JP2005533110A5 - - Google Patents
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- Publication number
- JP2005533110A5 JP2005533110A5 JP2004521686A JP2004521686A JP2005533110A5 JP 2005533110 A5 JP2005533110 A5 JP 2005533110A5 JP 2004521686 A JP2004521686 A JP 2004521686A JP 2004521686 A JP2004521686 A JP 2004521686A JP 2005533110 A5 JP2005533110 A5 JP 2005533110A5
- Authority
- JP
- Japan
- Prior art keywords
- tetracycline
- cmt
- pharmaceutical composition
- antibacterial
- analog
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000004098 Tetracycline Substances 0.000 claims 11
- 229960002180 tetracycline Drugs 0.000 claims 11
- 235000019364 tetracycline Nutrition 0.000 claims 11
- 229930101283 tetracycline Natural products 0.000 claims 11
- 150000003522 tetracyclines Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 230000000844 anti-bacterial effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 108010074051 C-Reactive Protein Proteins 0.000 claims 2
- 102100032752 C-reactive protein Human genes 0.000 claims 2
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims 2
- 229960004475 chlortetracycline Drugs 0.000 claims 2
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims 2
- 235000019365 chlortetracycline Nutrition 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- MWUTTXATIMURBN-VSAOOKSHSA-N (4aS,5aS,6S,12aR)-3,6,10,11-tetrahydroxy-6-methyl-1,12-dioxo-4a,5,5a,12a-tetrahydro-4H-tetracene-2-carboxamide Chemical compound C[C@]1(O)[C@H]2C[C@H]3CC(O)=C(C(N)=O)C(=O)[C@H]3C(=O)C2=C(O)c2c(O)cccc12 MWUTTXATIMURBN-VSAOOKSHSA-N 0.000 claims 1
- NBRQRXRBIHVLGI-OWXODZSWSA-N (4as,5ar,12ar)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=CC=CC(O)=C2C(O)=C(C2=O)[C@@H]1C[C@@H]1[C@@]2(O)C(O)=C(C(=O)N)C(=O)C1 NBRQRXRBIHVLGI-OWXODZSWSA-N 0.000 claims 1
- XCCHQGIGHCRZOS-KBKZQPOHSA-N (4as,5as,6s,12ar)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@@](C)(O)[C@@H](C[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)C3)(O)C3=O)C3=C(O)C2=C1O XCCHQGIGHCRZOS-KBKZQPOHSA-N 0.000 claims 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 1
- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 claims 1
- 101100221122 Caenorhabditis elegans cmt-1 gene Proteins 0.000 claims 1
- 239000004099 Chlortetracycline Substances 0.000 claims 1
- FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000004100 Oxytetracycline Substances 0.000 claims 1
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- HISOCSRUFLPKDE-KLXQUTNESA-N cmt-2 Chemical compound C1=CC=C2[C@](O)(C)C3CC4C(N(C)C)C(O)=C(C#N)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O HISOCSRUFLPKDE-KLXQUTNESA-N 0.000 claims 1
- BVFDLIAWTKFZQD-JXVDNWKRSA-N cmt-8 Chemical group O=C1C2=C(O)C=CC=C2C(C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)C[C@@H]1C2O BVFDLIAWTKFZQD-JXVDNWKRSA-N 0.000 claims 1
- 229960002398 demeclocycline Drugs 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- 229960004196 lymecycline Drugs 0.000 claims 1
- AHEVKYYGXVEWNO-UEPZRUIBSA-N lymecycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(=O)NCNCCCC[C@H](N)C(O)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O AHEVKYYGXVEWNO-UEPZRUIBSA-N 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- 229960000625 oxytetracycline Drugs 0.000 claims 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 1
- 235000019366 oxytetracycline Nutrition 0.000 claims 1
- 229940063650 terramycin Drugs 0.000 claims 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39546602P | 2002-07-12 | 2002-07-12 | |
| PCT/US2003/021740 WO2004006938A1 (en) | 2002-07-12 | 2003-07-11 | Method for reducing c-rective protein levels with non-antibacterial tetracycline formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533110A JP2005533110A (ja) | 2005-11-04 |
| JP2005533110A5 true JP2005533110A5 (https=) | 2006-10-12 |
Family
ID=30115878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521686A Abandoned JP2005533110A (ja) | 2002-07-12 | 2003-07-11 | 非抗菌性テトラサイクリン製剤によるｃ−反応性タンパク質レベルの減少方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050282786A1 (https=) |
| EP (1) | EP1531830A4 (https=) |
| JP (1) | JP2005533110A (https=) |
| KR (1) | KR20050034713A (https=) |
| AU (1) | AU2003256496A1 (https=) |
| CA (1) | CA2491655A1 (https=) |
| NZ (1) | NZ538198A (https=) |
| WO (1) | WO2004006938A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2534827T3 (es) * | 2003-04-07 | 2015-04-29 | Supernus Pharmaceuticals, Inc. | Formulaciones de tetraciclinas en dosis única diaria |
| CN104957154B (zh) * | 2015-06-24 | 2018-05-18 | 广东中迅农科股份有限公司 | 含有四霉素和醚菌酯的杀菌组合物 |
| CN105010359B (zh) * | 2015-06-24 | 2018-05-18 | 广东中迅农科股份有限公司 | 含有四霉素和氟环唑的杀菌组合物 |
| BR112021007969A2 (pt) | 2018-10-29 | 2021-07-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | complexos de tetraciclina com atividade controlada |
| PL3982956T3 (pl) * | 2019-06-14 | 2024-10-28 | Joshua O. Atiba | Potrójna kompozycja farmaceutyczna na zakażenie białkowe |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666897A (en) * | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
| US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| EP2329826A1 (en) * | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of multiple sclerosis |
-
2003
- 2003-07-11 AU AU2003256496A patent/AU2003256496A1/en not_active Abandoned
- 2003-07-11 KR KR1020057000506A patent/KR20050034713A/ko not_active Withdrawn
- 2003-07-11 JP JP2004521686A patent/JP2005533110A/ja not_active Abandoned
- 2003-07-11 NZ NZ538198A patent/NZ538198A/en unknown
- 2003-07-11 US US10/519,534 patent/US20050282786A1/en not_active Abandoned
- 2003-07-11 WO PCT/US2003/021740 patent/WO2004006938A1/en not_active Ceased
- 2003-07-11 CA CA002491655A patent/CA2491655A1/en not_active Abandoned
- 2003-07-11 EP EP03764515A patent/EP1531830A4/en not_active Withdrawn
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