JP2006334819A - Blister film and blister packaging container - Google Patents

Blister film and blister packaging container Download PDF

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Publication number
JP2006334819A
JP2006334819A JP2005159353A JP2005159353A JP2006334819A JP 2006334819 A JP2006334819 A JP 2006334819A JP 2005159353 A JP2005159353 A JP 2005159353A JP 2005159353 A JP2005159353 A JP 2005159353A JP 2006334819 A JP2006334819 A JP 2006334819A
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film
ptp
blister
adsorption layer
deodorant
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JP4659523B2 (en
Inventor
Tatsuya Ogawa
達也 小川
Shinichi Koizumi
真一 小泉
Saori Takahashi
抄織 高橋
Junpei Nakagawa
順平 中川
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Kyodo Printing Co Ltd
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Kyodo Printing Co Ltd
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Priority to JP2005159353A priority Critical patent/JP4659523B2/en
Priority to JP2006120585A priority patent/JP5429948B2/en
Priority to CN2006800229993A priority patent/CN101208244B/en
Priority to PCT/JP2006/308712 priority patent/WO2006115264A1/en
Priority to KR1020077027295A priority patent/KR100922490B1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/40—Applications of laminates for particular packaging purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B32B27/322—Layered products comprising a layer of synthetic resin comprising polyolefins comprising halogenated polyolefins, e.g. PTFE
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B9/00—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B9/00—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00
    • B32B9/04—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B9/041—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material of metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B9/00—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00
    • B32B9/04—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B9/045—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B65D81/267—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being in sheet form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/726—Permeability to liquids, absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/726—Permeability to liquids, absorption
    • B32B2307/7265—Non-permeable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2435/00—Closures, end caps, stoppers
    • B32B2435/02—Closures, end caps, stoppers for containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/40—Closed containers
    • B32B2439/62—Boxes, cartons, cases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging

Abstract

<P>PROBLEM TO BE SOLVED: To provide a PTP blister film constituted so that a barrier layer becoming the outermost layer and an adsorbing layer containing a deodorant are made almost equal in heat shrinkage factor and a deodorizing function is provided to a PTP film base material to make it impossible to feel the deterioration of content, and a blister packaging container using it. <P>SOLUTION: The PTP blister film is constituted by laminating the barrier layer becoming the outermost layer on the adsorbing layer containing the deodorant and contains hydrophobic zeolite as the deodorant. The packaging container using it is also disclosed. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

本発明は、医薬品包装のＰＴＰブリスター用フィルム及びその包装容器に関し、より詳しくは、臭い成分を吸着する機能を備えたＰＴＰブリスター用フィルム及びその包装容器に関する。   The present invention relates to a film for PTP blisters for pharmaceutical packaging and a packaging container thereof, and more particularly to a film for PTP blisters having a function of adsorbing odorous components and a packaging container thereof.

従来、医薬品梱包において、ＰＴＰと言われるブリスター包装が広く使われている。臭いが強い薬剤を包装する場合、医薬品の薬効優先の結果、そのまま市場に投入されることが多数あった。このに対して、ＰＴＰの外袋としてアルミニウム箔ピロー袋を使用して、吸臭剤を同梱する等の対策が採られていたが、煩雑であり、また充分な脱臭能力を有した吸着剤がなかったため、効率良く臭い成分を吸着できる包装形態が望まれていた。また、吸臭剤同梱では、吸臭剤の袋を薬の袋と間違え誤飲する恐れもあった。   Conventionally, blister packaging called PTP has been widely used in pharmaceutical packaging. When packaging drugs with strong odors, many drugs were put on the market as a result of prioritizing the efficacy of the drugs. On the other hand, measures such as using an aluminum foil pillow bag as an outer bag of PTP and bundling a deodorant have been taken, but the adsorbent is troublesome and has sufficient deodorizing ability. Since there was not, the packaging form which can adsorb | suck a odor component efficiently was desired. Moreover, when the odor absorbing agent is included, there is a risk that the odor absorbing agent bag may be mistaken for a medicine bag and accidentally swallowed.

