JP2006232716A - Externally applied agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an externally applied agent durably expressing excellent antimicrobial activities, preventing diseases caused by abnormal growth of normal microbes on the skin and unpleasant body odors and keeping the skin in a healthy state. <P>SOLUTION: The externally applied agent comprises compounding a composite compound prepared by mixing at least one compound selected from hinokitiol, its salts and its derivatives with ceramics, silicate compounds, cellulose or the like, and prevents bacteria, fungi and the like normally presenting in the skin by applying the agent to a part of the wet skin or the skin with plenty of water, diseases of mucous membranes and the like. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external preparation that exerts a continuous effect and is adapted to troubles of skin, mucous membranes, etc. in wet or wet sites involving bacteria, fungi and the like.

  Bacteria, etc. that inhabit the skin and are frequently observed and have no pathogenicity are called skin resident bacteria. In healthy skin, multiple resident bacteria form an ecosystem (skin flora) and are in a symbiotic state and need to be beneficial. It has become a presence. However, when the ecological balance of the resident bacteria is disrupted due to changes in the state of the skin, environmental changes, etc., and bacterial growth occurs, it causes various skin diseases and the like. For example, there are diaper dermatitis (diaper rash) worsened by the involvement of Candida, etc., and athlete's foot caused by ringworm. In addition, the occurrence of body odors such as sweat odor, scent odor or aging odor is considered to be caused by the decomposition of sweat, sebum, aging keratin (skin), etc. due to the presence of skin resident bacteria. Yes.

  For this reason, imidazole antifungal agents such as miconazole are used for skin diseases caused by the disruption of the balance of the resident bacteria that inhabit these skins and the growth of Candida and ringworm bacteria. For example, antibacterial agents such as halocarban and benzalkonium chloride are used.

  Any of the external preparations conventionally applied to abnormal growth of resident bacteria has room for improvement in terms of skin irritation and sustained effects. In addition, since bacterial growth is likely to occur on moist or wet skin, it is more likely to develop in hot and humid summers, particularly at sites where sweat is likely to accumulate, and body odor is also likely to occur. However, the butt of diaper dermatitis (diaper rash), feet that are susceptible to athlete's foot, and underarms that are deeply involved in the generation of body odor will rub against underwear, socks or skin, etc. It was difficult to apply a dosage form excellent in Therefore, it has been desired to develop an external preparation that can continuously exhibit excellent antibacterial action and the like and can maintain the skin in a healthy state.

  On the other hand, hinokitiol is a substance obtained by extraction, purification and chemical synthesis from Aomori hiba oil, Taiwan cypress oil, etc., and has an antibacterial and bactericidal action, as well as an anti-inflammatory action and a cell activation action. In the field of medicine, it is used for external medicines such as alveolar pyorrhea, ringworm, alopecia areata, hair restorer, medicinal cosmetics and the like. In recent years, antibacterial activity against MRSA (methicillin-resistant Staphylococcus aureus), which has been a problem in nosocomial infections, has also been confirmed, and has attracted attention as a naturally-occurring substance that does not show the expression of drug-resistant bacteria that are problematic with antibiotics. ing. However, since hinokitiol is highly absorbed into the skin and mucous membranes, it is not possible to exert its antibacterial action continuously with liquids, emulsions, ointments, etc., which are usually used especially in wet or moist skin areas. It was difficult.

  Therefore, in order to achieve the above-mentioned object, the present inventors have conducted intensive research to obtain a preparation that can be applied to moist or moist skin or mucous membrane sites and develop a continuous antibacterial action. As a result, hinokitiol and its A compound obtained by mixing at least one compound selected from salts and derivatives thereof with ceramics, silicic acid compounds, cellulose, or the like is used for the treatment of Candida and ringworm fungus in wet or wet skin and mucous membranes. The inventors have found that the antibacterial action and the like that are effectively effective against skin and mucous membrane diseases and body odor caused by proliferation have been found, and have completed the present invention.

  In the present invention, ceramics forming a composite with hinokitiol are not limited to clay minerals, and include inorganic powders such as calcium compounds, magnesium compounds, aluminum compounds, titanium compounds, and zinc compounds. As the silicic acid compound, silicon dioxide, particularly silica gel with high purity is preferable. Furthermore, organic powders derived from cellulose, silk, starch and the like can be used. Moreover, it is more preferable that any powder is a porous particle.

