JPH10265408A - Sterilizer composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a sterilizer composition reduced in the irritativity of a sterilizer and largely improved in the skin persistence and sustainability of the sterilizer. SOLUTION: This sterilizer composition excellent in skin protective effect contains the composite product of one or more kinds of sterilizers selected from piroctone olamine, ciclopiroxolamine, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, zinc pyrithione, isopropylmethylphenol, photosensitizers, undecylenic acid, resorcinol, hinokitiol, and azole antifungal agents with a waterswelling clay mineral having an average particle diameter of 0.01-50 μm.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a bactericide composition having an excellent skin protection effect and an excellent antibacterial activity.

[0002]

BACKGROUND OF THE INVENTION Disinfectants aimed at disinfecting microorganisms on the skin surface and bacteriostatic are used in the fields of cosmetics, quasi-drugs and pharmaceuticals, such as medicated soaps, antiperspirants,
Many are used, such as anti-acne agents, anti-dandruff agents, and hand disinfectants.

[0003] In other words, as a disinfectant for disinfecting microorganisms derived from the environment, such as soil and pets and faeces attached to hands and other bodies, in order to prevent food poisoning and opportunistic infections.
Also, as a disinfectant for Staphylococcus aureus, which is said to be one of the aggravating factors of atopic dermatitis, for the suppression of abnormal growth of indigenous skin bacteria that cause unpleasant odor, acne, dandruff, etc. due to sweat, Also, in hospitals and the like, it is often used as a hand disinfectant for nurses and doctors to prevent hospital infection.

However, antibacterial agents used for external use on the skin or for disinfecting hands are irritating to the skin, so that people with sensitive skin, acne,
A person who has inflammation due to atopic dermatitis, or a person who must frequently perform hand disinfection, such as a nurse, has a drawback that inflammation and rough hands due to skin irritation occur.

Therefore, various attempts have been made for the purpose of preventing hand roughness. For example, a disinfectant containing ethanol as a main component is used as a humectant (Japanese Patent Application Laid-Open No. 4-134036) or a humectant and a silicone compound (Japanese Patent Application Laid-open No. No. 165571) is known to prevent hand roughening and improve the usability.

However, in the conventional technology, people with sensitive skin,
For people with acne, atopic dermatitis, etc., and for hospital nurses and doctors who need to frequently perform hand disinfection, it is not enough to alleviate skin irritation and prevent rough hands. It is desired to develop a germicide which is less irritating to the skin and has a germicidal effect.

[0007] The present invention has been made in response to the above-mentioned demands, and has as its object to provide a fungicide composition having an excellent skin protection effect and a long lasting effect.

[0008]

Means for Solving the Problems and Embodiments of the Invention In order to achieve the above object, the present inventors have made intensive studies to develop a bactericide having little skin irritation and a long lasting antibacterial activity. As a result, they found that a composite of a clay mineral and the following specific disinfectant can be obtained to obtain an unprecedented excellent disinfectant composition, and completed the present invention.

That is, clay minerals have already been used in various fields as stabilizers, emulsifiers, and usability enhancers for pharmaceutical preparations due to their swelling properties, gelling properties, thixotropy, and skin affinity.

As a technique for blending an antimicrobial agent and a clay mineral, a photosensitive element-containing composition (JP-A-61-225110) is known.
JP, JP-A 61-23670)
No. 9), a skin cleanser containing an anionic surfactant, a bactericide and a clay mineral (JP-A-63-139998),
Hair cosmetics containing an anti-dandruff agent and a particulate oil-absorbing substance containing a clay mineral (JP-A-63-316716), and a skin external preparation containing synthetic bentonite, silicone oil and an antibacterial agent (JP-A-3-148208) However, when a bactericide and a clay mineral are independently blended, skin irritation caused by the bactericide can hardly be reduced. In addition, the bactericide easily flows out of the skin surface by washing with water, and the bactericidal activity cannot be maintained.