包装用フィルムに吸臭剤を混練したフィルムを使用する場合、疎水性ゼオライトを含有する紙からなる包装材料が開示され（例えば、特許文献１及び２参照）、また、材料に合成ゼオライトや活性炭を練り込んで含有させた容器等が開示されているが（例えば、特許文献３〜６参照）、先に空気中の水分を吸着してしまい、臭いを吸着することはできないという課題があった。また、バリアー層の樹脂と吸着層の樹脂の耐熱性の違いにより加熱成形する際に収縮率に差が出るなどの課題が生じていた。
特許第２５３８４８７号公報 特許第２９９４９２１号公報 特開平１１−３５０７７号公報 特開平１０−１６０９２号公報 特開平７−２２７９０号公報 登録実用新案第３０６３９６３号公報 When using a film in which a deodorant is kneaded in a packaging film, a packaging material made of paper containing a hydrophobic zeolite is disclosed (for example, see Patent Documents 1 and 2), and synthetic zeolite or activated carbon is kneaded into the material. However, there has been a problem that moisture in the air is first adsorbed and odor cannot be adsorbed. In addition, due to the difference in heat resistance between the resin of the barrier layer and the resin of the adsorption layer, there has been a problem such as a difference in shrinkage ratio when thermoforming.
Japanese Patent No. 2538487 Japanese Patent No. 2994921 JP 11-35077 A JP-A-10-16092 Japanese Patent Laid-Open No. 7-22790 Registered Utility Model No. 3063963

本発明の目的は、最外層のバリアー層と吸臭剤を含有する吸着層の熱収縮率をほぼ同等にしたＰＴＰブリスター用フィルムを提供することである。   An object of the present invention is to provide a film for PTP blisters in which the outermost barrier layer and the adsorption layer containing an odorant have substantially the same heat shrinkage rate.

本発明の別の目的は、ＰＴＰフィルム基材に吸臭機能を持たせることで、内容物の変質を感じさせないＰＴＰブリスター用フィルム及びその包装容器を提供することである。   Another object of the present invention is to provide a film for PTP blisters and a packaging container for the PTP blister that does not make the contents of the PTP film base material feel an alteration by giving the odor absorbing function.

本発明に従って、吸臭剤を含有する吸着層の上に、最外層となるバリアー層とを順に積層されたＰＴＰブリスター用フィルムであって、該吸臭剤として疎水性ゼオライトを含有していることを特徴とするＰＴＰブリスター用フィルム及びその包装容器が提供される。   According to the present invention, a PTP blister film in which an outermost barrier layer is laminated in order on an adsorption layer containing a deodorant, characterized in that it contains a hydrophobic zeolite as the deodorant. A film for a PTP blister and a packaging container thereof are provided.

本発明は、ＰＴＰフィルム基材に吸臭機能を持たせることで、誤飲事故を防ぐ包材であるＰＴＰブリスター用フィルム及びその包装容器を提供することが可能となった。   The present invention makes it possible to provide a PTP blister film that is a packaging material that prevents accidental ingestion and its packaging container by providing the PTP film substrate with an odor absorbing function.

更に、内容物保存中に、内容物から発生する異臭を吸臭し、内容物の変質を感じさせないフィルムを市場に流通させることができるようになった。これにより、製剤の費用を削減するＰＴＰブリスター用フィルム及びその包装容器を提供することが可能となった。   Furthermore, during storage of the contents, it has become possible to circulate in the market a film that absorbs the off-flavors generated from the contents and does not feel the deterioration of the contents. Thereby, it became possible to provide the film for PTP blisters which reduces the cost of a formulation, and its packaging container.

以下に、本発明の実施の形態について詳細に説明する。   Hereinafter, embodiments of the present invention will be described in detail.

図１に本発明のＰＴＰブリスター用フィルムの概略断面図を示す。本発明のＰＴＰブリスター用フィルム１は、最内層として吸臭剤を含有する吸着層２、最外層として外気から水分や酸素等の浸入を防ぐバリアー層３から構成されている。吸着層は更に、図２に示すように臭いの吸着は補助的に行う副吸着層２ｂ、吸臭剤の含有割合が副吸着層２ｂより多く、臭いの吸着を主に担う主吸着層２ａとしてもよい。   FIG. 1 shows a schematic cross-sectional view of the PTP blister film of the present invention. The film 1 for PTP blisters of the present invention is composed of an adsorption layer 2 containing a odorant as the innermost layer and a barrier layer 3 that prevents intrusion of moisture, oxygen and the like from the outside air as the outermost layer. Further, as shown in FIG. 2, the adsorbing layer is a sub-adsorbing layer 2b that performs odor adsorption in an auxiliary manner, and the content ratio of the odorant is larger than that of the sub-adsorbing layer 2b. Good.

