JP2006510657A - 中耳炎の処置のための方法および組成物 - Google Patents

中耳炎の処置のための方法および組成物 Download PDF

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Publication number
JP2006510657A
JP2006510657A JP2004558595A JP2004558595A JP2006510657A JP 2006510657 A JP2006510657 A JP 2006510657A JP 2004558595 A JP2004558595 A JP 2004558595A JP 2004558595 A JP2004558595 A JP 2004558595A JP 2006510657 A JP2006510657 A JP 2006510657A
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JP
Japan
Prior art keywords
otitis media
antitrypsin
aat
treatment
ear
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2004558595A
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English (en)
Japanese (ja)
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JP2006510657A5 (enExample
Inventor
フィリップ ジェー. バー,
フィリップ エー. ペンバートン,
パトリック ジェー. アントネリー,
グレゴリー エス. シュルツ,
ディビッド ジェー. サンディン,
Original Assignee
アライバ ファーマシューティカルズ,インコーポレイティド
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Publication of JP2006510657A publication Critical patent/JP2006510657A/ja
Publication of JP2006510657A5 publication Critical patent/JP2006510657A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2004558595A 2002-12-06 2003-12-08 中耳炎の処置のための方法および組成物 Pending JP2006510657A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43128602P 2002-12-06 2002-12-06
US43598502P 2002-12-20 2002-12-20
PCT/US2003/039053 WO2004052236A2 (en) 2002-12-06 2003-12-08 Methods and compositions for treatment of otitis media

Publications (2)

Publication Number Publication Date
JP2006510657A true JP2006510657A (ja) 2006-03-30
JP2006510657A5 JP2006510657A5 (enExample) 2007-02-01

Family

ID=32511553

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004558595A Pending JP2006510657A (ja) 2002-12-06 2003-12-08 中耳炎の処置のための方法および組成物

Country Status (6)