On the other hand, techniques for adsorbing a drug to a clay mineral to improve the stability of the drug and for providing a sustained-release property are known from a benzoic acid-montmorillonite complex and an aspirin-montmorillonite complex (The 21st Thermal Measurement Symposium). Abstracts of lectures,
1985) and a papaverine hydrochloride-montmorillonite complex (FORN F, e Coll., Il Farm).
aco-Ed. Pr. -Vol40-fasc. 4). In addition, a technique for increasing transmucosal and transdermal absorption of a drug by including a poorly soluble drug in a water-swellable clay mineral (Japanese Patent Laid-Open No. 1-93541;
37062) is also known.

In view of such circumstances, the present inventors have studied a fungicide that has both the effect of a fungicide and the effect of protecting the skin, and have the following fungicides: pirocton olamine, ciclopirox olamine, Triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, zinc pyrithione,
A water-swellable clay mineral having an average particle diameter of 0.01 to 50 μm, using one or more bactericides selected from isopropylmethylphenol, photosensitizers, undecylenic acid, resorcinol, hinokitiol, and azole antifungal agents. By using a composite of the above, the percutaneous absorption of the fungicide from the skin is suppressed, and the affinity of the clay mineral with the skin improves the persistence of the fungicide on the skin. It has been found that it is possible to reduce the irritation of the germ and to increase the sustainability of the sterilizing power.

Hereinafter, the present invention will be described in more detail.
The fungicidal composition of the present invention comprises piroctone olamine, ciclopirox olamine, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, zinc pyrithione,
One or more fungicides selected from isopropylmethylphenol, photosensitizers, undecylenic acid, resorcinol, hinokitiol, and azole antifungal agents, and an average particle size of 0.01
複合 50 μm containing a complex with a water-swellable clay mineral.

Here, in the above-mentioned bactericide, examples of photosensitizers include photosensitizers 101, 201, 301, and 401. Azole antifungals include ketoconazole, bifonazole, miconazole nitrate, clotrimazole, fluconazole, itraconazole, isoconazole, econazole, sulconazole, croconazole and the like. In addition, among the above germicides, in particular, pyrocton olamine, ciclopirox olamine, triclosan, chlorhexidine gluconate, hinokitiol, ketoconazole, bifonazole, and miconazole nitrate are preferable from the viewpoint of the effect of alleviating irritation. As the antibacterial agent, one or more of these compounds are arbitrarily selected as needed.

The water-swellable clay mineral used in the present invention includes, for example, smectites such as montmorillonite, beidellite, nontronite, saponite, hectorite, sauconite, and stevensite, and swellable mica. These clay minerals have exchangeable ions with water molecules between the layers and exhibit properties different from other clay minerals, such as forming an organic complex and swelling ability. Among such smectites, those produced from nature include, for example, those containing montmonillonite, from Wenjun Mining Co., Ltd. Wenger, Wenger HV, Wenger A, Wenger FW, Wenger 31, Wenger W -100 and the like, Kunipia G and Kunipia F from Kunimine Industries, Ltd., Western Bond from American Colloids, Yellowstone from Dresser Minerals, and the like. Vegum T, Vegum HV, Vegum F, Vegum K, etc., and those containing hectorite, such as Hectorable AW, Hectorable 200, Benton EW, etc. from American Colloid Co .; Commercially available . Various types of synthetic smectites are also sold. Ionite H and the like are marketed by Mizusawa Chemical Industry Co., Ltd., SWN and SAN are manufactured by Corp Chemical Co., Ltd., and Laponite and the like are marketed by Laporte Industries.

Further, as the smectite of the present invention, an alkali-treated acid clay can be used. Acid clay, the following pH of generally 1% aqueous dispersion 5-6, degree of swelling 10 ml / 2 g or _{less, SiO 2 / Al 2 O 3} = 6~ content of SiO ₂ and Al ₂ O ₃ is in a molar ratio 10 things. These include Nakajo, Koto, Kamikatani, acid clay from Itoigawa, Mizusawa from Yamagata, Kawasaki, Matsune,
In addition to the acid clay from Kamikatani, Mikawa, Ome, and Kamamimi, a fuller from England showing similar properties to these acid clays
r's earth, United States Florida ear
th, German-made Warkel erde, and the like. The exchangeable cations present in the acid clay include sodium ions, potassium ions, magnesium ions, iron ions and the like. These acid clays can be treated in the same manner as the above clay minerals by alkali treatment.

