JP2006034988A - 柔軟かつ石灰化された組織インプラント - Google Patents
柔軟かつ石灰化された組織インプラント Download PDFInfo
- Publication number
- JP2006034988A JP2006034988A JP2005246893A JP2005246893A JP2006034988A JP 2006034988 A JP2006034988 A JP 2006034988A JP 2005246893 A JP2005246893 A JP 2005246893A JP 2005246893 A JP2005246893 A JP 2005246893A JP 2006034988 A JP2006034988 A JP 2006034988A
- Authority
- JP
- Japan
- Prior art keywords
- bone
- implant
- dermis
- soft tissue
- assembled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1637—Hollow drills or saws producing a curved cut, e.g. cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1662—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body
- A61B17/1671—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body for the spine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8645—Headless screws, e.g. ligament interference screws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/446—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or elliptical cross-section substantially parallel to the axis of the spine, e.g. cylinders or frustocones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
- A61L27/3658—Intervertebral discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
- A61F2/0811—Fixation devices for tendons or ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
- A61F2002/2839—Bone plugs or bone graft dowels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30057—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis made from both cortical and cancellous adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30059—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30112—Rounded shapes, e.g. with rounded corners
- A61F2002/30113—Rounded shapes, e.g. with rounded corners circular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30112—Rounded shapes, e.g. with rounded corners
- A61F2002/30131—Rounded shapes, e.g. with rounded corners horseshoe- or crescent- or C-shaped or U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30112—Rounded shapes, e.g. with rounded corners
- A61F2002/30133—Rounded shapes, e.g. with rounded corners kidney-shaped or bean-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30138—Convex polygonal shapes
- A61F2002/30153—Convex polygonal shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30159—Concave polygonal shapes
- A61F2002/30179—X-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
- A61F2002/30225—Flat cylinders, i.e. discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
- A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30261—Three-dimensional shapes parallelepipedal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30261—Three-dimensional shapes parallelepipedal
- A61F2002/30266—Three-dimensional shapes parallelepipedal wedge-shaped parallelepipeds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/3028—Three-dimensional shapes polyhedral different from parallelepipedal and pyramidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
- A61F2002/30354—Cylindrically-shaped protrusion and recess, e.g. cylinder of circular basis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30383—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by laterally inserting a protrusion, e.g. a rib into a complementarily-shaped groove
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30383—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by laterally inserting a protrusion, e.g. a rib into a complementarily-shaped groove
- A61F2002/30387—Dovetail connection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30476—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism
- A61F2002/30492—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism using a locking pin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30563—Special structural features of bone or joint prostheses not otherwise provided for having elastic means or damping means, different from springs, e.g. including an elastomeric core or shock absorbers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30599—Special structural features of bone or joint prostheses not otherwise provided for stackable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
- A61F2002/30785—Plurality of holes parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30795—Blind bores, e.g. of circular cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3085—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30962—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using stereolithography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30975—Designing or manufacturing processes made of two halves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
- A61F2002/4649—Bone graft or bone dowel harvest sites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0015—Kidney-shaped, e.g. bean-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0058—X-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0082—Three-dimensional shapes parallelepipedal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
- A61F2250/0063—Nested prosthetic parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
- A61F2310/00383—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Abstract
まだ実現されていない組織源を与えるインプラント開発。
【解決手段】
少なくとも1つのアセンブルされた骨ブロックおよび該少なくとも1つの骨ブロックに付着している加工真皮の細長断片を含む、整形外科手術に有用な真皮由来骨端移植片であって、1つの実施形態において、
上記少なくとも1つのアセンブルされた骨ブロックのうちの少なくとも1つが、必要に応じて合成材料と組合わせて、ヒトまたは異種移植源から得られる皮質骨、海綿骨、皮質−海綿骨または脱無機質骨から構成される、移植片。
【選択図】 なし
Description
本出願は、2001年6月6日に出願された米国特許出願第60/296,530号の継続であり、2000年1月11日に出願された米国特許出願第09/481,319号の継続であり、2000年12月28日に出願された米国特許出願第09/750,192号の継続であり、2001年2月12日に出願された、それ自体が米国特許出願第60/181,622号の継続である米国特許出願第09/782,594号の継続である。米国特許法第119条、120条に基く優先利益は先の出願に関して主張されており、また、参照により組み込まれている。
前十字靭帯(ACL)断裂または後十字靭帯(PCL)断裂などの脊椎および一般的な関節外傷治療に同種移植骨片から作製された移植片を使用することの大きな可能性と利益についての整形外科医学の認識は益々増大している。外傷の場合、損傷靭帯の断裂部分を外科的に再接続することを伴う。しかし、この方法は特に、靭帯に対する損傷が広範囲の場合に不可能であることが多い。最近の骨/腱移植片の利用によって、重篤な外傷症例における関節修復の成績は劇的に改善された。関節靭帯に対する広範囲の損傷の症例においてすら、整形外科医は、ドナーの骨/腱移植片を使用して100パーセント領域の運動と安定性を達成している。
(項目2) 前記カルシウム溶液が飽和水酸化カルシウムであり、前記リン酸溶液が約pH7.0に調整されたリン酸緩衝液である、項目1に記載の方法。
(項目3) インプラント材料を石灰化する方法であって、
a)前記インプラント材料をウイルス不活化剤と接触させる工程;
b)前記インプラント材料を脱細胞形成剤と接触させる工程;
c)前記インプラント材料を飽和水酸化カルシウム溶液と接触させる工程;および
d)ステップcで処理した前記インプラント材料をリン酸溶液と接触させる工程、
を包含する、インプラント材料を石灰化する方法。
(項目4) 前記ウイルス不活化剤が塩化ベンザルコニウムを含み;前記脱細胞形成剤が約1重量パーセントのTween20および約0.5重量パーセントの過酸化水素を含む溶液を含有する溶液を含み;および前記方法がさらに、必要に応じて工程bの間に前記インプラント材料を超音波処理することを包含する、項目3に記載の方法。
(項目5) 項目4に記載の方法に従って作製されたインプラント材料の石灰化断片。
(項目6) 少なくとも1つのブロック、および該少なくとも1つのブロックに付着した可撓性材料の少なくとも1つの断片を含む、整形外科において有用なインプラント。
(項目7) 前記少なくとも1つのブロックが、少なくとも2つの実質的に平坦なセグメントを含む、アンセブルされたインプラントを含み、該少なくとも2つの実質的に平坦なセグメントのうち少なくとも1つが、その上に少なくとも1つの規定された溝を含み、該少なくとも2つの実質的に平坦なセグメントが、少なくとも1つの平坦なセグメントの該少なくとも1つの溝を、他方の実質的に平坦なセグメント上に滑らせることによって一緒に留める、項目6に記載のインプラント。
(項目8) 前記少なくとも1つのブロックが、第1の実質的に平坦なセグメントおよび第2の実質的に平坦なセグメントを含み、該第1の実質的に平坦なセグメントおよび第2の実質的に平坦なセグメントが、溝を付けられた部分と本体部分とを含むように、該第1および第2の実質的に平坦なセグメントがその上に長手方向に規定された溝を含んでなり、該第1および第2の実質的に平坦なセグメントが、各々の溝を付けられた部分を他方の本体部分の上に滑らせることによって一緒に結びつけられる、項目7に記載のインプラント。
(項目9) 前記インプラントが、無機質化骨、脱無機質骨もしくは合成材料、またはそれらの組合わせから作製された2つ以上のセグメントから構成されている少なくとも1つのアセンブルされたブロック、および該少なくとも1つのアセンブルされたブロックに付着した少なくとも1つの可撓性帯を含み、該帯が天然材料または合成材料から構成されている項目6に記載のインプラント。
(項目10) 可撓性材料の前記少なくとも1つの部分が真皮から構成されている項目6に記載のインプラント。
(項目11)
少なくとも1つの骨ブロックおよび該少なくとも1つの骨ブロックに付着した可撓性組織の少なくとも1つの部分を含む、整形外科において有用な骨端移植片。
