JP2006511463A5 - - Google Patents
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- Publication number
- JP2006511463A5 JP2006511463A5 JP2004532178A JP2004532178A JP2006511463A5 JP 2006511463 A5 JP2006511463 A5 JP 2006511463A5 JP 2004532178 A JP2004532178 A JP 2004532178A JP 2004532178 A JP2004532178 A JP 2004532178A JP 2006511463 A5 JP2006511463 A5 JP 2006511463A5
- Authority
- JP
- Japan
- Prior art keywords
- neisseria
- pharmaceutical composition
- protein
- composition according
- nspa protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 238000000034 method Methods 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 241000588653 Neisseria Species 0.000 claims 11
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 6
- 108010031133 Transferrin-Binding Protein A Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims 4
- 206010018612 Gonorrhoea Diseases 0.000 claims 3
- 208000034762 Meningococcal Infections Diseases 0.000 claims 3
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000001786 gonorrhea Diseases 0.000 claims 3
- 210000003000 inclusion body Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims 2
- 206010062212 Neisseria infection Diseases 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 108010031127 Transferrin-Binding Protein B Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- PKIFFNOAKKWUOS-UHFFFAOYSA-N 3-(2-methyltridecan-2-ylazaniumyl)propane-1-sulfonate Chemical compound CCCCCCCCCCCC(C)(C)[NH2+]CCCS([O-])(=O)=O PKIFFNOAKKWUOS-UHFFFAOYSA-N 0.000 claims 1
- 229910018072 Al 2 O 3 Inorganic materials 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 101000874355 Escherichia coli (strain K12) Outer membrane protein assembly factor BamA Proteins 0.000 claims 1
- 101710186862 Factor H binding protein Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 claims 1
- 101000873843 Homo sapiens Sorting and assembly machinery component 50 homolog Proteins 0.000 claims 1
- 108010002231 IgA-specific serine endopeptidase Proteins 0.000 claims 1
- 101150022636 MAFB gene Proteins 0.000 claims 1
- 101100212666 Neisseria meningitidis serogroup B (strain MC58) NMB0964 gene Proteins 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 101800001295 Putative ATP-dependent helicase Proteins 0.000 claims 1
- 101800001006 Putative helicase Proteins 0.000 claims 1
- 102100021119 Serine protease HTRA1 Human genes 0.000 claims 1
- 102100035853 Sorting and assembly machinery component 50 homolog Human genes 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 210000002615 epidermis Anatomy 0.000 claims 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 101150101156 slc51a gene Proteins 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0220197.8A GB0220197D0 (en) | 2002-08-30 | 2002-08-30 | Refolding method |
| PCT/EP2003/010085 WO2004020452A2 (en) | 2002-08-30 | 2003-08-28 | Method for refolding neisserial nspa protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010226544A Division JP2011057679A (ja) | 2002-08-30 | 2010-10-06 | ナイセリアＮｓｐＡタンパク質をリフォールディングする方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511463A JP2006511463A (ja) | 2006-04-06 |
| JP2006511463A5 true JP2006511463A5 (cg-RX-API-DMAC7.html) | 2006-09-21 |
| JP4652808B2 JP4652808B2 (ja) | 2011-03-16 |
Family
ID=9943240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532178A Expired - Fee Related JP4652808B2 (ja) | 2002-08-30 | 2003-08-28 | ナイセリアＮｓｐＡタンパク質をリフォールディングする方法 |
| JP2010226544A Pending JP2011057679A (ja) | 2002-08-30 | 2010-10-06 | ナイセリアＮｓｐＡタンパク質をリフォールディングする方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010226544A Pending JP2011057679A (ja) | 2002-08-30 | 2010-10-06 | ナイセリアＮｓｐＡタンパク質をリフォールディングする方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20080025993A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1532168B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4652808B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003273854A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2496045A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2505692T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0220197D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004020452A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220197D0 (en) * | 2002-08-30 | 2002-10-09 | Univ Utrecht | Refolding method |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| US8642733B2 (en) | 2009-11-06 | 2014-02-04 | Children's Hospital & Research Center Oakland | T-cell stimulating protein B and methods of use |
| CN103168046A (zh) * | 2010-10-20 | 2013-06-19 | 米迪缪尼有限公司 | 用于加工包涵体的方法 |
| CN104428008B (zh) | 2012-05-24 | 2020-10-09 | 美国政府(由卫生和人类服务部的部长所代表) | 多价脑膜炎球菌缀合物及制备缀合物的方法 |
| US10341850B2 (en) * | 2014-02-10 | 2019-07-02 | Mediatek Inc. | Method for identifying source BSS in WLAN |
| BR102018003245A2 (pt) * | 2018-02-20 | 2019-09-10 | Fundação Oswaldo Cruz | oligonucleotídeo, conjunto de oligonucleotídeos, método para detecção simultânea de neisseria meningitidis, streptococcus pneumoniae e haemophilus influenzae, e, kit. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117483A (en) * | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| NZ515935A (en) * | 1999-05-19 | 2004-01-30 | Chiron S | Combination Neisserial compositions and vaccines for the prevention of infections due to Neisseria bacteria such as meningococcal meningitis |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| GB0007432D0 (en) * | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| GB0220197D0 (en) * | 2002-08-30 | 2002-10-09 | Univ Utrecht | Refolding method |
-
2002
- 2002-08-30 GB GBGB0220197.8A patent/GB0220197D0/en not_active Ceased
-
2003
- 2003-08-28 WO PCT/EP2003/010085 patent/WO2004020452A2/en not_active Ceased
- 2003-08-28 JP JP2004532178A patent/JP4652808B2/ja not_active Expired - Fee Related
- 2003-08-28 AU AU2003273854A patent/AU2003273854A1/en not_active Abandoned
- 2003-08-28 US US10/525,889 patent/US20080025993A1/en not_active Abandoned
- 2003-08-28 ES ES03757819.2T patent/ES2505692T3/es not_active Expired - Lifetime
- 2003-08-28 CA CA002496045A patent/CA2496045A1/en not_active Abandoned
- 2003-08-28 EP EP03757819.2A patent/EP1532168B1/en not_active Expired - Lifetime
-
2010
- 2010-01-25 US US12/693,271 patent/US20100291137A1/en not_active Abandoned
- 2010-10-06 JP JP2010226544A patent/JP2011057679A/ja active Pending
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