Examples of the swellable mica include swellable synthetic mica ME series manufactured by Corp Chemical Co., Ltd., and sodium tetrasilicic mica manufactured by Topy Industry Co., Ltd. (trade name: DP-D).
M and DM clean).

The clay mineral salts used in the present invention include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, zinc salts, and the like.
Examples thereof include aluminum salts, zirconium salts, alkanolamine salts such as monoethanolamine, diethanolamine and triethanolamine, and basic amino acid salts such as lysine and arginine.

The average particle diameter of the clay mineral is preferably from 0.01 to 50 μm, particularly preferably 10 μm or less, having fine crystals or particles having colloidal properties. Particle size is 5
If it exceeds 0 μm, the effect of the bactericide to reduce irritation and the sustainability of the antibacterial activity will be poor.

Next, a method for producing a fungicide-clay mineral composite will be described. The fungicide complex of the present invention can be produced by the following production examples (1), (2) and (3).

[Production Example (1)] Water is added to a water-swellable clay mineral, and a sufficiently stirred suspension is mixed with a disinfectant solution in which one or more disinfectants are dissolved in water. 1-12
After stirring for an hour, the mixture is allowed to stand overnight, and the precipitated gel is collected by filtration or centrifugation. Next, a concentrated water suspension or dried by vacuum drying or freeze-drying, and then a fungicide
Obtain a clay mineral complex.

As a specific example, for example, 25 g of chlorhexidine gluconate (Hibitene / gluconate solution manufactured by Sumitomo Pharmaceutical Co., Ltd.) is dissolved in 25 kg of tap water. Separately 2
A solution in which 25 g of montmorillonite (Kunimine Kogyo Co., Ltd., Kunipia G) is uniformly dispersed in 5 kg of tap water is added to an aqueous chlorhexidine gluconate solution, and the mixture is stirred well and allowed to stand overnight. Since the gel composed of the chlorhexidine gluconate / montmorillonite complex precipitates in the lower layer, the supernatant is removed by decantation, followed by centrifugation to collect the lower layer gel. Then, it was freeze-dried to obtain a fine powder of chlorhexidine gluconate / montmorillonite complex.

[Production Example (2)] Water is added to a water-swellable clay mineral, and a well-stirred suspension is used. One or more of the disinfectants is sufficiently dissolved in a disinfectant such as methanol, ethanol or acetone. A bactericide solution dissolved in an organic solvent is mixed, stirred at room temperature for 1 to 12 hours, and allowed to stand overnight, and the precipitated gel is collected by filtration or centrifugation. Next, a bactericide-clay mineral complex is obtained as a powder after being made into a concentrated water suspension or dried by vacuum drying or freeze drying.

As a specific example, for example, 25 g of pyrocton olamine (Octopirox, manufactured by Hoechst Co., Ltd.) is dissolved in 25 kg of methanol. Separately, a liquid in which 25 g of hectorite (manufactured by American Colloid Co., Benton EW) is uniformly dispersed in 25 kg of tap water is added to a pyroctone olamine solution, stirred well, and allowed to stand overnight. Since the gel composed of the pyroctone olamine / montmorillonite complex precipitates in the lower layer, the supernatant is removed by decantation, followed by centrifugation to collect the lower layer gel. Subsequently, it was freeze-dried to obtain a fine powder of a pyroctone olamine / montmorillonite complex.

[Production Example (3)] A suspension obtained by adding water to a water-swellable clay mineral and sufficiently stirring the mixture and a bactericide such as water, methanol, ethanol or acetone is used as one or more bactericides. The disinfectant solution dissolved in the dissolving solvent is mixed and stirred at room temperature for 1 to 12 hours. This is concentrated by an evaporator to obtain a concentrated aqueous suspension, or further subjected to vacuum drying or freeze drying to obtain a fungicide-clay mineral complex as a powder.