(項目12) 前記可撓性組織が、軟組織、真皮、心膜、筋膜、織り込み軟組織、膀胱膜、硬膜、脱無機質骨、または骨格筋を含む、項目11に記載の骨端移植片。
(項目13) 前記可撓性組織が真皮である、項目11に記載の骨端移植片。
(項目14) 前記少なくとも1つのブロックが、第1の実質的に平坦なセグメントおよび第2の実質的に平坦なセグメントを含み、該第1および第2の実質的に平坦なセグメントが溝を付けられた部分と本体部分とを含むように、該第1および第2の実質的に平坦なセグメントが骨から作製され、かつその上に長手方向に規定された溝を含んでなり、該第1と第2の実質的に平坦なセグメントが、各々の溝を付けられた部分を他方の本体部分の上に滑らせることによって一緒に結びつけられる項目11に記載のインプラント。
(項目15) 前記少なくとも1つの骨ブロックが、2つ以上の長手向きのひれ状物を含んでなり、前記可撓性組織が、該2つ以上の長手向きのひれ状物うちの少なくとも1つとの接触により、前記少なくとも1つの骨ブロックに付着している、項目14に記載の骨端移植片。
(項目16) 前記少なくとも1つの骨ブロックが、固定ねじを収容させるのに十分な溝を供給するために切込まれている、項目11に記載の骨端移植片。
(項目17) 前記少なくとも1つの骨ブロックが、ドエルに形状化されている項目11に記載の骨端移植片。
(項目18) 前記少なくとも1つの骨ブロックの直径が、9mm、10mm、11mmまたは12mmである、項目11に記載の骨端移植片。
(項目19) 前記溝が、前記骨ブロックの長手方向に伸びるラジアス切込みである、項目11に記載の骨端移植片。
(項目20) 前記骨ブロックが、前記溝中に、その表面において配置されたネジ山の外形を有する、項目11に記載の骨端移植片。
(項目21) 前記腱が、第1の端と第2の端とを有し、前記1つ以上の骨ブロックが該第1の端に付着した第1の骨ブロックおよび該第2の端に付着した第2の骨ブロックを含む、項目11に記載の骨端移植片。
(項目22) 前記インプラント材料が、化学的焼きなまし、化学的接着、縫合(必要に応じて、骨に開けた穴を通って)、ピン留め、または骨端の周囲に加工真皮を巻き、かつ縛ること(必要に応じて、適切な接着剤を塗ること)により前記少なくとも1つの骨ブロックに付着されている、項目11に記載の骨端移植片。
(項目23) 前記少なくとも1つの骨ブロックのうちの少なくとも1つが、前記少なくとも1つの骨ブロックのうちの少なくとも1つの端から伸びる2つ以上の長手向きのひれ状物を含んでなる、項目11に記載の骨端移植片。
(項目24) 可撓性組織の前記少なくとも一部が、隣接したひれ状物の間の第1のルートを通り、骨端移植片の遠位端周囲に輪を作り、隣接したひれ状物の間の第2のルートを通って戻り、それ自体の部分に付着して、骨端移植片を取り囲む輪を形成する、項目23に記載の骨端
移植片。
(項目25) 前記加工インプラント材料が、骨端移植片の少なくとも1つのひれ状物にある少なくとも1つの穴を通り、それ自体の部分に付着して、骨端移植片を取り囲む輪を形成する、項目23に記載の骨端移植片。
(項目26) 前記材料の少なくとも1つの部分が、2つ以上のひれ状物の端に接触して、前記2つ以上のひれ状物にかかる圧迫によって正しく固定される、項目23に記載の骨端移植片。
(項目27) 前記少なくとも1つの骨ブロックに沿って配置されている少なくとも1つの干渉ねじをさらに含み、骨端移植片を必要とするレシピエントの骨の穴にそのように配置されているとき、該ねじが穴の壁の隣接部分を圧迫し、かつ、該骨端移植片を該穴の壁の他方の部分に対して圧迫する、項目11に記載の骨端移植片。
(項目28) 少なくとも一本の可撓性材料を伴う付着のためのアセンブル可能な固定プラグであって、
a.内側の対になっている面を少なくとも1つ含む第1のセグメントであって、該第1のセグメントの該内側の対になっている面がそこから伸びる少なくとも1つの突起を含む第1のセグメント;および
b.内側の対になっている面を少なくとも1つを含む第2のセグメントであって、該第2のセグメントの該内側の対になっている面が該第1のセグメント上の少なくとも1つの配列突起を受けるために、その上に形成された少なくとも1つの穴を含む第2のセグメント;
を含み、
該可撓性材料の一部が、第1と第2のセグメント内側の対になっている面の間に配置され、該セグメントがそのように接合されるとき、少なくとも1つの穴が少なくとも1つの突起を受け、該可撓性材料の一部が圧迫される、付着のためのアセンブル可能な固定プラグ。
(項目29) 内側の対になっている面が、実質的に平坦である、項目28に記載のアセンブル可能な固定プラグ。
(項目30) 前記第1および第2のセグメントが半円錐形であり、その上に規定されたネジ山を有する外面を含み、該第1および第2のセグメントが一緒にされたときに該ネジ山が配列される、項目28に記載のアセンブル可能な固定プラグ。
(項目31) 前記少なくとも1つの突起がピンを含む、項目28に記載のアセンブル可能な固定プラグ。
(項目32) 前記第1セグメント、第2のセグメントまたは双方の前記内側の対になっている面が、前記アセンブル可能な固定プラグがアセンブルされるとき、そこからの前記可撓性材料の滑りを防ぐための歯、隆起、溝または他のでこぼこ形状を含む、項目28に記載のアセンブル可能な固定プラグ。
(項目33) 打ち込み用具を受けるために少なくとも1つの端に形成された開口部をさらに含む、項目28に記載のアセンブル可能な固定プラグ。
(項目34) 内側の対になっている面の片方または双方にさらに窪みを含み、前記可撓性材料の部分が厚くされており、それによって、前記第1および第2のセグメントを締めつけた際に、厚くされた端がプラグからの滑り出すのを抑制している、項目28に記載のアセンブル可能な固定プラグ。
(項目35) 前記第1および第2のセグメントが、無機質化骨、脱無機質骨もしくは合成材料、またはそれらの組合わせから構成されており、かつ、少なくとも一本の前記可撓性材料が軟組織または合成材料から構成されている、項目28に記載のアセンブル可能な固定プラグ。
(項目36) 軟組織移植片を調製する方法であって、
a)最初に、軟組織断片の脱細胞化を含む軟組織断片を調製する工程;
b)所望の厚さの層化形状を形成するためにマンドレル周囲に該軟組織断片を層化する工程;および
c)該軟組織断片の一部を処理して該軟組織の層化形状を一緒に接着させる工程、
を包含する、方法。
(項目37) 前記マンドレルを除去することをさらに包含する、項目36に記載の方法。
(項目38) 前記脱細胞化工程後、前記接着処理の工程後、または前記双方の工程の後に、前記軟組織断片を乾燥する工程をさらに包含し、該乾燥が該軟組織断片をアルコールに接触させること、加熱乾燥、減圧乾燥および凍結乾燥のうち少なくとも1つ以上によりなされる、項目36に記載の方法。
(項目39) 前記軟組織断片を、ウイルス不活化剤と接触させることを含むウイルス不活化工程をさらに含み、該ウイルス不活化剤が、塩化ベンザルコニウム、水酸化ナトリウムもしくは過酸化水素、または双方の組合わせを含む、項目36に記載の方法。
(項目40) 前記接着処理は、前記軟組織断片をゼラチン溶液に浸漬することにより達成される、項目36に記載の方法。
(項目41) 前記脱細胞化が、前記軟組織断片を約0.5重量パーセント以上のTween 20および約0.5重量パーセント以上の過酸化水素を含む溶液に浸漬することによる、項目36に記載の方法。
(項目42) 軟組織の前記層化形状に圧力を加える工程をさらに含む、項目36に記載の方法。
(項目43) 前記軟組織が、真皮、筋膜、心膜、織り込み軟組織、膀胱膜マトリックス、腹膜またはSISから構成される、項目36に記載の方法。
(項目44) 項目36に記載の方法により製造される、軟組織移植片。
(項目45) 軟組織移植片の調製方法であって、
a)軟組織の脱細胞化、ウイルス不活化断片を得る工程;および
b)該軟組織の全体または部分を架橋化処理に供する工程、
を包含する、調製方法。
(項目46) 前記架橋化処理が、グルタルアルデヒド、ホルムアルデヒドまたは他のモノおよびジアルデヒド類;グリセロールポリグリシジルエーテル類、ポリエチレングリコールジグリシジルエーテル類または他のポリエポキシおよびジエポキシグリシジルエーテル類;二酸化チタン、二酸化クロム、二酸化アルミニウム、ジルコニウム塩または他の有機タンニンおよび植物由来の他のフェノール系酸化物;カルボキシ基のエステル化、その後ヒドラジドとの反応でコラーゲン中に活性化アシルアジド官能性を形成するための化学物質;ジシクロヘキシルカルボジイミドまたはその誘導体;ヘテロ二官能性架橋剤;ジイソシアン酸ヘキサメチレン;または糖類との接触を含む、項目45に記載の方法。
(項目47) 前記架橋処理が、トランスグルタミナーゼまたは他の酵素的架橋剤との接触を含んでなる項目46に記載の方法。
(項目48) 軟組織移植片の調製方法であって、
a)第1の端および第2の端を含んでなる軟組織断片を脱細胞化する工程;
b)該軟組織断片をマンドレルの周囲に層化して、所望の厚さの層化形状を形成する工程;および
c)該層化形状の軟組織の該第1の端、第2の端または双方を硬化処理に接触させる工程、
を包含する、調製方法。
(項目49) 前記硬化処理が部分的または完全石灰化を含む、項目48に記載の方法。
(項目50) 前記石灰化が、前記軟組織断片をカルシウム溶液と接触させること、その後前記断片をリン酸溶液と接触させることを含む、項目49に記載の方法。
(項目51) 前記カルシウム溶液が、飽和水酸化カルシウムであり、前記リン酸溶液が約pH7.0に調整されたリン酸緩衝液である、項目50に記載の方法。
(項目52) 前記軟組織断片が、真皮、筋膜、心膜、線維性軟組織、膀胱膜マトリックス、腹膜またはSISから構成される、項目48に記載の方法。
(項目53) 項目48に記載の方法により製造される、軟組織移植片。
(項目54) 真皮由来移植片の調製方法であって、
a)第1の端および第2の端を含む真皮組織断片を得る工程;
b)該第1の端もしくは該第2の端または双方に骨ブロックを付着させる工程、
を包含する、方法。
(項目55) 前記付着が、化学的焼きなまし、化学的接着、縫合、ピン留め、または前記骨ブロックの周囲に前記加工真皮を巻きかつ縛ることによる、項目54に記載の方法。
(項目56) 項目54に記載の方法によって製造される、真皮由来移植片。
(項目57) 第1の端および第2の端を含んでなる加工真皮を含む真皮由来骨端移植片であって、少なくとも1つの骨ブロックが該第1の端、該第2の端または双方に固定できる前記移植片を得る工程、および
該少なくとも1つの骨ブロックを、それを必要としている動物の所望の位置に付着する工程、
を包含する、動物に整形外科手術を行う方法。
(項目58) 前記少なくとも1つの骨ブロックが、予めドエルに形状化させており、前記骨ブロックが固定ネジを適応させるのに好適な溝を有し、前記固定ネジが溝を通る、項目57に記載の方法。
(項目59) 前記第1の端および前記第2の端の前記骨ブロックのサイズが異なっている、項目58に記載の方法。
(項目60) 前記少なくとも1つの骨ブロックの前記付着が動物の少なくとも1つの骨に対するもので
ある、項目57に記載の方法。
(項目61) 前記動物の少なくとも1つの骨が、膝蓋骨、大腿骨および脛骨よりなる骨群から選択される、項目60に記載の方法。
(項目62) 動物に整形外科手術を行う方法であって、
該方法は骨端移植片を得る工程を包含し、該移植片が2つの端および該骨端移植片に付着した1つ以上の骨ブロックを有する軟組織の一区間を含み、
該1つ以上の骨ブロックのうちの少なくとも1つが予め目釘状物に形状化されている、方法。
(項目63) 前記整形外科手術が前十字靭帯または後十字靭帯の修復または代替である、項目62に記載の方法。
(項目64) 少なくとも1つの骨ブロックおよび該少なくとも1つの骨ブロックに付着している加工真皮の細長断片を含む、整形外科手術に有用な真皮由来骨端移植片。
(項目65) 前記少なくとも1つの骨ブロックのうちの少なくとも1つが、必要に応じて合成材料と組合わせて、ヒトまたは異種源から得られる皮質骨、海綿骨、皮質−海綿骨または脱無機質骨から構成される、項目64に記載の移植片。
(項目66) 前記少なくとも1つの骨ブロックのうちの少なくとも1つが、少なくとも2つのセグメントから構成される、項目65に記載の移植片。
(項目67) 前記少なくとも2つのセグメントが円盤の形状である、項目66に記載の移植片。
(項目68) a.屈曲可能な中央部分;
b.付着手段用の少なくとも1つの開口部を有する隣接最上部分;および
c.付着手段用の少なくとも1つの開口部を有する隣接最下部分;
を備える、2つ以上の椎骨を繋ぐための、または骨折部位を繋ぐための軟組織インプラントであって、
2つ以上の椎骨を繋ぐ場合、または骨折部位を繋ぐ場合、前記軟組織が付着手段によって前記椎骨または骨の部位に付着し、前記加工真皮インプラントが少なくとも1つの椎骨間円板接合点または骨折部位に前部、後部または測部を覆う、軟組織インプラント。
(項目69) 前記軟組織が、真皮、筋膜、心膜、織り込み軟組織、膀胱膜マトリックス、腹膜またはSISから構成される、項目68に記載の軟組織移植片。
(項目70) 前記最上部分と前記最下部分とが石灰化されている項目68に記載の軟組織移植片。
(項目71) 前記最上部分および前記最下部分の各々が、前記インプラントの椎体への付着のために配置された付着用の2つの開口部を有する、項目68に記載の軟組織移植片。
(項目72) 前記最上部分および前記最下部分の各々が、2つの椎骨上への付着のために配置された付着用の2つの開口部を有し、前記椎骨の各々が棘状突起を有し、前記開口部を通って、前記棘状突起内へ固定手段によって、前記インプラントが前記2つの椎骨の棘状突起へ付着する、項目68に記載の軟組織移植片。
(項目73) 最上部分、最下部分、および中間部分を有する長手方向部分を含んでなる、インプラントを必要とする患者における椎骨面への付着用インプラントであって、中間部分は可撓性で
あり、最上部分および最下部分の各々が、前記インプラントを少なくとも2つの椎骨に付着させる付着手段の通過に適切な複数の穴を有する、インプラント。
(項目74) 前記インプラントが、必要に応じて生体適合性の合成材料と組合わせてセグメントの脱無機質骨;筋膜;心膜;靭帯;腱;筋肉;硬膜;異種移植片;脱無機質骨;異種移植片セグメント脱無機質骨;またはこれらの物質の任意の組合わせ、よりなる群から選択される材料から組立てられる、項目73に記載のインプラント。
本発明の一局面は、関節における靭帯再建のための、より容易でより効率的な手術を助長する新規の真皮由来移植片(DDG)に関するの生産法および組成物に関する。本明細書中の実施形態は、真皮組織の利用を例示しているが、本明細書の教示に従った他の組織タイプが使用のためにに改造できることが解される。具体的には、靭帯、腱、筋肉、硬膜、心膜、筋膜および腹膜ならびに無機質除去骨などの他の柔軟組織が使用できる。組織は同種源、自家源または異種源由来であり得る。他に、合成材料を単独で、または天然材料と組合わせて使用できる。一実施形態において、本発明は、円筒形に巻かれた加工真皮の断片、およびこの巻かれた真皮の両端に配置された2個の骨ブロックを含んでなるDDGであって、この骨ブロックがレシピエントの骨内における均一で密着した配置を目的に予め形状化されているDDGに関する。
本発明は、腱、靭帯などの代替または補強として使用できるインプラント用材料として加工真皮を使用する。本発明の方法と製品の特定の特徴は真皮ベースのインプラントを「新規の」代替腱または代替靭帯へと改造することを提供する。本発明はまた、真皮および軟組織、心膜、筋膜、線維性軟組織(骨格筋からのものなど)、膀胱膜(UBM)、およびSISなどの他の組織の石灰化のための方法も開示する。これらは集合的に「インプラント材料」そして加工された場合には「加工インプラント材料」と称される。本用途で、使用される骨、例えば、骨ブロックの構成に使用される骨は、ヒトまたは異種源から得られる皮質骨、海綿骨、皮質−海綿骨または脱無機質骨から選択できる。必要に応じて、合
成材料を、そのような骨と組合わせることができる。また、骨ブロックは、アセンブルされる同種異系移植片プラントにおいて共にアセンブルされる2種以上の部分から構成することができる。アセンブルされる同種異系移植片プラントの構造および利用は、米国特許出願第09/782,594号明細書により十分に記載されており、それは参考として援用される。
