JP2006508985A5 - - Google Patents
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- Publication number
- JP2006508985A5 JP2006508985A5 JP2004553817A JP2004553817A JP2006508985A5 JP 2006508985 A5 JP2006508985 A5 JP 2006508985A5 JP 2004553817 A JP2004553817 A JP 2004553817A JP 2004553817 A JP2004553817 A JP 2004553817A JP 2006508985 A5 JP2006508985 A5 JP 2006508985A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject animal
- ring system
- phenyl ring
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001465754 Metazoa Species 0.000 claims 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 13
- 239000000126 substance Substances 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 9
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 8
- 125000000524 functional group Chemical group 0.000 claims 8
- 239000002207 metabolite Substances 0.000 claims 8
- 231100000252 nontoxic Toxicity 0.000 claims 8
- 230000003000 nontoxic effect Effects 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 5
- 229960002428 fentanyl Drugs 0.000 claims 5
- 125000004962 sulfoxyl group Chemical group 0.000 claims 5
- 150000001336 alkenes Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 230000004060 metabolic process Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/299,027 US7049326B2 (en) | 2000-05-12 | 2002-11-18 | Method and compositions for temporarily incapacitating subjects |
| PCT/US2003/036700 WO2004045536A2 (en) | 2002-11-18 | 2003-11-17 | Method and compositions for temporarily incapaciting subjets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508985A JP2006508985A (ja) | 2006-03-16 |
| JP2006508985A5 true JP2006508985A5 (enExample) | 2006-12-21 |
Family
ID=32324369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553817A Pending JP2006508985A (ja) | 2002-11-18 | 2003-11-17 | 対象動物を一時的に活動無能力化する方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7049326B2 (enExample) |
| EP (1) | EP1565192A2 (enExample) |
| JP (1) | JP2006508985A (enExample) |
| AU (1) | AU2003295574A1 (enExample) |
| CA (1) | CA2503316A1 (enExample) |
| WO (1) | WO2004045536A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7049326B2 (en) * | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| AU2001281746C1 (en) * | 2000-07-31 | 2010-09-09 | ISTITUTO GENTILI S.r.l. | Fentanyl composition for nasal administration |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US20060018837A1 (en) * | 2004-07-26 | 2006-01-26 | Victory Pharma, Inc. | Pharmaceutical compositions and methods for the prevention of drug misuse |
| US20060039865A1 (en) * | 2004-07-26 | 2006-02-23 | Preston David M | Pharmaceutical compositions and methods for the prevention of drug misuse |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| KR101660996B1 (ko) * | 2008-09-16 | 2016-09-28 | 넥타르 테라퓨틱스 | 남용에 대한 낮은 잠재성을 갖는 페길화 오피오이드 |
| US10793519B2 (en) | 2018-05-02 | 2020-10-06 | Academic Pharmaceuticals Incorporated | Ultra short acting anti-arrhythmic agents |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3150137A (en) | 1964-09-22 | Carbamate derivative of s-hydroxy- | ||
| US3636010A (en) | 1968-12-23 | 1972-01-18 | Ciba Geigy Corp | Esters of steroid-17-carboxylic acids |
| US4093721A (en) | 1974-08-30 | 1978-06-06 | Glaxo Laboratories Limited | Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof |
| US4163058A (en) * | 1977-04-22 | 1979-07-31 | Interx Research Corporation | Derivatives of 5,5-diphenylhydantoin exhibiting enhanced solubility and the therapeutic use thereof |
| DE2832310A1 (de) | 1978-07-22 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| US4304781A (en) | 1978-11-30 | 1981-12-08 | John Wyeth & Brother Limited | Treatment of ulcers and hypertension |
| US4405642A (en) | 1980-11-28 | 1983-09-20 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
| US4387103A (en) | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
| US4450173A (en) | 1980-11-28 | 1984-05-22 | American Hospital Supply Corporation | Compounds and method for treatment or prophylaxis of cardiac disorders |
| US4604481A (en) | 1980-11-28 | 1986-08-05 | American Hospital Supply Corporation | Compounds for treatment or prophylaxis of cardiac disorders |
| US4593119A (en) | 1980-11-28 | 1986-06-03 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
