JP2006503913A5 - - Google Patents
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- Publication number
- JP2006503913A5 JP2006503913A5 JP2005501572A JP2005501572A JP2006503913A5 JP 2006503913 A5 JP2006503913 A5 JP 2006503913A5 JP 2005501572 A JP2005501572 A JP 2005501572A JP 2005501572 A JP2005501572 A JP 2005501572A JP 2006503913 A5 JP2006503913 A5 JP 2006503913A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- benzalkonium chloride
- composition according
- ophthalmic
- eye drop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 26
- 229960000686 Benzalkonium Chloride Drugs 0.000 claims 8
- 239000003889 eye drop Substances 0.000 claims 6
- 208000010412 Glaucoma Diseases 0.000 claims 4
- GGXICVAJURFBLW-CEYXHVGTSA-N Latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 4
- 206010030043 Ocular hypertension Diseases 0.000 claims 4
- 229960001160 latanoprost Drugs 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 2
- 208000001344 Macular Edema Diseases 0.000 claims 2
- 206010025415 Macular oedema Diseases 0.000 claims 2
- 229940068968 Polysorbate 80 Drugs 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 201000010230 macular retinal edema Diseases 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229960004605 timolol Drugs 0.000 claims 2
- 229940012356 Eye Drops Drugs 0.000 claims 1
- 229940054534 Ophthalmic Solution Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002997 ophthalmic solution Substances 0.000 claims 1
Claims (18)
- 有効成分としてラタノプロストを含み、実質的に塩化ベンザルコニウムを含まない、高眼圧症および緑内障の処置のための点眼用組成物。
- 点眼用組成物が溶解剤を含む、請求項１に記載の組成物。
- 溶解剤がポリソルベート８０および／またはＥＤＴＡである、請求項２に記載の組成物。
- 塩化ベンザルコニウム濃度が０．０２％未満である、請求項１に記載の組成物。
- 塩化ベンザルコニウム濃度が０．０１％以下である、請求項１に記載の組成物。
- 点眼用組成物が、単一ユニット・ドーズ・調製物として製剤化されたものである、請求項１に記載の組成物。
- 点眼用組成物がさらにチモロールを含む、請求項１に記載の組成物。
- 点眼用組成物が点眼液である、請求項１に記載の組成物。
- 有効成分としてラタノプロストを含み、塩化ベンザルコニウムを実質的に含まない、角結膜障害および／または黄斑浮腫に罹患しているか罹患するおそれのある患者における高眼圧症および緑内障の処置のための点眼用組成物。
- 点眼用組成物が溶解剤を含む、請求項９に記載の組成物。
- 溶解剤がポリソルベート８０および／またはＥＤＴＡである、請求項１０に記載の組成物。
- 塩化ベンザルコニウム濃度が０．０２％未満である、請求項９に記載の組成物。
- 塩化ベンザルコニウム濃度が０．０１％以下である、請求項９に記載の組成物。
- 点眼用組成物が、単一ユニット・ドーズ・調製物として製剤化されたものである、請求項９に記載の組成物。
- 点眼用組成物がさらにチモロールを含む、請求項９に記載の組成物。
- 点眼用組成物が点眼液である、請求項９に記載の組成物。
- 実質的に塩化ベンザルコニウムを含まない高眼圧症および緑内障の処置のための点眼用組成物を製造するためのラタノプロストの使用。
- 角結膜障害および／または黄斑浮腫に罹患しているか罹患するおそれのある患者における、実質的に塩化ベンザルコニウムを含まない、高眼圧症および緑内障の処置のための点眼用組成物の製造のためのラタノプロストの使用。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42077602P | 2002-10-24 | 2002-10-24 | |
| US42104402P | 2002-10-25 | 2002-10-25 | |
| US10/429,677 US7074827B2 (en) | 2002-10-24 | 2003-05-06 | Method for treating ocular hypertension and glaucoma |
| PCT/JP2003/013452 WO2004037267A1 (en) | 2002-10-24 | 2003-10-22 | Method and composition containing latanoprost for treating ocular hypertension and glaucoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012125019A Division JP2012162570A (ja) | 2002-10-24 | 2012-05-31 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006503913A JP2006503913A (ja) | 2006-02-02 |
| JP2006503913A5 true JP2006503913A5 (ja) | 2006-12-07 |
Family
ID=32110845
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501572A Pending JP2006503913A (ja) | 2002-10-24 | 2003-10-22 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
| JP2012125019A Pending JP2012162570A (ja) | 2002-10-24 | 2012-05-31 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012125019A Pending JP2012162570A (ja) | 2002-10-24 | 2012-05-31 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7074827B2 (ja) |
| EP (2) | EP2253322A1 (ja) |
| JP (2) | JP2006503913A (ja) |
| AT (1) | ATE480240T1 (ja) |
| AU (1) | AU2003274734A1 (ja) |