本開示の目的のため、用語「腱」とは、他に指示しない限り筋肉を骨に付着させる柔軟線維性結合組織を意味すると解される。骨/腱/骨移植片の文脈において、腱は膝蓋骨を大腿骨および脛骨に繋ぐ線維性結合組織のことを言うことができる。用語「靭帯」とは、より全般的な用語として1つの身体部分を他の身体部分に繋ぐ任意の線維性構造体を意味し、より具体的には、骨と骨とを繋ぐ、または器官を正しく保持する柔軟線維性結合組織を意味すると解される。また、用語「加工真皮」とは、本明細書に記載された最初の加工により、または他の真皮脱細胞形成法により加工された真皮、ならびに初期加工真皮がインプラントに形成される本明細書に記載の第2の加工により加工された真皮を意味すると解される。真皮由来移植片(DDG)は、真皮由来インプラントと同義であり、これらの用語は実質的に加工真皮から構成された移植片またはインプラントを示すと定義される。
1.ドナーの真皮を、塩化ベンザルコニウムを含むウイルス不活化剤と接触させ;
2.前記真皮を1種以上の脱細胞化剤、例えば、約0.5パーセントのツィーン20および約0.5パーセントの過酸化水素と接触させる。
1.ドナー(単数または複数)から得られた真皮をモノリン酸ナトリウム緩衝液、pH=7.0中で洗浄し、1パーセントのBZK(塩化ベンザルコニウム)溶液を含有する瓶に移す。凍結保存する。
2.真皮を解凍し、1モルのNaCl溶液へ移し、室温で一晩温置する。これにより表皮が分離する。
3.表皮を取り除き、真皮を滅菌脱イオン水の中で濯ぐ。適宜、所望のサイズに切断する。
4.真皮を0.5%の過酸化水素溶液の中に入れ、室温で15分間音波処理する。このステップの間、真皮全体を溶液で覆わなければならない。
5.この真皮を、以下のいずれかの溶液(真皮サンプルに比して過剰)へ移す:0.5%Tween−20;0.5%ドデシル硫酸ナトリウム;1.0% Triton X−100。次に室温で15分間音波処理する。
6.真皮をろ過した飽和CaOH過剰溶液(真皮サンプルに比して)へ移す。次に室温で15分間音波処理する。
7.脱イオン水で2回濯いでから、約0.1%のEDTA溶液へ移し、15分間浸し、脱イオン水で2回濯ぐ。
8.モノリン酸ナトリウム緩衝液(pH=7.0)の過剰溶液中で真皮サンプル(単数または複数)を3回、各々5分間づつ濯ぐ。
9.滅菌脱イオン水中で真皮サンプル(単数または複数)を濯ぐ。
10.真皮サンプルを過剰の70%イソプロパノールへ15分間移し、真皮を脱水する(音波処理はしない)。
11.真皮を包装するか、またはサイズに切断(まだ切断されていない場合)してから、凍結乾燥用に包装する。
12.サンプル(単数または複数)を凍結乾燥する。
13.低線量のガンマ線放射により真皮を処理する。
加工真皮の両端、他の部分、または全体が以下の過程によって石灰化され得ることが教示されている。水酸化カルシウム溶液との接触直後に、リン酸緩衝液に接触させるように上記に示した12ステップの方法を変更することによって、カルシウムが真皮上に析出し、またはその上に沈澱する。真皮サンプルを石灰化する方法としては、真皮部分を保持している溶液を交替させるなどして、リン酸緩衝液に徐々に接触させること、または水酸化カルシウムを含有する容器からリン酸緩衝液を含有する容器へ真皮部分を移すなど、リン酸緩衝液に迅速に接触させることが挙げられる。リン酸緩衝液の好ましいpHは、6.8
から7.2pH単位の範囲にある。特定の理論には拘束されないが、pHの変化が加工真皮上へのカルシウム沈澱を生じさせると考えられている。析出したカルシウムは、前記部分に剛性を付与する。水酸化カルシウムステップとリン酸緩衝液ステップとの間にEDTA溶液をが用いられる場合は、石灰化の発生が明らかでないことがわかってきた。本発明に従って調製された石灰化真皮の一利用法を以下の評価により例示する。
第I節に記載した12ステップ法を、結果の表に示したように界面活性剤のタイプと量を変化させて用いて真皮サンプルを調製した。
1.)凍結乾燥した真皮を、約1×1cmインプラントへと切断し(無菌的に)、重量測定(前移植乾燥重量)してから水和し、抗生物質を含有する滅菌生理食塩水で再水和する。
2.)サンプルを変更したSOP#に従って無胸腺ヌードラットモデルへ移植した(ラット1匹につき4個)。インプラントを正しく保持するために1回だけ縫合を用いた。
3.)インプラントは移植後、3、6、12週目に回収し(ドナー1件当り、処置1回当り、1時点当り週2つのサンプル−合計で1時点当り各処置で6個)、1〜2個は組織学的分析用に保管、4〜5個は取り出して凍結乾燥し、移植後の乾燥重量を測定した(インビボ曝露後の組織の損失パーセント測定のため)。
1.)外科的処置を以下のとおり実施した:ケタミン(100mg/kg)とキシラジン(15mg/kg)の筋肉内注射(大腿または殿筋)によりラットを麻酔にかけた。滅菌法を用いて外科的処置をクラス100のフード内で実施した。アルコールおよびプロビドンヨードをラットの腹部に塗った。切開は、腹部の中心線に平行に、胸骨先端部直下から臍のすぐ上まで行った。腹部両側の下部筋肉から皮膚を分離する。筋肉を単離し、筋膜の0.5×0.5cm領域を、筋肉が出血するまで筋肉に、各々が腹部の四分の一円の刻みをつけた。真皮の1×1cmピースを、非吸収性3−Oプロリエン縫合糸を用いて、真皮の2つの隅が適切に合されるように、前もって刻みをつけた領域の筋肉に縫合した。皮膚を創傷クリップにより、連続線で閉じた。プロビドンヨードを創傷部に再び塗り、ラットをケージに戻す。以下の例外の他はラットアッセイ骨誘導外科的処置に従う;
2.)3、6、12週目に、人道的な方法に従い、ラットを殺処理した:
3.)使い捨てかみそりまたは毛髪用はさみを用いて、腹部の皮膚を剃った。
4.)垂れ下がっている筋肉片を覆っている皮膚を共に取り除いた;
5.)筋肉片全体を顕微鏡観察用に写真撮影した;
6.)インプラント材料を取り出し(各試験サンプルに関し、1時点につき6回)、ラベルした滅菌ペトリ皿に置いて乾燥した。インプラントが取り出しにくい場合は、筋肉片全体を取り出し、実験室でメスを用いて注意深くインプラントを切除した。切除前に各インプラント部位は証拠資料を目的に写真撮影した。
7.)各時点につき、各サンプル3個のインプラントを組織学的処置用に調製した(H&E染色)。
上記のとおり加工された真皮、または他の方法により加工された真皮は、それを必要とするレシピエントの腱または靭帯の代替となるか、または交換されるインプラントへと組立てることができる。真皮由来のインプラントは、腱再生および靭帯再性の足場として、インプラントとして選択された他のもの(例えば、無機質除去靭帯、膀胱マトリックス、小腸粘膜下組織)よりも優れたリモデリングの場所として利用できる。特定の理論には拘束されないが、これは、インプラントとして選択された他のものよりも酵素的分解に対して不安定性の少ないコラーゲン構造の存在および基底膜の存在によるものと考えられる。しかし、本明細書の教示に従って、限定はしないが、同種移植片源および異種移植片源から無機質除去骨(部分または全体)、靭帯、腱、腹膜、膀胱マトリックス、硬膜および筋肉などの他の材料を利用できることが解される。
組織505の長い部分と共にレシピエントの骨526を完全に通過する穴537の中へ挿入することである。固定プラグが締めつけられる開口部に較べて比較的小さな穴から軟組織コンポーネントが通過するように、先細りの穴が使用できる。2つの半分502と503を含んでなるプラグ501が穴537の中に固定されるときに、それらが軟組織505を圧迫し、固定する。
本発明の他の局面では、部分的にまたは完全に前縦靭帯(ALL)を切断する手術(円板交換インプラントまたは補綴物挿入時など)の後、またはALLに対する他の損傷(例えば外傷)の後などに、ALLの機能を増強または代替するために、加工真皮(DDG)が使用される。DDGは、より強力な付着手段の使用が可能になるように、両端を石灰化することが好ましい。手術の性質に依存するが、円板交換/脊椎固定の操作は、部分的にまたは完全にALLを切断することにより、椎骨にアクセスできることが特記される。無傷のALLは脊椎の前方域を引っ張るのだが、そのALLが十分に機能的でないと、過剰な後屈から背椎骨を損傷させる危険性がある。また、DDGは分節の動きを前方へ安定化する。これは、脊椎癒合術にさらに貢献する。
Claims (11)
- 少なくとも1つのアセンブルされた骨ブロックおよび該少なくとも1つの骨ブロックに付着している加工真皮の細長断片を含む、整形外科手術に有用な真皮由来骨端移植片。
- 前記少なくとも1つのアセンブルされた骨ブロックのうちの少なくとも1つが、必要に応じて合成材料と組合わせて、ヒトまたは異種移植源から得られる皮質骨、海綿骨、皮質−海綿骨または脱無機質骨から構成される、請求項1に記載の移植片。
- 前記少なくとも1つのアセンブルされた骨ブロックのうちの少なくとも1つが、2つのセグメントから構成される、請求項2に記載の移植片。
- 前記2つのセグメントが円盤の形状である、請求項3に記載の移植片。
- a.屈曲可能であり、かつ第一端および対向する第二端を有する中央部分;
b.該中央部分の第一端に付着しており、第一の椎骨に付着するかまたは骨折の第一側面上にある骨切片に付着するための少なくとも1つの開口部を有する第一のアセンブルした骨ブロックを備える最上部分;および
c.該中央部分の第二端に付着しており、第二の椎骨に付着するかまたは骨折の対向面上にある骨切片に付着するための少なくとも1つの開口部を有する第二のアセンブルした骨ブロックを備える隣接最下部分であって、該第二のアセンブルした骨ブロックが、皮質骨の2つのセグメントを備える、隣接最下部分;
を備える、軟組織インプラント。 - 前記中央部分が、真皮、筋膜、心膜、織り込み軟組織、膀胱膜マトリックス、腹膜またはSISを包含する、請求項5に記載の軟組織インプラント。
- 前記中央部分の第一端および第二端が石灰化されている請求項5に記載の軟組織インプラント。
- 前記最上部分および前記最下部分が、同種移植骨を含む、請求項5に記載の軟組織インプラント。
- 前記最上部分および前記最下部分が、異種移植骨を含む、請求項5に記載の軟組織インプラント。
- 最上部分、最下部分、および中間部分を有する長手方向デバイスを備える、インプラントを必要とする患者における椎骨の間のテンションバンドとして使用されるインプラントであって、該中間部分は可撓性であり、該最上部分および該最下部分の各々が、対応する椎骨への付着を容易にする複数の穴を有するアセンブルした骨ブロックを備える、インプラント。
- 請求項10に記載のインプラントであって、前記中央部分が、以下:
セグメントの脱無機質塩;筋膜;心膜;靭帯;腱;筋肉;硬膜;異種移植片;脱無機質骨;異種移植片セグメント脱無機質骨およびそれらの物質の任意の組合せからなる群より選択される物質から組み立てられる、インプラント。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/942,537 US6893462B2 (en) | 2000-01-11 | 2001-08-29 | Soft and calcified tissue implants |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003524426A Division JP2005503850A (ja) | 2001-08-29 | 2002-08-27 | 柔軟かつ石灰化された組織インプラント |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2006034988A true JP2006034988A (ja) | 2006-02-09 |
Family
ID=25478229
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003524426A Pending JP2005503850A (ja) | 2001-08-29 | 2002-08-27 | 柔軟かつ石灰化された組織インプラント |
JP2005246893A Pending JP2006034988A (ja) | 2001-08-29 | 2005-08-26 | 柔軟かつ石灰化された組織インプラント |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003524426A Pending JP2005503850A (ja) | 2001-08-29 | 2002-08-27 | 柔軟かつ石灰化された組織インプラント |
Country Status (7)
Country | Link |
---|---|
US (5) | US6893462B2 (ja) |
EP (2) | EP1427322B1 (ja) |
JP (2) | JP2005503850A (ja) |
AU (1) | AU2002323425B8 (ja) |
CA (1) | CA2459050A1 (ja) |
DE (1) | DE60229539D1 (ja) |
WO (1) | WO2003020107A2 (ja) |
Families Citing this family (219)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010031254A1 (en) * | 1998-11-13 | 2001-10-18 | Bianchi John R. | Assembled implant |
US6482584B1 (en) | 1998-11-13 | 2002-11-19 | Regeneration Technologies, Inc. | Cyclic implant perfusion cleaning and passivation process |
US6497726B1 (en) * | 2000-01-11 | 2002-12-24 | Regeneration Technologies, Inc. | Materials and methods for improved bone tendon bone transplantation |
US6258124B1 (en) * | 1999-05-10 | 2001-07-10 | C. R. Bard, Inc. | Prosthetic repair fabric |
FR2897259B1 (fr) | 2006-02-15 | 2008-05-09 | Ldr Medical Soc Par Actions Si | Cage intersomatique transforaminale a greffon de fusion intervetebrale et instrument d'implantation de la cage |
US7935147B2 (en) | 1999-10-20 | 2011-05-03 | Anulex Technologies, Inc. | Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus |
US6592625B2 (en) | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US7052516B2 (en) | 1999-10-20 | 2006-05-30 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and deformable spinal disc annulus stent |
US7615076B2 (en) | 1999-10-20 | 2009-11-10 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8632590B2 (en) | 1999-10-20 | 2014-01-21 | Anulex Technologies, Inc. | Apparatus and methods for the treatment of the intervertebral disc |
US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
US7951201B2 (en) | 1999-10-20 | 2011-05-31 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8128698B2 (en) | 1999-10-20 | 2012-03-06 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US6893462B2 (en) * | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
