JPS63215618A - Prevention of body odor - Google Patents

Abstract

PURPOSE:To absorb sweating and eliminate the smell emitted from the armpit, by spraying or applying a composition containing a quaternary ammonium alginate to the armpit. CONSTITUTION:A composition containing preferably 0.5-5wt.% quaternary ammonium salt (e.g. cetyl pyridinium salt, methylbenzethonium and dodecyldimethylbenzylammonium salt) as an active ingredient is sprayed upon or applied to the armpit to prevent the offensive smell of the armpit. The compound is water-insoluble white powder having slight water vapor absorption, has dry touch, excellent soft feeling, relatively mild sterilizing action, no fear of side effects even by continuous use and improved adhesivity to the skin.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a method for preventing armpit odor, which absorbs perspiration from the armpits and deodorizes odors emitted from the armpits.

[Conventional technology and points in between]

Conventionally, various products have been commercially available for the purpose of preventing armpit odor, but many of these products include antiperspirants containing astringent aluminum compounds as active ingredients, or oil-nol alone or as an active ingredient, as appropriate. This is a blended masking agent. These products are then applied and used by underarm Kxf spray application.

Incidentally, although antiperspirants have the effect of reducing sweat, which is a source of underarm odor, it is impossible to completely control sweat from a physiological perspective. On the other hand, masking agents have the disadvantage that their scent components mix with armpit odor, making it even more unpleasant.

Therefore, the above-mentioned conventional anti-armpit odor agents including antiperspirants and masking agents have had drawbacks in that they are not fully satisfactory in terms of effectiveness and usability.

t7t, The odor in my armpits is more noticeable when I sweat a lot.

However, when sweat is collected aseptically directly through the sweat pores, it remains odorless after two hours, but when sweat is collected while it comes into contact with bacteria on the skin, it is said to emit an odor. The armpits are given a suitable temperature and humidity, which is favorable for the presence of bacteria, and there K is staphylococcus! There are reports that rotius bacteria, candida bacteria, etc. are found.

Certain quaternary ammonium salts are known to have bactericidal effects, and are also effective against the above-mentioned fine INK.
Spraying or applying an aqueous solution of these gc4 ammonium salts to the armpits is thought to be effective in preventing armpit odor, but
It has problems such as a poor feeling of use, 1) it washes off due to perspiration, 2) lack of long-lasting efficacy, and 2) an unfavorable effect on the skin, making it impossible to continue using it.

[Ninth way to solve the interval U point]

The present inventors have found that the bactericidal effect of quaternary ammonium alginate is lower than that of the corresponding quaternary ammonium salt with a low molecular weight, such as chlorine salt, but the absolute value of the effect itself is lower, but the antibacterial spectrum is similar. The present invention was completed based on the discovery that a deodorizing effect based on sterilization can be obtained by using the following.

The present invention is characterized in that armpit A is prevented by spraying or applying a composition containing quaternary ammonium alinate as an active ingredient to the armpits.

The quaternary ammonium alginate salt used in the present invention is synthesized by reacting sodium alginate with a quaternary ammonium halogen salt. Since this reaction occurs quantitatively, a slight excess of quaternary ammonium halogen salt is applied to the carbyl group of sodium alginate, and unreacted Ti
By washing the tetraammonium halide salt and the produced sodium halide with water, a completely substituted quaternary ammonium alginate can be obtained. Suitable quaternary ammonium halogen salts include cetylpyridinium salt, benzethonium salt, methylbenzethonium salt, dodecyldimethylbenzylammonium salt, and tetradecyldimethylpenzylammonium salt as described in the Japanese Pharmacopoeia Law.

This quaternary ammonium alginate salt can be obtained as a white powder which is insoluble in water but slightly hygroscopic.

This powder has a smooth feel and feels good on the skin.

