JP2006500337A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006500337A5 JP2006500337A5 JP2004525233A JP2004525233A JP2006500337A5 JP 2006500337 A5 JP2006500337 A5 JP 2006500337A5 JP 2004525233 A JP2004525233 A JP 2004525233A JP 2004525233 A JP2004525233 A JP 2004525233A JP 2006500337 A5 JP2006500337 A5 JP 2006500337A5
- Authority
- JP
- Japan
- Prior art keywords
- benzazepine
- phenylpropyl
- ethoxycarbonyl
- tetrahydro
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004519 manufacturing process Methods 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- XPCFTKFZXHTYIP-ANYOKISRSA-N 2-[3-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3h-1-benzazepin-1-yl]acetic acid Chemical compound C([C@@H](C(=O)OCC)NC1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-ANYOKISRSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- RUOYMXFSAHQJBB-UHFFFAOYSA-N 2-(1-benzazepin-1-yl)acetic acid;hydrochloride Chemical compound Cl.OC(=O)CN1C=CC=CC2=CC=CC=C12 RUOYMXFSAHQJBB-UHFFFAOYSA-N 0.000 claims 1
- VLWRYAIAFBRQDZ-UHFFFAOYSA-N 2-(2-oxo-3h-1-benzazepin-1-yl)acetic acid Chemical compound C1=CCC(=O)N(CC(=O)O)C2=CC=CC=C21 VLWRYAIAFBRQDZ-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02405653 | 2002-07-26 | ||
| PCT/EP2003/007771 WO2004013105A1 (en) | 2002-07-26 | 2003-07-17 | Crystalline polymorphic and amorphous forms of benazepril hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006500337A JP2006500337A (ja) | 2006-01-05 |
| JP2006500337A5 true JP2006500337A5 (https=) | 2006-08-31 |
Family
ID=31198001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525233A Withdrawn JP2006500337A (ja) | 2002-07-26 | 2003-07-17 | 塩酸ベナゼプリルの結晶多形形態および非晶質形態 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050107359A1 (https=) |
| EP (1) | EP1525189A1 (https=) |
| JP (1) | JP2006500337A (https=) |
| AU (1) | AU2003250086A1 (https=) |
| CA (1) | CA2492949A1 (https=) |
| WO (1) | WO2004013105A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1711493A2 (en) * | 2004-02-06 | 2006-10-18 | CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement | Crystalline forms of zolmitriptan |
| WO2006084761A1 (en) * | 2005-02-11 | 2006-08-17 | Albemarle Corporation | Crystalline polymorphs of benazepril hydrochloride |
| EP1891014B1 (en) * | 2005-05-12 | 2009-03-11 | Lupin Ltd. | Improved process for crystallization of benazepril hydrochloride |
| KR101324862B1 (ko) * | 2011-07-12 | 2013-11-01 | (주)에이에스텍 | 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법 |
| WO2014080259A1 (en) * | 2012-11-21 | 2014-05-30 | Enaltec Labs Pvt. Ltd. | Novel polymorphic forms of alcaftadine |
| CN104788376A (zh) * | 2014-01-17 | 2015-07-22 | 海门慧聚药业有限公司 | 一种盐酸贝那普利的新晶型及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0072352B1 (de) * | 1981-08-11 | 1986-03-05 | Ciba-Geigy Ag | Benzazepin-2-one, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese Verbindungen enthalten, sowie die Verbindungen zur therapeutischen Verwendung |
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| JP2004513112A (ja) * | 2000-10-31 | 2004-04-30 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | フルバスタチンナトリウムの結晶形 |
| PL361912A1 (en) * | 2000-10-31 | 2004-10-04 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of venlafaxine hydrochloride |
| EP1345903A1 (en) * | 2000-12-21 | 2003-09-24 | Ciba SC Holding AG | Crystalline forms of cerivastatin sodium |
| WO2003013512A2 (en) * | 2001-08-03 | 2003-02-20 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of fluvastatin sodium |
-
2003
- 2003-07-17 US US10/500,910 patent/US20050107359A1/en not_active Abandoned
- 2003-07-17 WO PCT/EP2003/007771 patent/WO2004013105A1/en not_active Ceased
- 2003-07-17 AU AU2003250086A patent/AU2003250086A1/en not_active Abandoned
- 2003-07-17 JP JP2004525233A patent/JP2006500337A/ja not_active Withdrawn
- 2003-07-17 EP EP03766204A patent/EP1525189A1/en not_active Withdrawn
- 2003-07-17 CA CA002492949A patent/CA2492949A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7612214B2 (en) | Organic amine salts of glutamic acid derivatives and their application | |
| JP5395901B2 (ja) | Ｒ−β−アミノフェニル酪酸誘導体の調製方法 | |
| JP5319885B2 (ja) | モナティンの製造方法 | |
| US6872853B1 (en) | Polymorphic forms of sertraline hydrochloride | |
| US20090221595A1 (en) | Crystalline form of sitagliptin | |
| US9227915B2 (en) | Process for the preparation of a crystalline L-MGDA trialkali metal salt | |
| JP5503546B2 (ja) | ４，５−ジメトキシ−１−（メチルアミノメチル）−ベンゾシクロブタンの分離 | |
| TW200815344A (en) | Polymorphs of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide | |
| ME02750B (me) | Kristalni oblik gama - d iv abradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže | |
| JP2005509025A5 (https=) | ||
| JP2006518354A5 (https=) | ||
| JP2006500337A5 (https=) | ||
| PL160103B1 (pl) | Sposób wytwarzania kwasu L-/-/-2-amino-3-/3,4-dwuhydroksyfenylo/propionowego PL PL PL PL PL | |
| JP3872344B2 (ja) | Ｎ−〔（ｓ）−１−カルボキシブチル〕−（ｓ）−アラニンエステルの新規合成方法及びペリンドプリルの合成における適用 | |
| WO2006109671A1 (ja) | モルヒナン誘導体の結晶及びその製造法 | |
| JP3930322B2 (ja) | Ｎ−〔（ｓ）−１−カルボキシブチル〕−（ｓ）−アラニンエステルの新規合成方法及びペリンドプリルの合成における適用 | |
| TWI325416B (en) | Improved process for the production of nitroisourea derivative | |
| TWI327138B (en) | Improved process for the production of nitroguanidine derivative | |
| US20090240064A1 (en) | Crystalline form of atorvastatin hemi-calcium | |
| JP2008526836A (ja) | シブトラミンの無機酸塩 | |
| HU230148B1 (hu) | Eljárás alkoxi-furanon-amin-származékok előállítására, az eljárással kapott vegyületek és a vegyületek alkalmazása | |
| US6130331A (en) | Chemical synthesis of a chiral 1,4-oxazin-2-one | |
| AU6086599A (en) | Method for producing (-)-alpha-(difluoromethyl)ornithine-monohydrochloride monohydrate | |
| CN101228179B (zh) | 制备培哚普利特丁胺的方法 | |
| US20050113309A1 (en) | Crystalline forms(2s)-n-5[amino(imino)methyl]-2-thienylmethyl-1-(2r)-2[(carboxymethyl) amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nh2o |