JP2006045221A - Vermin repellent and vermin controlling method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means for effectively preventing the damage of vermin such as clothes moth and mite and having low toxicity to human body and environment. <P>SOLUTION: The vermin repellent contains iodine as an active component. The vermin controlling method has a step to control vermin by using a vermin repellent containing iodine as an active component. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an insect repellent and a method for controlling pests.

  There are various pests that are harmful to our living environment.

  For example, in order to store clothing over a long period of time, it is common to use storage furniture such as a chiffon or closet and store the clothing in these storage furniture.

  However, if clothing is stored in these storage furniture and left for a long period of time, in some cases, damage caused by various clothing pests may occur, and the stored clothing may be damaged.

  Conventionally, sublimable solid compounds such as naphthalene and paradichlorobenzene have been used as insect repellents for clothing pests in order to prevent such food damage. Recently, an insecticide for clothing pests that does not smell has been developed that uses a room temperature volatile oily compound such as a pyrethroid compound such as empentrin as an active ingredient (see, for example, Patent Document 1).

  On the other hand, in addition to clothing pests, mites also cause various harms to our living environment. For example, it is known to cause inflammation such as itchiness or redness by contacting the human skin, or to act as an allergen for allergic diseases such as atopic dermatitis.

  It is disclosed that the above-described pyrethroid compound is effective as an acaricide for controlling mites (see, for example, Patent Document 2). Further, diethyltoluamide, benzyl benzoate, diethyl phthalate, IBTA, dehydroacetic acid and the like are also used as an acaricide for textile processing.

  However, the above-mentioned various compounds have a problem that they have a great burden on the environment, such as toxicity to the human body and fish toxicity.

  For example, in terms of toxicity to the human body, naphthalene is known to cause inflammatory reactions such as swelling and redness when directly in contact with the skin. Paradichlorobenzene and pyrethroid compounds are known to be irritating to the eyes, nose, throat, and the like, and when worsened, cause headaches, dizziness, general illness, and the like. Furthermore, there are reports that pyrethroid compounds exhibit immunotoxicity and mutagenicity. Here, even if the content of these compounds contained in the insect repellent is very small, it cannot be denied that it adversely affects indoor and outdoor organisms and the environment in the form of atmospheric emissions.

By the way, it is widely known that iodine (I ₂ ) exhibits an excellent action against various organisms, particularly microorganisms. Moreover, the safety to the human body is high and the burden on the environment is small. For this reason, bactericides, fungicides, antiseptics, disinfectants, and the like containing iodine as an active ingredient have been developed (see, for example, Non-Patent Document 1) and have been put into practical use.

However, whether iodine is effective for controlling pests has not been known so far, and no knowledge about this has been described in any known literature.
Japanese Patent Laid-Open No. 10-87407 JP-A-10-87404 Isao Shibasaki, Food Industry, Volume 29, Late January, 60-71, 1986

  Accordingly, an object of the present invention is to provide means that has low toxicity to the human body and the environment and can effectively prevent damage caused by pests such as clothing pests and mites.

  The present invention is an insect repellent characterized by containing iodine as an active ingredient.

  Moreover, this invention is a pest control method which has a step which controls a pest by using the insect repellent which contains an iodine as an active ingredient.

According to the insect repellent and the pest control method of the present invention, damage caused by pests such as clothing pests and mites can be effectively prevented. In the present invention, since iodine (I ₂ ) is used as an active ingredient, toxicity to the human body and the environment can be reduced.

  Embodiments of the present invention will be described below.

  The first of the present invention is an insect repellent characterized by containing iodine as an active ingredient.

As a result of intensive studies on means capable of preventing damage caused by pests such as clothing pests and mites, the present inventors have found that iodine (I ₂ ) has an action of preventing such damage. In particular, it has been found that by using an iodine-cyclodextrin inclusion compound in which iodine is included in cyclodextrin, damage by pests can be prevented over a long period of time, and the present invention has been completed.