ＰＴＰブリスター用包装容器は、薬剤等の内容物５等を中心に包装した時、図３のように一方の側をアルミニウム箔とし、そしてＰＴＰブリスター用フィルムを貼り合わせる。   When the packaging container for PTP blisters is packed around the contents 5 such as medicines, the aluminum foil is used on one side as shown in FIG. 3, and the film for PTP blisters is bonded.

本発明にかかる吸着層は、吸臭剤として疎水性ゼオライトを含有する。疎水性ゼオライトは、ゼオライトの結晶骨格内のアルミニウム原子を脱アルミニウム処理して減少させ、シリカアルミナ比を高めて、いわゆるハイシリカゼオライトとすると、水等の極性物質に対する親和性を失い、臭い成分等の非極性物質をより強く吸着するゼオライトである。   The adsorption layer according to the present invention contains hydrophobic zeolite as a deodorant. Hydrophobic zeolite reduces the aluminum atoms in the zeolite crystal skeleton by dealumination and increases the silica-alumina ratio. So-called high silica zeolite loses its affinity for polar substances such as water, odor components, etc. It is a zeolite that more strongly adsorbs nonpolar substances.

本発明にかかるＰＴＰブリスター用フィルムの吸着層において、吸臭剤である疎水性ゼオライトの含有率は５〜７０重量％であることが好ましく、特に好ましくは１０〜７０重量％である。含有率が５重量％未満であると、成形品が十分な吸着性能を得ることは困難であり、７０重量％超とすると、成形が困難となる。臭いの吸着を補助的に行う副吸着層の吸臭剤の含有割合は、臭いの吸着を主に担う主吸着層より少なくてよく、５〜５０重量％が好ましい。   In the adsorption layer of the PTP blister film according to the present invention, the content of the hydrophobic zeolite as the odorant is preferably 5 to 70% by weight, particularly preferably 10 to 70% by weight. If the content is less than 5% by weight, it is difficult for the molded product to obtain sufficient adsorption performance, and if it exceeds 70% by weight, molding becomes difficult. The content of the odorant in the sub-adsorption layer that assists in odor adsorption may be less than the main adsorption layer mainly responsible for odor adsorption, and is preferably 5 to 50% by weight.

本発明にかかる吸着層は、吸臭剤である疎水性ゼオライトを含む総顔料成分を３０〜７０重量％含有することが好ましく、より好ましくは４５〜６５重量％である。含有率が３０重量％未満であると、吸着層の熱収縮率の差違がバリアー層と大きくなり加熱成型時にしわ等が発生し易い、７０重量％超とすると、成形が困難となる。前記吸臭剤以外の顔料成分としては、吸湿性能やガス吸着性能等の機能性を特に持たない顔料を用いてもよいし、機能を有する顔料を含有させれば様々な複合的な効果が得られる。このような顔料としては、合成ゼオライト、酸化カルシウム、炭酸カルシウム、酸化チタン、酸化亜鉛、酸化ジルコニウム、アルミナ、シリカ、マイカ、タルク、カーボン及び活性炭が挙げられる。   The adsorption layer according to the present invention preferably contains 30 to 70% by weight, more preferably 45 to 65% by weight, of the total pigment component including the hydrophobic zeolite as the odorant. If the content is less than 30% by weight, the difference in the heat shrinkage rate of the adsorption layer becomes larger than that of the barrier layer, and wrinkles are likely to occur during heat molding. If it exceeds 70% by weight, molding becomes difficult. As the pigment component other than the odor absorbing agent, a pigment that does not particularly have functionality such as moisture absorption performance and gas adsorption performance may be used, and various composite effects can be obtained by including pigments having functionality. . Such pigments include synthetic zeolite, calcium oxide, calcium carbonate, titanium oxide, zinc oxide, zirconium oxide, alumina, silica, mica, talc, carbon and activated carbon.