  The amount of at least one compound selected from hinokitiol and its salts and derivatives used in the present invention is not limited, but is preferably 0.001 to 5.0% by weight, more preferably 0.01 to 2.0% by weight. % Is more preferable.

Although it does not limit as an external preparation by this invention, Preferably it is a powder and can mix | blend the support | carrier for a formulation normally used, an excipient | filler, and another additive, The formulation can be performed by a conventional method. .

  The hybrid method of hinokitiol and ceramics, silicate compound or cellulose can be performed by a conventional method. For example, it can be obtained by suspending ceramics in an aqueous solution of hinokitiol and drying the suspension. At this time, when the composite is blended into the preparation and applied to the skin and mucous membrane by drying by heat treatment, the sustained release can be further enhanced.

  INDUSTRIAL APPLICABILITY According to the present invention, it is possible to obtain a highly effective external preparation containing hinokitiol which is excellent in sustainability against skin and mucous membrane diseases and body odor caused by Candida, ringworm, etc.

  EXAMPLES Next, although an Example is given and this invention is demonstrated further in detail, this invention is not limited to these.

Example 1 (powder)
40% composite containing hinokitiol attached to porous silica gel (containing 0.5% hinokitiol), 45% talc, 10% lauroyllysine and 5% silk powder are uniformly mixed and filled into a container to obtain an external preparation. . This external preparation is applied to a relatively moist or wet skin site.

Example 2 (powder spray)
Add 5% composite containing hinokitiol in spherical cellulose (containing 1% hinokitiol), 5% lauroyllysine, 2% methylcyclopolysiloxane, 88% propellant (liquefied petroleum gas or nitrogen gas) and fill into spray container It should be used as an external preparation. This external preparation is applied to a relatively moist or wet skin site.

Comparative Example 1 (Lotion)
Add 0.2% hinokitiol, 0.5% polyoxyethylene hydrogenated castor oil, and 5% ethanol, and add 94.3% purified water to this, mix uniformly, and fill into a container.

Comparative Example 2 (powder spray)
Add 5% spherical cellulose, 5% lauroyl lysine, 2% methylcyclopolysiloxane, 88% propellant (liquefied petroleum gas or nitrogen gas) and fill into a spray container to make an external preparation.

(Diaper dermatitis improvement effect, athlete's foot improvement effect)
About 1 external medicine of Example 1, Example 2, Comparative Example 1, and Comparative Example 2, 20 children suffering from diaper dermatitis (diaper rash) and 20 adults having athlete's foot (rinchoderma) respectively A continuous use test was conducted to evaluate the improvement effect for each symptom. The results are as shown in Tables 1 and 2, but very good results were obtained for the improvement of diaper dermatitis and athlete's foot.

(Body odor prevention effect)
For the topical preparations of Example 2 and Comparative Example 2, 10 adults whose body odor is anxious are used as subjects, and each topical preparation is applied to only one side (on the specified side) after taking a bath every day, and a continuous use test for one week. After carrying out, the body odor prevention effect was determined by sensory evaluation by a specialized panelist. The results are as shown in Table 3, but very good results were obtained for the prevention of body odor.

By applying the external preparation containing hinokitiol having excellent durability and high durability according to the present invention to diseases of skin and mucous membranes particularly in areas with high water content, normal skin bacteria are kept in a healthy state, and Candida and ringworm Since it can prevent skin and mucous membrane diseases and body odor due to abnormal growth of bacteria and the like, demand for new external preparations is expected.

Claims (2)

  It contains at least one compound selected from hinokitiol and its salts and derivatives, and gradually releases the compound from the preparation to continuously exert its antibacterial effect, thereby preventing abnormal growth of resident skin bacterium. An external preparation characterized by Skin and mucous membrane diseases in wet or moist areas containing at least one compound selected from hinokitiol and its salts and derivatives and composites obtained by mixing with ceramics, silicate compounds or cellulose, etc. An external preparation that is adapted to prevent abnormal growth of bacteria and fungi.