JP2005532822A - 過剰な希釈剤を有する精製カラムを備える微小流体デバイスおよび方法 - Google Patents
過剰な希釈剤を有する精製カラムを備える微小流体デバイスおよび方法 Download PDFInfo
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Abstract
Description
本願は、以前に出願された米国仮特許出願番号60/398,852および60/398,778(共に2002年6月26日に出願された)からの利益を主張し、そして米国特許出願番号10/414,179(2003年4月14日に出願された)の一部係属出願であり、そして米国特許出願番号10/426,587(2003年4月30日に出願された)の一部係属出願である。引用がまた、本明細書により、米国特許出願番号10/336,706;10/336,274;および10/336,330(全て2003年1月3日に出願された)に対してなされる。本明細書中に参照される仮特許出願および特許出願の全ては、その全体において参考として本明細書中に援用される。
本教示は、サンプルの精製のための方法、デバイス、およびシステムに関する。
微小流体サンプル調製の場合において、装填されたサンプル容量は、マイクロリットル以下のサイズであり得る。このような小さな容量は、キャピラリー分析デバイスおよびシステム(例えば、キャピラリーシークエンサー注入デバイス(capillary sequencer injection device)およびシステム)に不適合であり得る。マイクロリットル以下のサンプル体積をキャピラリーシークエンサーを用いて使用するために、サンプル容量は、緩衝液または希釈剤の構成容量と共に増大され得る。
種々の実施形態に従って、精製カラム、出力チャンバ、精製カラムと出力チャンバとの間の第1の流体連絡、ならびに流体流連絡を通る流体流を妨げるための開放可能で、かつ再閉鎖可能な第1のバルブを備える微小流体デバイスが、提供される。過剰な希釈剤を含む精製物質が、精製カラム中に、例えば最初に、配置され得る。このデバイスは、過剰な希釈剤が精製カラムから出力チャンバ中に移動して取り出された希釈剤を提供することを可能にするバルブを備え得る。次いで、この精製カラムは、流体サンプルを精製し、出力チャンバ中の精製された種を提供するために使用され得る。種々の実施形態に従って、精製カラムは、反応産物(例えば、核酸配列増幅反応産物)を受け得る。
種々の実施形態に従って、入口ポートまたは入口開口、精製カラム、出力リザーバー、精製カラムと出力リザーバーとの間の流体連絡、および流体連絡を通る流体を中断し得る、操作可能でかつ閉鎖可能なバルブを備える微小流体デバイスが提供される。精製カラム、入口開口、出力リザーバー、および流体連絡は、全て単一の基板中または基板上に形成され得る。種々の実施形態に従って、微小流体デバイスは2つ以上の基板層から形成され得、その結果、精製カラム、入口開口、出力リザーバー、または流体連絡の特徴の少なくとも1つは、1つ以上の他の特徴ではなく異なる基板層に形成され得る。種々の実施形態に従って、1つより多いサンプル処理経路は、基板上または基板中に形成され得、例えば、デバイスは、マルチチャネルデバイスであり得る。基板としては、例えば、以下が挙げられ得る:シリコン材料、ガラス材料、ポリマー材料(例えば、ポリジメチルシロキサン、ポリカーボネート、アクリロニトリル−ブタジエン−スチレンコポリマー(ABS)、ポリカーボネート/ABSブレンド、ポリビニルクロリド、ポリスチレン、ポリプロピレンオキシド、アクリル含有材料、ポリブチレンテレフタレート、ポリエチレンテレフタレートのブレンド、ナイロン、ナイロンのブレンド)、またはこのような材料の組み合わせ。基板としては、ポリアルキリン材料、フルオロポリマー材料、環状オレフィンポリマー材料、またはこれらの組み合わせ、または他の材料との組み合わせが挙げられ得る。基板は、任意の適切な形状(例えば、正方形、矩形、多角形、円形、楕円形、または任意の他の幾何学的形状)であり得る。
Claims (32)
- 流体サンプルを精製するための方法であって、該方法が、以下:
入口ポートを有する流体デバイスを提供する工程であって、精製カラムが該入口ポートと流体連絡しており、出力リザーバーが該精製カラムと流体連絡している、工程;
該精製カラムに、希釈剤に浸した精製物質、および過剰な希釈剤を提供する工程;
該過剰な希釈剤を、該精製カラムから該出力リザーバーに移動し、取り出された希釈剤を提供する工程;
該流体サンプルを該入口ポートを介して該精製カラムに導入する工程;
該流体サンプルを該精製カラムを介して該出力リザーバー中に移動し、該出力リザーバー中の精製されたサンプルを提供する工程;ならびに
該精製されたサンプルを該出力リザーバー中で該取り出された希釈剤と混合する工程
を包含する、方法。 - 請求項1に記載の方法であって、前記過剰な希釈剤が、移動力を生成する工程を包含する、方法。
- 請求項2に記載の方法であって、前記移動力が、求心力を含む、方法。
- 請求項2に記載の方法であって、前記移動力が、水圧力を含む、方法。
- 請求項2に記載の方法であって、前記移動力が、空圧力を含む、方法。
- 請求項1に記載の方法であって、前記流体サンプルを移動する工程が,移動力を生成する工程を包含する、方法。
- 請求項6に記載の方法であって、前記移動力が、求心力を含む、方法。
- 請求項6に記載の方法であって、前記移動力が、水圧力を含む、方法。
- 請求項6に記載の方法であって、前記移動力が、空圧力を含む、方法。
- 請求項1に記載の方法であって、前記流体サンプルが、生物学的サンプルを含む、方法。
- 請求項1に記載の方法であって、前記流体サンプルが、核酸配列を含む、方法。
- 請求項1に記載の方法であって、前記過剰な希釈剤が、精製チャンバを通って移動し、その後前記流体サンプルが、前記精製カラムに導入される、方法。
- 請求項1に記載の方法であって、前記精製カラムに、希釈剤で浸した精製物質、および過剰な希釈剤を提供する工程が、精製カラムに希釈剤で浸した精製物質を充填し、そして該カラムに過剰な希釈剤を加える工程を包含する、方法。
- 請求項1に記載の方法であって、前記精製カラムに希釈剤で浸した精製物質、および過剰な希釈剤を提供する工程が、該精製カラムに浸した精製物質と過剰な物質との混合物を充填する工程を包含する、方法。
- 請求項1に記載の方法であって、前記精製カラムに精製物質を提供する工程が、該精製物質を前記入口ポートを介して該カラムに加える工程を包含する、方法。
