JP2006508994A5 - - Google Patents
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- Publication number
- JP2006508994A5 JP2006508994A5 JP2004554480A JP2004554480A JP2006508994A5 JP 2006508994 A5 JP2006508994 A5 JP 2006508994A5 JP 2004554480 A JP2004554480 A JP 2004554480A JP 2004554480 A JP2004554480 A JP 2004554480A JP 2006508994 A5 JP2006508994 A5 JP 2006508994A5
- Authority
- JP
- Japan
- Prior art keywords
- formoterol
- roflumilast
- pharmaceutical
- daily dose
- lung disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 12
- BPZSYCZIITTYBL-YJYMSZOUSA-N Formoterol Chemical compound C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-YJYMSZOUSA-N 0.000 claims 11
- MNDBXUUTURYVHR-UHFFFAOYSA-N Roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 11
- 229960002586 Roflumilast Drugs 0.000 claims 11
- 229960002848 formoterol Drugs 0.000 claims 11
- 208000009856 Lung Disease Diseases 0.000 claims 6
- 230000035492 administration Effects 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
Claims (10)
- ヒトにおける気道疾患の発症の抑制又は治療におけるロフルミラストとホルモテロールとの組合せ使用に適した医薬品であって、ロフルミラストとホルモテロールとを固定された又は自由な組合せで有する医薬品。
- 固定された経口組合せである、請求項１記載の医薬品。
- ロフルミラストを１００〜５００μｇの日用量で、かつホルモテロールを１０〜１２０μｇの日用量で含有する固定された経口組合せである、請求項１記載の医薬品。
- ロフルミラストを経口製剤中に含有し、かつホルモテロールを吸入投与に適した製剤中に含有する自由な組合せである、請求項１記載の医薬品。
- ロフルミラストを経口製剤中に１００〜５００μｇの日用量で含有し、かつホルモテロールを吸入による投与に適した製剤中に１０〜５０μｇの日用量で含有する自由な組合せである、請求項１記載の医薬品。
- ロフルミラストを経口製剤中に含有し、かつホルモテロールを吸入投与に適した製剤中に含有する２つのパック単位を含有する医薬品パックである、請求項１記載の医薬品。
- 肺疾病の発症を抑制又は低減させる又は肺疾病の重傷度を治療又は緩和させるための医薬品であって、有効量のロフルミラストとホルモテロールとを単一の組み合わせた形で、別個に、又は別個かつ順次に投与される形のいずれかで含有し、順次の投与は時間的に接近又は離れている医薬品。
- ロフルミラストを１００〜５００μｇの日用量で、かつホルモテロールを１０〜５０μｇの日用量で含有する、請求項７記載の医薬品。
- 有効成分としてロフルミラストを含有する医薬品パックであって、肺疾病の発症を低減させる又は肺疾病の重傷度を治療又は緩和させるために、ロフルミラストと一緒にホルモテロールを順次に投与し、その際、順次の投与は時間的に接近して又は時間的に離して、任意の順序で投与するという記載を含む医薬品パック。
- 有効成分としてホルモテロールを含有する医薬品パックであって、肺疾病の発症を低減させる又は肺疾病の重傷度を治療又は緩和させるために、ホルモテロールと一緒にロフルミラストを順次に投与し、その際、順次の投与は時間的に接近して又は時間的に離して、任意の順序で投与するという記載を含む医薬品パック。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026505 | 2002-11-27 | ||
| PCT/EP2003/013275 WO2004047829A1 (en) | 2002-11-27 | 2003-11-26 | New synergistic combination comprising roflumilast and formoterol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508994A JP2006508994A (ja) | 2006-03-16 |
| JP2006508994A5 true JP2006508994A5 (ja) | 2006-11-30 |
Family
ID=32338002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554480A Pending JP2006508994A (ja) | 2002-11-27 | 2003-11-26 | ロフルミラスト及びホルモテロールを含有する新規の相乗組合せ |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20060142308A1 (ja) |
| EP (1) | EP1567139B1 (ja) |
| JP (1) | JP2006508994A (ja) |
| KR (1) | KR101071798B1 (ja) |
| CN (1) | CN100346777C (ja) |
| AT (1) | ATE399543T1 (ja) |
| AU (1) | AU2003292120B2 (ja) |
| BR (1) | BR0316451A (ja) |
| CA (1) | CA2506962C (ja) |
| CO (1) | CO5690570A2 (ja) |
| CY (1) | CY1110369T1 (ja) |
| DE (1) | DE60321953D1 (ja) |
| DK (1) | DK1567139T3 (ja) |
| EA (1) | EA009935B1 (ja) |
| ES (1) | ES2309357T3 (ja) |
| HK (1) | HK1081861A1 (ja) |
| HR (1) | HRP20050579B1 (ja) |
| IL (1) | IL168308A (ja) |
| IS (1) | IS2575B (ja) |
| MA (1) | MA27539A1 (ja) |
| ME (1) | ME00489B (ja) |
| MX (1) | MXPA05005437A (ja) |
| NO (1) | NO334247B1 (ja) |
| NZ (1) | NZ540659A (ja) |
| PL (1) | PL216752B1 (ja) |
| PT (1) | PT1567139E (ja) |
| RS (1) | RS51081B (ja) |
| SI (1) | SI1567139T1 (ja) |
| TN (1) | TNSN05131A1 (ja) |
| UA (1) | UA83018C2 (ja) |
| WO (1) | WO2004047829A1 (ja) |
| ZA (1) | ZA200503308B (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| PT1606261E (pt) | 2003-03-10 | 2010-01-11 | Nycomed Gmbh | Novo processo para a preparação de roflumilast |
| CA2601250C (en) * | 2005-03-16 | 2014-10-28 | Nycomed Gmbh | Taste masked dosage form containing roflumilast |
| DE102005030733A1 (de) * | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| UA101556C2 (uk) * | 2006-07-05 | 2013-04-10 | Нікомед Гмбх | Комбіноване застосування інгібітора pde 4 та інгібітора hmg-coa-редуктази для профілактики або зцілювального лікування запального захворювання легенів |
