JP2006509801A - 新規ｍｃｈ受容体アンタゴニスト - Google Patents
新規ｍｃｈ受容体アンタゴニスト Download PDFInfo
- Publication number
- JP2006509801A JP2006509801A JP2004559142A JP2004559142A JP2006509801A JP 2006509801 A JP2006509801 A JP 2006509801A JP 2004559142 A JP2004559142 A JP 2004559142A JP 2004559142 A JP2004559142 A JP 2004559142A JP 2006509801 A JP2006509801 A JP 2006509801A
- Authority
- JP
- Japan
- Prior art keywords
- biphenyl
- carboxylic acid
- ethylsulfanylmethyl
- phenoxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C(C1)C2N1*=C2 Chemical compound C(C1)C2N1*=C2 0.000 description 8
- NCTVJZZCBNDOOB-UHFFFAOYSA-N CCOC(c(cc1)ccc1-c1cccc(CSCCOc2ccccc2)c1)=O Chemical compound CCOC(c(cc1)ccc1-c1cccc(CSCCOc2ccccc2)c1)=O NCTVJZZCBNDOOB-UHFFFAOYSA-N 0.000 description 1
- IIXXRUDYYUINQJ-UHFFFAOYSA-N CCOC(c1cc(-c2ccc(CSCCO)cc2)ccc1)=O Chemical compound CCOC(c1cc(-c2ccc(CSCCO)cc2)ccc1)=O IIXXRUDYYUINQJ-UHFFFAOYSA-N 0.000 description 1
- ZXMLJRDQSDGZAD-UHFFFAOYSA-N CCOC(c1ccccc1-c1ccc(CSCCOc2ccccc2)cc1)=O Chemical compound CCOC(c1ccccc1-c1ccc(CSCCOc2ccccc2)cc1)=O ZXMLJRDQSDGZAD-UHFFFAOYSA-N 0.000 description 1
- WFBDWTZOYPUBQZ-UHFFFAOYSA-N CN(C)CCCNC=O Chemical compound CN(C)CCCNC=O WFBDWTZOYPUBQZ-UHFFFAOYSA-N 0.000 description 1
- WUPJWBCAEKWGDY-UHFFFAOYSA-N CN(C)CCNC(c(cc1)ccc1-c1c(CSCCOc2ccccc2)cccc1)=O Chemical compound CN(C)CCNC(c(cc1)ccc1-c1c(CSCCOc2ccccc2)cccc1)=O WUPJWBCAEKWGDY-UHFFFAOYSA-N 0.000 description 1
- DLMBMQNMBCWDEE-UHFFFAOYSA-N CN(C)CCNC(c(cc1)ccc1-c1cc(CSCCOc2ccccc2)ccc1)=O Chemical compound CN(C)CCNC(c(cc1)ccc1-c1cc(CSCCOc2ccccc2)ccc1)=O DLMBMQNMBCWDEE-UHFFFAOYSA-N 0.000 description 1
- IZKADXKYGNXDBR-UHFFFAOYSA-N CN(C)CCNC(c1ccccc1-c1cc(/[O]=C(\C(O)=O)/O)c(CSCCOc2ccccc2)cc1)=O Chemical compound CN(C)CCNC(c1ccccc1-c1cc(/[O]=C(\C(O)=O)/O)c(CSCCOc2ccccc2)cc1)=O IZKADXKYGNXDBR-UHFFFAOYSA-N 0.000 description 1
- LEUBZGIKQCNSLF-UHFFFAOYSA-N CN(C)CCNC(c1ccccc1-c1cc(CSCCOc2ccccc2)ccc1)=O Chemical compound CN(C)CCNC(c1ccccc1-c1cc(CSCCOc2ccccc2)ccc1)=O LEUBZGIKQCNSLF-UHFFFAOYSA-N 0.000 description 1
- XHNDTOIDDFTOSR-MUUNZHRXSA-N C[C@@]1(CSCCOc2ccccc2)C=CC(c(cccc2)c2C(NCCCN(C)C)=O)=CC1 Chemical compound C[C@@]1(CSCCOc2ccccc2)C=CC(c(cccc2)c2C(NCCCN(C)C)=O)=CC1 XHNDTOIDDFTOSR-MUUNZHRXSA-N 0.000 description 1
- XKQXLVJSIBNOIB-JOCHJYFZSA-N C[C@H](C=C(C=C1C(NCCCN(C)C)=O)c2c(CSCCOc3ccccc3)cccc2)C1=C Chemical compound C[C@H](C=C(C=C1C(NCCCN(C)C)=O)c2c(CSCCOc3ccccc3)cccc2)C1=C XKQXLVJSIBNOIB-JOCHJYFZSA-N 0.000 description 1
- DVTVIARLMYRPDW-UHFFFAOYSA-N OC(c1cccc(-c2c(CNCCOc3ccccc3)cccc2)c1)=O Chemical compound OC(c1cccc(-c2c(CNCCOc3ccccc3)cccc2)c1)=O DVTVIARLMYRPDW-UHFFFAOYSA-N 0.000 description 1
- KLOFYERXNUPFDL-UHFFFAOYSA-N OC(c1ccccc1-c1c(CSCCOc2ccccc2)cccc1)=O Chemical compound OC(c1ccccc1-c1c(CSCCOc2ccccc2)cccc1)=O KLOFYERXNUPFDL-UHFFFAOYSA-N 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N c1ccccc1 Chemical compound c1ccccc1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43270102P | 2002-12-11 | 2002-12-11 | |
| PCT/US2003/037071 WO2004052848A1 (en) | 2002-12-11 | 2003-12-03 | Novel mch receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006509801A true JP2006509801A (ja) | 2006-03-23 |