| CA (1) | CA2502437C (ja) |
| DE (1) | DE60334134D1 (ja) |
| DK (1) | DK1553953T3 (ja) |
| WO (1) | WO2004037267A1 (ja) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005039619A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan, Inc. | Compositions and methods comprising prostaglandin-related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia |
| EP1655021B1 (en) * | 2004-11-09 | 2008-10-29 | Novagali Pharma SA | Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential |
| GB0501192D0 (en) * | 2005-01-20 | 2005-03-02 | Resolution Chemicals Ltd | Stable prostaglandin-containing compositions |
| DE102005035986B4 (de) * | 2005-07-28 | 2009-10-15 | Bausch & Lomb Incorporated | Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat |
| AU2006301493B2 (en) * | 2005-10-10 | 2013-01-10 | Santen Sas | Ophthalmic emulsions containing prostaglandins |
| US7666912B2 (en) * | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
| TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| CN101522171A (zh) * | 2006-09-28 | 2009-09-02 | 爱尔康研究有限公司 | 自身防腐的水性药物组合物 |
| FR2912207B1 (fr) * | 2007-02-01 | 2012-10-26 | Air Liquide | Procede et appareil de production de monoxyde de carbone par distillation cryogenique |
| EP2123278B1 (en) * | 2007-02-07 | 2013-01-09 | Teika Pharmaceutical Co., Ltd. | Eye drop preparation comprising latanoprost |
| JP2008247828A (ja) * | 2007-03-30 | 2008-10-16 | Wakamoto Pharmaceut Co Ltd | ラタノプロストを含有する水性医薬組成物。 |
| FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
| JP2009040727A (ja) * | 2007-08-09 | 2009-02-26 | Towa Yakuhin Kk | ラタノプロストを有効成分とする安定な点眼液剤 |
| PT2193795E (pt) * | 2007-08-29 | 2014-10-22 | Wakamoto Pharma Co Ltd | Composição farmacêutica aquosa contendo latanoprost |
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| TWI544927B (zh) * | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| DK2254549T4 (da) * | 2008-03-17 | 2019-07-22 | Alcon Res Ltd | Vandige farmaceutiske sammensætninger, indeholdende borat-polyolkomplekser |
| EP2127638A1 (en) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| JP2010275259A (ja) * | 2009-05-29 | 2010-12-09 | Toa Yakuhin Kk | 均一、かつ安定なラタノプロスト点眼液剤組成物 |
| TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
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| FR2961694B1 (fr) | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
| US9061034B2 (en) | 2010-07-29 | 2015-06-23 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
| CA2807081C (en) * | 2010-07-29 | 2018-09-18 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
| EP2598117A2 (en) * | 2010-07-29 | 2013-06-05 | Allergan, Inc. | Preservative free bimatoprost solutions |
| EP2452669A1 (en) | 2010-10-29 | 2012-05-16 | Omnivision GmbH | Ophthalmic composition |
| EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
| EP2982373B1 (en) | 2011-01-19 | 2018-06-13 | Topokine Therapeutics, Inc. | Methods and compostions for reducing body fat |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| AU2013245946A1 (en) * | 2012-04-10 | 2014-11-27 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume opthalmic administration |
| CA2870966C (en) | 2012-04-20 | 2021-07-27 | Eyenovia, Inc. | Spray ejector device and methods of use |
| CN104602653B (zh) | 2012-05-14 | 2018-02-16 | 艾诺维亚股份有限公司 | 层流液滴发生器装置以及使用方法 |
| SG11201407431RA (en) | 2012-05-15 | 2014-12-30 | Eyenovia Inc | Ejector devices, methods, drivers, and circuits therefor |
| CN104755073B (zh) | 2012-09-12 | 2017-12-26 | 诺瓦利克有限责任公司 | 半氟化烷烃组合物 |