The insect repellent of the present invention (hereinafter abbreviated as “the present insect repellent”) contains iodine (I ₂ ) as an active ingredient. For this reason, according to the present insect repellent, damage caused by pests such as clothing pests and mites can be effectively prevented. In addition, as described above, iodine is extremely toxic to the human body and the environment, so that contamination of the living environment due to use can be suppressed, and safety during production can be improved.

  In general, the term “insect protection” is a concept of exterminating or preventing damage caused by harmful insects to our living environment. The concept of “insect repellent” in the insect repellent of the present invention is the same as this, and is a concept of controlling pests or preventing damage caused by pests (for example, eating damage caused by clothing pests and dermatitis caused by ticks). The “clothing pest” refers to a pest that causes damage such as food damage or damage to the clothing.

  Hereinafter, the preferable form of this insect repellent is demonstrated.

In this insect repellent, iodine (I ₂ ) is the main form of the insect repellent action. Volatilization of iodine contained in the present insect repellent exerts an insect repellent action against clothing pests, thereby preventing food damage caused by clothing pests. The detailed mechanism of how iodine acts on clothing pests and exerts its insect-repelling action is still unknown, but it is due to the repellent action based on the unpleasant odor and irritation of iodine (I ₂ ). Guessed. Note that this is just a guess, and even if the above guess is different from the actual mechanism, the technical scope of the present invention is not affected at all.

  In this insect repellent, the form in which iodine is contained is not particularly limited. However, the simple substance of iodine is highly volatile and has a unique odor. Furthermore, the simple substance of iodine may be corrosive to metals or the like. Therefore, from the viewpoint of alleviating these, it is preferable that iodine is contained in the form of iodophor in the present insect repellent. However, it is not restricted only to such a form, and depending on the case, simple iodine may be contained as it is.

In the present application, “iodohol” means a preparation in which iodine is supported on a suitable carrier capable of supporting iodine (I ₂ ). In this insect repellent, if iodine is contained in the form of iodophor, the problem is that the iodine contained will volatilize at a time and sustainability will not be obtained, and there will be problems such as the specific odor of iodine associated with this Can be mitigated.

  The specific form of iodophor is not particularly limited, and any form in which iodine is supported on an appropriate carrier can be used. Examples of suitable carriers on which iodine can be supported include various surfactants such as cyclodextrin (CD), polyvinylpyrrolidone (PVP), and nonionic surfactants. Newly developed carriers may be used.

  As a result of further investigations, the present inventors have used cyclodextrin as a carrier and contained iodine in the form of an iodine-cyclodextrin inclusion compound (hereinafter abbreviated as “CDI”), whereby the effect of the insect repellent is achieved. Has been found to be further improved. That is, in this insect repellent, it is more preferable that iodine is contained in the form of CDI. Therefore, although the preferable form of this insect repellent is demonstrated in detail hereafter taking the form in which the iodine is contained with the form of CDI as an example, the technical scope of this invention is not restrict | limited only to the following form.

  As described above, CDI is a compound having a structure in which iodine is included by cyclodextrin. CDI is easy to control the retention and release of iodine, and by appropriately adjusting the abundance ratio of iodine and cyclodextrin as necessary, the anti-corrosion action by iodine can be adjusted.

  In addition, iodine constituting CDI is an essential mineral in animals and has been used as a disinfectant and a mouthwash for a long time. Furthermore, among cyclodextrins, unsubstituted products are approved as food additives. In addition, these components are biodegradable, iodine is ionized to become potassium salts and sodium salts, and unsubstituted cyclodextrins are decomposed into water, carbon dioxide and the like by microorganisms in the soil. For this reason, this insect repellent has almost no burden on the environment and has high safety.