合成ゼオライトは、吸着速度が速いため水分を素速く吸着することができる。合成ゼオライトであるモレキュラーシーブは、分子の大きさの違いによって物質を分離するのに用いられる多孔質の粒状物質であり、均一な細孔をもつ構造であって、細孔の空洞に入る小さな分子を吸着して一種のふるいの作用をする。本発明において吸着口径は０．３ｎｍ〜１ｎｍが好ましい。通常、細孔径が０．３ｎｍ、０．４ｎｍ、０．５ｎｍ、１ｎｍのモレキュラーシーブを、それぞれモレキュラーシーブ３Ａ、モレキュラーシーブ４Ａ、モレキュラーシーブ５Ａ、モレキュラーシーブ１３Ｘと称する。また、モレキュラーシーブの平均粒子径は、例えば１０μｍ前後のものが用いられる。   Since synthetic zeolite has a high adsorption rate, it can adsorb moisture quickly. Molecular sieve, a synthetic zeolite, is a porous granular material used to separate materials according to the difference in molecular size, and has a structure with uniform pores, which are small molecules that enter the pore cavity. Adsorbs and acts as a kind of sieve. In the present invention, the adsorption port diameter is preferably 0.3 nm to 1 nm. In general, molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively. The average particle diameter of the molecular sieve is, for example, about 10 μm.

なお、モレキュラーシーブの吸着特性は、細孔径が関与しており、水分の吸着特性を高めるには、モレキュラーシーブの粉末をより細かくすることで、実質的に表面積を広くし、細孔の数を増やすことで対応することができる。   The adsorption characteristics of molecular sieves are related to the pore size. To increase the adsorption characteristics of moisture, the molecular sieve powder is made finer, the surface area is substantially increased, and the number of pores is reduced. We can cope by increasing.

主吸着層の樹脂成分は、少なくとも１種類のメルトフローレートが１０以上であり、かつ低融点（低軟化点）、低温ドローダウン性に優れた樹脂であることが好ましい。メルトフローレートが１０以上の樹脂であれば、吸臭剤を添加することでメルトフローレートが低下しても、ある程度の流れ特性を確保することができる。また、低融点であれば、樹脂が低温で軟化することで、低温押出が可能となり、発泡のおそれを回避できる。低温ドローダウン性に優れた樹脂であれば、吸臭剤を添加したとしても押出成形機による押出成形が容易である。   The resin component of the main adsorption layer is preferably a resin having at least one melt flow rate of 10 or more, a low melting point (low softening point), and excellent low-temperature drawdown properties. If the resin has a melt flow rate of 10 or more, even if the melt flow rate is lowered by adding an odorant, a certain degree of flow characteristics can be secured. In addition, if the melting point is low, the resin softens at a low temperature, thereby enabling low-temperature extrusion and avoiding the possibility of foaming. If it is resin excellent in low temperature drawdown property, even if it adds a odorant, extrusion molding with an extruder is easy.

このような観点から主吸着層の樹脂としては、例えば、ＬＤＰＥ（低密度ポリエチレン）、ＬＬＤＰＥ（直鎖状低密度ポリエチレン）、ＰＰ（ポリプロピレン）、各種共重合体（コポリマー）として、アイオノマー（例えば、エチレンアクリル酸共重合体の塩）、ＥＡＡ（エチレンアクリル酸共重合体）、ＥＭＡＡ（エチレンメタクリル酸共重合体）、ＥＶＡ（エチレン酢酸ビニル共重合体）、ＥＥＡ（エチレンエチレンアクリレート共重合体）、ＥＭＡ（エチレンメチルアクリレート共重合体）及びＥＭＭＡ（エチレンメチルメタクリレート共重合体）等が挙げられ、前記顔料を高含有率で含むことで熱収縮率をポリプロピレンと同等とするためには本発明でバリアー層に好ましく用いられるポリプロピレン、該ポリプロピレンの熱収縮率に近いＬＤＰＥ及びＬＬＤＰＥが好ましい。   From this point of view, as the resin of the main adsorption layer, for example, LDPE (low density polyethylene), LLDPE (linear low density polyethylene), PP (polypropylene), various copolymers (copolymers), ionomer (for example, Salt of ethylene acrylic acid copolymer), EAA (ethylene acrylic acid copolymer), EMAA (ethylene methacrylic acid copolymer), EVA (ethylene vinyl acetate copolymer), EEA (ethylene ethylene acrylate copolymer), Examples thereof include EMA (ethylene methyl acrylate copolymer) and EMMA (ethylene methyl methacrylate copolymer). In order to make the heat shrinkage rate equal to that of polypropylene by including the pigment in a high content, a barrier is used in the present invention. Polypropylene preferably used for the layer, heat shrinkage rate of the polypropylene Nearby LDPE and LLDPE are preferred.

