JP2006314601A - 結合組織体形成基材およびそれを用いた結合組織体の製造方法 - Google Patents
結合組織体形成基材およびそれを用いた結合組織体の製造方法 Download PDFInfo
- Publication number
- JP2006314601A JP2006314601A JP2005141044A JP2005141044A JP2006314601A JP 2006314601 A JP2006314601 A JP 2006314601A JP 2005141044 A JP2005141044 A JP 2005141044A JP 2005141044 A JP2005141044 A JP 2005141044A JP 2006314601 A JP2006314601 A JP 2006314601A
- Authority
- JP
- Japan
- Prior art keywords
- connective tissue
- forming substrate
- main material
- tube
- sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002808 connective tissue Anatomy 0.000 title claims abstract description 306
- 239000000758 substrate Substances 0.000 title claims abstract description 95
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 239000000463 material Substances 0.000 claims abstract description 267
- 210000001519 tissue Anatomy 0.000 description 26
- 238000000034 method Methods 0.000 description 22
- 238000005538 encapsulation Methods 0.000 description 11
- 210000004204 blood vessel Anatomy 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 229920001296 polysiloxane Polymers 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 230000009772 tissue formation Effects 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 5
- 238000004804 winding Methods 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 241000700157 Rattus norvegicus Species 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 239000002861 polymer material Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 239000004925 Acrylic resin Substances 0.000 description 3
- 229920000178 Acrylic resin Polymers 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000002473 artificial blood Substances 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920002799 BoPET Polymers 0.000 description 2
- 229910001200 Ferrotitanium Inorganic materials 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 229920013716 polyethylene resin Polymers 0.000 description 2
- 229920005990 polystyrene resin Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 210000000626 ureter Anatomy 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 102000007547 Laminin Human genes 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 102100037369 Nidogen-1 Human genes 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010077077 Osteonectin Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 102100037599 SPARC Human genes 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 108060008245 Thrombospondin Proteins 0.000 description 1
- 102000002938 Thrombospondin Human genes 0.000 description 1
- 108010031318 Vitronectin Proteins 0.000 description 1
- 102100035140 Vitronectin Human genes 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 108010008217 nidogen Proteins 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920002557 polyglycidol polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
【解決手段】 結合組織体形成基材は、体内に埋入させて、その表面に細胞の結合組織体を成長させる足場基材であり、厚みのある管状の結合組織体を形成させるために、結合組織管を形成する主材と、主材で形成された結合組織管を覆うことのできる結合組織シートを形成するための副材を備えた構造を有する。
【選択図】図1
Description
11、11a〜e…主材
12、12a〜e…副材
13、13a〜e…隙間
14、14a〜e…連結部
16…結合組織体
17…隙間で形成された結合組織部
18…主材の周囲で形成された結合組織管
19、19a〜c…副材の周囲で形成された結合組織シート
20…結合組織体形成基材
22…結合組織体
23…主材の周囲で形成された結合組織部と副材の周囲で形成された結合組織部との連結部
24…主材の周囲で形成された結合組織管
25…副材の周囲で形成された結合組織部
26…主材を残した状態の結合組織体
27…厚みの増加した管状の結合組織体
28…結合組織体形成基材
29…結合組織体形成基材
30…結合組織体形成基材
31…結合組織体形成基材
Claims (11)
- 管状の結合組織体が周囲に形成される主材およびその表面から外向きに延在する副材を有して成る結合組織体形成基材。
- 体内に埋入することによって、細胞を含む結合組織体に覆われる請求項1に記載の結合組織体形成基材。
- 副材は、主材に形成された結合組織管に重ね合わせることができる結合組織シートを、結合組織管と一体に形成させる請求項1または2に記載の結合組織体形成基材。