As a specific example, for example, 25 g of triclosan (manufactured by Nippon Ciba Geigy) is added to 25 kg of methanol.
To dissolve. Separately, a liquid in which 25 g of montmorillonite (Kunimine Industry Co., Ltd., Kunipia G) is uniformly dispersed in 25 kg of tap water is added to the triclosan solution, and the mixture is stirred well. After concentration with an evaporator, the solution was freeze-dried to obtain a fine powder of a triclosan / montmorillonite complex.

The above production examples (1), (2) and (3)
In the above, the concentration of the clay mineral in the suspension is desirably 10% or less, and above this, stirring and formation of a complex are insufficient. Also, the mixing ratio of the water-swellable clay mineral and the fungicide is
The fungicide is 5-250 per 100 parts of water-swellable clay mineral.
If the amount is less than 5 parts, the disinfectant will be insufficient, and if it exceeds 250 parts, the disinfectant which does not form a complex will be excessive, and the expected effect will not be sufficiently obtained.

In the practice of the present invention, the bactericide composition may contain, in addition to the above complex components, surfactants, oils, alcohols, and the like generally used in cosmetics, quasi-drugs, pharmaceuticals, and the like. It can coexist with humectants, thickeners, preservatives, antioxidants, chelating agents, pH adjusters, fragrances, pigments, ultraviolet absorbing / scattering agents, vitamins, amino acids, water, etc. The agent composition is effective for skin and scalp, and is suitable as a bactericide component of cosmetics for skin and scalp.

[0029]

The germicidal composition of the present invention has a reduced irritancy of the bactericide and a significantly improved skin persistence and persistence of the bactericide.

[0030]

EXAMPLES Next, examples of the present invention and comparative examples will be shown to specifically explain the effects of the present invention, but the present invention is not limited to these examples.