The composition containing the quaternary ammonium alginate salt can be a composition for ordinary cosmetics or external medicines,
The quaternary ammonium salt of alginate in this composition is 0.5
It is preferable to mix in an amount of 5 to 5% by weight. As the ingredients in the composition at this time, any ingredients conventionally known as cosmetics or external medicines can be included. Examples of such ingredients include ethanol, iso! Alcohols such as lonotanol, waxes such as honeysuckle, lanolin, liquid lanolin, natural water-soluble polymer compounds such as gelatin, agar, starch, tragat, pectin, semi-synthetic polymer compounds such as methylcellulose, ethylcellulose, crystalline cellulose, Surfactants such as dialkyl sulfonate II salts, alkylaryl sulfonates, and phosphate esters, and HX agents such as methyl oxybenzoate and ethyl p-oxybenzoate.

Organic pigments such as Red No. 2, Blue No. 1, and Yellow No. 201, inorganic pigments such as aluminum powder, Merck, kaolin, bentonite, antiperspirants such as aluminum sulfate, aluminum hydroxychloride, skatole, lavender oil, jasmine, etc. Masking agent, Freon 11. Freon 12. Examples include propellants such as carbon dioxide gas, purified water, and the like.

The method for blending the quaternary ammonium alginate in the composition is that it may be mixed as a powder itself, or it may be impregnated into another powder carrier from a methanol solution if it is soluble in a solvent such as methanol. It can also be blended after being dried and supported.

Next, the antibacterial properties of quaternary ammonium alginate will be described.

Tetradecyldimethylpendylammonium salt was selected from among the quaternary ammonium alginic acid salts, and an antibacterial activity test against Staphylococcus aureus and Candida was conducted, and the results shown in Table 1 were obtained.

Table 1 As is clear from the results, the quaternary ammonium salt of cellulose acid is most likely to be effective as an anti-yellowiasis agent and an anti-candida solidifying agent.

The anti-doxifying power test at this time was conducted under the following conditions. - Bacterial strain used: Staphylococcus aureus 1 (Stiphyloeoeus a
ir/usFDA 209P) Candida albioans I
Preparation of aim for FO scion;
Er i! Candida was cultured at 35°C for 18 hours in 1nton Br@th (Dlfea), and sr* was cultured at 25°C in Glylpedeton medium (Hinaga).

A flat plate for measuring susceptibility was made of m;
10111j was added and mixed, dispensed into a Petri dish, and solidified, which was used as an agar plate for measuring the susceptibility of Staphylococcus aureus.

In addition, after sterilization, 1.0 tatami (mah) of the prepared bacterial solution for Candida inoculation was added to L596 agar-glucose-e7') medium (Hinaga) kept at about 50°C, and mixed. Petri dish KIO! The agar plate for measuring Candida Tagawa susceptibility was prepared by dispensing and solidifying the agar plate.

Test procedure Nialginate tetradecyl dimethyl penzol ammonium salt IJIK methanol 1001! Add and dissolve Alt to make a t-i solution (10,000 ppm), and dilute it in a 2-fold dilution series (5,000 to 5 ppm) using methanol.
m) test solution was prepared. Prepare 50 μj of each test solution (
-/#- disk (diameter 8 cm, '7' hick e Toyo Ronobu) IIc was immersed, and then left to volatilize the solvent.

These Ba.l-discs were then placed on agar plates for sensitivity determination, and those for Staphylococcus aureus were 35c.

After culturing for 18 hours and for Candida tubes at 25°C for 48 hours, observe the inhibition circle formed on the plate.

Next, the present invention will be specifically explained based on examples.

〔Example〕

Compositions 1 to 3 containing alginic acid tetraammonium salt as an active ingredient - as follows! Made in 11F14.

Composition 1: Deodorizing and deodorizing Noudalginate tetradecyl dimethyl penzol ammonium salt 1. Dissolve OJ' in ethanol 10017, add 1ooII of Avicel PH-MO6 (cosmetic microcrystalline cellulose, manufactured by Seikasei Co., Ltd., average particle size of about 6 μm) K, and stir well. Thereafter, ethanol is evaporated in a vacuum dryer to obtain Avicel carrying the active ingredient. Next, this Avicel was mixed with Merck and magnesium stearate to obtain deodorizing/#Kuda having the composition shown in Table 2.

Table 2 Composition 2; Deodorizing spray benzethonium alginate 1.0 #t Dissolve in 1001jlC of ethanol and add this to 100J' of Avicel RC-591NF (Kyoto Kasei Co., Ltd., Goroidal grade cosmetic grade microcrystalline cellulose). Add and stir well.