  In this insect repellent, iodine released from CDI provides an antibacterial effect and a deodorizing effect in addition to the effect of preventing damage by pests. In addition, deodorization is performed by the cyclodextrin present in CDI. For this reason, when CDI is employ | adopted in this insect repellent, in addition to the effect which prevents the damage by a pest, the combined effect of an antibacterial and deodorizing is acquired. For example, wrinkles are likely to occur in clothes, closets, and the like in which clothing is stored for a long period of time, which causes a strange odor. When CDI is blended with this insect repellent, not only is the food damage caused by clothing pests prevented, but it is also possible to remove wrinkles generated inside the storage furniture and the off-flavors associated therewith. It should be noted that the technical scope of the present invention should be determined based on the description of the scope of claims, and even if a combined effect such as antibacterial and deodorizing cannot be obtained, from the technical scope of the present invention. It is not excluded.

  In the present invention, iodine is not particularly limited, and a commercially available product may be used as it is. In addition, iodine synthesized by a known method such as heating distillation of potassium iodide and potassium dichromate may be used. This is the same when iodine is contained not only in the form of CDI in the present insect repellent but also in other forms.

In the present invention, the cyclodextrin is not particularly limited, and a commercially available product may be used as it is. The cyclodextrin may be synthesized by itself by a known method such as causing amylase derived from Bacillus macerans to act on starch. In the present application, “cyclodextrin” means α-, β-, and γ composed of 6, 7, and 8 cyclic α- (1 → 4) linked D-glucopyranose units, respectively. -In addition to cyclodextrins, including, for example, alkylated (methylated, ethylated, propylated, isopropylated, butylated, etc.), monoacetylated, triacetylated, monochlorotriazinylated chemical modifications . Specific examples of commercial products of cyclodextrin include α-cyclodextrin marketed as CAVAMAX (registered trademark) W6 series, β-cyclodextrin marketed as CAVAMAX (registered trademark) W7 series, and CAVAMAX (registered trademark) W8 series. Γ-cyclodextrin, commercially available as CAVASOL (registered trademark) W7 M series, methyl-β-cyclodextrin, commercially available as CAVASOL (registered trademark) W7 HP series, hydroxypropyl-β-cyclodextrin, CAVASOL ( (Registered trademark) Triacetyl-β-cyclodextrin marketed as W7 TA, monochlorotriazinyl-β-cyclodextrin marketed as CAVASOL (registered trademark) W7 MCT, etc. Both available from Corporation Shikurokemu).

  The cyclodextrin constituting CDI can be appropriately selected in consideration of the use and availability. For example, when CDI is dissolved in water and used as an insect repellent in the form of an aqueous solution, methyl-β-cyclodextrin (hereinafter abbreviated as “MCDI”), α-cyclodextrin, γ-cyclodextrin having excellent water solubility. CDI may be prepared using dextrin or the like. When CDI is used in the present insect repellent in a solid form, CDI may be prepared using β-cyclodextrin (hereinafter abbreviated as “BCDI”). However, it is not necessarily limited to these forms.

  In consideration of ease of adjustment of the amount of iodine included in CDI and economic efficiency, cyclodextrin constituting CDI is β-cyclodextrin or a chemical modification thereof (for example, methyl-β-cyclodextrin). Preferably there is. From the viewpoint of safety, the cyclodextrin constituting CDI is preferably an unsubstituted cyclodextrin approved as a food additive.

  In the present insect repellent, when iodine is contained in the form of CDI, the effective iodine in the contained CDI is preferably 1 to 35% by mass, more preferably 5 to 25% by mass, and more preferably 5 to 25% by mass, Preferably it is 10-20 mass%. When the effective iodine is in such a range, the stability of iodine is improved, and this insect repellent has a particularly effective effect of preventing damage caused by pests and a combined effect of antibacterial effect and deodorization. To express. Effective iodine in CDI can be controlled by adjusting the amount of cyclodextrin or iodine used in producing CDI. Also, by controlling the effective iodine in CDI, the release of iodine from CDI can be controlled.

  The method for producing CDI used in the present invention is not particularly limited, and a conventionally known method or a combination thereof can be appropriately employed. For example, methods described in JP-A-51-88625, JP-A-51-100892, etc .; iodine is adjusted by adjusting the amount of iodine and the amount of iodine dissolution aid (for example, potassium iodide) to a predetermined range. Examples include a method of dissolving and adding cyclodextrin thereto; or a method of adding cyclodextrin to the CDI obtained by these methods to bring the iodine amount to a value within a desired range.