副吸着層の樹脂材料は、主吸着層が本発明でバリアー層に好ましく用いられるポリプロピレンと熱収縮率を同等とするため、該主吸着層を挟み込む副吸着層も熱収縮率を同等とするため、ＬＤＰＥ、ＬＬＤＰＥ及びポリプロピレンが好ましい。   The resin material of the sub-adsorption layer has the same heat shrinkage rate as that of the main adsorption layer that is preferably used for the barrier layer in the present invention, so that the sub-adsorption layer sandwiching the main adsorption layer also has the same heat shrinkage rate. LDPE, LLDPE and polypropylene are preferred.

吸着層は、樹脂と吸着剤をインフレーション法、Ｔダイ法、共押出等の押出成型又は射出成型することによりフィルム状又はシート状に形成され、特にはインフレーション法又はＴダイ法による多層フィルムが好ましい。多層のインフレーション法は、複数の押出し機で溶融した樹脂をチューブ状に押出しし、この中に空気を送って膨らませ、多層フィルムを製造する方法である。吸着層の構造としては、２種３層又は３種３層が好ましい。   The adsorption layer is formed into a film shape or a sheet shape by extrusion molding or injection molding such as inflation method, T-die method, co-extrusion and the like, and particularly a multilayer film by inflation method or T-die method is preferable. . The multilayer inflation method is a method for producing a multilayer film by extruding a resin melted by a plurality of extruders into a tube shape, and sending air into the tube to be expanded. As the structure of the adsorption layer, two or three layers or three or three layers are preferable.

本発明における吸着層の膜厚は３０μｍ〜２００μｍが好ましい。主吸着層の膜厚は１０μｍ〜１９０μｍが好ましく、副吸着層は５μｍ〜１９０μｍが好ましい。   The thickness of the adsorption layer in the present invention is preferably 30 μm to 200 μm. The film thickness of the main adsorption layer is preferably 10 μm to 190 μm, and the sub adsorption layer is preferably 5 μm to 190 μm.

バリアー層に用いられる樹脂としては、外部からの水分や酸素等の浸入を防ぎ、防湿性に優れているものがよく、ポリプロピレン、ポリ塩化ビニル及びポリエチレンテレフタレート等が挙げられる、特にはポリプロピレンが好ましい。   The resin used for the barrier layer is preferably a resin that prevents entry of moisture, oxygen, and the like from the outside and has excellent moisture resistance, and includes polypropylene, polyvinyl chloride, polyethylene terephthalate, and the like, with polypropylene being particularly preferred.

吸着層とバリアー層とを貼り合わせる方法としては、ドライラミネート、サンドラミネーション及び押出しラミネート等が挙げられる。ドライラミネートは接着剤を塗布し乾燥させた後、加圧し、接着剤を硬化させて貼り合わせる方法で、押出しラミネートは複数の押出し機で溶融した接着層用樹脂を押出し貼り合わせる方法で、サンドラミネーションは接着剤で塗布した基材と貼り合わせる側のフィルムとの間に溶融した吸着層用樹脂を押出し貼り合わせる方法である。   Examples of the method for bonding the adsorption layer and the barrier layer include dry lamination, sand lamination, extrusion lamination, and the like. Dry lamination is a method in which an adhesive is applied and dried, then pressure is applied, the adhesive is cured and bonded, and extrusion laminating is a method in which the adhesive layer resin melted by multiple extruders is extruded and bonded together. Is a method of extruding and adhering the molten resin for the adsorbing layer between the base material coated with the adhesive and the film to be bonded.