Thereafter, ethanol is evaporated in a nitrogen dryer to obtain Avicel carrying the active ingredient. Next, this Avicel and Merck were mixed, and this mixed system was mixed with Freon 11. It was sealed together with a propellant of Freon 12 to obtain a deodorizing spray having the composition shown in Table 3.

Table 3 Composition 3: Deodorizing cream Cetylpyridinium alinate salt (60 Metsu Kotsu: A
),zinc! i1. and Vaseline were mixed and pressed to obtain a deodorizing cream having the composition shown in @49.

4. After determining the results, these compositions were sprayed or applied to the armpits of healthy people (5 men and 5 men) who were aware of having armpit odor to conduct an efficacy test for preventing armpit odor.

Test method: The product was simply applied to the affected area twice a day, in the morning and in the evening.

The evaluation of effectiveness was based on the following three-level criteria.

Effective: Slightly effective, no armpit odor; Slightly weak armpit odor and a feeling of discomfort Ineffective: Changes in the strength of armpit odor The test results are shown in Table 5. In addition, the numbers in Table 5 indicate the number of people in the judgment item. 7ta 5 From the results in Table 5, it can be seen that all methods for preventing armpit odor using Compositions 1 to 3 are effective.

Furthermore, regarding other salts of fg4 ammonium alginate, methylbenzethonium salt, and dodecyldimethylbenzylammonium salt, composition 1 containing these as active ingredients! : I prepared it and tried a similar efficacy test and obtained almost the same results as above.

t7? However, if you use the method using composition 1.2, the feeling of use may be affected by the mixing of lubricants such as talc into the composition. The comfort of use is even better.

〔Effect of the invention〕

As described above, according to the method of the present invention, the activity of bacteria that decompose sweat and generate bad odor can be stopped by the bactericidal action of quaternary ammonium alginate, thereby effectively preventing armpit odor. Furthermore, since the bactericidal action is relatively mild, there is no risk of side effects even if the product is used continuously, and it also has good adhesion to the skin.

The alginic acid@tetraammonium salt of the present invention is a powder with a smooth texture and is therefore comfortable to use, but the comfort of use can be further improved by incorporating appropriate sweat absorbents and lubricants into the composition. It can be stopped.

Patent applicant: Daicel Chemical Industries, Ltd. Agent, Patent attorney: Takashi Koshiba Procedural amendment (voluntary) April 20, 1985 1, Indication of the case 1988 Patent Application No. 47682 2, Name of the invention Armpit odor prevention method 3 , Relationship with the case of the person making the amendment Patent applicant (290) Daicel Chemical Industries, Ltd. 4, Agent 3-8-1-5 Kasumigaseki, Chiyoda-ku, Tokyo, Subject of amendment -''-Scope of claims in the specification Column 6. Contents of amendment (1) The scope of the specification and claims shall be amended in a separate document.

(2) "Cellular glycolic acid quaternary ammonium salt" in the second to third lines from the bottom of page 7 of the specification is corrected to "alginic acid quaternary ammonium salt".

(3) Correct the statement on page 8, lines 11 and 12 of the specification to read "Glycol-e7') Glucose Peptone Medium."

Attachment ``(1) A method for preventing armpit odor, which comprises spraying or applying a composition containing quaternary ammonium alginate as an active ingredient to the armpits.

The method for preventing armpit odor according to claim (1), which is a rhizonium salt, a benzethonium salt, a methylbenzethonium salt, a dodecyldimethylbenzylammonium salt, or a tetradecyldimethylpenzylammonium salt. ”

Claims (2)

[Claims] (1) A method for preventing armpit odor, which comprises spraying or applying a composition containing quaternary ammonium alginate as an active ingredient to the armpits. (2) Prevention of armpit odor according to claim (1), wherein the cellulose glycolic acid quaternary ammonium salt is cetylpyridinium salt, benzethonium salt, methylbenzethonium salt, dodecyldimethylbenzylammonium salt, or tetradecyldimethylbenzylammonium salt. Law.