US20030023304A1 (en) * | 2000-01-11 | 2003-01-30 | Carter Kevin C. | Materials and methods for improved bone tendon bone transplantation |
US20030097179A1 (en) * | 2000-01-11 | 2003-05-22 | Carter Kevin C. | Materials and methods for improved bone tendon bone transplantation |
WO2001078798A1 (en) * | 2000-02-10 | 2001-10-25 | Regeneration Technologies, Inc. | Assembled implant |
US20020119437A1 (en) * | 2000-09-20 | 2002-08-29 | Grooms Jamie M. | Method of preparing and processing transplant tissue |
US6752831B2 (en) * | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
US6562073B2 (en) * | 2001-02-06 | 2003-05-13 | Sdgi Holding, Inc. | Spinal bone implant |
US7195642B2 (en) | 2001-03-13 | 2007-03-27 | Mckernan Daniel J | Method and apparatus for fixing a graft in a bone tunnel |
GB0107708D0 (en) | 2001-03-28 | 2001-05-16 | Imp College Innovations Ltd | Bone fixated,articulated joint load control device |
FR2827156B1 (fr) | 2001-07-13 | 2003-11-14 | Ldr Medical | Dispositif de cage vertebrale avec fixation modulaire |
US8512376B2 (en) | 2002-08-30 | 2013-08-20 | Arthrex, Inc. | Method and apparatus for internal fixation of an acromioclavicular joint dislocation of the shoulder |
AU2002328762B2 (en) * | 2001-10-11 | 2007-08-23 | Straumann Holding Ag | Osteophilic implants |
US8501396B2 (en) | 2001-11-05 | 2013-08-06 | Medgenics Medical Israel Ltd. | Dermal micro-organs, methods and apparatuses for producing and using the same |
US8088568B2 (en) | 2001-11-05 | 2012-01-03 | Medgentics, Inc. | Dermal micro-organs, methods and apparatuses for producing and using the same |
US7468242B2 (en) | 2001-11-05 | 2008-12-23 | Medgenics, Inc. | Dermal micro organs, methods and apparatuses for producing and using the same |
AU2002353465B2 (en) * | 2001-11-21 | 2008-10-16 | Yeda Research And Development Co. Ltd. | Process for the manufacture of human mononuclear phagocytic leukocytes |
MXPA05000186A (es) * | 2002-07-03 | 2005-08-17 | Pericor Science Inc | Composiciones de acido hialuronico y metodos de uso. |
US20040068262A1 (en) * | 2002-10-02 | 2004-04-08 | Mark Lemos | Soft tissue fixation implant |
US7682392B2 (en) * | 2002-10-30 | 2010-03-23 | Depuy Spine, Inc. | Regenerative implants for stabilizing the spine and devices for attachment of said implants |
GB0227161D0 (en) * | 2002-11-21 | 2002-12-24 | Xiros Plc | Prosthetic implant assembly |
US7449025B1 (en) | 2002-12-17 | 2008-11-11 | O'donnell Pat D | Surgical instrument to secure body tissues |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
CA2748670A1 (en) * | 2003-05-01 | 2004-11-18 | Medgenics Inc. | Dermal micro organs, methods and apparatuses for producing and using the same |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7815665B2 (en) * | 2003-09-24 | 2010-10-19 | N Spine, Inc. | Adjustable spinal stabilization system |
US20050065516A1 (en) | 2003-09-24 | 2005-03-24 | Tae-Ahn Jahng | Method and apparatus for flexible fixation of a spine |
US7763052B2 (en) * | 2003-12-05 | 2010-07-27 | N Spine, Inc. | Method and apparatus for flexible fixation of a spine |
US8979900B2 (en) | 2003-09-24 | 2015-03-17 | DePuy Synthes Products, LLC | Spinal stabilization device |
US20050203513A1 (en) * | 2003-09-24 | 2005-09-15 | Tae-Ahn Jahng | Spinal stabilization device |
WO2005063314A1 (ja) * | 2003-12-26 | 2005-07-14 | Cardio Incorporated | 脱細胞化組織およびその作成方法 |
AU2005215772B2 (en) * | 2004-02-13 | 2011-11-17 | Frantz Medical Development, Ltd | Soft tissue repair apparatus and method |
US7407511B2 (en) * | 2004-05-13 | 2008-08-05 | Wright Medical Technology Inc | Methods and materials for connective tissue repair |
US7799081B2 (en) | 2004-09-14 | 2010-09-21 | Aeolin, Llc | System and method for spinal fusion |
US20060069436A1 (en) * | 2004-09-30 | 2006-03-30 | Depuy Spine, Inc. | Trial disk implant |
DE102004048938B4 (de) * | 2004-10-07 | 2015-04-02 | Synthes Gmbh | Vorrichtung zur dynamischen Stabilisierung von Rückenwirbelkörpern |
US7837740B2 (en) * | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7909851B2 (en) | 2006-02-03 | 2011-03-22 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7905904B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7857830B2 (en) * | 2006-02-03 | 2010-12-28 | Biomet Sports Medicine, Llc | Soft tissue repair and conduit device |
US8118836B2 (en) | 2004-11-05 | 2012-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7749250B2 (en) | 2006-02-03 | 2010-07-06 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US8840645B2 (en) | 2004-11-05 | 2014-09-23 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8128658B2 (en) | 2004-11-05 | 2012-03-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US8137382B2 (en) | 2004-11-05 | 2012-03-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US8361113B2 (en) | 2006-02-03 | 2013-01-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8298262B2 (en) | 2006-02-03 | 2012-10-30 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8303604B2 (en) | 2004-11-05 | 2012-11-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US9801708B2 (en) | 2004-11-05 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7658751B2 (en) | 2006-09-29 | 2010-02-09 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US8088130B2 (en) | 2006-02-03 | 2012-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9017381B2 (en) | 2007-04-10 | 2015-04-28 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US8998949B2 (en) | 2004-11-09 | 2015-04-07 | Biomet Sports Medicine, Llc | Soft tissue conduit device |
US20060111786A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation | Metallic prosthetic implant for use in minimally invasive acromio-clavicular shoulder joint hemi-arthroplasty |
US20060111780A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation | Minimally invasive facet joint hemi-arthroplasty |
US20060111779A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation, A Florida Corporation | Minimally invasive facet joint fusion |
US8021392B2 (en) * | 2004-11-22 | 2011-09-20 | Minsurg International, Inc. | Methods and surgical kits for minimally-invasive facet joint fusion |
US7901437B2 (en) | 2007-01-26 | 2011-03-08 | Jackson Roger P | Dynamic stabilization member with molded connection |
US8470038B2 (en) * | 2005-03-04 | 2013-06-25 | Rti Biologics, Inc. | Adjustable and fixed assembled bone-tendon-bone graft |
US7776089B2 (en) * | 2005-03-04 | 2010-08-17 | Rti Biologics, Inc. | Assembled bone-tendon-bone grafts |
US7727278B2 (en) * | 2005-03-04 | 2010-06-01 | Rti Biologics, Inc. | Self fixing assembled bone-tendon-bone graft |
US7763071B2 (en) * | 2005-03-04 | 2010-07-27 | Rti Biologics, Inc. | Bone block assemblies and their use in assembled bone-tendon-bone grafts |
US9788821B2 (en) * | 2005-04-29 | 2017-10-17 | Cook Biotech Incorporated | Physically modified extracellular matrix materials and uses thereof |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US8128552B2 (en) * | 2005-08-22 | 2012-03-06 | O'donnell Pat D | Surgical instrument for treating female pelvic prolapse |
EP1926459B1 (en) | 2005-09-19 | 2015-01-07 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
FR2891135B1 (fr) | 2005-09-23 | 2008-09-12 | Ldr Medical Sarl | Prothese de disque intervertebral |
US20070123984A1 (en) * | 2005-10-26 | 2007-05-31 | Zimmer Technology, Inc. | Ligament attachment and repair device |