  Among these, according to the method of adjusting iodine amount and iodine solubilizing agent (for example, potassium iodide) amount within a predetermined range to dissolve iodine, and adding cyclodextrin thereto, the amount of cyclodextrin to be added is By adjusting, the amount of iodine included in the cyclodextrin can be controlled. If such a method is used, it is possible to obtain CDI having effective iodine exceeding 19 mass%.

  The “dissolution aid” refers to a compound that assists in dissolving iodine in a solution. Examples of solubilizers include halogen acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, and hydrofluoric acid, sodium iodide, potassium iodide, magnesium iodide, calcium iodide, barium iodide, iodine. Alkali metal or alkaline earth metal halides such as ammonium chloride, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, barium chloride, sodium bromide, potassium bromide, magnesium bromide, calcium bromide, barium bromide Illustrated.

  In the above description, the form in which iodine is contained in the insect repellent as CDI formed by inclusion in cyclodextrin has been described in detail. However, as described above, the technical scope of the present invention is as follows. It is not limited only to the form.

  This insect repellent may contain components other than the components described above as additives.

  Additives that can be added to this insect repellent include fragrances, antioxidants, antiseptics, fungicides, antibacterial agents, deodorants, essential oils, synergists, UV absorbers, dyes, pigments, fragrances (herbs, etc.) ) And the like. Further, other insect repellents, insecticides, repellents and the like that can prevent damage caused by pests may be contained as additives. The specific form of these additives is not limited at all, and the form of the additive conventionally added to the insect repellents can be similarly adopted.

  When the additive as described above is contained, the preferred range of effective iodine in the insect repellent can vary depending on the method of use, the place of use, the type of pest, etc. The effective iodine in the present insect repellent is 0.2 to 35% by mass, more preferably 1 to 25% by mass based on the total mass of the insect repellent when used against clothing pests. If the effective iodine with respect to the total mass of the insect repellent is less than 0.2% by mass, the insect repellent effect may not be sufficiently obtained. On the other hand, mites are considered to be highly sensitive to iodine, and it is difficult to set the lower limit of the use range. For example, in Example 7.4, which will be described later, it is shown that only 0.012 mg of iodine is present in a 850 mL space, affecting the growth of mites.

  The formulation form of the insect repellent is not particularly limited, and may be a solid formulation or a liquid formulation. If possible, it may be a gel-like preparation. By appropriately selecting these formulation forms, release of iodine from the present insect repellent can be controlled.

  Examples of the form of the solid preparation include a form in which solid iodophor (for example, BCDI) is used as a powder, granule, or tablet, or a form in which it is supported (impregnated or spread) on an appropriate carrier. . Here, examples of suitable carriers include conventionally known excipients such as starch in addition to paper, non-woven fabric, resin, and wood. Needless to say, iodoholes such as CDI may be used as they are without being supported on the carrier. Examples of the form of the liquid preparation include a form in which iodophor is used in a state of being dispersed or dissolved in an appropriate solvent. Suitable solvents include water, alcohols such as ethanol, ketones such as methyl ethyl ketone, ethers such as tetrahydrofuran, hydrocarbons such as hexane and toluene, esters such as ethyl acetate, methylene chloride, and the like. And the like. Taking CDI as an example, since MCDI is water-soluble, MCDI can be used as a liquid formulation in a state dissolved in water.

  In addition, from the viewpoint that the insect repellent action can be exhibited with a small amount of effective iodine, a powder preparation is preferable as the form of the insect repellent. Thereby, effective utilization of iodine which is a limited natural resource is achieved. When the form of the insect repellent is a powder formulation, the insect repellent can be used, for example, in a form enclosed in a suitable container that is permeable to iodine. However, it is not limited only to this form, and if possible, it may be used as it is without being enclosed in a container.