Country Link
US (1) US20040175383A1 (enExample)
EP (1) EP1567183A4 (enExample)
JP (1) JP2006510657A (enExample)
AU (1) AU2003296378A1 (enExample)
CA (1) CA2508762A1 (enExample)
WO (1) WO2004052236A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7850970B2 (en) * 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
US7468350B2 (en) 2004-06-16 2008-12-23 Pneumrx, Inc. Glue composition for lung volume reduction
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US7553810B2 (en) 2004-06-16 2009-06-30 Pneumrx, Inc. Lung volume reduction using glue composition
US7608579B2 (en) 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
CA2570261C (en) 2004-07-08 2014-06-10 Pneumrx, Inc. Pleural effusion treatment device, method and material
WO2006029074A2 (en) * 2004-09-03 2006-03-16 Piedmont Pharmaceuticals, Llc Methods for transmembrane treatment and prevention of otitis media
CA2622002A1 (en) * 2005-09-26 2007-04-05 Piedmont Pharmaceuticals Llc Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery into the middle ear
US20080269187A1 (en) * 2005-09-26 2008-10-30 Campbell William R Methods for Treatment and Prevention of Otitis Media Using Chemical Penetration Enhancers to Facilitate Transmembrane Drug Delivery Into the Middle Ear
US7767217B2 (en) 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20090263345A1 (en) * 2008-01-28 2009-10-22 Foresight Biotherapeutics, Inc. Otic compositions for the treatment of infections of the internal and external ear in mammals
US9326943B1 (en) 2009-06-23 2016-05-03 Sandra M. Skovlund Biodegradable prosthesis
DK2366408T3 (da) * 2010-03-01 2012-10-22 Salvat Lab Sa Vandige, klare opløsninger af fluocinolonacetonid til behandling af inflammation i øret
US9309456B2 (en) 2011-04-15 2016-04-12 Lawrence Livermore National Security, Llc Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection
US9938353B2 (en) 2011-06-24 2018-04-10 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
US9121947B2 (en) 2012-01-23 2015-09-01 Lawrence Livermore National Security, Llc Stress reduction for pillar filled structures
US9650564B2 (en) 2012-05-14 2017-05-16 Lawrence Livermore National Security, Llc System and plastic scintillator for discrimination of thermal neutron, fast neutron, and gamma radiation
US9274237B2 (en) 2013-07-26 2016-03-01 Lawrence Livermore National Security, Llc Lithium-containing scintillators for thermal neutron, fast neutron, and gamma detection
KR102121969B1 (ko) 2019-05-22 2020-06-11 주식회사 안지오랩 멜리사엽 추출물 분획을 포함하는 약학적 조성물
CN111742887A (zh) * 2019-12-19 2020-10-09 广西医科大学第一附属医院 放疗后分泌性中耳炎树鼩模型的建立方法
CN113577253A (zh) * 2021-08-17 2021-11-02 胡高连 一种非手术治疗化脓性中耳炎的配方及使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037806A1 (en) * 1999-11-28 2001-05-31 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
WO2002050287A2 (en) * 2000-12-18 2002-06-27 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
JP2002525326A (ja) * 1998-09-30 2002-08-13 アルコン ラボラトリーズ,インコーポレイテッド 眼、耳および鼻治療用の抗生物質組成物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025620A (en) * 1975-10-22 1977-05-24 Leo Pharmaceutical Products Ltd., A/S Treatment of canine otitis and composition therefor
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4752576A (en) * 1984-06-14 1988-06-21 Chiron Corporation Expression of α-1 antitrypsin in yeast
US4732973A (en) * 1984-06-14 1988-03-22 Chiron Corporation Active site modified protease α-1-antitrypsin inhibitors
US5190917A (en) * 1986-12-24 1993-03-02 John Lezdey Treatment of psoriasis
US5114917A (en) * 1986-12-24 1992-05-19 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US5008242A (en) * 1986-12-24 1991-04-16 John Lezdey Treatment of inflammation using 1-antichymotrypsin
US5290762A (en) * 1986-12-24 1994-03-01 John Lezdey Treatment of inflammation
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
US5217951A (en) * 1986-12-24 1993-06-08 John Lezdey Treatment of inflammation
US5061729A (en) * 1988-06-08 1991-10-29 Biogal Gyogyszergyar Pharmaceutical composition and process for preparing the same
US6068994A (en) * 1989-08-07 2000-05-30 Chiron Corporation Ubiquitin expression system
US5215965A (en) * 1990-10-02 1993-06-01 John Lezdey Treatment of inflammation
US5134119A (en) * 1990-10-16 1992-07-28 Lezdey John Treatment of inflammation using 358 substituted alpha-antitrypsin
US5376633A (en) * 1992-09-30 1994-12-27 Lezdey; John Method for deactivating viruses in blood component containers
ES2079994B1 (es) * 1992-10-07 1996-08-01 Cusi Lab Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica.
US5604201A (en) * 1993-01-08 1997-02-18 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Methods and reagents for inhibiting furin endoprotease
US5346886A (en) * 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
US5780440A (en) * 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
WO2000051623A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6174859B1 (en) * 1999-04-06 2001-01-16 J & D Sciences, Inc. Method of treatment
EP1181039A2 (en) * 1999-05-24 2002-02-27 Xoma (US) LLC Therapeutic uses of bpi protein products in humans with otitis media with effusion
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US6511960B2 (en) * 2001-01-05 2003-01-28 Alphamed Pharmaceuticals Corp Cromolyn for eye and ear infections
JP2006508971A (ja) * 2002-11-20 2006-03-16 アライバ−プロメティック インコーポレイティド プロテアーゼ阻害剤を使用して炎症性疾患を治療する組成物及び方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525326A (ja) * 1998-09-30 2002-08-13 アルコン ラボラトリーズ,インコーポレイテッド 眼、耳および鼻治療用の抗生物質組成物
WO2001037806A1 (en) * 1999-11-28 2001-05-31 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
WO2002050287A2 (en) * 2000-12-18 2002-06-27 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease

Also Published As

Publication number Publication date
AU2003296378A1 (en) 2004-06-30
WO2004052236A2 (en) 2004-06-24
US20040175383A1 (en) 2004-09-09
WO2004052236A3 (en) 2004-08-26
EP1567183A2 (en) 2005-08-31
CA2508762A1 (en) 2004-06-24
EP1567183A4 (en) 2006-08-09

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