JP2006501139A5 - - Google Patents
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- Publication number
- JP2006501139A5 JP2006501139A5 JP2003575926A JP2003575926A JP2006501139A5 JP 2006501139 A5 JP2006501139 A5 JP 2006501139A5 JP 2003575926 A JP2003575926 A JP 2003575926A JP 2003575926 A JP2003575926 A JP 2003575926A JP 2006501139 A5 JP2006501139 A5 JP 2006501139A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- tpm
- abf
- angiogenic
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 75
- 230000001772 anti-angiogenic effect Effects 0.000 claims 49
- 239000000203 mixture Substances 0.000 claims 39
- 229920001184 polypeptide Polymers 0.000 claims 38
- 102000004196 processed proteins & peptides Human genes 0.000 claims 38
- 230000033115 angiogenesis Effects 0.000 claims 25
- 108010044853 histidine-rich proteins Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 21
- 102100027619 Histidine-rich glycoprotein Human genes 0.000 claims 17
- 210000002889 endothelial cell Anatomy 0.000 claims 14
- 238000012360 testing method Methods 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 102100035792 Kininogen-1 Human genes 0.000 claims 12
- 108010077861 Kininogens Proteins 0.000 claims 12
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 12
- 238000001727 in vivo Methods 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 9
- 108010029485 Protein Isoforms Proteins 0.000 claims 7
- 102000001708 Protein Isoforms Human genes 0.000 claims 7
- 230000009545 invasion Effects 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000001023 pro-angiogenic effect Effects 0.000 claims 6
- 230000035755 proliferation Effects 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 238000012216 screening Methods 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000033001 locomotion Effects 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 102000001189 Cyclic Peptides Human genes 0.000 claims 3
- 108010069514 Cyclic Peptides Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 102000007079 Peptide Fragments Human genes 0.000 claims 2
- 108010033276 Peptide Fragments Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 2
- 238000013508 migration Methods 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- VGIRNWJSIRVFRT-UHFFFAOYSA-N 2',7'-difluorofluorescein Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(F)C(=O)C=C2OC2=CC(O)=C(F)C=C21 VGIRNWJSIRVFRT-UHFFFAOYSA-N 0.000 claims 1
- 102000007469 Actins Human genes 0.000 claims 1
- 108010085238 Actins Proteins 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 101001081399 Homo sapiens Histidine-rich glycoprotein Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108010053210 Phycocyanin Proteins 0.000 claims 1
- 108010004729 Phycoerythrin Proteins 0.000 claims 1
- 102000003672 Tropomodulin Human genes 0.000 claims 1
- 108090000089 Tropomodulin Proteins 0.000 claims 1
- 102000005937 Tropomyosin Human genes 0.000 claims 1
- 108010030743 Tropomyosin Proteins 0.000 claims 1
- 102000004987 Troponin T Human genes 0.000 claims 1
- 108090001108 Troponin T Proteins 0.000 claims 1
- 108010004469 allophycocyanin Proteins 0.000 claims 1
- 239000002870 angiogenesis inducing agent Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 102000028861 calmodulin binding Human genes 0.000 claims 1
- 108091000084 calmodulin binding Proteins 0.000 claims 1
- 102000006783 calponin Human genes 0.000 claims 1
- 108010086826 calponin Proteins 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004528 endothelial cell apoptotic process Effects 0.000 claims 1
- 230000010595 endothelial cell migration Effects 0.000 claims 1
- ZFKJVJIDPQDDFY-UHFFFAOYSA-N fluorescamine Chemical compound C12=CC=CC=C2C(=O)OC1(C1=O)OC=C1C1=CC=CC=C1 ZFKJVJIDPQDDFY-UHFFFAOYSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 238000005462 in vivo assay Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229940054441 o-phthalaldehyde Drugs 0.000 claims 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36404702P | 2002-03-15 | 2002-03-15 | |
| PCT/US2003/008060 WO2003077872A2 (en) | 2002-03-15 | 2003-03-17 | Cell surface tropomyosin as a target of angiogenesis inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006501139A JP2006501139A (ja) | 2006-01-12 |
| JP2006501139A5 true JP2006501139A5 (enExample) | 2006-06-15 |
Family
ID=28041863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003575926A Pending JP2006501139A (ja) | 2002-03-15 | 2003-03-17 | 血管形成阻害の標的としての細胞表面トロポミオシン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050124794A1 (enExample) |
| EP (1) | EP1575525A4 (enExample) |
| JP (1) | JP2006501139A (enExample) |
| AU (1) | AU2003218194A1 (enExample) |
| CA (1) | CA2478962A1 (enExample) |
| WO (1) | WO2003077872A2 (enExample) |
| ZA (1) | ZA200407373B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301988D0 (sv) * | 2003-07-07 | 2003-07-07 | Innoventus Project Ab | Active subfragment of an endogenous peptide |
| WO2006058375A1 (en) * | 2004-12-01 | 2006-06-08 | The Royal Alexandra Hospital For Children | Identification of compounds for the treatment of proliferative disorders |
| DE102005002110A1 (de) * | 2005-01-17 | 2006-07-27 | Protagen Ag | Regulatorische-T-Zellen enthaltend Proteine zur Therapie und Diagnose von Erkrankungen |
| US20090170123A1 (en) | 2005-10-21 | 2009-07-02 | Fernando Donate | Identification of Novel Protein Targets on the Surface of Stressed Cells |
| AU2016372159B2 (en) | 2015-12-15 | 2022-03-24 | Takeda Pharmaceutical Company Limited | Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK |
| US12274720B2 (en) | 2017-05-24 | 2025-04-15 | Viktor Veniaminovich Tets | Methods for treating and preventing diseases |
| EP3787638A4 (en) * | 2018-04-30 | 2023-10-18 | Tets, Viktor, Veniaminovich | Tetz-proteins and prion-like proteins and associated methods |
| US11918610B2 (en) | 2018-06-29 | 2024-03-05 | Viktor Veniaminovich Tets | Methods for diagnosis and treatment of type 1 diabetes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6201104B1 (en) * | 1998-12-04 | 2001-03-13 | Entremed, Inc. | Angiogenesis—inhibiting protein binding peptides and proteins and methods of use |
| WO2000064946A2 (en) * | 1999-04-28 | 2000-11-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| WO2001034195A1 (en) * | 1999-11-12 | 2001-05-17 | Temple University Of The Commonwealth System Of Higher Education | Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5 |
| WO2001093897A2 (en) * | 2000-06-02 | 2001-12-13 | Entremed, Inc. | Angiostatin and endostatin binding proteins and methods of use |
-
2003
- 2003-03-17 WO PCT/US2003/008060 patent/WO2003077872A2/en not_active Ceased
- 2003-03-17 AU AU2003218194A patent/AU2003218194A1/en not_active Abandoned
- 2003-03-17 EP EP03714186A patent/EP1575525A4/en not_active Withdrawn
- 2003-03-17 CA CA002478962A patent/CA2478962A1/en not_active Abandoned
- 2003-03-17 US US10/507,734 patent/US20050124794A1/en not_active Abandoned
- 2003-03-17 JP JP2003575926A patent/JP2006501139A/ja active Pending
-
2004
- 2004-09-14 ZA ZA200407373A patent/ZA200407373B/en unknown
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