  The production method of the preparation is not particularly limited, and conventionally known knowledge can be appropriately referred to for the production of the insect repellent preparation. When manufacturing the solid preparation described above, for example, the liquid preparation described above may be prepared first, supported on a suitable carrier and dried.

  According to the present application, a pest control method is also provided. That is, the second aspect of the present invention is a method for controlling pests, which comprises the step of controlling pests by using an insect repellent containing iodine as an active ingredient.

  The insect repellent used in the second control method of the present invention is not particularly limited as long as it contains iodine as an active ingredient, but preferably, the first insect repellent of the present invention can be used.

  In the control method of the present invention, the place where the insect repellent is used is not particularly limited, and can be used in various places where clothing is stored. Specifically, in the case where clothes pests are used as the place of use, examples include clothes hanging space for drawers, drawers, costume boxes, closets, fancy cases, closets, warehouses, stores, and the like. Moreover, when it is going to acquire the tick-proof effect, it can be applied to carpets, tatami lining, bedding and the like.

Pests are control of the target in the control method of the present invention is not particularly limited, as the clothing pests, for example, Tinea spp Ige (Tinea pellinella), Tineola genus webbing clothes moth (Tineola bisselliella), Attagenus genus Anthrenus beetle ( Attagenus picus ), Anthrenus spp. ( Anthrenus verbasci ) and the like. In addition to these, Hofmannophila genus, Endrosis genus, Dermestes genus and the like can be mentioned. Moreover, the kind of mite is not particularly limited, and various conventionally known mites can be targeted by the control method of the present invention. Examples of types of ticks include, for example, house dust mites (Yokehida mite, Kona leopard mites, etc.), claw mites (Mustocarid mites, staghorn mites, etc.), mite mites (Chano mites, Cyclamen mites, etc.), mite mites (M. mites, mites, mites, etc.) Species belonging to the family (such as mosquito mite) and the family Saladaceae (such as Shrimp). In particular, mites of the house dust mite are attracting attention as allergens for allergic diseases such as bronchial asthma and allergic rhinitis. Moreover, it is known that when a large number of mites belonging to the urticae family are generated indoors, dermatitis accompanied by itching and the like is caused by pointing to a person who accidentally contacts.

The amount of the insect repellent used in the control method of the present invention is not particularly limited, and can be set as appropriate. In determining the amount of insect repellent used, it is advisable to consider the effective amount of iodine for the target pests. For example, for clothing pests, when an insect repellent is used in a closed space such as a chiffon or closet, the amount of iodine contained in the insect repellent used is iodine (I ₂ ) per liter of space used. As a mass, Preferably it is 1-350 mg, More preferably, it is 5-250 mg, More preferably, it is 10-200 mg. Here, if the amount of iodine is below the above range, there is a possibility that the insect-repellent effect cannot be obtained sufficiently. On the other hand, even if the amount of iodine exceeds the above range, the insect repellent effect is not improved so much. On the other hand, as described above, mites are considered to be extremely sensitive to iodine, and it is difficult to set the lower limit of the amount used. Therefore, it can be appropriately determined according to the form in which the insect repellent is used (in the form of powder, granules, tablets, etc., as well as the form supported on a carrier), the type of mite desired to be controlled, the usage environment, and the like.

  In the control method of the present invention, the insect repellent containing iodine may be used in combination with various conventionally known agents. Examples of the drugs that can be used in combination include insect repellents other than the insect repellent of the present invention, various deodorants, antibacterial agents, and fragrances (herbs and the like).

  As described above, the insect repellent and the pest control method of the present invention have been described in detail by taking as an example the case where they are used against clothing pests and ticks, but it goes without saying that these may be applied to other pests. is there.

  Hereinafter, the present invention will be described in more detail with reference to examples.

<Eating damage prevention test using MCDI (Forced eating damage law)>
Example 1.1
An aqueous iodine-methyl-β-cyclodextrin clathrate compound aqueous solution having an effective iodine content of 6% by mass, which is commercially available as “MCDI-6” from Niho Chemical Co., Ltd., was prepared. This stock solution of MCDI-6 was impregnated into a paper disk (diameter: 7 mm, thickness: 1 mm) and dried to prepare an insect repellent sample of the present invention.