貼り合わせることにより得られたＰＴＰブリスター用フィルムの膜厚は、５０μｍ〜５００μｍが好ましく、より好ましくは１００μｍ〜４００μｍである。５０μｍ未満ではバリアー性と強度が不足し、５００μｍを超えると硬過ぎて薬剤等のＰＴＰ内容物を押す際に変形しづらくなり内容物の取り出しが困難になる。   As for the film thickness of the film for PTP blisters obtained by bonding together, 50 micrometers-500 micrometers are preferable, More preferably, they are 100 micrometers-400 micrometers. If the thickness is less than 50 μm, the barrier properties and strength are insufficient. If the thickness exceeds 500 μm, the film is too hard to be easily deformed when the PTP content such as a medicine is pressed, and it is difficult to take out the content.

以下に、具体的な実施例を挙げて本発明をより詳細に説明するが、本発明はこれらの実施例に限定されるものではない。   Hereinafter, the present invention will be described in more detail with specific examples, but the present invention is not limited to these examples.

マスターバッチ１（ＭＢ１）として、疎水性ゼオライト（商品名：ＡＢＳＣＥＮＴＳ３０００）が５０重量部に対して、ＬＤＰＥ（商品名：ペトロセン２０４、東ソー社製）５０重量部を混練してペレット状の粒状樹脂を形成した。   As master batch 1 (MB1), 50 parts by weight of LDPE (trade name: Petrocene 204, manufactured by Tosoh Corp.) is mixed with 50 parts by weight of hydrophobic zeolite (trade name: ABSCENTTS 3000) to obtain a pellet-shaped granular resin. Formed.

マスターバッチ２（ＭＢ２）として、モレキュラーシーブ３Ａが７５重量部に対して、ＬＤＰＥ（商品名：ペトロセン２０４）２５重量部を混練してペレット状の粒状樹脂を形成した。   As master batch 2 (MB2), 25 parts by weight of LDPE (trade name: Petrocene 204) was kneaded with 75 parts by weight of molecular sieve 3A to form a pellet-like granular resin.

マスターバッチ３（ＭＢ３）として、モレキュラーシーブ１３Ｘが５０重量部に対して、ＬＤＰＥ（商品名：ペトロセン２０４）７５重量部を混練してペレット状の粒状樹脂を形成した。   As master batch 3 (MB3), 75 parts by weight of LDPE (trade name: Petrocene 204) was kneaded with 50 parts by weight of molecular sieve 13X to form a pellet-like granular resin.

マスターバッチ４（ＭＢ４）として、疎水性ゼオライトが１０重量部に対して、ＬＤＰＥ（商品名：ペトロセン２０４）９０重量部を混練してペレット状の粒状樹脂を形成した。   As master batch 4 (MB4), 10 parts by weight of hydrophobic zeolite was kneaded with 90 parts by weight of LDPE (trade name: Petrocene 204) to form a pellet-shaped granular resin.

（実施例１−１）
吸着層の樹脂として、主吸着層にマスターバッチ１のみ、副吸着層にマスターバッチ４のみ、を用いて多層インフレーション法により２種３層フィルムを作製した。２種３層フィルムの膜厚は、副吸着層／主吸着層／副吸着層＝１０μｍ／５０μｍ／１０μｍである。 (Example 1-1)
A two-type three-layer film was produced by a multilayer inflation method using only master batch 1 as the main adsorption layer and only master batch 4 as the sub-adsorption layer as the resin for the adsorption layer. The film thickness of the two-type three-layer film is sub-adsorption layer / main adsorption layer / sub-adsorption layer = 10 μm / 50 μm / 10 μm.

得られた２種３層フィルムの一方のポリプロピレン１０μｍ側の接着性を向上させるためにコロナ処理を行った。このポリプロピレン１０μｍ側に熱収縮履歴を追い焼きにより解除した膜厚２５０μｍのＰＴＰ用ポリプロピレンフィルム（商品名：ＣＰＰＥ００２５ＮＡ、三菱樹脂社製）を、ドライラミネート法により貼り合わせてＰＴＰブリスター用フィルムを形成した。   In order to improve the adhesiveness of one of the two types and three layers of the obtained polypropylene on the 10 μm side, corona treatment was performed. A polypropylene film for PTP having a film thickness of 250 μm (trade name: CPPE0025NA, manufactured by Mitsubishi Plastics Co., Ltd.) whose heat shrinkage history was canceled by additional baking on the 10 μm side of polypropylene was bonded by a dry laminating method to form a film for PTP blister.

