CA2508762A1 - Methods and compositions for treatment of otitis media - Google Patents
Methods and compositions for treatment of otitis media Download PDFInfo
- Publication number
- CA2508762A1 CA2508762A1 CA002508762A CA2508762A CA2508762A1 CA 2508762 A1 CA2508762 A1 CA 2508762A1 CA 002508762 A CA002508762 A CA 002508762A CA 2508762 A CA2508762 A CA 2508762A CA 2508762 A1 CA2508762 A1 CA 2508762A1
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- CA
- Canada
- Prior art keywords
- otitis media
- ilomastat
- aat
- treatment
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229960004320 triamcinolone diacetate Drugs 0.000 description 1
- 229960004221 triamcinolone hexacetonide Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960005041 troleandomycin Drugs 0.000 description 1
- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 230000004572 zinc-binding Effects 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43128602P | 2002-12-06 | 2002-12-06 | |
| US60/431,286 | 2002-12-06 | ||
| US43598502P | 2002-12-20 | 2002-12-20 | |
| US60/435,985 | 2002-12-20 | ||
| PCT/US2003/039053 WO2004052236A2 (en) | 2002-12-06 | 2003-12-08 | Methods and compositions for treatment of otitis media |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2508762A1 true CA2508762A1 (en) | 2004-06-24 |
Family
ID=32511553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002508762A Abandoned CA2508762A1 (en) | 2002-12-06 | 2003-12-08 | Methods and compositions for treatment of otitis media |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040175383A1 (enExample) |
| EP (1) | EP1567183A4 (enExample) |
| JP (1) | JP2006510657A (enExample) |
| AU (1) | AU2003296378A1 (enExample) |
| CA (1) | CA2508762A1 (enExample) |
| WO (1) | WO2004052236A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7850970B2 (en) * | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| US7468350B2 (en) | 2004-06-16 | 2008-12-23 | Pneumrx, Inc. | Glue composition for lung volume reduction |
| US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
| US7553810B2 (en) | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
| US7608579B2 (en) | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
| CA2570261C (en) | 2004-07-08 | 2014-06-10 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
| WO2006029074A2 (en) * | 2004-09-03 | 2006-03-16 | Piedmont Pharmaceuticals, Llc | Methods for transmembrane treatment and prevention of otitis media |
| CA2622002A1 (en) * | 2005-09-26 | 2007-04-05 | Piedmont Pharmaceuticals Llc | Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery into the middle ear |
| US20080269187A1 (en) * | 2005-09-26 | 2008-10-30 | Campbell William R | Methods for Treatment and Prevention of Otitis Media Using Chemical Penetration Enhancers to Facilitate Transmembrane Drug Delivery Into the Middle Ear |
| US7767217B2 (en) | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| US20090263345A1 (en) * | 2008-01-28 | 2009-10-22 | Foresight Biotherapeutics, Inc. | Otic compositions for the treatment of infections of the internal and external ear in mammals |
| US9326943B1 (en) | 2009-06-23 | 2016-05-03 | Sandra M. Skovlund | Biodegradable prosthesis |
| DK2366408T3 (da) * | 2010-03-01 | 2012-10-22 | Salvat Lab Sa | Vandige, klare opløsninger af fluocinolonacetonid til behandling af inflammation i øret |
| US9309456B2 (en) | 2011-04-15 | 2016-04-12 | Lawrence Livermore National Security, Llc | Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection |
| US9938353B2 (en) | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US9121947B2 (en) | 2012-01-23 | 2015-09-01 | Lawrence Livermore National Security, Llc | Stress reduction for pillar filled structures |
| US9650564B2 (en) | 2012-05-14 | 2017-05-16 | Lawrence Livermore National Security, Llc | System and plastic scintillator for discrimination of thermal neutron, fast neutron, and gamma radiation |
| US9274237B2 (en) | 2013-07-26 | 2016-03-01 | Lawrence Livermore National Security, Llc | Lithium-containing scintillators for thermal neutron, fast neutron, and gamma detection |
| KR102121969B1 (ko) | 2019-05-22 | 2020-06-11 | 주식회사 안지오랩 | 멜리사엽 추출물 분획을 포함하는 약학적 조성물 |