  Next, a petri dish (diameter: 90 mm, thickness: 18 mm) was prepared, and a plain woven wool muslin cloth (size: 3 cm × 3 cm, mass: 198.32 g) was placed in the center of the petri dish. Moreover, the insecticide sample produced above was mounted in one corner of the same petri dish. The effective iodine contained in the insect repellent sample was 0.125 mg.

Next, 15 larvae of garments ( Tinea pelinella ) were released on a wool muslin cloth in a petri dish, and a food damage prevention test was performed under a temperature of 25 ° C. The petri dish was sealed by covering the petri dish.

  After standing for 15 days, the mass of the wool muslin cloth in the petri dish was measured. Moreover, the amount of food damage was calculated by subtracting the mass after the test from the mass before the test. Furthermore, the food damage rate was calculated by the following formula (1). These values are shown in Table 1 below.

Examples 1.2-1.6
By adjusting the number of insecticide samples, the effective iodine contained in the insecticide samples used was controlled to the values shown in Table 1 below, and the mass of the wool muslin cloth was set to the values shown in Table 1 below. Except for this, the damage prevention test was conducted in the same manner as in Example 1.1.

Comparative Example 1
The insect damage prevention test was conducted by the same method as in Example 1.1 except that the insect repellent sample was not used and the mass of the wool muslin cloth was changed to the value shown in Table 1 below.

  Using the amount of damage calculated in Comparative Example 1, the insect repellent efficiency in each Example was calculated by the following formula (2). These results are shown in Table 1 below. Moreover, the photograph which shows the mode of the wool muslin cloth after the test in each Example and a comparative example is shown in FIG.

Examples 2.1-2.6
Example 1.1 except that the worm larvae instead of moth larvae were used as clothing pests and the mass of the wool muslin cloth used in the test was changed to the values shown in Table 2 below. In the same manner as above, a food damage prevention test was conducted.

Comparative Example 2
The insect damage prevention test was conducted by the same method as in Example 2.1 except that the insect repellent sample was not used and the mass of the wool muslin cloth was changed to the value shown in Table 2 below.

  The above results are shown in Table 2 below. Moreover, the photograph which shows the mode of the wool muslin cloth after the test in each Example and a comparative example is shown in FIG.

<Eating damage prevention test using BCDI (Forced eating damage method)>
Example 3.1
An iodine-β-cyclodextrin clathrate compound powder having an effective iodine content of 20% by mass, which is commercially available as “BCDI-20” from Niho Chemical Co., Ltd., was prepared.

Except that this bulk powder was directly placed in a petri dish as an insect repellent sample of the present invention, a test for preventing damage to larvae of iga ( Tinea pelinella ) was performed in the same manner as in Example 1.1. . In addition, the effective iodine contained in the used insect repellent sample was 0.098 mg.

Examples 3.2 to 3.6
By adjusting the amount of BCDI-20 bulk powder as an insect repellent sample, the effective iodine contained in the used insect repellent sample is controlled to the value shown in Table 3 below, and the mass of the wool muslin cloth is as follows. The damage prevention test was conducted by the same method as in Example 3.1 except that the values shown in Table 3 were used.

Comparative Example 3
A food damage prevention test was performed by the same method as in Example 3.1 except that the insect repellent sample was not used and the mass of the wool muslin cloth was changed to the value shown in Table 3 below.

  The above results are shown in Table 3 below. Moreover, the photograph which shows the mode of the wool muslin cloth after the test in each Example and a comparative example is shown in FIG.

Examples 4.1 to 4.6 and Comparative Example 4
Example 3.1, except that larvae of Atsagenus piceus were used as clothing pests instead of moth larvae, and the mass of the wool muslin cloth used in the test was changed to the values shown in Table 4 below. In the same manner as above, a food damage prevention test was conducted.

Comparative Example 4
The insect damage prevention test was performed by the same method as in Example 4.1, except that the insect repellent sample was not used and the mass of the wool muslin cloth was changed to the value shown in Table 4 below.