WO2007053516A2 (en) * | 2005-10-28 | 2007-05-10 | Halkey-Roberts Corporation | Tapered anchor for tendon graft |
US8287914B2 (en) | 2006-01-12 | 2012-10-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite synthesis |
US20100040668A1 (en) * | 2006-01-12 | 2010-02-18 | Rutgers, The State University Of New Jersey | Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof |
US9538998B2 (en) | 2006-02-03 | 2017-01-10 | Biomet Sports Medicine, Llc | Method and apparatus for fracture fixation |
US9468433B2 (en) | 2006-02-03 | 2016-10-18 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8506597B2 (en) | 2011-10-25 | 2013-08-13 | Biomet Sports Medicine, Llc | Method and apparatus for interosseous membrane reconstruction |
US8771352B2 (en) | 2011-05-17 | 2014-07-08 | Biomet Sports Medicine, Llc | Method and apparatus for tibial fixation of an ACL graft |
US9078644B2 (en) | 2006-09-29 | 2015-07-14 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8562647B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for securing soft tissue to bone |
US8652172B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Flexible anchors for tissue fixation |
US9271713B2 (en) | 2006-02-03 | 2016-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for tensioning a suture |
US10517587B2 (en) | 2006-02-03 | 2019-12-31 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8251998B2 (en) | 2006-08-16 | 2012-08-28 | Biomet Sports Medicine, Llc | Chondral defect repair |
US8597327B2 (en) | 2006-02-03 | 2013-12-03 | Biomet Manufacturing, Llc | Method and apparatus for sternal closure |
US11311287B2 (en) | 2006-02-03 | 2022-04-26 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8968364B2 (en) | 2006-02-03 | 2015-03-03 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US9149267B2 (en) | 2006-02-03 | 2015-10-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US11259792B2 (en) | 2006-02-03 | 2022-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US8801783B2 (en) | 2006-09-29 | 2014-08-12 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US8574235B2 (en) * | 2006-02-03 | 2013-11-05 | Biomet Sports Medicine, Llc | Method for trochanteric reattachment |
US8562645B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8652171B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US20070270854A1 (en) * | 2006-03-30 | 2007-11-22 | Zhigang Li | Bone anchoring device |
WO2008003047A2 (en) * | 2006-06-28 | 2008-01-03 | Synthes (U.S.A.) | Dynamic fixation system |
WO2008030668A2 (en) * | 2006-07-26 | 2008-03-13 | Lambert Systems, L.L.C. | Biocompatible anchoring device for a soft tissue graft, method of making and method of using |
US8454948B2 (en) | 2006-09-14 | 2013-06-04 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
JP2010504909A (ja) | 2006-09-14 | 2010-02-18 | メドジェニクス・メディカル・イスラエル・リミテッド | 長期持続性の医薬製剤 |
US9918826B2 (en) | 2006-09-29 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US11259794B2 (en) | 2006-09-29 | 2022-03-01 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US8500818B2 (en) | 2006-09-29 | 2013-08-06 | Biomet Manufacturing, Llc | Knee prosthesis assembly with ligament link |
US8672969B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US20080195230A1 (en) * | 2007-02-09 | 2008-08-14 | Quijano Rodolfo C | Pericardial tissue sheet |
US8007533B2 (en) * | 2007-02-12 | 2011-08-30 | Rti Biologics, Inc. | Progressive grip assembled bone-tendon-bone grafts, methods of making, and methods of use |
US20080260794A1 (en) * | 2007-02-12 | 2008-10-23 | Lauritzen Nels J | Collagen products and methods for producing collagen products |
US9056151B2 (en) * | 2007-02-12 | 2015-06-16 | Warsaw Orthopedic, Inc. | Methods for collagen processing and products using processed collagen |
US20090105762A1 (en) * | 2007-10-23 | 2009-04-23 | Jackson Roger P | Dynamic stabilization member with fin supported segment |
US8858633B2 (en) * | 2007-02-20 | 2014-10-14 | Shriners Hospital For Children | In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US7766964B2 (en) * | 2007-03-30 | 2010-08-03 | Biomet Sports Medicine, Llc | In situ graft preparation for knee ligament reconstruction |
US20100137996A1 (en) | 2007-05-01 | 2010-06-03 | Moximed, Inc. | Femoral and tibial base components |
US9907645B2 (en) * | 2007-05-01 | 2018-03-06 | Moximed, Inc. | Adjustable absorber designs for implantable device |
US20080275567A1 (en) | 2007-05-01 | 2008-11-06 | Exploramed Nc4, Inc. | Extra-Articular Implantable Mechanical Energy Absorbing Systems |
US20110245928A1 (en) | 2010-04-06 | 2011-10-06 | Moximed, Inc. | Femoral and Tibial Bases |
US8709090B2 (en) | 2007-05-01 | 2014-04-29 | Moximed, Inc. | Adjustable absorber designs for implantable device |
US20080275557A1 (en) | 2007-05-01 | 2008-11-06 | Exploramed Nc4, Inc. | Adjustable absorber designs for implantable device |
US8894714B2 (en) | 2007-05-01 | 2014-11-25 | Moximed, Inc. | Unlinked implantable knee unloading device |
US8123805B2 (en) | 2007-05-01 | 2012-02-28 | Moximed, Inc. | Adjustable absorber designs for implantable device |
US10022154B2 (en) * | 2007-05-01 | 2018-07-17 | Moximed, Inc. | Femoral and tibial base components |
US7611540B2 (en) | 2007-05-01 | 2009-11-03 | Moximed, Inc. | Extra-articular implantable mechanical energy absorbing systems and implantation method |
FR2916956B1 (fr) | 2007-06-08 | 2012-12-14 | Ldr Medical | Cage intersomatique,prothese intervertebrale,dispositif d'ancrage et instrumentation d'implantation |
US20090024225A1 (en) * | 2007-07-16 | 2009-01-22 | Stubbs James B | Implant for Targeting Therapeutic Procedure |
KR20100051617A (ko) * | 2007-08-07 | 2010-05-17 | 신세스 게엠바하 | 동적 케이블 시스템 |
WO2009036279A1 (en) | 2007-09-14 | 2009-03-19 | Purdue Research Foundation | Demineralized cancellous bone scaffolds |
JP5212933B2 (ja) | 2007-09-18 | 2013-06-19 | 国立大学法人 東京医科歯科大学 | 硬組織接触具用材の製造方法、及び硬組織接触具 |
JP5270925B2 (ja) | 2008-02-07 | 2013-08-21 | 雪印メグミルク株式会社 | 微生物保護剤及び微生物の凍結又は凍結乾燥菌体の製造方法 |
CA2717725A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
BRPI0914950A2 (pt) * | 2008-06-19 | 2015-10-20 | Synthes Gmbh | implantes, sistemas e técnicas de aumento da vantagem mecânica de parafusos ósseos |
US20090318934A1 (en) * | 2008-06-20 | 2009-12-24 | Johnson Chad E | Compressible/expandable medical graft products, and methods for applying hemostasis |
US20100049258A1 (en) * | 2008-08-19 | 2010-02-25 | Dougherty Christopher P | Single tunnel double bundle posterior cruciate ligament reconstruction |
US8470036B2 (en) * | 2008-09-30 | 2013-06-25 | William S. Barnes | Method and apparatus for reconstructing a ligament |
US8163022B2 (en) | 2008-10-14 | 2012-04-24 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8333803B2 (en) * | 2008-11-21 | 2012-12-18 | Lifecell Corporation | Reinforced biologic material |
US8524253B2 (en) * | 2008-11-25 | 2013-09-03 | Warsaw Orthopedic, Inc. | Bone regeneration device |
BRPI0919600A2 (pt) * | 2008-12-17 | 2015-12-08 | Synthes Gmbh | estabilizador espinhal posterior e dinâmico |
US20100249929A1 (en) * | 2009-03-24 | 2010-09-30 | Joint Restoration Foundation | Adjustable patella ligament for acl repair |
EP2238944B1 (en) | 2009-03-31 | 2015-10-21 | Arthrex Inc | Adjustable suture button construct for tissue reconstruction |