| CN111742887A (zh) * | 2019-12-19 | 2020-10-09 | 广西医科大学第一附属医院 | 放疗后分泌性中耳炎树鼩模型的建立方法 |
| CN113577253A (zh) * | 2021-08-17 | 2021-11-02 | 胡高连 | 一种非手术治疗化脓性中耳炎的配方及使用方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025620A (en) * | 1975-10-22 | 1977-05-24 | Leo Pharmaceutical Products Ltd., A/S | Treatment of canine otitis and composition therefor |
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US4474751A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US4752576A (en) * | 1984-06-14 | 1988-06-21 | Chiron Corporation | Expression of α-1 antitrypsin in yeast |
| US4732973A (en) * | 1984-06-14 | 1988-03-22 | Chiron Corporation | Active site modified protease α-1-antitrypsin inhibitors |
| US5190917A (en) * | 1986-12-24 | 1993-03-02 | John Lezdey | Treatment of psoriasis |
| US5114917A (en) * | 1986-12-24 | 1992-05-19 | John Lezdey | Treatment of inflammation using alpha 1-antichymotrypsin |
| US5008242A (en) * | 1986-12-24 | 1991-04-16 | John Lezdey | Treatment of inflammation using 1-antichymotrypsin |
| US5290762A (en) * | 1986-12-24 | 1994-03-01 | John Lezdey | Treatment of inflammation |
| US5166134A (en) * | 1986-12-24 | 1992-11-24 | John Lezdey | Treatment of allergic rhinitis |
| US5217951A (en) * | 1986-12-24 | 1993-06-08 | John Lezdey | Treatment of inflammation |
| US5061729A (en) * | 1988-06-08 | 1991-10-29 | Biogal Gyogyszergyar | Pharmaceutical composition and process for preparing the same |
| US6068994A (en) * | 1989-08-07 | 2000-05-30 | Chiron Corporation | Ubiquitin expression system |
| US5215965A (en) * | 1990-10-02 | 1993-06-01 | John Lezdey | Treatment of inflammation |
| US5134119A (en) * | 1990-10-16 | 1992-07-28 | Lezdey John | Treatment of inflammation using 358 substituted alpha-antitrypsin |
| US5376633A (en) * | 1992-09-30 | 1994-12-27 | Lezdey; John | Method for deactivating viruses in blood component containers |
| ES2079994B1 (es) * | 1992-10-07 | 1996-08-01 | Cusi Lab | Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica. |
| US5604201A (en) * | 1993-01-08 | 1997-02-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization | Methods and reagents for inhibiting furin endoprotease |
| US5346886A (en) * | 1993-11-15 | 1994-09-13 | John Lezdey | Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin |
| US5780440A (en) * | 1996-06-17 | 1998-07-14 | Protease Sciences Inc. | Treatment of pulmonary disease with protease inhibitors |
| WO2000018404A1 (en) * | 1998-09-30 | 2000-04-06 | Alcon Laboratories, Inc. | Antibiotic compositions for treatment of the eye, ear and nose |
| WO2000051623A2 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| US6174859B1 (en) * | 1999-04-06 | 2001-01-16 | J & D Sciences, Inc. | Method of treatment |
| EP1181039A2 (en) * | 1999-05-24 | 2002-02-27 | Xoma (US) LLC | Therapeutic uses of bpi protein products in humans with otitis media with effusion |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| WO2002050287A2 (en) * | 2000-12-18 | 2002-06-27 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
| US7247704B2 (en) * | 2000-12-18 | 2007-07-24 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
| US6511960B2 (en) * | 2001-01-05 | 2003-01-28 | Alphamed Pharmaceuticals Corp | Cromolyn for eye and ear infections |
| JP2006508971A (ja) * | 2002-11-20 | 2006-03-16 | アライバ−プロメティック インコーポレイティド | プロテアーゼ阻害剤を使用して炎症性疾患を治療する組成物及び方法 |
-
2003
- 2003-12-08 CA CA002508762A patent/CA2508762A1/en not_active Abandoned
- 2003-12-08 JP JP2004558595A patent/JP2006510657A/ja active Pending
- 2003-12-08 EP EP03812891A patent/EP1567183A4/en not_active Withdrawn
- 2003-12-08 WO PCT/US2003/039053 patent/WO2004052236A2/en not_active Ceased
- 2003-12-08 US US10/731,375 patent/US20040175383A1/en not_active Abandoned
- 2003-12-08 AU AU2003296378A patent/AU2003296378A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003296378A1 (en) | 2004-06-30 |
| WO2004052236A2 (en) | 2004-06-24 |
| JP2006510657A (ja) | 2006-03-30 |
| US20040175383A1 (en) | 2004-09-09 |
| WO2004052236A3 (en) | 2004-08-26 |
| EP1567183A2 (en) | 2005-08-31 |
| EP1567183A4 (en) | 2006-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |