JP2006509841A5 - - Google Patents
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- Publication number
- JP2006509841A5 JP2006509841A5 JP2005508300A JP2005508300A JP2006509841A5 JP 2006509841 A5 JP2006509841 A5 JP 2006509841A5 JP 2005508300 A JP2005508300 A JP 2005508300A JP 2005508300 A JP2005508300 A JP 2005508300A JP 2006509841 A5 JP2006509841 A5 JP 2006509841A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- tris
- physiologically acceptable
- carboxylic acid
- contrast agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000009472 formulation Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 15
- 239000007983 Tris buffer Substances 0.000 claims 7
- 150000001412 amines Chemical class 0.000 claims 7
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 7
- 239000002872 contrast media Substances 0.000 claims 7
- 239000000872 buffer Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- DLPPIGPJCKKVBA-UHFFFAOYSA-N Iosimenol Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)N)=C(I)C(N(CC(O)CO)C(=O)CC(=O)N(CC(O)CO)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(N)=O)C=2I)I)=C1I DLPPIGPJCKKVBA-UHFFFAOYSA-N 0.000 claims 4
- 229950004246 iosimenol Drugs 0.000 claims 4
- -1 2,3-dihydroxypropylcarbamoyl Chemical group 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical group CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000007689 inspection Methods 0.000 claims 1
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims 1
- 229960004359 iodixanol Drugs 0.000 claims 1
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical compound NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43287902P | 2002-12-12 | 2002-12-12 | |
| US10/701,586 US7250153B2 (en) | 2002-12-12 | 2003-11-05 | Contrast media formulations having improved biological tolerance |
| PCT/US2003/035762 WO2004054637A2 (en) | 2002-12-12 | 2003-11-07 | Contrast media formulations having improved biological tolerance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509841A JP2006509841A (ja) | 2006-03-23 |
| JP2006509841A5 true JP2006509841A5 (https=) | 2006-12-14 |
Family
ID=34107426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005508300A Abandoned JP2006509841A (ja) | 2002-12-12 | 2003-11-07 | 生物学的許容量が改善された造影剤配合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7250153B2 (https=) |
| EP (1) | EP1575621B1 (https=) |
| JP (1) | JP2006509841A (https=) |
| KR (1) | KR101067159B1 (https=) |
| CN (1) | CN1738651A (https=) |
| AT (1) | ATE447416T1 (https=) |
| AU (1) | AU2003295442B2 (https=) |
| CA (1) | CA2509035C (https=) |
| CY (1) | CY1110105T1 (https=) |
| DE (1) | DE60329939D1 (https=) |
| DK (1) | DK1575621T3 (https=) |
| ES (1) | ES2333863T3 (https=) |
| IL (1) | IL169119A (https=) |
| NO (1) | NO332350B1 (https=) |
| NZ (1) | NZ541139A (https=) |
| PT (1) | PT1575621E (https=) |
| SI (1) | SI1575621T1 (https=) |
| WO (1) | WO2004054637A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE529135T1 (de) * | 2004-03-11 | 2011-11-15 | Mallinckrodt Llc | Röntgenkontrastformulierung mit einem gemisch aus einem jodierten monomer und dimer |
| FR2899581B1 (fr) * | 2006-04-07 | 2008-06-27 | Guerbet Sa | Procede d'atomisation du ioxilan |
| EP2240432B1 (en) | 2008-01-14 | 2012-07-04 | Mallinckrodt LLC | Process for the preparation of iosimenol |
| JP5947784B2 (ja) * | 2010-03-23 | 2016-07-06 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 安定化ｘ線診断用組成物の製法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU523295B2 (en) | 1978-07-04 | 1982-07-22 | Nycomed Imaging As | X-ray contrast agent |
| US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| AU6114396A (en) * | 1995-06-16 | 1997-01-15 | Biophysica Foundation | Formyl derivatives as nonionic contrast media |
| DE19648650C2 (de) | 1996-01-29 | 1998-07-02 | Schering Ag | Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung |
-
2003
- 2003-11-05 US US10/701,586 patent/US7250153B2/en not_active Expired - Lifetime
- 2003-11-07 EP EP03786628A patent/EP1575621B1/en not_active Expired - Lifetime
- 2003-11-07 ES ES03786628T patent/ES2333863T3/es not_active Expired - Lifetime
- 2003-11-07 SI SI200331689T patent/SI1575621T1/sl unknown
- 2003-11-07 CN CNA2003801090166A patent/CN1738651A/zh active Pending
- 2003-11-07 DE DE60329939T patent/DE60329939D1/de not_active Expired - Lifetime
- 2003-11-07 NZ NZ541139A patent/NZ541139A/en not_active IP Right Cessation
- 2003-11-07 JP JP2005508300A patent/JP2006509841A/ja not_active Abandoned
- 2003-11-07 WO PCT/US2003/035762 patent/WO2004054637A2/en not_active Ceased
- 2003-11-07 CA CA2509035A patent/CA2509035C/en not_active Expired - Lifetime
- 2003-11-07 DK DK03786628T patent/DK1575621T3/da active
- 2003-11-07 PT PT03786628T patent/PT1575621E/pt unknown
- 2003-11-07 AT AT03786628T patent/ATE447416T1/de active
- 2003-11-07 AU AU2003295442A patent/AU2003295442B2/en not_active Ceased
- 2003-11-07 KR KR1020057010571A patent/KR101067159B1/ko not_active Expired - Fee Related
-
2005
- 2005-06-09 IL IL169119A patent/IL169119A/en active IP Right Grant
- 2005-07-08 NO NO20053343A patent/NO332350B1/no not_active IP Right Cessation
-
2010
- 2010-02-01 CY CY20101100092T patent/CY1110105T1/el unknown
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