JP2006506969A5 - - Google Patents
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- Publication number
- JP2006506969A5 JP2006506969A5 JP2004521702A JP2004521702A JP2006506969A5 JP 2006506969 A5 JP2006506969 A5 JP 2006506969A5 JP 2004521702 A JP2004521702 A JP 2004521702A JP 2004521702 A JP2004521702 A JP 2004521702A JP 2006506969 A5 JP2006506969 A5 JP 2006506969A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- diabetes
- group
- active ingredient
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 41
- 102000004196 processed proteins & peptides Human genes 0.000 claims 41
- 108090000765 processed proteins & peptides Proteins 0.000 claims 41
- 206010012601 diabetes mellitus Diseases 0.000 claims 27
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000004480 active ingredient Substances 0.000 claims 17
- 230000001225 therapeutic effect Effects 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 208000035475 disorder Diseases 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 13
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 7
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- 239000008177 pharmaceutical agent Substances 0.000 claims 6
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 5
- 102000004877 Insulin Human genes 0.000 claims 5
- 108090001061 Insulin Proteins 0.000 claims 5
- 229940122199 Insulin secretagogue Drugs 0.000 claims 5
- 229940122355 Insulin sensitizer Drugs 0.000 claims 5
- 229940100389 Sulfonylurea Drugs 0.000 claims 5
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 5
- 239000000883 anti-obesity agent Substances 0.000 claims 5
- 229940125710 antiobesity agent Drugs 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000002440 hepatic effect Effects 0.000 claims 5
- 229940125396 insulin Drugs 0.000 claims 5
- BNYHRGTXRPWASY-UHFFFAOYSA-N nonylsulfonylurea Chemical compound CCCCCCCCCS(=O)(=O)NC(N)=O BNYHRGTXRPWASY-UHFFFAOYSA-N 0.000 claims 5
- 230000000580 secretagogue effect Effects 0.000 claims 5
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 4
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 4
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- 208000032928 Dyslipidaemia Diseases 0.000 claims 3
- 208000002705 Glucose Intolerance Diseases 0.000 claims 3
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 3
- 206010056997 Impaired fasting glucose Diseases 0.000 claims 3
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 201000001421 hyperglycemia Diseases 0.000 claims 3
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 3
- 201000008980 hyperinsulinism Diseases 0.000 claims 3
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 201000009104 prediabetes syndrome Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 2
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 229940030600 antihypertensive agent Drugs 0.000 claims 2
- 239000002220 antihypertensive agent Substances 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 239000003613 bile acid Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229940125753 fibrate Drugs 0.000 claims 2
- 238000001415 gene therapy Methods 0.000 claims 2
- 208000004104 gestational diabetes Diseases 0.000 claims 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960003512 nicotinic acid Drugs 0.000 claims 2
- 235000001968 nicotinic acid Nutrition 0.000 claims 2
- 239000011664 nicotinic acid Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 208000030090 Acute Disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 229940126033 PPAR agonist Drugs 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000023852 carbohydrate metabolic process Effects 0.000 claims 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000019439 energy homeostasis Effects 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000003914 insulin secretion Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000002307 peroxisome proliferator activated receptor agonist Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39573802P | 2002-07-12 | 2002-07-12 | |
| PCT/US2003/021761 WO2004006839A2 (en) | 2002-07-12 | 2003-07-11 | Pituitary adenylate cyclase activating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506969A JP2006506969A (ja) | 2006-03-02 |
| JP2006506969A5 true JP2006506969A5 (https=) | 2006-08-10 |
Family
ID=30115918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521702A Pending JP2006506969A (ja) | 2002-07-12 | 2003-07-11 | 下垂体アデニル酸シクラーゼ活性化ペプチド（ｐａｃａｐ）受容体（ｖｐａｃ２）アゴニストおよびそれらの薬理学的使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7378494B2 (https=) |
| EP (1) | EP1578358A2 (https=) |
| JP (1) | JP2006506969A (https=) |
| CN (1) | CN101405298A (https=) |
| AR (1) | AR040548A1 (https=) |
| AU (1) | AU2003267990A1 (https=) |
| BR (1) | BR0312621A (https=) |
| CA (1) | CA2491279A1 (https=) |
| DO (1) | DOP2003000669A (https=) |
| GT (1) | GT200300142A (https=) |
| HN (1) | HN2003000217A (https=) |
| IL (1) | IL165499A (https=) |
| MX (1) | MXPA04012305A (https=) |
| PE (1) | PE20040677A1 (https=) |
| PL (1) | PL377025A1 (https=) |
| RU (1) | RU2360922C2 (https=) |
| TW (1) | TW200409641A (https=) |
| UY (1) | UY27893A1 (https=) |