US8439976B2 (en) * | 2009-03-31 | 2013-05-14 | Arthrex, Inc. | Integrated adjustable button-suture-graft construct with two fixation devices |
CN102481187B (zh) | 2009-03-31 | 2016-06-08 | 医学嵌入公司暨Imds共同创新公司 | 双束前十字韧带修复 |
US8343227B2 (en) | 2009-05-28 | 2013-01-01 | Biomet Manufacturing Corp. | Knee prosthesis assembly with ligament link |
US9014787B2 (en) | 2009-06-01 | 2015-04-21 | Focal Therapeutics, Inc. | Bioabsorbable target for diagnostic or therapeutic procedure |
US9668771B2 (en) | 2009-06-15 | 2017-06-06 | Roger P Jackson | Soft stabilization assemblies with off-set connector |
AU2010286513B2 (en) | 2009-08-27 | 2015-03-05 | Cotera, Inc. | Method and apparatus for force redistribution in articular joints |
US9668868B2 (en) | 2009-08-27 | 2017-06-06 | Cotera, Inc. | Apparatus and methods for treatment of patellofemoral conditions |
US10349980B2 (en) | 2009-08-27 | 2019-07-16 | The Foundry, Llc | Method and apparatus for altering biomechanics of the shoulder |
US9861408B2 (en) | 2009-08-27 | 2018-01-09 | The Foundry, Llc | Method and apparatus for treating canine cruciate ligament disease |
US9278004B2 (en) | 2009-08-27 | 2016-03-08 | Cotera, Inc. | Method and apparatus for altering biomechanics of the articular joints |
EP3011934B1 (en) | 2009-09-17 | 2017-12-13 | LDR Holding Corporation | Intervertebral implant having extendable bone fixation members |
US8449612B2 (en) | 2009-11-16 | 2013-05-28 | Arthrocare Corporation | Graft pulley and methods of use |
US9833331B2 (en) | 2009-12-31 | 2017-12-05 | Ldr Medical | Anchoring device and system for an intervertebral implant, intervertebral implant and implantation instrument |
US8460319B2 (en) | 2010-01-11 | 2013-06-11 | Anulex Technologies, Inc. | Intervertebral disc annulus repair system and method |
US20110184468A1 (en) * | 2010-01-28 | 2011-07-28 | Warsaw Orthopedic, Inc., An Indiana Corporation | Spinous process fusion plate with osteointegration insert |
US8834568B2 (en) * | 2010-02-04 | 2014-09-16 | Paul S. Shapiro | Surgical technique using a contoured allograft cartilage as a spacer of the carpo-metacarpal joint of the thumb or tarso-metatarsal joint of the toe |
US8444699B2 (en) * | 2010-02-18 | 2013-05-21 | Biomet Manufacturing Corp. | Method and apparatus for augmenting bone defects |
US20110224720A1 (en) * | 2010-03-11 | 2011-09-15 | Cvdevices, Llc | Devices, systems, and methods for closing a hole in cardiac tissue |
US8790699B2 (en) | 2010-04-23 | 2014-07-29 | Warsaw Orthpedic, Inc. | Foam-formed collagen strand |
US8460691B2 (en) | 2010-04-23 | 2013-06-11 | Warsaw Orthopedic, Inc. | Fenestrated wound repair scaffold |
EP2582396A4 (en) | 2010-06-15 | 2014-01-01 | Medgenics Medical Israel Ltd | REMEDY FORMULATIONS WITH LONG-TERM EFFECT |
EP2455040B1 (en) | 2010-11-17 | 2015-03-04 | Arthrex, Inc. | Adjustable suture-button construct for knotless stabilization of cranial cruciate deficient ligament stifle |
EP3527144B1 (en) | 2010-11-17 | 2023-12-13 | Arthrex Inc | Adjustable suture-button construct for ankle syndesmosis repair |
EP2455001B1 (en) | 2010-11-17 | 2020-07-22 | Arthrex, Inc. | Adjustable suture-button constructs for ligament reconstruction |
CA2826359A1 (en) | 2011-02-14 | 2012-08-23 | Mimedx Group Inc. | Tissue grafts modified with a cross-linking agent and methods of making and using the same |
US9044270B2 (en) | 2011-03-29 | 2015-06-02 | Moximed, Inc. | Apparatus for controlling a load on a hip joint |
US9694106B2 (en) | 2011-07-11 | 2017-07-04 | Mimedx Group, Inc. | Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods |
US9301745B2 (en) | 2011-07-21 | 2016-04-05 | Arthrex, Inc. | Knotless suture constructs |
US9332979B2 (en) | 2011-07-22 | 2016-05-10 | Arthrex, Inc. | Tensionable knotless acromioclavicular repairs and constructs |
WO2013016571A1 (en) | 2011-07-28 | 2013-01-31 | Harbor Medtech, Inc. | Crosslinked human or animal tissue products and their methods of manufacture and use |
US9107653B2 (en) | 2011-09-22 | 2015-08-18 | Arthrex, Inc. | Tensionable knotless anchors with splice and methods of tissue repair |
US10245016B2 (en) | 2011-10-12 | 2019-04-02 | Arthrex, Inc. | Adjustable self-locking loop constructs for tissue repairs and reconstructions |
US8968402B2 (en) | 2011-10-18 | 2015-03-03 | Arthrocare Corporation | ACL implants, instruments, and methods |
US9357991B2 (en) | 2011-11-03 | 2016-06-07 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US9357992B2 (en) | 2011-11-10 | 2016-06-07 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9370350B2 (en) | 2011-11-10 | 2016-06-21 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US9381013B2 (en) | 2011-11-10 | 2016-07-05 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9782248B2 (en) | 2011-12-09 | 2017-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Decellularized composite tissue bioscaffolds for musculoskeletal tissue interface reconstruction and methods of production |
EP2601894B1 (en) | 2011-12-09 | 2018-08-29 | Arthrex, Inc. | Tensionable knotless anchor systems |
TWI448270B (zh) * | 2011-12-22 | 2014-08-11 | Spine Asia Co Ltd A | A compound grade intervertebral disc reduction device |
JP6254094B2 (ja) * | 2011-12-22 | 2017-12-27 | ミメディクス グループ インコーポレイテッド | 架橋脱水された胎盤組織移植片ならびにそれを作製および使用する方法 |
EP3461508A1 (en) * | 2012-01-24 | 2019-04-03 | LifeCell Corporation | Elongated tissue matrices |
FR2987256B1 (fr) | 2012-02-24 | 2014-08-08 | Ldr Medical | Dispositif d'ancrage pour implant intervertebral, implant intervertebral et instrumentation d'implantation |
US20130289389A1 (en) | 2012-04-26 | 2013-10-31 | Focal Therapeutics | Surgical implant for marking soft tissue |
US9737292B2 (en) | 2012-06-22 | 2017-08-22 | Arthrex, Inc. | Knotless suture anchors and methods of tissue repair |
US11338063B2 (en) | 2012-08-15 | 2022-05-24 | Mimedx Group, Inc. | Placental tissue grafts modified with a cross-linking agent and methods of making and using the same |
US9468466B1 (en) | 2012-08-24 | 2016-10-18 | Cotera, Inc. | Method and apparatus for altering biomechanics of the spine |
US9737294B2 (en) | 2013-01-28 | 2017-08-22 | Cartiva, Inc. | Method and system for orthopedic repair |
EP2948068A4 (en) | 2013-01-28 | 2016-09-28 | Cartiva Inc | SYSTEMS AND METHOD FOR ORTHOPEDIC REPAIRS |
US9757119B2 (en) | 2013-03-08 | 2017-09-12 | Biomet Sports Medicine, Llc | Visual aid for identifying suture limbs arthroscopically |
US9918827B2 (en) | 2013-03-14 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
US9345589B2 (en) * | 2013-12-19 | 2016-05-24 | Ilion Medical, Inc. | Bone implants for orthopedic procedures and corresponding methods |
US10136886B2 (en) | 2013-12-20 | 2018-11-27 | Biomet Sports Medicine, Llc | Knotless soft tissue devices and techniques |
WO2015109329A1 (en) | 2014-01-17 | 2015-07-23 | Mimedx Group, Inc. | Method for inducing angiogenesis |
US9615822B2 (en) | 2014-05-30 | 2017-04-11 | Biomet Sports Medicine, Llc | Insertion tools and method for soft anchor |
US9700291B2 (en) | 2014-06-03 | 2017-07-11 | Biomet Sports Medicine, Llc | Capsule retractor |
US9615915B2 (en) | 2014-07-25 | 2017-04-11 | Focal Therapeutics, Inc. | Implantable devices and techniques for oncoplastic surgery |
US10039543B2 (en) | 2014-08-22 | 2018-08-07 | Biomet Sports Medicine, Llc | Non-sliding soft anchor |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US9955980B2 (en) | 2015-02-24 | 2018-05-01 | Biomet Sports Medicine, Llc | Anatomic soft tissue repair |