  The above results are shown in Table 4 below. Moreover, the photograph which shows the mode of the wool muslin cloth after the test in each Example and a comparative example is shown in FIG.

  According to Tables 1 to 4 and FIGS. 1 to 4, it can be seen that as the effective iodine contained in the insect repellent sample of the present invention is increased, the amount of food damage decreases and the insect repellent efficiency increases.

  Thereby, it is shown that the insect repellent and the pest control method of the present invention are means that can effectively prevent food damage caused by clothing pests such as moths and spider worms.

  Moreover, from the comparison of Examples 1.1 to 1.6 and Examples 2.1 to 2.6, and Examples 3.1 to 3.6 and Examples 4.1 to 4.6, insect repellent samples It is shown that the case where BCDI is used exhibits a food damage prevention effect with less effective iodine than the case where MCDI is used.

  It should be noted that the rate of feeding damage is generally lower in the case of using Himetsuobushimushi as clothing pests than in the case of using squid. This is considered to be due to the fact that the Himekatsuobushimushi generally has a lower feeding damage rate than the squid.

<Mite prevention test using MCDI (repellency test)>
Example 5.1
MCDI-6 similar to Example 1.1 described above was prepared, and this stock solution was diluted with water to a concentration of 1% by mass. On the other hand, a filter paper was prepared, and this filter paper was impregnated with the diluted solution prepared above in an amount of 10 mL / 1 m ² .

  Next, MCDI-impregnated filter paper cut out to a diameter of 4 cm was laid in a petri dish with a diameter of 4 cm, and in the center, a powdered feed for experimental animals (made by Oriental Yeast Co., Ltd.) and a pharmacopoeia dry yeast that passed through a sieve with an opening of 300 μm. The bait (0.05 g) of the tick invitation which is a 1: 1 mass mixture with Ebios powder (Asahi Brewery Co., Ltd. product) was mounted. At this time, the effective iodine in MCDI impregnated in the filter paper was 0.081 mg.

  Subsequently, the petri dish was placed concentrically in the center of a petri dish having a diameter of 9 cm, and a tick medium containing 10,000 live leopard mites was applied between the two petri dishes, and a repelling test was started.

  24 hours after the start of the test, the number of surviving mites that had moved into the petri dish having a diameter of 4 cm was measured. As a control, a test was conducted by using a filter paper not impregnated with MCDI by the same method, and the percentage of the number of moving ticks compared to the control was used as the repelling rate. As a result of performing this experiment twice, the repelling rates were 58.8% and 68.6%, respectively.

Example 5.2
A repelling test for mites was performed in the same manner as in Example 5.1, except that the MCDI stock solution was diluted to a concentration of 5% by mass. In this example, the effective iodine in MCDI impregnated on a filter paper having a diameter of 4 cm was 0.405 mg. As a result of performing this experiment twice, the repelling rates were 81.9% and 64.5%, respectively.

<Mite prevention test using BCDI (repellency test)>
Example 6.1
A cotton cloth cut to a diameter of 4 cm was prepared and laid in a petri dish having a diameter of 4 cm. On the other hand, an iodine-β-cyclodextrin clathrate compound powder having an effective iodine content of 5% by mass, which is commercially available as “BCDI-5” from Niho Chemical Co., Ltd., is prepared, and 0.002 g of the powder is placed on a cotton cloth in a petri dish. Sprayed uniformly. In this example, the effective iodine in BCDI sprayed on the cotton cloth was 0.1 mg.

  About the other method, the repelling test with respect to a tick was done by the method similar to said Example 5.1. As a result, the repelling rate was 66.6%.

Example 6.2
A tick repellent test was performed in the same manner as in Example 6.1 except that 0.008 g of BCDI was sprayed. In this example, the effective iodine in BCDI sprayed on the cotton cloth was 0.4 mg. As a result, the repelling rate was 69.8%.

  From the results of Examples 5 and 6, it is shown that the insect repellent and the pest control method of the present invention can exert an effective repellent action against mites.