（実施例１−２）
実施例１−１において、主吸着層でマスターバッチ１を８０重量部とＬＬＤＰＥ（商品名：エボリーＳＰ２０２０）２０重量部に変更した以外は、同様にしてＰＴＰブリスター用フィルムを作製した。 (Example 1-2)
A film for PTP blisters was produced in the same manner as in Example 1-1 except that the master batch 1 was changed to 80 parts by weight and 20 parts by weight of LLDPE (trade name: Evory SP2020) in the main adsorption layer.

（実施例１−３〜１−６）
実施例１−２において、主吸着層のマスターバッチ１とＬＬＤＰＥとの混合比率を表１に示した様に変更した以外は、同様にして吸着フィルムを作製した。 (Examples 1-3 to 1-6)
In Example 1-2, an adsorption film was produced in the same manner except that the mixing ratio of master batch 1 of the main adsorption layer and LLDPE was changed as shown in Table 1.

（比較例１−１）
実施例１−１において、主吸着層のマスターバッチ１をマスターバッチ２に変更した以外は、同様にしてＰＴＰブリスター用フィルムを作製した。 (Comparative Example 1-1)
A film for PTP blister was produced in the same manner as in Example 1-1 except that the master batch 1 of the main adsorption layer was changed to the master batch 2.

（比較例１−２〜１−６）
実施例１−２において、主吸着層のマスターバッチ１とＬＬＤＰＥとの混合比率を表２に示した様に変更した以外は、同様にして吸着フィルムを作製した。 (Comparative Examples 1-2 to 1-6)
In Example 1-2, an adsorption film was produced in the same manner except that the mixing ratio of the master batch 1 of the main adsorption layer and LLDPE was changed as shown in Table 2.

（実施例２−１）
実施例１−１において、主吸着層でマスターバッチ１を９０重量部とマスターバッチ３を１０重量部に変更した以外は、同様にして吸着フィルムを作製した。 (Example 2-1)
In Example 1-1, an adsorption film was prepared in the same manner except that the master adsorption layer was changed to 90 parts by weight and the master batch 3 to 10 parts by weight in the main adsorption layer.

（実施例２−２〜２−６）
実施例２−１において、主吸着層のマスターバッチ１とマスターバッチ３との混合比率を表３に示した様に変更した以外は、同様にして吸着フィルムを作製した。 (Examples 2-2 to 2-6)
An adsorption film was produced in the same manner as in Example 2-1, except that the mixing ratio of the master batch 1 and the master batch 3 of the main adsorption layer was changed as shown in Table 3.

上記の作製方法により得られたＰＴＰブリスター用フィルムを、ブリスターパック成形機（ＣＫＤ（株）製）にてＰＴＰ成形を行い、成形性を次の様に評価した。結果を表１〜表３に示す。
成形性の評価方法は、
○：ＰＴＰ成形時にしわ等がよらず良好
△：ＰＴＰ成形時に一部にしわの発生が見られる
×：ＰＴＰ成形時にしわが発生し不良 The PTP blister film obtained by the above production method was subjected to PTP molding with a blister pack molding machine (manufactured by CKD), and the moldability was evaluated as follows. The results are shown in Tables 1 to 3.
The formability evaluation method is
○: Wrinkles etc. are good during PTP molding. Δ: Wrinkles are partly observed during PTP molding. ×: Wrinkles are generated during PTP molding.

また、２本のバイアル瓶にトリエチルアミン又はトルエンを滴下し、一方にはＰＴＰブリスター用フィルムを入れ、密栓する。バイアル瓶を４０℃の恒温槽中に２４時間置く。その後開封した時の臭いを嗅ぎ（官能試験）、吸臭性を○：臭いが減少した、×：変化なしと評価した。結果を表１〜表３に示す。   In addition, triethylamine or toluene is dropped into two vials, and a PTP blister film is placed on one side and sealed. Place the vial in a constant temperature bath at 40 ° C. for 24 hours. After that, the odor when opened was sniffed (sensory test), and the odor absorption was evaluated as ○: the odor decreased, x: no change. The results are shown in Tables 1 to 3.