| WO2013077830A1 (en) * | 2011-11-25 | 2013-05-30 | Mahmut Bilgic | Synergistilly active combinations of roflumilast and carmoterol |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| SG11201505835QA (en) * | 2013-01-28 | 2015-08-28 | Incozen Therapeutics Pvt Ltd | Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide |
| CN104800214A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入气雾剂复方及制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| CN1046939C (zh) * | 1993-07-02 | 1999-12-01 | 比克·古尔顿·劳姆贝尔格化学公司 | 氟烷氧基取代的苯甲酰胺类及其制备方法和应用 |
| ATE336254T1 (de) * | 1997-02-17 | 2006-09-15 | Altana Pharma Ag | Zusammensetzungen zur behandlung von irds oder ards die 3-(calcopropylmethoxy)-n-(3,5-dichloro-4-pyridi yl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten |
| US6624181B1 (en) * | 1997-02-28 | 2003-09-23 | Altana Pharma Ag | Synergistic combination |
| DE59814173D1 (de) * | 1997-02-28 | 2008-04-03 | Nycomed Gmbh | Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten |
| EP1107747A4 (en) * | 1998-08-26 | 2003-04-23 | Smithkline Beecham Corp | COMPOSITIONS FOR THE TREATMENT OF PULMONARY DISEASES |
| US6303145B2 (en) * | 1999-05-10 | 2001-10-16 | Sepracor Inc. | (S,R) formoterol methods and compositions |
| AU777012B2 (en) * | 1999-08-21 | 2004-09-30 | Takeda Gmbh | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist |
| GB0103630D0 (en) * | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| JP4143413B2 (ja) * | 2001-03-22 | 2008-09-03 | グラクソ グループ リミテッド | β２−アドレナリン受容体アゴニストとしてのホルムアニリド誘導体 |
| EP1383786B1 (en) * | 2001-04-30 | 2008-10-15 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
-
2003
- 2003-11-26 UA UAA200505966A patent/UA83018C2/uk unknown
- 2003-11-26 ME MEP-2008-782A patent/ME00489B/me unknown
- 2003-11-26 AU AU2003292120A patent/AU2003292120B2/en not_active Ceased
- 2003-11-26 PL PL377732A patent/PL216752B1/pl unknown
- 2003-11-26 DE DE60321953T patent/DE60321953D1/de not_active Expired - Lifetime
- 2003-11-26 EP EP03767663A patent/EP1567139B1/en not_active Expired - Lifetime
- 2003-11-26 BR BR0316451-9A patent/BR0316451A/pt not_active IP Right Cessation
- 2003-11-26 AT AT03767663T patent/ATE399543T1/de active
- 2003-11-26 DK DK03767663T patent/DK1567139T3/da active
- 2003-11-26 JP JP2004554480A patent/JP2006508994A/ja active Pending
- 2003-11-26 RS YUP-2005/0382A patent/RS51081B/sr unknown
- 2003-11-26 NZ NZ540659A patent/NZ540659A/en not_active IP Right Cessation
- 2003-11-26 CA CA2506962A patent/CA2506962C/en not_active Expired - Fee Related
- 2003-11-26 CN CNB2003801037450A patent/CN100346777C/zh not_active Expired - Fee Related
- 2003-11-26 PT PT03767663T patent/PT1567139E/pt unknown
- 2003-11-26 US US10/535,816 patent/US20060142308A1/en not_active Abandoned
- 2003-11-26 MX MXPA05005437A patent/MXPA05005437A/es active IP Right Grant
- 2003-11-26 SI SI200331344T patent/SI1567139T1/sl unknown
- 2003-11-26 KR KR1020057009210A patent/KR101071798B1/ko not_active IP Right Cessation
- 2003-11-26 EA EA200500774A patent/EA009935B1/ru not_active IP Right Cessation
- 2003-11-26 WO PCT/EP2003/013275 patent/WO2004047829A1/en active IP Right Grant
- 2003-11-26 ES ES03767663T patent/ES2309357T3/es not_active Expired - Lifetime
-
2005
- 2005-04-25 ZA ZA200503308A patent/ZA200503308B/en unknown
- 2005-05-01 IL IL168308A patent/IL168308A/en not_active IP Right Cessation
- 2005-05-10 TN TNP2005000131A patent/TNSN05131A1/en unknown
- 2005-06-16 MA MA28343A patent/MA27539A1/fr unknown
- 2005-06-17 NO NO20052999A patent/NO334247B1/no not_active IP Right Cessation
- 2005-06-20 IS IS7898A patent/IS2575B/is unknown
- 2005-06-20 HR HRP20050579AA patent/HRP20050579B1/hr not_active IP Right Cessation
- 2005-06-27 CO CO05062787A patent/CO5690570A2/es not_active Application Discontinuation
-
2006
- 2006-02-20 HK HK06102226A patent/HK1081861A1/xx not_active IP Right Cessation
-
2008
- 2008-09-17 CY CY20081101017T patent/CY1110369T1/el unknown
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