<Mite growth inhibition test using MCDI>
Example 7.1
MCDI-6 similar to the above was prepared. 20 μL of the prepared MCDI stock solution was applied to filter paper, and the applied filter paper was suspended in a bottle having a volume of 850 mL. In this example, the effective iodine in MCDI applied on the filter paper was 1.2 mg.

  On the other hand, 0.1 g of mite medium, 20 male leopard mites, and 50 females are placed in a high-density nylon bag made of nylon taffeta with a side of 4 cm. gave.

  Place the sealed bag on the bottom of the bottle prepared above, put a container containing saturated saline solution for humidity control, seal the bottle with a lid, and raise it at 25 ° C, 76Rh% for 6 weeks, The number of ticks in the bag was counted. As a control, the same method was used to test using a bottle without hanging MCDI filter paper, and the growth inhibition rate was calculated by the following formula (3).

  As a result, the growth inhibition rate in this example was 43%.

Example 7.2
A tick growth inhibition test was performed in the same manner as in Example 7.1, except that a solution obtained by diluting a stock solution of MCDI to a concentration of 50% by mass was applied to filter paper. In this example, the effective iodine in MCDI applied on the filter paper was 0.6 mg. As a result, the growth inhibition rate was 19%.

Example 7.3
A tick growth inhibition test was performed in the same manner as in Example 7.1, except that a solution obtained by diluting a stock solution of MCDI to a concentration of 10% by mass was applied to filter paper. In this example, the effective iodine in MCDI applied on the filter paper was 0.12 mg. As a result, the growth inhibition rate was 19%.

Example 7.4
A tick growth inhibition test was conducted in the same manner as in Example 7.1, except that a solution obtained by diluting a stock solution of MCDI to a concentration of 1% by mass was applied to filter paper. In this example, the effective iodine in MCDI applied on the filter paper was 0.012 mg. As a result, the growth inhibition rate was 18%.

  The result of Example 7 shows that the insect repellent and the pest control method of the present invention can suppress the growth of mites almost in a dose-dependent manner.

It is a photograph which shows the mode of the wool muslin cloth after the corrosion damage prevention test of Examples 1.1-1.6 and the comparative example 1. FIG. It is a photograph which shows the mode of the wool muslin cloth after the food damage prevention test of Examples 2.1-2.6 and Comparative Example 2. It is a photograph which shows the mode of the wool muslin cloth after the eating damage prevention test of Example 3.1-3.6 and the comparative example 3. FIG. It is a photograph which shows the mode of the wool muslin cloth after the food damage prevention test of Examples 4.1-4.6 and the comparative example 4. FIG.

Claims (13)

  An insect repellent characterized by containing iodine as an active ingredient.   The insect repellent according to claim 1, wherein the iodine is contained in the form of iodophor.   The insect repellent according to claim 2, wherein the iodophor is an iodine-cyclodextrin inclusion compound in which iodine is included in cyclodextrin.   The insecticide of Claim 3 whose effective iodine in the said iodine-cyclodextrin inclusion compound is 1-35 mass% with respect to the iodine-cyclodextrin inclusion compound total mass.   The insect repellent according to claim 3 or 4, wherein the cyclodextrin constituting the iodine-cyclodextrin is β-cyclodextrin or a chemically modified product thereof.   The insect repellent according to any one of claims 1 to 5, which is in the form of a powder preparation.   The insect repellent according to any one of claims 1 to 5, which is in a form supported on a carrier.   The insect repellent of any one of Claims 1-7 used for control of clothing pests.   The insect repellent of any one of Claims 1-7 used for control of a tick.   A pest control method comprising a step of controlling pests by using an insect repellent containing iodine as an active ingredient. The amount of iodine contained in the insect repellent used is a pest control method according to claim 10, wherein the iodine (I ₂ ) mass is 1 to 350 mg per liter of space used.   The pest control method according to claim 10 or 11, wherein the pest is a clothing pest.   The pest control method according to claim 10 or 11, wherein the pest is a tick.