- 前記主材が棒状であり、前記副材がフィルム状であることを特徴とする請求項1〜3のいずれかに記載の結合組織体形成基材。
- 前記主材と前記副材がともに棒状であることを特徴とする請求項1〜3のいずれかに記載の結合組織体形成基材。
- 前記主材または前記副材の少なくとも1つの断面が円、楕円または多角形の形状を有することを特徴とする請求項1〜5のいずれかに記載の結合組織体形成基材。
- 前記主材と前記副材は、元々一体に形成されている請求項1〜6のいずれかに記載の結合組織体形成基材。
- 前記主材と前記副材は、独立した部材であり、組み合わせることによって一体にできる請求項1〜6のいずれかに記載の結合組織体形成基材。
- 主材と副材とは相互に離間し、これらの間に隙間が存在する請求項1〜8のいずれかに記載の結合組織体形成基材。
- 結合組織管および結合組織シートを有して成る結合組織体を用いて、結合組織管の周囲に結合組織シートを配置することを含む管状の結合組織体を得ることを含む結合組織管状体を製造する方法。
- 結合組織体は、請求項1〜9のいずれかに記載の結合組織体形成基材を使用して形成する請求項10に記載の結合組織管状体を製造する方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005141044A JP5127120B2 (ja) | 2005-05-13 | 2005-05-13 | 結合組織体形成基材およびそれを用いた結合組織体の製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005141044A JP5127120B2 (ja) | 2005-05-13 | 2005-05-13 | 結合組織体形成基材およびそれを用いた結合組織体の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006314601A true JP2006314601A (ja) | 2006-11-24 |
JP5127120B2 JP5127120B2 (ja) | 2013-01-23 |
Family
ID=37535800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005141044A Expired - Fee Related JP5127120B2 (ja) | 2005-05-13 | 2005-05-13 | 結合組織体形成基材およびそれを用いた結合組織体の製造方法 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5127120B2 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009538245A (ja) * | 2006-05-24 | 2009-11-05 | ネリックス・インコーポレーテッド | 多層フィルムを生成する材料及びそれを製造する方法 |
WO2012067137A1 (ja) | 2010-11-18 | 2012-05-24 | 独立行政法人国立循環器病研究センター | 弁付き管腔形状組織形成用基材、弁付き管腔形状組織の生産方法、及び弁付き人工血管 |
WO2015029891A1 (ja) * | 2013-08-30 | 2015-03-05 | 独立行政法人国立循環器病研究センター | 結合組織体形成用基材、及び結合組織体の生産方法 |
EP2873428A4 (en) * | 2012-07-11 | 2016-01-20 | Nat Cerebral & Cardiovascular Ct | SUBSTRATE FOR MEMBRANE CONJUNCTIVE TISSUE FORMATION AND METHOD FOR PRODUCING MEMBRANE-TYPE CONJUNCTIVE TISSUE USING THE SAME |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0866469A (ja) * | 1994-08-12 | 1996-03-12 | Meadox Medicals Inc | ヘパリン含有コラーゲンシーラントを含浸した管状グラフト |
JP2000503572A (ja) * | 1996-02-28 | 2000-03-28 | インプラ・インコーポレーテッド | 端側吻合用フランジ付き移植片 |
JP2004261260A (ja) * | 2003-02-28 | 2004-09-24 | National Cardiovascular Center | 人工血管 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2297836T3 (es) * | 1996-02-28 | 2008-05-01 | Bard Peripheral Vascular, Inc. | Aparato y metodo par arealizar un injerto rebordeado para anastomosis terminolateral. |
DE69634278T2 (de) * | 1996-02-28 | 2006-01-05 | Bard Peripheral Vascular, Inc., Tempe | Mit einem flansch ausgestattetes transplantat für eine end-zu-seit-anastomose |
-
2005
- 2005-05-13 JP JP2005141044A patent/JP5127120B2/ja not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0866469A (ja) * | 1994-08-12 | 1996-03-12 | Meadox Medicals Inc | ヘパリン含有コラーゲンシーラントを含浸した管状グラフト |
JP2000503572A (ja) * | 1996-02-28 | 2000-03-28 | インプラ・インコーポレーテッド | 端側吻合用フランジ付き移植片 |
JP2000503573A (ja) * | 1996-02-28 | 2000-03-28 | インプラ・インコーポレーテッド | 端側吻合用フランジ付き移植片を製造するための装置と方法 |
JP2004261260A (ja) * | 2003-02-28 | 2004-09-24 | National Cardiovascular Center | 人工血管 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009538245A (ja) * | 2006-05-24 | 2009-11-05 | ネリックス・インコーポレーテッド | 多層フィルムを生成する材料及びそれを製造する方法 |
WO2012067137A1 (ja) | 2010-11-18 | 2012-05-24 | 独立行政法人国立循環器病研究センター | 弁付き管腔形状組織形成用基材、弁付き管腔形状組織の生産方法、及び弁付き人工血管 |
US8685082B2 (en) | 2010-11-18 | 2014-04-01 | National Cerebral And Cardiovascular Center | Base material for forming valved lumen shape tissue, method for producing valved lumen shape tissue, and valved artificial blood vessel |
EP2873428A4 (en) * | 2012-07-11 | 2016-01-20 | Nat Cerebral & Cardiovascular Ct | SUBSTRATE FOR MEMBRANE CONJUNCTIVE TISSUE FORMATION AND METHOD FOR PRODUCING MEMBRANE-TYPE CONJUNCTIVE TISSUE USING THE SAME |