| JP2006509801A5 JP2006509801A5 (enExample) | 2006-12-28 |
Family
ID=32507985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559142A Withdrawn JP2006509801A (ja) | 2002-12-11 | 2003-12-03 | 新規ｍｃｈ受容体アンタゴニスト |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7132456B2 (enExample) |
| EP (1) | EP1572637A1 (enExample) |
| JP (1) | JP2006509801A (enExample) |
| CN (1) | CN1726189A (enExample) |
| AU (1) | AU2003302925A1 (enExample) |
| BR (1) | BR0316948A (enExample) |
| CA (1) | CA2509042A1 (enExample) |
| MX (1) | MXPA05006272A (enExample) |
| WO (1) | WO2004052848A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008026614A1 (en) * | 2006-08-30 | 2008-03-06 | Semiconductor Energy Laboratory Co., Ltd. | Method for synthesizing anthracene derivative and anthracene derivative, light emitting element, light emitting device, electronic device |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7446204B2 (en) | 2004-10-08 | 2008-11-04 | H. Lundbeck A/S | Amino substituted aryloxybenzylpiperidine derivatives |
| US7329656B2 (en) | 2004-10-08 | 2008-02-12 | H. Lundbeck A/S | Arylthiobenzylpiperidine derivatives |
| US7902356B2 (en) | 2004-12-17 | 2011-03-08 | Eli Lilly And Company | Thiazolopyridinone derivates as MCH receptor antagonists |
| CN101184732B (zh) * | 2005-03-28 | 2012-05-16 | 株式会社半导体能源研究所 | 蒽衍生物、发光元件用材料、发光元件、发光装置和电子器件 |
| US7731377B2 (en) * | 2006-03-21 | 2010-06-08 | Semiconductor Energy Laboratory Co., Ltd. | Backlight device and display device |
| US7772162B2 (en) | 2006-03-27 | 2010-08-10 | Board Of Regents, The University Of Texas System | Use of fluorocarbon surfactants to improve the productivity of gas and gas condensate wells |
| US20070225176A1 (en) * | 2006-03-27 | 2007-09-27 | Pope Gary A | Use of fluorocarbon surfactants to improve the productivity of gas and gas condensate wells |
| EP2402317B1 (en) * | 2006-03-31 | 2013-07-03 | Novartis AG | DGAT inhibitor |
| CN101522614B (zh) | 2006-08-09 | 2014-06-25 | 史密丝克莱恩比彻姆公司 | 作为阿片样物质受体的拮抗剂或反向激动剂的化合物 |
| MX2009010091A (es) * | 2007-03-23 | 2010-02-17 | Univ Texas | Metodo para tratar una formacion de hidrocarburos. |
| CN101821305A (zh) * | 2007-03-23 | 2010-09-01 | 德克萨斯州立大学董事会 | 用溶剂处理地层的方法 |
| US7723722B2 (en) | 2007-03-23 | 2010-05-25 | Semiconductor Energy Laboratory Co., Ltd. | Organic compound, anthracene derivative, and light-emitting element, light-emitting device, and electronic device using anthracene derivative |
| US20080286445A1 (en) * | 2007-05-17 | 2008-11-20 | Semiconductor Energy Laboratory Co., Ltd. | Composition, and method of fabricating light-emitting element |
| AR066169A1 (es) * | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
| MX2010005870A (es) * | 2007-11-30 | 2010-08-02 | Univ Texas | Metodos para mejorar la productividad de pozos productores de petroleo. |
| CN102089282A (zh) * | 2008-07-08 | 2011-06-08 | 株式会社半导体能源研究所 | 咔唑衍生物、发光元件用材料、发光元件以及发光装置 |
| EP2166001B1 (en) * | 2008-09-19 | 2011-07-20 | Semiconductor Energy Laboratory Co., Ltd. | Carbazole Derivative and Method for Producing the Same |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| MX348131B (es) | 2011-02-25 | 2017-05-26 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos. |
| WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2014130608A1 (en) | 2013-02-22 | 2014-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| KR102844041B1 (ko) | 2016-02-26 | 2025-08-11 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 유기 화합물, 발광 소자, 발광 장치, 전자 기기, 및 조명 장치 |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298B1 (en) | 2016-12-20 | 2026-03-11 | Merck Sharp & Dohme LLC | Antidiabetic spirochroman compounds |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| UA126421C2 (uk) | 2018-07-13 | 2022-09-28 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN121925305A (zh) | 2023-11-09 | 2026-04-24 | 切弗朗菲利浦化学公司 | 用于铬催化剂活化的系统和方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3535330A (en) * | 1968-04-29 | 1970-10-20 | Sandoz Ag | 2,6-diphenyl - 4 - (p-(dilower-alkyl amino lower - alkoxy)phenyl)pyridines and derivatives thereof |
| US3928449A (en) * | 1969-04-03 | 1975-12-23 | Sandoz Ag | Aminoalkoxy-terphenyls and the salts thereof |
| LU78484A1 (de) * | 1977-11-10 | 1979-06-13 | Ciba Geigy Ag | Verfahren zur herstellung von benzoxazolyl-phenyl-stilbenen |
| DE2752361A1 (de) | 1977-11-24 | 1979-06-07 | Troponwerke Gmbh & Co Kg | Neue indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US7115750B1 (en) | 1999-09-20 | 2006-10-03 | Takeda Pharmaceutical Company Limited | Melanin concentrating hormone antagonist |
-
2003
- 2003-12-03 AU AU2003302925A patent/AU2003302925A1/en not_active Abandoned
- 2003-12-03 CA CA002509042A patent/CA2509042A1/en not_active Abandoned
- 2003-12-03 MX MXPA05006272A patent/MXPA05006272A/es unknown
- 2003-12-03 CN CNA2003801059746A patent/CN1726189A/zh active Pending
- 2003-12-03 BR BR0316948-0A patent/BR0316948A/pt not_active Application Discontinuation
- 2003-12-03 WO PCT/US2003/037071 patent/WO2004052848A1/en not_active Ceased
- 2003-12-03 US US10/536,053 patent/US7132456B2/en not_active Expired - Fee Related
- 2003-12-03 JP JP2004559142A patent/JP2006509801A/ja not_active Withdrawn
- 2003-12-03 EP EP03812783A patent/EP1572637A1/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008026614A1 (en) * | 2006-08-30 | 2008-03-06 | Semiconductor Energy Laboratory Co., Ltd. | Method for synthesizing anthracene derivative and anthracene derivative, light emitting element, light emitting device, electronic device |
| US8183793B2 (en) | 2006-08-30 | 2012-05-22 | Semiconductor Energy Laboratory Co., Ltd. | Method for synthesizing anthracene derivative and anthracene derivative, light emitting element, light emitting device, electronic device |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003302925A1 (en) | 2004-06-30 |
| US20060052449A1 (en) | 2006-03-09 |
| WO2004052848A1 (en) | 2004-06-24 |
| CA2509042A1 (en) | 2004-06-24 |
| BR0316948A (pt) | 2005-10-18 |
| CN1726189A (zh) | 2006-01-25 |
| EP1572637A1 (en) | 2005-09-14 |
| MXPA05006272A (es) | 2005-08-19 |
| US7132456B2 (en) | 2006-11-07 |
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