| US4804677A (en) | 1981-11-12 | 1989-02-14 | E. I. Du Pont De Nemours And Company | Esters of aryloxypropanolamine derivatives |
| US4906661A (en) | 1981-11-12 | 1990-03-06 | E. I. Du Pont De Nemours And Company | Esters of aryloxypropanolamine derivatives |
| US4623652A (en) | 1981-11-12 | 1986-11-18 | American Hospital Supply Corporation | Esters of thiadiazole oxypropanolaine derivatives and pharmaceutical uses |
| US4692446A (en) | 1981-11-12 | 1987-09-08 | E. I. Du Pont De Nemours & Co., Inc. | Esters of aryloxypropanolamine derivatives and medicinal uses |
| US4508725A (en) | 1982-12-22 | 1985-04-02 | American Hospital Supply Corporation | Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives |
| US4556668A (en) | 1983-07-15 | 1985-12-03 | American Hospital Supply Corporation | Ethylenediamine derivatives of aryloxypropanolamine aryl esters having various medicinal properties |
| US4505926A (en) | 1983-09-15 | 1985-03-19 | Beecham Group P.L.C. | Quaternary amino imidazolidines, compositions and use |
| FI91859C (fi) | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
| TW243449B (enExample) | 1991-02-15 | 1995-03-21 | Hokuriku Pharmaceutical | |
| US5843900A (en) * | 1991-04-01 | 1998-12-01 | Cortech, Inc. | Bradykinin antagonists |
| RU2051092C1 (ru) * | 1991-12-25 | 1995-12-27 | Научно-производственное объединение "Алтай" | Алмазсодержащее вещество и способ его получения |
| RU2041165C1 (ru) * | 1993-02-12 | 1995-08-09 | Научно-производственное объединение "Алтай" | Алмазоуглеродное вещество и способ его получения |
| US5364880A (en) | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| US6316487B1 (en) | 1993-06-16 | 2001-11-13 | Aryx Therapeutics | Compounds for treatment of cardiac arrhythmia synthesis, and methods of use |
| US6159665A (en) | 1993-06-17 | 2000-12-12 | Lucent Technologies Inc. | Processes using photosensitive materials including a nitro benzyl ester photoacid generator |
| US6114344A (en) | 1998-07-16 | 2000-09-05 | Aryx Therapeutics | Long-acting local anesthetics |
| US6683195B2 (en) | 1999-10-15 | 2004-01-27 | Aryx Therapeutics | Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use |
| US6372783B1 (en) | 1999-10-15 | 2002-04-16 | Aryx Therapeutics | Enantiomeric compounds for treatment of cardiac arrhythmias and methods of use |
| EP1276728A2 (en) * | 2000-04-24 | 2003-01-22 | ARYx Therapeutics | Ultrashort acting hypnotic barbiturates |
| WO2001080845A2 (en) | 2000-04-24 | 2001-11-01 | Aryx Therapeutics | (2-aminoethyl) oxime derivatives for the treatment of depression |
| US6756047B2 (en) * | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| US7049326B2 (en) * | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| US6750238B1 (en) * | 2000-05-12 | 2004-06-15 | The University Of Toledo | Aralkyl ester soft drugs |
| AU2001275326C1 (en) | 2000-06-07 | 2006-09-21 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| AU2001294673A1 (en) | 2000-09-21 | 2002-04-02 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis |
| SE0004229D0 (sv) | 2000-11-17 | 2000-11-17 | Aga Ab | Inhalation of nitric oxide |
| AU2002243643A1 (en) | 2001-01-25 | 2002-08-06 | Yale University | Estradiol-16alpha-carboxylic acid esters as locally active estrogens |
| US6686377B2 (en) * | 2001-04-03 | 2004-02-03 | Aryx Therapeutics | Ultrashort-acting opioids for transdermal application |
| WO2002096855A2 (en) | 2001-04-03 | 2002-12-05 | Aryx Therapeutics | Anticholinergic compounds and methods of use |
| US7236201B1 (en) * | 2004-02-12 | 2007-06-26 | The United States Of America As Represented By The Secertary Of The Navy | Method of generating an image in a turbid medium |
| ATE356623T1 (de) * | 2002-01-18 | 2007-04-15 | Aryx Therapeutics | 5-ht3-rezeptorantagonisten und verwendungsverfahren |
-
2002
- 2002-11-18 US US10/299,027 patent/US7049326B2/en not_active Expired - Fee Related
-
2003
- 2003-11-17 AU AU2003295574A patent/AU2003295574A1/en not_active Abandoned
- 2003-11-17 JP JP2004553817A patent/JP2006508985A/ja active Pending
- 2003-11-17 EP EP03786772A patent/EP1565192A2/en not_active Withdrawn
- 2003-11-17 CA CA002503316A patent/CA2503316A1/en not_active Abandoned
- 2003-11-17 WO PCT/US2003/036700 patent/WO2004045536A2/en not_active Ceased
-
2006
- 2006-04-19 US US11/406,902 patent/US20060223784A1/en not_active Abandoned
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