WO2015029891A1 (ja) * | 2013-08-30 | 2015-03-05 | 独立行政法人国立循環器病研究センター | 結合組織体形成用基材、及び結合組織体の生産方法 |
JP2015047196A (ja) * | 2013-08-30 | 2015-03-16 | 独立行政法人国立循環器病研究センター | 結合組織体形成用基材、及び結合組織体の生産方法 |
CN105555230A (zh) * | 2013-08-30 | 2016-05-04 | 国立研究开发法人国立循环器病研究中心 | 结缔组织体形成用基材和结缔组织体的生产方法 |
EP3040053A4 (en) * | 2013-08-30 | 2017-03-01 | National Cerebral and Cardiovascular Center | Base material for forming connective tissue structure and method for producing connective tissue structure |
Also Published As
Publication number | Publication date |
---|---|
JP5127120B2 (ja) | 2013-01-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103068413B (zh) | 用于使组织基质成形的方法 | |
US5549675A (en) | Method for implanting tissue in a host | |
ES2209715T3 (es) | Procedimiento de preparacion in vitro de protesis de valvula cardiaca o de vasos. | |
US11638640B2 (en) | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material | |
EP2841010B1 (en) | Supports for engineered tissue scaffolds | |
US20050209687A1 (en) | Artificial vessel scaffold and artifical organs therefrom | |
AU2020210244B2 (en) | Implantable apparatus for retention of biological moieties | |
Lee et al. | Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia | |
JP5127120B2 (ja) | 結合組織体形成基材およびそれを用いた結合組織体の製造方法 | |
US7875072B2 (en) | Cellular transplant stent | |
US8685082B2 (en) | Base material for forming valved lumen shape tissue, method for producing valved lumen shape tissue, and valved artificial blood vessel | |
JP2010088625A (ja) | 人工弁 | |
CN111686309A (zh) | 一种3d打印皮肤的制备方法 | |
Adamowicz et al. | Constructing artificial urinary conduits: current capabilities and future potential | |
Watanabe et al. | Development of biotube vascular grafts incorporating cuffs for easy implantation | |
ES2925746T3 (es) | Tejidos modificados que tienen componentes estructurales incorporados en los mismos, y procedimientos de fabricación y uso | |
JP2006238987A (ja) | 結合組織シート(バイオシート)の形成基材およびバイオシートの製造方法 | |
JP2014030598A (ja) | 膜状結合組織体形成用基材及びこれを用いた膜状結合組織体の生産方法 | |
JP5658008B2 (ja) | 弁付き人工血管形成用基材、これを用いた弁付き人工血管の生産方法及び弁付き人工血管 | |
US11458688B2 (en) | Tubular tissue preparation device, tubular tissue preparation kit, and tubular tissue preparation method | |
JP2017169778A (ja) | 結合組織体形成基材 | |
JP2016136984A (ja) | 管状組織体形成基材 | |
CN210301825U (zh) | 一种3d打印皮肤 | |
CN104411342A (zh) | 膜状结缔组织体形成用基材和使用该基材的膜状结缔组织体的生产方法 | |
JP5252538B2 (ja) | 弾性線維組織を有する培養血管の製造方法及び弾性線維組織を有する培養血管 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080509 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20100421 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20100803 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20100916 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20101207 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20110331 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110331 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110802 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110929 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111018 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120904 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120920 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20121009 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20121030 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5127120 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20151109 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |