JP2021046381A - Antiperspirant composition - Google Patents

Abstract

To provide an antiperspirant composition that can control the secretion of sweat without closing sweat pores.SOLUTION: An antiperspirant composition contains a specific amount of carbenoxolone disodium and further may contain glycyrrhizinic acid or a salt thereof and glycyrrhetinic acid, a derivative or a salt thereof.SELECTED DRAWING: None

Description

The present invention relates to an antiperspirant composition.

The human sweat glands are important organs that regulate body temperature mainly by the secretion of sweat. However, an unnecessarily large amount of sweat for thermoregulation, as well as the odor of biotransforms decomposed by microorganisms and the odor produced by oxidation, can be offensive to humans. Therefore, conventionally, as an antiperspirant, a body odor-suppressing cosmetic containing an antiperspirant component that exhibits a physical antiperspirant effect by blocking sweat holes with metal ions such as aluminum chloride, and further containing a bactericidal agent or an antibacterial agent. Antiperspirants and antiperspirants are known.

By the way, Patent Document 1 discloses a sweating inhibitor containing glycyrrhizic acid or a salt thereof as an active ingredient.

Japanese Unexamined Patent Publication No. 52-105221

However, although a sweating inhibitor containing glycyrrhizic acid as an active ingredient in Patent Document 1 has been reported, its antiperspirant effect is not sufficient and there is room for improvement.

The present invention has been made in view of the above problems, and an object of the present invention is to provide an antiperspirant composition capable of acting on sweat glands to control sweat secretion without obstructing sweat pores.

As a result of diligent studies by the present inventor in order to solve the above problems, carbenoxolone disodium has an antiperspirant effect, and further, from carbenoxolone 2 sodium, glycyrrhetinic acid, its derivative and its salt, and glycyrrhizic acid and its salt. It has been found that a more excellent antiperspirant composition can be obtained by using in combination with at least one selected from the above group.

That is, the present invention includes the following configurations.

<1> An antiperspirant composition containing sodium carbenoxolone 2 as an active ingredient and having a content of sodium carbenoxolone 2 sodium in an amount of 0.10 to 1.00% by mass.

<2> The antiperspirant composition according to <1>, further containing at least one compound selected from the group consisting of glycyrrhizic acid and a salt thereof, glycyrrhetinic acid, a derivative thereof and a salt thereof.

<3> Carbenoxolone disodium and at least one compound selected from the group consisting of glycyrrhizic acid and its salt and glycyrrhetinic acid, its derivative and its salt are contained as active ingredients, and the following (i) and (ii) are contained. ) Satisfying antiperspirant composition:
(I) The content of carbenoxolone disodium is 0.01% by mass or more.
(Ii) The total content of carbenoxolone disodium disodium and at least one compound selected from the group consisting of glycyrrhizic acid and its salt and glycyrrhetinic acid, its derivative and its salt is 0.10 to 1.00% by mass. is there.

According to the present invention, it is possible to provide an antiperspirant composition that can act on sweat glands to control sweat secretion without obstructing sweat pores.

The present invention will be described below, but the present invention is not limited thereto. The present invention is not limited to the configurations described below, and various modifications can be made within the scope of the claims. The technical scope of the present invention also includes embodiments or examples obtained by appropriately combining the technical means disclosed in the different embodiments or examples. Furthermore, new technical features can be formed by combining the technical means disclosed in each embodiment. In addition, all the academic documents and patent documents described in the present specification are incorporated as references in the present specification.

Unless otherwise specified in the present specification, "X to Y" representing a numerical range is intended to be "X or more and Y or less". Further, unless otherwise specified in the present specification, the mass% representing the content of the component is a value in which the mass of the entire antiperspirant composition is 100% by mass.

[1. Antiperspirant composition]
The antiperspirant composition according to the present invention contains carbenoxolone disodium 2 sodium (also known as 3-succinyloxyglycyrrhetinate disodium) as an active ingredient, and the content of the carbenoxolone disodium 2 sodium is 0.10 to 1.00% by mass. Is.

According to the antiperspirant composition according to the present invention, sweat secretion can be controlled without blocking the sweat pores. The present inventor has found that a predetermined compound containing carbenoxolone acts on the sweat glands and exhibits an antiperspirant effect as shown in International Application No. PCT / JP2019 / 011137. Since the above-mentioned carbenoxolone disodium has a structure common to that of carbenoxolone, it is considered to exhibit a similar mechanism of action. Although carbenoxolone disodium has been conventionally used as an antiperspirant, it has not been used as an antiperspirant, and it is surprising that carbenoxolone disodium can be used as an antiperspirant from this viewpoint as well.

When the content of carbenoxolone disodium 2 sodium is 0.10% by mass or more, it is preferable from the viewpoint of the effect of suppressing sweating. The content is more preferably 0.20% by mass or more, and further preferably 0.30% by mass or more. When the content is 1.00% by mass or less, it is preferable from the viewpoint of reducing the load on the user. The content is more preferably 0.90% by mass or less, and further preferably 0.80% by mass or less.

The antiperspirant composition may contain at least one compound selected from the group consisting of glycyrrhizic acid or a salt thereof and glycyrrhetinic acid, a derivative thereof or a salt thereof. When the compound is contained, the content is preferably 0.03 to 0.80% by mass, more preferably 0.10 to 0.50% by mass.

Examples of the salt include metal salts, inorganic base salts, organic amine salts and the like. Examples of the metal salt include, but are not limited to, alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as magnesium salt and calcium salt. Examples of the inorganic base salt include, but are not limited to, ammonium salts. Examples of the organic amine salt include, but are not limited to, triethanolamine salts and triethylamine salts.

Of glycyrrhizic acid or a salt thereof and glycyrrhetinic acid, a derivative thereof or a salt thereof, an alkali metal salt or an ammonium salt is preferable.

Examples of glycyrrhizic acid and salts thereof include ammonium glycyrrhizinate, sodium glycyrrhizinate, potassium glycyrrhizinate, dipotassium glycyrrhizinate, disodium glycyrrhizinate, disodium glycyrrhizinate and the like. Examples of glycyrrhetinic acid, its derivatives and salts thereof include 18α-glycyrrhetinic acid, 18β-glycyrrhetinic acid, allantoin β-glycyrrhetinic acid, glyceryl glycyrrhetinate, stearyl glycyrrhetinate, pyridoxin glycyrrhetinate, glycyrrhetinyl stearate and the like. In addition, in this specification, glycyrrhetinic acid, a derivative thereof and a salt thereof shall not contain carbenoxolone disodium.

When the antiperspirant composition contains as an active ingredient, carbenoxolone disodium, glycyrrhizic acid and a salt thereof, and at least one compound selected from the group consisting of glycyrrhetinic acid, a derivative thereof and a salt thereof, the content of carbenoxolone disodium is contained. The total content of carbenoxolone disodium in an amount of 0.01% by mass or more and at least one compound selected from the group consisting of glycyrrhizic acid and its salt and glycyrrhetinic acid, its derivative and its salt is 0. It may be 10 to 1.00% by mass.

When carbenoxolone disodium is used in combination with at least one compound selected from the group consisting of glycyrrhizic acid and its salt and glycyrrhetinic acid, its derivative and its salt, the content of carbenoxolone disodium is less than 0.10% by mass. Can also suppress sweating. Even if the content of carbenoxolone disodium 2 sodium in the antiperspirant composition is a content that does not exhibit an antiperspirant effect by itself, at least one selected from the group consisting of glycyrrhizic acid and its salt and glycyrrhetinic acid and its salt. It is surprising that when used in combination with the above compound, carbenoxolone disodium 2 sodium alone can obtain the same effect as an antiperspirant having an antiperspirant effect.

When used in combination, if the content of carbenoxolone disodium 2 sodium is 0.01% by mass or more, the effect of suppressing sweating can be sufficiently obtained. The content is more preferably 0.03% by mass or more, and further preferably 0.05% by mass or more. The upper limit is not particularly limited, but if the content is 1.00% by mass or less, it is preferable from the viewpoint of reducing the load on the user. The content is more preferably 0.90% by mass or less, and further preferably 0.80% by mass or less.

Further, when used in combination, if the total content of the active ingredients is 0.10% by mass or more, the effect of suppressing sweating can be sufficiently obtained. The total content is more preferably 0.20% by mass or more, and further preferably 0.30% by mass or more. When the total content is 1.00% by mass or less, it is preferable from the viewpoint of reducing the load on the user. The total content is more preferably 0.90% by mass or less, and further preferably 0.80% by mass or less.

The antiperspirant composition according to the present invention may contain other components as long as the functions of the present invention are not impaired. Other ingredients include, but are limited to, for example, water, surfactants, alcohols, refreshing agents, plant extracts, fragrances, sequestrants, antioxidants, preservatives, thickeners and the like. It's not something.

Examples of the surfactant include alkyl glyceryl ether, polyoxyalkylene alkyl ether, polyoxyalkylene cured castor oil, glycol fatty acid ester, glycerin fatty acid ester, polyoxyalkylene glyceryl ether fatty acid ester, sorbitan fatty acid ester, and polyoxyalkylene sorbitan. Nonionic surfactants such as fatty acid esters and silicone surfactants; anionic surfactants such as alkyl sulfates, polyoxyethylene alkyl ether sulfates, acyl N-methyltaurine salts, alkyl ether phosphoric acid ester salts, and N-acyl amino acid salts. Activators: Cationic surfactants such as alkyltrimethylammonium chloride and dialkyldimethylammonium chloride; and amphoteric surfactants such as betaine alkyldimethylaminoacetate and betaine alkylamide propyldimethylaminoacetate can be mentioned.

Examples of the alcohol include ethanol and the like.

Examples of the refreshing agent include menthol, menthyl glyceryl ether, menthyl lactate, peppermint oil, peppermint oil, camphor, icillin and the like.

Examples of the antioxidant include tocopherol and its derivatives, ascorbic acid and its derivatives, and the like.

Examples of the sequestrant include edetate, phosphoric acid, sodium polyphosphate and the like.

Examples of the thickener include dextran, pullulan, arabinogalactan, guar gum, tara gum, locust bean gum, konjac mannan, tamarind seed gum and the like.

The antiperspirant composition may or may not contain an antiperspirant component (aluminum compound or the like) that exhibits a physical antiperspirant effect by closing the sweat pores.

As described above, according to the antiperspirant composition according to the present invention, since the above-mentioned carbenoxolone disodium 2 is contained as an active ingredient for controlling the secretion of sweat by the sweat glands, it acts on the secretory duct of the sweat glands. It is possible to control the movement of the secretory duct of the sweat glands during the secretion of sweat. From this, according to the antiperspirant composition according to the present invention, it is possible to control the secretion of sweat by acting on the sweat glands without blocking the sweat pores.

[2. Dosage form, manufacturing method and use of antiperspirant composition]
Dosage forms of the antiperspirant composition according to the present invention include aerosols, lotions, mists, emulsions, gels, creams, sticks, sheets and the like.

The commercial form of the antiperspirant composition according to the present invention is not particularly limited, but may be a commercial form filled in a pump container, a tube container, a jar container, an aerosol container, or the like.

The method for producing the antiperspirant composition according to the present invention is not particularly limited, and a known production method can be used. Examples of the method for producing the antiperspirant composition include a method in which each of the above components is mixed and stirred with a known mixing device such as a propeller mixer, a disper mixer, a paddle mixer, or the like to homogenize each component.

The antiperspirant composition according to the present invention is expected to be used, for example, as an antiperspirant used for cosmetic purposes, an antiperspirant used for medical purposes, and the like. Further, the antiperspirant composition according to the present invention is an antiperspirant according to the user's request, such as an antiperspirant for completely inhibiting sweat secretion and an antiperspirant for alleviating sweat secretion. It is expected to be used as.

Hereinafter, the present invention will be specifically described with reference to examples, but the embodiments of the present invention are not limited to these examples. The content in Table 1 is an amount (mass%) converted into a pure content.

[Measurement method of sweat suppression rate]
At room temperature, the obtained composition shown in Table 1 was applied to the skin on the outer side of the forearm in a circular shape of ^{1 cm 2.} Then, the lower limbs were warmly bathed in warm water at about 42 ° C. to promote sweating. Here, a portion (equipment name: SKN-2000, manufactured by Nishizawa Denki Keiki Seisakusho Co., Ltd.) was used to apply the compositions of the following Examples and Comparative Examples during a period in which the amount of perspiration was stable for 10 minutes. The average sweating amount (mg / min) of the sample application part) was measured. Then, the sweating suppression rate based on Comparative Example 1 was calculated from the following formula (1).

Sweating suppression rate (%) = 100-[(Average sweating amount of the corresponding Example or Comparative Example other than Comparative Example 1 / Average sweating amount of Comparative Example 1) × 100] ... (1)
[Examples 1 and 2 and Comparative Examples 1 to 3]
By blending each component as shown in Table 1, antiperspirants of Examples 1 and 2 and Comparative Examples 1 and 3 were prepared. Table 1 also shows the measurement results of the sweat suppression rate.

From Table 1, Example 1 containing 0.10% by mass or more of carbenoxolone disodium has a higher sweat suppression rate than Comparative Examples 1 and 2. From this, it can be seen that a certain amount or more of carbenoxolone disodium has an effect of suppressing sweating.

Further, Example 2 has a higher sweat suppression rate than Comparative Example 2. From this, it can be seen that when glycyrrhetinic acid and a salt thereof are used in combination, a high antiperspirant suppression rate is exhibited even if the content of carbenoxolone disodium 2 sodium alone does not show an antiperspirant effect.

In addition, from Example 2 and Comparative Examples 2 and 3, it was found that a remarkable synergistic effect can be obtained when either sodium carbenoxolone or glycyrrhetinic acid is used alone as compared with the case where they are used in combination. It was.

The present invention can be suitably used as an antiperspirant.

Claims (3)

Contains carbenoxolone disodium as an active ingredient,
An antiperspirant composition having a content of 2 sodium carbenoxolon of 0.10 to 1.00% by mass. The antiperspirant composition according to claim 1, further comprising at least one compound selected from the group consisting of glycyrrhizic acid and a salt thereof, and glycyrrhetinic acid, a derivative thereof and a salt thereof. It contains carbenoxolone disodium disodium, glycyrrhizic acid and a salt thereof, and at least one compound selected from the group consisting of glycyrrhetinic acid, a derivative thereof and a salt thereof as an active ingredient, and satisfies the following (i) and (ii). Antiperspirant composition:
(I) The content of carbenoxolone disodium is 0.01% by mass or more.
(Ii) The total content of carbenoxolone disodium disodium and at least one compound selected from the group consisting of glycyrrhizic acid and its salt and glycyrrhetinic acid, its derivative and its salt is 0.10 to 1.00% by mass. is there.