US9974534B2 (en) | 2015-03-31 | 2018-05-22 | Biomet Sports Medicine, Llc | Suture anchor with soft anchor of electrospun fibers |
JP6816889B2 (ja) * | 2015-05-28 | 2021-01-20 | 4テック インコーポレイテッド | 引張り部材を有する偏心組織アンカー |
ITUB20152560A1 (it) * | 2015-07-28 | 2017-01-28 | Tt Tooth Transf S R L | Apparato per la trasformazione di denti in materiale osseo |
US10265060B2 (en) | 2015-08-20 | 2019-04-23 | Arthrex, Inc. | Tensionable constructs with multi-limb locking mechanism through single splice and methods of tissue repair |
US10335136B2 (en) | 2015-08-20 | 2019-07-02 | Arthrex, Inc. | Tensionable constructs with multi-limb locking mechanism through single splice and methods of tissue repair |
US10470872B1 (en) * | 2016-04-07 | 2019-11-12 | Michael A. Scarpone | Implantable articles for attaching tendons and/or ligaments to bone and/or cartilage, assemblies thereof, and methods of use thereof |
US10707531B1 (en) | 2016-09-27 | 2020-07-07 | New Dominion Enterprises Inc. | All-inorganic solvents for electrolytes |
US11219502B2 (en) | 2017-09-11 | 2022-01-11 | Medtronic Advanced Energy, Llc | Transformative shape-memory polymer tissue cavity marker devices, systems and deployment methods |
US11324567B2 (en) | 2018-02-01 | 2022-05-10 | Medtronic Advanced Energy, Llc | Expandable tissue cavity marker devices, systems and deployment methods |
KR102150326B1 (ko) * | 2018-07-04 | 2020-09-01 | (주)서한케어 | 생체 조직 친화성 금속재료의 표면처리 방법 |
US11583609B2 (en) | 2018-08-08 | 2023-02-21 | Mimedx Group, Inc. | Collagen constructs and methods of making the same |
WO2023141208A1 (en) * | 2022-01-19 | 2023-07-27 | Restoration Biologics Llc | Tissue graft and processing methods |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4744793A (en) * | 1985-09-06 | 1988-05-17 | Zimmer, Inc. | Prosthetic ligament connection assembly |
FI80605C (fi) * | 1986-11-03 | 1990-07-10 | Biocon Oy | Benkirurgisk biokompositmaterial. |
US4828562A (en) * | 1988-02-04 | 1989-05-09 | Pfizer Hospital Products Group, Inc. | Anterior cruciate ligament prosthesis |
US4950296A (en) * | 1988-04-07 | 1990-08-21 | Mcintyre Jonathan L | Bone grafting units |
DE3835237C1 (ja) * | 1988-10-15 | 1989-12-28 | B. Braun Melsungen Ag, 3508 Melsungen, De | |
US4990163A (en) * | 1989-02-06 | 1991-02-05 | Trustees Of The University Of Pennsylvania | Method of depositing calcium phosphate cermamics for bone tissue calcification enhancement |
US5067962A (en) * | 1989-04-18 | 1991-11-26 | Baxter International Inc. | Bioprosthetic ligament |
US4927421A (en) * | 1989-05-15 | 1990-05-22 | Marlowe Goble E | Process of endosteal fixation of a ligament |
US5139520A (en) * | 1990-01-31 | 1992-08-18 | American Cyanamid Company | Method for acl reconstruction |
US5062843A (en) * | 1990-02-07 | 1991-11-05 | Mahony Iii Thomas H | Interference fixation screw with integral instrumentation |
ES2110448T3 (es) * | 1990-09-04 | 1998-02-16 | Hip Dev Pty Ltd | Tornillo quirurgico. |
US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
US5320115A (en) * | 1991-01-16 | 1994-06-14 | Applied Biological Concepts | Method and apparatus for arthroscopic knee surgery |
US5116337A (en) * | 1991-06-27 | 1992-05-26 | Johnson Lanny L | Fixation screw and method for ligament reconstruction |
US5366457A (en) * | 1991-12-13 | 1994-11-22 | David A. McGuire | Method and apparatus for preparing a bone and tendon graft |
US5562669A (en) * | 1994-01-13 | 1996-10-08 | Mcguire; David A. | Cruciate ligament reconstruction with tibial drill guide |
US5391169A (en) * | 1991-12-13 | 1995-02-21 | Mcguire; David A. | Patellar tendon harvester |
US5234430A (en) * | 1991-12-18 | 1993-08-10 | Huebner Randall J | Orthopedic fixation screw and method |
US5425773A (en) * | 1992-01-06 | 1995-06-20 | Danek Medical, Inc. | Intervertebral disk arthroplasty device |
US5425733A (en) | 1992-02-19 | 1995-06-20 | Arthrex, Inc. | Interference screw with rounded back end and cannulated sheath for endosteal fixation of ligaments |
AU5342594A (en) * | 1992-10-27 | 1994-05-24 | Neoligaments Limited | Ligament graft harvesting |
ATE197665T1 (de) * | 1992-11-02 | 2000-12-15 | Sulzer Orthopaedie Ag | Verankerung für ein künstliches band |
US5443509A (en) * | 1992-12-10 | 1995-08-22 | Linvatec Corporation | Interference bone-fixation screw with multiple interleaved threads |
US5397356A (en) | 1993-01-15 | 1995-03-14 | Depuy Inc. | Pin for securing a replacement ligament to a bone |
US5397357A (en) * | 1993-02-18 | 1995-03-14 | Arthrex, Inc. | Method for preparing a bone-tendon-bone core graft |
US5632748A (en) * | 1993-06-14 | 1997-05-27 | Linvatec Corporation | Endosteal anchoring device for urging a ligament against a bone surface |
US5454811A (en) * | 1993-11-08 | 1995-10-03 | Smith & Nephew Dyonics, Inc. | Cam lock orthopedic fixation screw and method |
US5769899A (en) * | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
US5645589A (en) * | 1994-08-22 | 1997-07-08 | Li Medical Technologies, Inc. | Anchor and method for securement into a bore |
AU713540B2 (en) * | 1994-10-25 | 1999-12-02 | Osteonics Corp. | Interlocking structural elements and method for bone repair, augmentation and replacement |
US6106556A (en) * | 1994-12-02 | 2000-08-22 | Omeros Medical Systems, Inc. | Tendon and ligament repair system |
US5728118A (en) * | 1995-03-29 | 1998-03-17 | Linvatec Corporation | Apparatus and method for harvesting a bone-tendon-bone ligament graft |
US6231608B1 (en) * | 1995-06-07 | 2001-05-15 | Crosscart, Inc. | Aldehyde and glycosidase-treated soft and bone tissue xenografts |
US5814084A (en) * | 1996-01-16 | 1998-09-29 | University Of Florida Tissue Bank, Inc. | Diaphysial cortical dowel |
US5681314A (en) * | 1996-06-21 | 1997-10-28 | Lawrence M. Shall | Cutting a bone graft |
US5782832A (en) * | 1996-10-01 | 1998-07-21 | Surgical Dynamics, Inc. | Spinal fusion implant and method of insertion thereof |
US5772664A (en) * | 1997-02-12 | 1998-06-30 | Wright Medical Technology, Inc. | Instrument for harvesting bone grafts having substantially cylindrical bone plugs |
ES2206918T3 (es) * | 1997-04-22 | 2004-05-16 | Washington Research Foundation | Injertos y protesis oseos recubiertos con fosfatasa acida resistente al tratado. |
US6206917B1 (en) * | 1997-05-02 | 2001-03-27 | St. Jude Medical, Inc. | Differential treatment of prosthetic devices |
US6613278B1 (en) | 1998-11-13 | 2003-09-02 | Regeneration Technologies, Inc. | Tissue pooling process |
WO1999009914A1 (en) | 1997-08-27 | 1999-03-04 | University Of Florida Tissue Bank, Inc. | Cortical bone cervical smith-robinson fusion implant |
US5891146A (en) * | 1997-10-15 | 1999-04-06 | Applied Biological Concepts, Inc. | Wedge orthopedic screw |
US6090998A (en) * | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
US6146420A (en) * | 1997-12-10 | 2000-11-14 | Sdgi Holdings, Inc. | Osteogenic fusion device |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
US6258125B1 (en) * | 1998-08-03 | 2001-07-10 | Synthes (U.S.A.) | Intervertebral allograft spacer |
EP1064031B1 (en) * | 1998-03-23 | 2002-02-06 | Bio-Vascular, Inc. | Implants and method of making |
US6019792A (en) * | 1998-04-23 | 2000-02-01 | Cauthen Research Group, Inc. | Articulating spinal implant |
WO1999053871A1 (en) * | 1998-04-23 | 1999-10-28 | Cauthen Research Group, Inc. | Articulating spinal implant |