| MX2015006390A (es) | 2012-11-21 | 2015-08-05 | Topokine Therapeutics Inc | Metodos y composiciones para incrementar localmente la grasa corporal. |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| NO2753788T3 (ja) | 2013-05-10 | 2018-06-16 | ||
| US9820993B2 (en) | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| TW201542196A (zh) * | 2013-08-26 | 2015-11-16 | Rohto Pharma | 眼科用製劑 |
| GR1008483B (el) * | 2013-12-23 | 2015-05-12 | Rafarm Α.Ε.Β.Ε., | Οφθαλμικη φαρμακευτικη συνθεση και μεθοδος για την παρασκευη αυτης |
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| WO2016021371A1 (ja) | 2014-08-05 | 2016-02-11 | ソニー株式会社 | 直流電力送電装置、直流電力受電装置及び直流電力送電システム |
| DE202016008738U1 (de) | 2015-09-30 | 2019-04-09 | Novaliq Gmbh | Semifluorierte Verbindungen und ihre Zusammensetzungen |
| JP6642935B2 (ja) | 2015-09-30 | 2020-02-12 | ノバリック ゲーエムベーハー | 眼投与用の半フッ素化化合物 |
| GR1009040B (el) * | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου |
| PL3442480T3 (pl) | 2016-06-23 | 2020-04-30 | Novaliq Gmbh | Sposób podawania miejscowego |
| CN109890374A (zh) | 2016-09-22 | 2019-06-14 | 诺瓦利克有限责任公司 | 用于治疗睑缘炎的药物组合物 |
| AU2017329983B2 (en) | 2016-09-23 | 2022-05-05 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| WO2018206656A1 (en) | 2017-05-12 | 2018-11-15 | Novaliq Gmbh | Pharmaceutical compositions comprosing semifluorinated alkanes for the treatment of contact lense-related conditions |
| BR112020006072A2 (pt) | 2017-09-27 | 2020-10-06 | Novaliq Gmbh | composições oftalmáticas compreendendo latanoprost para uso no tratamento de doenças oculares |
| CN111182893A (zh) | 2017-10-04 | 2020-05-19 | 诺瓦利克有限责任公司 | 包含f6h8的眼用组合物 |
| WO2019166631A1 (en) | 2018-03-02 | 2019-09-06 | Novaliq Gmbh | Pharmaceutical compositions comprising nebivolol |
| WO2020074697A1 (en) | 2018-10-12 | 2020-04-16 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| EP3886799B1 (en) | 2019-08-07 | 2023-11-15 | Aneira Pharma, Inc. | Compositions for the treatment of hair loss |
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| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
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| US20020035148A1 (en) * | 2000-07-20 | 2002-03-21 | Ryuji Ueno | Treatment of ocular hypertension |
| JP3876355B2 (ja) * | 2000-09-13 | 2007-01-31 | 参天製薬株式会社 | 点眼液 |
| DE60143615D1 (de) * | 2000-09-13 | 2011-01-20 | Asahi Glass Co Ltd | Augentropfen |
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| CA2496540C (en) * | 2002-08-23 | 2011-01-25 | Santen Pharmaceutical Co., Ltd. | Stable ophthalmic solution comprising latanoprost as active ingredient |
| AU2003261981A1 (en) | 2002-09-09 | 2004-03-29 | Santen Pharmaceutical Co., Ltd. | Transparent eye drops containing latanoprost |
-
2003
- 2003-05-06 US US10/429,677 patent/US7074827B2/en not_active Expired - Fee Related
- 2003-10-22 JP JP2005501572A patent/JP2006503913A/ja active Pending
- 2003-10-22 EP EP10171708A patent/EP2253322A1/en not_active Withdrawn
- 2003-10-22 WO PCT/JP2003/013452 patent/WO2004037267A1/en active Application Filing
- 2003-10-22 DK DK03758746.6T patent/DK1553953T3/da active
- 2003-10-22 AT AT03758746T patent/ATE480240T1/de active
- 2003-10-22 EP EP03758746A patent/EP1553953B1/en not_active Expired - Lifetime
- 2003-10-22 AU AU2003274734A patent/AU2003274734A1/en not_active Abandoned
- 2003-10-22 CA CA2502437A patent/CA2502437C/en not_active Expired - Fee Related
- 2003-10-22 DE DE60334134T patent/DE60334134D1/de not_active Expired - Lifetime
-
2006
- 2006-05-23 US US11/438,290 patent/US8673973B2/en not_active Expired - Fee Related
-
2012
- 2012-05-31 JP JP2012125019A patent/JP2012162570A/ja active Pending
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