| WO (1) | WO2004006839A2 (https=) |
| ZA (1) | ZA200501118B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301431D0 (sv) * | 2003-05-19 | 2003-05-19 | Dermagen | Novel antimicrobial peptides |
| US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
| US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
| KR20070009554A (ko) * | 2004-01-27 | 2007-01-18 | 바이엘 파마슈티칼스 코포레이션 | 뇌하수체 아데닐레이트 사이클라제 활성화 펩티드(ｐａｃａｐ) 수용체 (ｖｐａｃ２) 작용제 및 이의약리학적 사용 방법 |
| WO2005113594A1 (en) * | 2004-05-21 | 2005-12-01 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| ES2302201T3 (es) * | 2004-05-21 | 2008-07-01 | Eli Lilly And Company | Agonistas peptidicos del receptor vpac2 selectivos. |
| WO2005119524A2 (en) | 2004-06-04 | 2005-12-15 | Therasense, Inc. | Diabetes care host-client architecture and data management system |
| CA2575101A1 (en) * | 2004-06-12 | 2005-12-29 | Bayer Pharmaceuticals Corporation | Pegylation of vasoactive intestinal peptide (vip)/pituitary adenylate cyclase activating peptide (pacap) receptor 2 (vpac2) agonists and methods of use |
| US20080085860A1 (en) * | 2004-08-18 | 2008-04-10 | Eli Lilly And Company | Selective Vpac2 Receptor Peptide Agonists |
| EP1781692A2 (en) * | 2004-08-18 | 2007-05-09 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| BRPI0516126A (pt) | 2004-10-08 | 2008-08-26 | Forbes Medi Tech Res Inc | produtos farmacêuticos de polipeptìdeos intestinais vasoativos |
| US20070293429A1 (en) * | 2004-10-08 | 2007-12-20 | Therapei Pharmaceuticals, Inc. | Vasoactive Intestinal Polypeptide Compositions |
| US7595294B2 (en) * | 2004-10-08 | 2009-09-29 | Transition Therapeutics, Inc. | Vasoactive intestinal polypeptide pharmaceuticals |
| US20080214440A1 (en) * | 2004-10-08 | 2008-09-04 | Forbes Medi-Tech (Research), Inc. | Vasoactive intestinal polypeptide compositions |
| US20090170775A1 (en) * | 2004-10-08 | 2009-07-02 | Transition Therapeutics, Inc. | Vasoactive intestinal polypeptide compositions |
| JP2008520600A (ja) * | 2004-11-19 | 2008-06-19 | ノヴォソム アクチェンゲゼルシャフト | 局所投与のための医薬組成物におけるまたはそれに関する改善 |
| WO2006068813A1 (en) * | 2004-12-21 | 2006-06-29 | Noveon, Inc. | Compositions |
| US20080200383A1 (en) * | 2005-04-08 | 2008-08-21 | Amylin Pharmaceuticals, Inc. | Pharmaceutical Formulations Comprising Incretin Peptide and Aprotic Polar Solvent |
| CA2607273A1 (en) * | 2005-05-06 | 2006-11-16 | Bayer Pharmaceuticals Corporation | Pituitary adenylate cyclase activating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use |
| WO2007021498A1 (en) * | 2005-08-11 | 2007-02-22 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| CN101296708B (zh) | 2005-10-26 | 2011-12-07 | 伊莱利利公司 | 选择性vpac2受体肽激动剂 |
| US20100048460A1 (en) * | 2006-02-28 | 2010-02-25 | Lianshan Zhang | Selective vpac2 receptor peptide agonists |
| EP2011506A1 (en) * | 2007-07-05 | 2009-01-07 | Nestec S.A. | Supplementation of maternal diet |
| AU2009283157B2 (en) * | 2008-08-21 | 2015-02-26 | Alvine Pharmaceuticals, Inc. | Formulation for oral administration of proteins |
| US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
| CN106794217A (zh) * | 2014-08-06 | 2017-05-31 | 血管生物科学 | 包含对患病组织具有选择性的药效团的组合物及其制备方法 |
| US10899834B2 (en) | 2015-04-16 | 2021-01-26 | H. Lundbeck A/S | Anti-PACAP antibodies |
| KR102444717B1 (ko) | 2016-04-15 | 2022-09-16 | 하. 룬드벡 아크티에셀스카브 | 인간화 항-pacap 항체 및 그의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6972319B1 (en) * | 1999-09-28 | 2005-12-06 | Bayer Pharmaceuticals Corporation | Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use |
-
2003
- 2003-07-11 PL PL377025A patent/PL377025A1/pl unknown
- 2003-07-11 CA CA002491279A patent/CA2491279A1/en not_active Abandoned
- 2003-07-11 JP JP2004521702A patent/JP2006506969A/ja active Pending
- 2003-07-11 EP EP03748938A patent/EP1578358A2/en not_active Withdrawn
- 2003-07-11 DO DO2003000669A patent/DOP2003000669A/es unknown
- 2003-07-11 UY UY27893A patent/UY27893A1/es not_active Application Discontinuation
- 2003-07-11 US US10/618,126 patent/US7378494B2/en not_active Expired - Fee Related
- 2003-07-11 MX MXPA04012305A patent/MXPA04012305A/es unknown
- 2003-07-11 PE PE2003000697A patent/PE20040677A1/es not_active Application Discontinuation
- 2003-07-11 BR BR0312621-8A patent/BR0312621A/pt not_active IP Right Cessation
- 2003-07-11 RU RU2005103396/13A patent/RU2360922C2/ru not_active IP Right Cessation
- 2003-07-11 GT GT200300142A patent/GT200300142A/es unknown
- 2003-07-11 TW TW092118986A patent/TW200409641A/zh unknown
- 2003-07-11 AR AR20030102511A patent/AR040548A1/es unknown
- 2003-07-11 AU AU2003267990A patent/AU2003267990A1/en not_active Abandoned
- 2003-07-11 CN CNA038166445A patent/CN101405298A/zh active Pending
- 2003-07-11 HN HN2003000217A patent/HN2003000217A/es unknown
- 2003-07-11 WO PCT/US2003/021761 patent/WO2004006839A2/en not_active Ceased
-
2004
- 2004-12-01 IL IL165499A patent/IL165499A/en not_active IP Right Cessation
-
2005
- 2005-02-08 ZA ZA200501118A patent/ZA200501118B/en unknown
-
2008
- 2008-05-23 US US12/154,468 patent/US20090258826A1/en not_active Abandoned
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