JPH11345175A (ja) * | 1998-06-02 | 1999-12-14 | Nec Kofu Ltd | 代替パス制御システム及び方法 |
US6355066B1 (en) * | 1998-08-19 | 2002-03-12 | Andrew C. Kim | Anterior cruciate ligament reconstruction hamstring tendon fixation system |
US6497726B1 (en) * | 2000-01-11 | 2002-12-24 | Regeneration Technologies, Inc. | Materials and methods for improved bone tendon bone transplantation |
US6025538A (en) * | 1998-11-20 | 2000-02-15 | Musculoskeletal Transplant Foundation | Compound bone structure fabricated from allograft tissue |
US20020165611A1 (en) * | 1998-12-22 | 2002-11-07 | Robert-Jan Enzerink | Graft material convenience package |
US6200347B1 (en) * | 1999-01-05 | 2001-03-13 | Lifenet | Composite bone graft, method of making and using same |
WO2000054821A1 (en) | 1999-03-16 | 2000-09-21 | Regeneration Technologies, Inc. | Molded implants for orthopedic applications |
IT1310423B1 (it) * | 1999-07-29 | 2002-02-13 | Giovanni Zaccherotti | Mezzo di fissazione femorale dei tendini di semitendinoso e delgragile per la ricostruzione del legamento crociato anteriore. |
US6494883B1 (en) * | 2000-05-26 | 2002-12-17 | Bret A. Ferree | Bone reinforcers |
US6737053B1 (en) * | 1999-11-12 | 2004-05-18 | National University Of Singapore | Tissue-engineered ligament |
US6893462B2 (en) * | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
US20030097179A1 (en) * | 2000-01-11 | 2003-05-22 | Carter Kevin C. | Materials and methods for improved bone tendon bone transplantation |
EP1294313B1 (en) * | 2000-06-14 | 2006-09-06 | Teppo Järvinen | Fixation anchor |
US6517579B1 (en) * | 2000-09-06 | 2003-02-11 | Lonnie E. Paulos | Method and apparatus for securing a soft tissue graft to bone during an ACL reconstruction |
US6579295B1 (en) * | 2000-09-25 | 2003-06-17 | Robert S. Supinski | Tendon anchors |
WO2002041930A2 (en) * | 2000-11-24 | 2002-05-30 | UNIVERSITé LAVAL | Connective tissue substitutes, method of preparation and uses thereof |
JP2004533276A (ja) * | 2001-01-25 | 2004-11-04 | リジェネレーション テクノロジーズ インク. | 注射可能な多孔性骨グラフト材料 |
US7195642B2 (en) * | 2001-03-13 | 2007-03-27 | Mckernan Daniel J | Method and apparatus for fixing a graft in a bone tunnel |
GB0116605D0 (en) * | 2001-07-07 | 2001-08-29 | Atlantech Medical Devices Ltd | Expandable bone anchor |
US6887271B2 (en) * | 2001-09-28 | 2005-05-03 | Ethicon, Inc. | Expanding ligament graft fixation system and method |
US20030078659A1 (en) * | 2001-10-23 | 2003-04-24 | Jun Yang | Graft element |
EP1334702B1 (de) * | 2002-02-08 | 2004-07-07 | Karl Storz GmbH & Co. KG | Ankerelement zum Verankern eines Ligamenttransplantates |
US6730124B2 (en) * | 2002-03-08 | 2004-05-04 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with cancellous allograft bone block |
US6890354B2 (en) * | 2002-03-08 | 2005-05-10 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with allograft bone block and method for inserting same |
US20030212456A1 (en) * | 2002-05-09 | 2003-11-13 | John Lipchitz | Implant for tissue repair |
US7357803B2 (en) * | 2002-11-05 | 2008-04-15 | Linvatec Corporation | Rotating ring ligament fixation |
DE102004025332A1 (de) * | 2003-05-26 | 2004-12-16 | Huber, Jakob, Dipl.-Ing. | Alloplastisches Band |
US8226715B2 (en) * | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
US7648676B2 (en) * | 2004-04-20 | 2010-01-19 | Rti Biologics, Inc. | Process and apparatus for treating implants comprising soft tissue |
US20060067971A1 (en) * | 2004-09-27 | 2006-03-30 | Story Brooks J | Bone void filler |
US7727278B2 (en) * | 2005-03-04 | 2010-06-01 | Rti Biologics, Inc. | Self fixing assembled bone-tendon-bone graft |
EP1832246B1 (en) * | 2006-03-08 | 2019-06-12 | Arthrex, Inc. | Bundle graft and method of making same |
US8298284B2 (en) * | 2006-03-21 | 2012-10-30 | Arthrex, Inc. | Whip stitched graft construct and method of making the same |
US8007533B2 (en) * | 2007-02-12 | 2011-08-30 | Rti Biologics, Inc. | Progressive grip assembled bone-tendon-bone grafts, methods of making, and methods of use |
-
2001
- 2001-08-29 US US09/942,537 patent/US6893462B2/en not_active Expired - Fee Related
-
2002
- 2002-08-27 DE DE60229539T patent/DE60229539D1/de not_active Expired - Lifetime
- 2002-08-27 AU AU2002323425A patent/AU2002323425B8/en not_active Ceased
- 2002-08-27 EP EP02757406A patent/EP1427322B1/en not_active Expired - Fee Related
- 2002-08-27 CA CA002459050A patent/CA2459050A1/en not_active Abandoned
- 2002-08-27 JP JP2003524426A patent/JP2005503850A/ja active Pending
- 2002-08-27 WO PCT/US2002/027236 patent/WO2003020107A2/en active Application Filing
- 2002-08-27 EP EP08017750A patent/EP2048226A1/en not_active Withdrawn
-
2004
- 2004-12-08 US US11/007,679 patent/US20050119744A1/en not_active Abandoned
- 2004-12-08 US US11/007,525 patent/US7513910B2/en not_active Expired - Fee Related
-
2005
- 2005-08-26 JP JP2005246893A patent/JP2006034988A/ja active Pending
-
2008
- 2008-10-29 US US12/260,898 patent/US20110301707A1/en not_active Abandoned
-
2012
- 2012-08-23 US US13/593,218 patent/US20120323324A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003020107A2 (en) | 2003-03-13 |
EP1427322A4 (en) | 2005-06-29 |
WO2003020107A3 (en) | 2003-12-04 |
CA2459050A1 (en) | 2003-03-13 |
EP1427322A2 (en) | 2004-06-16 |
EP2048226A9 (en) | 2009-09-30 |
US20020072806A1 (en) | 2002-06-13 |
US6893462B2 (en) | 2005-05-17 |
US7513910B2 (en) | 2009-04-07 |
US20050101957A1 (en) | 2005-05-12 |
AU2002323425B8 (en) | 2006-11-23 |
EP2048226A1 (en) | 2009-04-15 |
US20120323324A1 (en) | 2012-12-20 |
EP1427322B1 (en) | 2008-10-22 |
JP2005503850A (ja) | 2005-02-10 |
US20050119744A1 (en) | 2005-06-02 |
DE60229539D1 (de) | 2008-12-04 |
US20110301707A1 (en) | 2011-12-08 |
AU2002323425B2 (en) | 2006-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2006034988A (ja) | 柔軟かつ石灰化された組織インプラント | |
AU2002323425A1 (en) | Soft and calcified tissue implants | |
JP4197158B2 (ja) | 天然に発生する生物学的に誘導されている材料による装置 | |
US6730124B2 (en) | Bone-tendon-bone assembly with cancellous allograft bone block | |
US8252056B2 (en) | Biocompatible osteogenic band for repair of spinal disorders | |
JP3544660B2 (ja) | 組織の自己成長を促進する移植片 | |
US20150012107A1 (en) | Novel biological implant compositions, implants and methods | |
US20100274355A1 (en) | Bone-tendon-bone assembly with cancellous allograft bone block having cortical end portion | |
US20030078659A1 (en) | Graft element | |
JP2004535250A5 (ja) | ||
JP2019018006A (ja) | 網を有する骨インプラント | |
US20100211174A1 (en) | Method For Repairing A Rotator Cuff | |
JPH05501975A (ja) | 天然の骨組織から骨形成術のための材料を製造する方法及びこれによって得られた材料 | |
US20230022665A1 (en) | Preshaped biologic scaffolds | |
CA2536547C (en) | Improved bone-tendon-bone assembly with cancellous allograft bone block | |
JP2005510258A (ja) | 混合組成物セグメントを備える、組み立てられた移植物 | |
US20100217390A1 (en) | Rotator cuff bone-tendon allograft |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090427 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090724 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090729 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090826 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090831 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090907 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090910 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20091225 |