In the following examples, perfumes having the following formulation were used. Example of perfume formulation used (parts by weight) Aldehyde C8 0.2 Aldehyde C9 0.2 Aldehyde C10 0.2 Aldehyde C11 0.2 Aldehyde C12 0.2 Aldehyde C12 MNA 0.2 Anisaldehyde 2.0 Acetal R 0.2 Adoxal 0.2 Acetyl Cedrene 2.0 Allyl Amyl Glycolate 0.2 Allyl Cyclohexane Propionate 2.0 Alpha Damascon 0.2 Beta Damascon 0.2 Delta Damascon 0.2 Ambrette Lid 0.2 Ambroxane 0.2 amylcinamic aldehyde 20.0 amylcinnamaldehyde dimethyl acetal 2.0 amyl valerianate 0.2 amyl salicylate 2.0 isoamyl acetate 2.0 isoamyl salicylate 2.0 Aurantio 2.0 Acetyl eugenol 20.0 Bactanol 2.0 Benzyl acetate 20.0 Benzyl alcohol 2.0 Benzyl salicylate 2.0 Bergamyl acetate 0.2 Bornyl acetate 2.0 Butyl butyrate 20.0 Hexanol 2.0 Para-tert-aryl butylcyclohexyl acetate 0.2 Ortho-tert-aryl butyl cyclohexanol 2.0 Benzaldehide 0.2 Benzyl formate 0.2 Caryophyllene 0.2 Casimerane 2.0 Carvone 2.0 Cedrum bar 2.0 Sed Reel acetate 0.2 Cedrol 2.0 Celestrid 0.2 Thin alcohol Alcohol 2.0 Thin aldehyde 0.2 Cis jasmon 0.2 Citral 0.2 Cyto Methyl acetal 2.0 citrasal 2.0 citronellal 0.2 citronellol 2.0 citronellyl acetate 2.0 citronellyl formate 0.2 citronellyl nitrile cycla set 0.2 cyclamenaldehyde 20.0 cyclaprop 20. 0 caron 0.2 coumarin 2.0 cinamyl acetate 2.0 gamma-decalactone 0.2 delta-decalactone 0.2 dimethylbenzyl carbinol 2.0 dihydrojasmon 0.2 dihydrolinalool 2.0 dihydromyrcenol 2 2.0 Dimethol 2.0 Dimyrcetol 2.0 Diphenyl oxide 0.2 Ethyl vanillin 0.2 Eugenol 2.0 Fluate 2.0 Fentyl alcohol 0.2 Phenyl ethyl acetate 2.0 Gala Solid 20.0 Gamma-Undecalactone 0.2 Geraniol 20.0 Geranyl Acetate 2.0 Geranyl Formate 2.0 Geranyl Nitrile 0.2 Hedion 20.0 Helional 0.2 Heliotropin 2.0 Cis-3-hexenol 0 0.2 cis-3-hexenyl acetate 0.2 cis-3-hexenyl salicylate 0.2 hexylcinnamic aldehyde 20.0 hexyl salicylate 2.0 Hyacinthaldehyde methyl acetal 0.2 Hydrotropic alcohol 0.2 Hydroxycitronellal 2.0 Indole 0.2 Ionone 20.0 Isobornyl acetate 0.2 Isocyclocitral 0.2 Iso-E super 2.0 Isoeugenol 0.2 Iononylacetate 0.2 Isobut Luquinoline 0.2 Jasmar 2.0 Jasmolactone 0.2 Jasmophylan 2.0 Koabon 2.0 Ligstral 0.2 Lilial 20.0 Lime oxide 0.2 Limonene 20.0 Linalool 20.0 Linalool oxide 0.2 Linalyl acetate 2.0 Lillal 20.0 Manzanate 0.2 Mayol 2.0 Mentyl acetate 2.0 Mensonate 2.0 Methyl anthranilate 2.0 Methyl eugenol 0.2 Menthol 0.2 Alpha methyl yonone 20. 0 beta-methylyonone 2.0 gamma-methylyonone 20.0 methylisoeugenol 0.2 methyl lavender ketone 0.2 methyl salicylate 0.2 mugealdehyde 2.0 mugol 2.0 musk TM-II 2.0 musk 81 2.0 Musk C14 2.0 Musk T 2.0 Musk Ketone 0.2 Musk Tibetin 0.2 Musk Mosken 0.2 Mirac Aldehyde 2.0 Methyl Phenyl Acetate 2.0 Nerol 2.0 Neryl Acetate 2.0 Nopyr Acetate 2.0 Nopyr alcohol 2.0 Neobergamate 2.0 1 0.2 Oribund 0.2 Oxyphenylone 0.2 Parakresyl methyl ether 0.2 Pentalid 2.0 Phenylethyl alcohol 20.0 Phenylethyl acetate 2.0 Alpha pinene 2.0 Lubafuran 0.2 Rosephenone 2 2.0 Rose oxide 0.2 Sandalore 2.0 Sandella 2.0 Santarex 2.0 Styrilyl acetate 2.0 Styrilyl propionate 2.0 Terpineol 20.0 Terpinyl acetate 2.0 Tetrahydrolinalool 2 2.0 Tetrahydrolinalyl acetate 2.0 Tetrahydrogeraniol 2.0 Tetrahydrogeranyl acetate 2.0 Tonalid 20.0 Traseolide 2.0 Tripral 0.2 Thymol 0.2 Vanillin 0.2 Yarara 0.2 Belldox 0.2 Anise oil 0.2 Bay oil 0.2 Bodorose oil 2.0 Kananga oil 2.0 Cardamom oil 0.2 Cassia oil 0.2 Cedarwood oil 2.0 Orange oil 20.0 Mandarin oil 2.0 Tangerine oil 2.0 Basil oil 0.2 Nutmeg oil 0.2 Citronella oil 0.2 Clove oil 0.2 Coriander oil 0.2 Elemiresinoid 2.0 Eucalyptus oil 0.2 Fennel oil 0.2 Galvanum oil 0.2 Geranium oil 2.0 Hiba oil 2.0 Hinoki oil 2.0 Jasmine absolute 0.2 Lavandin oil 2.0 Lavender oil 2.0 Lemon oil 2.0 Lemongrass oil 0.2 Lime oil 2.0 Neroli Oil 0.2 Yuzu oil 0.2 Oak moss absolute 0.2 Tea tree oil 0.2 Patchouli oil 2.0 Peppermint oil 2. 0 Perilla oil 0.2 Petitgrain oil 2.0 Pine oil 0.2 Rose oil 0.2 Rosemary oil 0.2 Camphor oil 0.2 Berry oil 2.0 Clarice sage oil 0.2 Sandalwood oil 0.2 Spearmint oil 2.0 Spike lavender oil 0.2 Star anise oil 0.2 Thyme oil 0.2 Tonka bean tincture 0.2 Turpentine oil 0.2 Vanilla bean tincture 0.2 Vetiver oil 2.0 Ylang ylang oil 2.0 Grapefruit oil 2.0 Benzoin Resinoid 0.2 Peruvian Sam Resinoid 0.2 Tolubal Sam Resinoid 0.2 Tuberose Absolute 0.2 Mustin Quinki 0.2 Castorium Tincture 0.2 Civet Tincture 0.2 Ambergris Tincture 0.2 Diethylphthalate 100. 0 Dipropylene glycol 100.0 Benzylbenzoe Doo 100.0 isopropyl myristate 50.0 hercolyn 13.6 Total 1000.0

