JP2005537329A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005537329A5 JP2005537329A5 JP2004534522A JP2004534522A JP2005537329A5 JP 2005537329 A5 JP2005537329 A5 JP 2005537329A5 JP 2004534522 A JP2004534522 A JP 2004534522A JP 2004534522 A JP2004534522 A JP 2004534522A JP 2005537329 A5 JP2005537329 A5 JP 2005537329A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- group
- cooh
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 claims 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000005024 alkenyl aryl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005248 alkyl aryloxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40723902P | 2002-09-03 | 2002-09-03 | |
| PCT/US2003/027607 WO2004022569A1 (en) | 2002-09-03 | 2003-09-03 | Akt inhibitors, pharmaceutical compositions, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005537329A JP2005537329A (ja) | 2005-12-08 |
| JP2005537329A5 true JP2005537329A5 (enExample) | 2006-10-12 |
| JP4641796B2 JP4641796B2 (ja) | 2011-03-02 |
Family
ID=31978442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534522A Expired - Fee Related JP4641796B2 (ja) | 2002-09-03 | 2003-09-03 | Ａｋｔ阻害剤、医薬組成物、及びその用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7378403B2 (enExample) |
| EP (1) | EP1537129B1 (enExample) |
| JP (1) | JP4641796B2 (enExample) |
| AU (1) | AU2003270087B2 (enExample) |
| CA (1) | CA2497572C (enExample) |
| WO (1) | WO2004022569A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632669B (zh) * | 2000-08-04 | 2011-05-18 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| AU2003279761B2 (en) * | 2002-10-02 | 2009-11-12 | Luoxis Diagnostics, Inc. | Diagnosis and monitoring of diseases |
| KR20150080004A (ko) | 2003-05-15 | 2015-07-08 | 앰피오 파마슈티컬스 인코퍼레이티드 | Ｔ-세포 매개성 질환의 치료 방법 |
| WO2008070823A2 (en) * | 2006-12-07 | 2008-06-12 | University Of South Florida | Substrate-mimetic akt inhibitor |
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
| EP2393827B1 (en) | 2009-02-05 | 2015-10-07 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| JP2013537195A (ja) | 2010-09-07 | 2013-09-30 | ディエムアイ アクイジション コーポレイション | 疾患の治療 |
| AU2012323305B2 (en) | 2011-10-10 | 2017-07-27 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| BR112014007657A2 (pt) | 2011-10-10 | 2017-04-11 | Ampio Pharmaceuticals Inc | dispositivos médicos implantáveis com tolerância imune aperfeiçoada e métodos para produção e implantação |
| MX355446B (es) | 2011-10-28 | 2018-04-18 | Ampio Pharmaceuticals Inc | Tratamiento de rinitis. |
| SG11201507093WA (en) | 2013-03-14 | 2015-10-29 | Univ Maryland Baltimore Office Of Technology Transfer | Androgen receptor down-regulating agents and uses thereof |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| SG11201600525XA (en) | 2013-08-12 | 2016-02-26 | Tokai Pharmaceuticals Inc | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| US10526660B2 (en) | 2013-09-12 | 2020-01-07 | Dana-Farber Cancer Institute, Inc. | Methods for evaluating and treating Waldenstrom's macroglobulinemia |
| CA2958080A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| HK1246669A1 (zh) | 2015-06-22 | 2018-09-14 | Ampio Pharmaceuticals, Inc. | 人血清白蛋白低分子量组分在疾病治疗中的应用 |
| WO2021118924A2 (en) | 2019-12-12 | 2021-06-17 | Ting Therapeutics Llc | Compositions and methods for the prevention and treatment of hearing loss |
| CN111704546A (zh) * | 2020-06-30 | 2020-09-25 | 海南师范大学 | 一种含氧环己烷衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4585762A (en) * | 1982-07-30 | 1986-04-29 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same |
| JPS59187786A (ja) * | 1983-04-11 | 1984-10-24 | Meito Sangyo Kk | 酵素法リン脂質二級アルコ−ル誘導体の製法 |
| EP0122151B1 (en) * | 1983-04-11 | 1989-02-15 | Meito Sangyo Kabushiki Kaisha | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| US5227508A (en) | 1992-01-24 | 1993-07-13 | Mayo Foundation For Medical Education And Research | 3-deoxy-3-substituted analogs of phosphatidylinositol |
| AU4427199A (en) * | 1998-06-26 | 2000-01-17 | Georgetown University | Inhibitors of phosphatidyl (myo)-inositol cycle |
-
2003
- 2003-09-03 WO PCT/US2003/027607 patent/WO2004022569A1/en not_active Ceased
- 2003-09-03 AU AU2003270087A patent/AU2003270087B2/en not_active Ceased
- 2003-09-03 US US10/526,851 patent/US7378403B2/en not_active Expired - Fee Related
- 2003-09-03 JP JP2004534522A patent/JP4641796B2/ja not_active Expired - Fee Related
- 2003-09-03 EP EP03751981.6A patent/EP1537129B1/en not_active Expired - Lifetime
- 2003-09-03 CA CA2497572A patent/CA2497572C/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005537329A5 (enExample) | ||
| RU2203894C2 (ru) | Новые производные пиримидина (варианты) | |
| Testut et al. | A new hepadnavirus endemic in arctic ground squirrels in Alaska | |
| RU2345065C2 (ru) | Ингибиторы протеаз, расщепляющих за пролином | |
| JP2005041880A5 (enExample) | ||
| JP2005528325A5 (enExample) | ||
| JP2005053931A5 (enExample) | ||
| JP2005511699A5 (enExample) | ||
| JP2001518496A5 (enExample) | ||
| JP2003530432A5 (enExample) | ||
| JP2010504908A5 (enExample) | ||
| JP2002539156A5 (enExample) | ||
| JP2005511592A5 (enExample) | ||
| RU96119964A (ru) | Нафтиламиды в качестве средств воздействия на центральную нервную систему | |
| JP2006526608A5 (enExample) | ||
| KR930701916A (ko) | 선축박멸법 | |
| JP2004502684A5 (enExample) | ||
| JP2007505180A5 (enExample) | ||
| JP2007526998A5 (enExample) | ||
| RU2005131872A (ru) | Производные бензотиазола (варианты), фармацевтическая композиция для детекции отложений амилоида и способ их детекции у млекопитающего | |
| ATE304522T1 (de) | Verfahren zur hemmung von amyloidprotein aggregation und zur diagnostischen nachweis von amyloidablagerung unter verwendung von aminoindanderivaten | |
| JP2001233852A5 (enExample) | ||
| JP2004517891A5 (enExample) | ||
| JP2003295438A5 (enExample) | ||
| KR960700230A (ko) | 다중-약물 내성종양 제제로서 유용한 디아릴알킬 피페리딘(Diarylalkyl piperidines useful as multi-drug resistant tumor agents) |