Figure 2006334819
Figure 2006334819

Figure 2006334819
Figure 2006334819

Figure 2006334819
Figure 2006334819

表１〜表３の結果から、アルミニウムピロー袋に吸臭剤を同梱しなくても、吸臭効果を維持することのできるＰＴＰブリスター用フィルム及びその包装容器を提供することが可能となった。   From the results of Tables 1 to 3, it has become possible to provide a film for PTP blisters and a packaging container thereof that can maintain the odor absorbing effect even if the odor absorbing agent is not included in the aluminum pillow bag.

本発明のＰＴＰブリスター用フィルムの概略断面図である。It is a schematic sectional drawing of the film for PTP blisters of this invention. 本発明のＰＴＰブリスター用フィルムの別の概略断面図である。It is another schematic sectional drawing of the film for PTP blisters of this invention. 本発明のＰＴＰブリスター用包装容器の概略断面図である。It is a schematic sectional drawing of the packaging container for PTP blisters of this invention.

符号の説明Explanation of symbols

１ 吸着フィルム
２ 吸着層
２ａ 主吸着層
２ｂ 副吸着層
３ バリアー層
４ アルミニウム箔
５ 内容物 DESCRIPTION OF SYMBOLS 1 Adsorption film 2 Adsorption layer 2a Main adsorption layer 2b Sub adsorption layer 3 Barrier layer 4 Aluminum foil 5 Contents

Claims (7)

吸臭剤を含有する吸着層の上に、最外層となるバリアー層とを順に積層されたＰＴＰブリスター用フィルムであって、該吸臭剤として疎水性ゼオライトを含有していることを特徴とするＰＴＰブリスター用フィルム。   A PTP blister film in which an outermost barrier layer is laminated in order on an adsorption layer containing a deodorant, wherein the PTP blister contains a hydrophobic zeolite as the deodorant Film. 前記疎水性ゼオライトを５〜７０重量％含有している請求項１に記載のＰＴＰブリスター用フィルム。   The film for PTP blisters according to claim 1, containing 5 to 70% by weight of the hydrophobic zeolite. 前記吸着層が、更に総顔料成分として３０〜７０重量％含有している請求項１又は２に記載のＰＴＰブリスター用フィルム。   The film for PTP blisters according to claim 1 or 2, wherein the adsorption layer further contains 30 to 70% by weight as a total pigment component. 前記顔料成分が合成ゼオライトである請求項１〜３のいずれかに記載のＰＴＰブリスター用フィルム。   The film for PTP blisters according to any one of claims 1 to 3, wherein the pigment component is a synthetic zeolite. 前記ＰＴＰブリスター用フィルムがインフレーションダイ法又はＴダイ法により成形された請求項１〜４のいずれかに記載のＰＴＰブリスター用フィルム。   The PTP blister film according to any one of claims 1 to 4, wherein the PTP blister film is formed by an inflation die method or a T-die method. 前記吸着層に用いられる樹脂の少なくとも１種はメルトフローレートが１０以上である請求項１〜５のいずれかに記載のＰＴＰブリスター用フィルム。   The film for PTP blisters according to any one of claims 1 to 5, wherein at least one of the resins used in the adsorption layer has a melt flow rate of 10 or more. 吸臭剤を含有する吸着層の上に、最外層となるバリアー層とを順に積層されたＰＴＰブリスター用包装容器であって、該吸臭剤として疎水性ゼオライトを含有していることを特徴とするＰＴＰブリスター用包装容器。   A PTP blister packaging container in which an outermost barrier layer is laminated in order on an adsorption layer containing a deodorant, the PTP comprising a hydrophobic zeolite as the deodorant Blister packaging container.
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CN2006800229993A CN101208244B (en) 2005-04-26 2006-04-26 Film for PTP or blister pack, and packaging container for PTP or blister pack
PCT/JP2006/308712 WO2006115264A1 (en) 2005-04-26 2006-04-26 Film for ptp or blister pack, and packaging container for ptp or blister pack
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