JP2006500337A5 - - Google Patents
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- Publication number
- JP2006500337A5 JP2006500337A5 JP2004525233A JP2004525233A JP2006500337A5 JP 2006500337 A5 JP2006500337 A5 JP 2006500337A5 JP 2004525233 A JP2004525233 A JP 2004525233A JP 2004525233 A JP2004525233 A JP 2004525233A JP 2006500337 A5 JP2006500337 A5 JP 2006500337A5
- Authority
- JP
- Japan
- Prior art keywords
- benzazepine
- phenylpropyl
- ethoxycarbonyl
- tetrahydro
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004519 manufacturing process Methods 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- XPCFTKFZXHTYIP-ANYOKISRSA-N 2-[3-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3h-1-benzazepin-1-yl]acetic acid Chemical compound C([C@@H](C(=O)OCC)NC1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-ANYOKISRSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- RUOYMXFSAHQJBB-UHFFFAOYSA-N 2-(1-benzazepin-1-yl)acetic acid;hydrochloride Chemical compound Cl.OC(=O)CN1C=CC=CC2=CC=CC=C12 RUOYMXFSAHQJBB-UHFFFAOYSA-N 0.000 claims 1
- VLWRYAIAFBRQDZ-UHFFFAOYSA-N 2-(2-oxo-3h-1-benzazepin-1-yl)acetic acid Chemical compound C1=CCC(=O)N(CC(=O)O)C2=CC=CC=C21 VLWRYAIAFBRQDZ-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02405653 | 2002-07-26 | ||
| PCT/EP2003/007771 WO2004013105A1 (en) | 2002-07-26 | 2003-07-17 | Crystalline polymorphic and amorphous forms of benazepril hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006500337A JP2006500337A (ja) | 2006-01-05 |
| JP2006500337A5 true JP2006500337A5 (enExample) | 2006-08-31 |
Family
ID=31198001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525233A Withdrawn JP2006500337A (ja) | 2002-07-26 | 2003-07-17 | 塩酸ベナゼプリルの結晶多形形態および非晶質形態 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050107359A1 (enExample) |
| EP (1) | EP1525189A1 (enExample) |
| JP (1) | JP2006500337A (enExample) |
| AU (1) | AU2003250086A1 (enExample) |
| CA (1) | CA2492949A1 (enExample) |
| WO (1) | WO2004013105A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005075467A2 (en) * | 2004-02-06 | 2005-08-18 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of zolmitriptan |
| WO2006084761A1 (en) * | 2005-02-11 | 2006-08-17 | Albemarle Corporation | Crystalline polymorphs of benazepril hydrochloride |
| US20090082559A1 (en) * | 2005-05-12 | 2009-03-26 | Lupin Limited | Process for Crystallization of Benazepril Hydrochloride |
| KR101324862B1 (ko) * | 2011-07-12 | 2013-11-01 | (주)에이에스텍 | 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법 |
| US9409913B2 (en) * | 2012-11-21 | 2016-08-09 | Enaltec Labs Private Limited | Polymorphic forms of alcaftadine |
| CN104788376A (zh) * | 2014-01-17 | 2015-07-22 | 海门慧聚药业有限公司 | 一种盐酸贝那普利的新晶型及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE18397T1 (de) * | 1981-08-11 | 1986-03-15 | Ciba Geigy Ag | Benzazepin-2-one, verfahren zu ihrer herstellung, pharmazeutische praeparate die diese verbindungen enthalten, sowie die verbindungen zur therapeutischen verwendung. |
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| ES2247193T3 (es) * | 2000-10-31 | 2006-03-01 | Ciba Specialty Chemicals Holding Inc. | Formas cristalinas del fluvastatin sodico. |
| CN100338028C (zh) * | 2000-10-31 | 2007-09-19 | 山道士有限公司 | 盐酸文拉法辛的晶形 |
| WO2002050036A1 (en) * | 2000-12-21 | 2002-06-27 | Ciba Speciality Chemicals Holding Inc. | Crystalline forms of cerivastatin sodium |
| CA2454072A1 (en) * | 2001-08-03 | 2003-02-20 | Paul Adriaan Van Der Schaaf | Crystalline forms of fluvastatin sodium |
-
2003
- 2003-07-17 AU AU2003250086A patent/AU2003250086A1/en not_active Abandoned
- 2003-07-17 EP EP03766204A patent/EP1525189A1/en not_active Withdrawn
- 2003-07-17 WO PCT/EP2003/007771 patent/WO2004013105A1/en not_active Ceased
- 2003-07-17 JP JP2004525233A patent/JP2006500337A/ja not_active Withdrawn
- 2003-07-17 CA CA002492949A patent/CA2492949A1/en not_active Abandoned
- 2003-07-17 US US10/500,910 patent/US20050107359A1/en not_active Abandoned
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