Test Example 1 The stimulant of the fungicide-clay mineral composite was examined by the following method. The hair on the ventral side of a Hartley-type guinea pig (female, weighing 300 to 400 g) is cut with an electric clipper and further shaved with an electric razor. After the hair removal time, 30 μg of the sample (bactericide composition) shown in Table 1 was applied to a 2 cm × 2 cm square once a day for 4 hours continuously (n = 5). For the determination, erythema of each applied portion was determined 24 hours after the final sample application according to the following criteria. [Judgment Criteria] Score No erythema 0 Slight erythema 1 Slight erythema 2 Medium erythema 3 Extremely erythema 4 In addition, the pyrocton olamine-Benclay SL complex is manufactured in Production Example (2), and the triclosan-Vegum T complex is manufactured. Prepared according to example (3).

The results of the study are shown in Table 1. The results were shown as relative values when the average value of the erythema scores of pyroctone olamine and triclosan alone was 100.

From the results shown in Table 1, it can be seen that the fungicide and the clay mineral coexist with the fungicide, and the irritation of the fungicide is slightly reduced as compared with the fungicide alone. all right.

[0035]

[Table 1]

Test Example 2 The persistence of a bactericide in a skin model was examined by the following method. That is, a gel was prepared by mixing the components shown in Table 2. The content is% by weight
Indicated by

0.1 g of the gel thus prepared was applied to moistened pig skin (2 cm × 2 cm square), allowed to stand for 10 minutes, then washed with water, and considered to be one of the causes of acne. Anaerobic bacterium Propionib
acterium acnes was about 10 ⁶ inoculation.
After 10 hours, 0.7% polysorbate-80, 0.1%
Stir in physiological saline containing soy lecithin, serially dilute, apply to modified GAM agar medium (Nissui),
After anaerobic culture at 7 ° C. for 48 hours, the number of bacteria was measured. The pyroctone olamine-Benclay SL complex was prepared according to Production Example (2).

From the results shown in Table 2, it can be seen that the number of surviving bacteria of the product of the present invention is greatly reduced as compared with the comparative example, and the bactericidal activity is strong. This is presumed to be due to the affinity between the clay mineral and the protein, the pyrocton olamine-Benclay complex remained on the pig skin even after washing with water, and the bactericidal activity was maintained.

[0039]

[Table 2] Number of inoculated bacteria: 3.3 × 10 ⁶

Test Example 3 A medicated soap was prepared by mixing the components shown in Table 3. The compounding amount is shown by weight%. The triclosan-Kunipia G complex was prepared according to Production Example (3).

Using the medicated soap thus prepared,
The effects of irritation reduction and bactericidal activity were evaluated as described below. That is, 15 women who are susceptible to hand roughening in winter are divided into three groups. In January, when hand roughening occurs, each person wash their hands at least three times a day with each of medicated soaps, and two weeks later, they feel rough hands, itchy hands, and rough hands. Self-evaluation of feeling. The evaluation was performed by taking an average value of 5 persons in each group based on the following criteria. [Evaluation Criteria] Feeling of rough hands, itching of hands, and rough feeling 3: Present 2: Slightly present 1: Slightly present 0: Almost none