- 請求項1に記載の方法であって、前記精製物質が、サイズ排除粒子を含む、方法。
- 請求項1に記載の方法であって、前記精製物質が、サイズ排除イオン交換粒子を含む、方法。
- 請求項1に記載の方法であって、前記サンプルが、少なくとも1分の間前記精製物質と接触される、方法。
- 請求項1に記載の方法であって、前記サンプルをポリメラーゼ連鎖反応に供し、その後前記流体サンプルを前記精製カラム中に導入する工程をさらに包含する、方法。
- 請求項1に記載の方法であって、前記サンプルを配列決定反応に供し、その後前記流体を前記精製カラム中に導入する工程をさらに包含する、方法。
- 請求項1に記載の方法であって、前記取り出された希釈剤と混合された精製された種を、キャピラリー電気泳動に供する工程をさらに包含する、方法。
- 請求項1に記載の方法であって、前記流体サンプルが塩化物イオンを含み、そして該方法が、前記精製カラム中の該塩化物イオンをイオン交換する工程を包含する、方法。
- 請求項1に記載の方法であって、前記流体デバイスが、微小流体デバイスである、方法。
- 微小流体デバイスであって、以下:
精製カラムであって、チャンバおよび該チャンバ中に保持される精製物質を含み、該精製物質が、過剰の精製物質希釈剤を含む、カラム;
出力チャンバ;
該精製カラムと該出力チャンバとの間の第1の流体連絡;ならびに
該第1の流体連絡を通る流体流を妨げ得る、開放可能で、かつ再閉鎖可能な第1のバルブ
を備える、微小流体デバイス。 - 請求項24に記載のデバイスであって、前記第1のバルブが、閉められる、デバイス。
- 請求項24に記載のデバイスであって、前記第1のバルブが、開いている、デバイス。
- 請求項24に記載のデバイスであって、以下:
反応チャンバ;
前記精製カラムと該反応チャンバとの間の第2の連絡;
前記第2の流体連絡を通る流体流を妨げ得る、開放可能で、かつ再閉鎖可能な第2のバルブ
をさらに備える、デバイス。 - 請求項24に記載のデバイスであって、前記精製物質が、平均粒子直径を有する粒子を含み、そして前記第1の流体連絡が、平均粒子直径より大きい最小の寸法を有する、デバイス。
- 請求項24に記載のデバイスであって、前記過剰な希釈剤が、前記精製物質のための緩衝液を含む、デバイス。
- サンプル処理システムであって、以下:
請求項24に記載の微小流体デバイス;
回転軸を有する圧盤;
該微小流体デバイスを該圧盤上にまたは圧盤内に保持し得るホルダ;および
該圧盤を該回転軸の周りに回転し得る駆動ユニット
を備える、サンプル処理システム。 - 請求項30に記載のサンプル処理システムであって、前記駆動ユニット制御し得る駆動制御ユニットをさらに備える、サンプル処理システム。
- 請求項30に記載のサンプル処理システムであって、以下:
前記デバイスを熱し得る熱ユニット;および
該熱ユニットを制御し得る熱制御ユニット
をさらに備える、サンプル処理システム。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39885202P | 2002-07-26 | 2002-07-26 | |
US39877802P | 2002-07-26 | 2002-07-26 | |
US10/414,179 US20040018559A1 (en) | 2002-07-26 | 2003-04-14 | Size-exclusion ion-exchange particles |
US10/426,587 US6817373B2 (en) | 2002-07-26 | 2003-04-30 | One-directional microball valve for a microfluidic device |
PCT/US2003/023599 WO2004011681A1 (en) | 2002-07-26 | 2003-07-28 | Microfluidic device including purification column with excess diluent, and method |
Related Child Applications (1)
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2003
- 2003-07-28 JP JP2004524977A patent/JP4225972B2/ja not_active Expired - Fee Related
- 2003-07-28 EP EP03772000A patent/EP1552013A1/en not_active Withdrawn
- 2003-07-28 WO PCT/US2003/023599 patent/WO2004011681A1/en active Application Filing
- 2003-07-28 AU AU2003252177A patent/AU2003252177A1/en not_active Abandoned
- 2003-07-28 US US10/628,281 patent/US20040055956A1/en not_active Abandoned
- 2003-07-28 CA CA002492450A patent/CA2492450A1/en not_active Abandoned
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2008
- 2008-10-24 JP JP2008274850A patent/JP2009050276A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
JP4225972B2 (ja) | 2009-02-18 |
JP2009050276A (ja) | 2009-03-12 |
AU2003252177A1 (en) | 2004-02-16 |
US20110172403A1 (en) | 2011-07-14 |
WO2004011681A1 (en) | 2004-02-05 |
US20040055956A1 (en) | 2004-03-25 |
CA2492450A1 (en) | 2004-02-05 |
EP1552013A1 (en) | 2005-07-13 |
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