B2/en not_active Ceased
- 2003-10-01 EP EP03774525A patent/EP1556352A1/en not_active Withdrawn
- 2003-10-01 WO PCT/US2003/031188 patent/WO2004031151A1/en not_active Ceased
- 2003-10-01 JP JP2004542034A patent/JP2006511482A/ja active Pending
-
2004
- 2004-10-22 US US10/971,543 patent/US7045538B2/en not_active Expired - Fee Related
-
2006
- 2006-03-28 US US11/277,664 patent/US20060293289A1/en not_active Abandoned
-
2009
- 2009-12-08 US US12/633,308 patent/US20100121061A1/en not_active Abandoned
-
2011
- 2011-03-09 JP JP2011051171A patent/JP2011144192A/ja active Pending
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