Before the start of the test, the number of bacteria on the fingers was measured by the finger streak method using a blood agar medium (Nissui Pharmaceutical), and after the test was completed, the hands were washed with warm water, and 2 hours after the test was completed. The number of bacteria on the fingers was measured by the finger streak method. The evaluation of the bactericidal effect was performed according to the following criteria, and the number of persons at each level was shown. [Evaluation criteria] Significant effect: 100 or more bacteria decreased to 10 or less Effective: 100 or more bacteria decreased markedly Slightly effective: 500 or more bacteria decreased to 100 or more Invalid: Number of bacteria decreased No change or increase

From the results shown in Table 3, it was found that the product of the present invention suppressed the feeling of rough hands and irritations and was excellent in the persistence of the bactericidal activity as compared with the comparative example.

[0044]

[Table 3]

Test Example 4 Medicinal Hand Soap The components shown in Table 4 were mixed by a conventional method. The triclosan-Benclay SL composite was prepared according to Production Example (3).

[0046]

[Table 4]

Test Example 5 Body Shampoo The components shown in Table 5 were mixed by a conventional method. The ciclopirox olamine-Vegum T complex was prepared according to Production Example (2).

[0048]

[Table 5]

Test Example 6 Dandruff shampoo The components shown in Table 6 were mixed by a conventional method. The pyroctone olamine-Kunipia F complex was prepared according to Production Example (2).

[0050]

[Table 6]

Test Example 7 Powder spray type antiperspirant The components shown in Table 7 were mixed by a conventional method. The triclosan-Benclay SL composite was prepared according to Production Example (3).

[0052]

[Table 7]

Test Example 8 Roll-On Type Antiperspirant The components shown in Table 8 were mixed by a conventional method. The chlorhexidine gluconate-kunipia G complex was prepared in Production Example (1).
Prepared by

[0054]

[Table 8]

Test Example 9 Deodorant Agent The components shown in Table 9 were mixed by a conventional method. The isopropylmethylphenol-ionite H complex was prepared according to Production Example (3).

[0056]

[Table 9]

Test Example 10 Cream-type athlete's foot The components shown in Table 10 were mixed by a conventional method. The miconazole nitrate-laponite complex was prepared according to Production Example (2).

[0058]

[Table 10]

[Test Example 11] Liquid type athlete's foot medicine The components shown in Table 11 were mixed by a conventional method. The bifonazole-Vegum T complex was prepared according to Production Example (2).

[0060]

[Table 11]

Test Example 12 Acne Treatment The components shown in Table 12 were mixed by a conventional method. The resorcinol-laponite complex was prepared according to Production Example (1).

[0062]

[Table 12]

Test Example 13 Hand Disinfectant The components shown in Table 13 were mixed by a conventional method. The chlorhexidine gluconate-kunipia G complex was prepared according to Production Example (1).

[0064]

[Table 13]

Test Example 14 A lotion for atopic dermatitis The components shown in Table 14 were mixed by a conventional method. The pyroctone olamine-Benclay SL complex was prepared according to Production Example (2).

[0066]

[Table 14]

Test Example 15 Hair restorer The components shown in Table 15 were mixed by a conventional method. The ciclopirox olamine-laponite complex was prepared according to Production Example (2).

[0068]

[Table 15]

Test Example 16 Whitening Agent The components shown in Table 16 were mixed by a conventional method. The ketoconazole-veegum T complex was prepared according to Production Example (2).

[0070]

[Table 16]

Test Example 17 Hand Cream The components shown in Table 17 were mixed by a conventional method. The ketoconazole-veegum T complex was prepared according to Production Example (3).

[0072]

[Table 17]

In all of Test Examples 4 to 17, the product of the present invention was found to have reduced skin irritation and sustained antibacterial activity, as compared with Comparative Examples.

Claims (1)

[Claims] 1. A bactericidal selected from pyrocton olamine, ciclopirox olamine, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, zinc pyrithione, isopropylmethylphenol, photosensitizers, undecylenic acid, resorcin, hinokitiol, and azole antifungal agents. One or more agents and an average particle diameter of 0.01 to 50 μm
A fungicidal composition comprising a complex with a water-swellable clay mineral and having an excellent skin protection effect.