JP2005532399A - Ｍｃｈ１アンタゴニストとしての二級アミノアニリンピペリジン類およびその使用 - Google Patents
Ｍｃｈ１アンタゴニストとしての二級アミノアニリンピペリジン類およびその使用 Download PDFInfo
- Publication number
- JP2005532399A JP2005532399A JP2004520047A JP2004520047A JP2005532399A JP 2005532399 A JP2005532399 A JP 2005532399A JP 2004520047 A JP2004520047 A JP 2004520047A JP 2004520047 A JP2004520047 A JP 2004520047A JP 2005532399 A JP2005532399 A JP 2005532399A
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- compound
- branched
- alkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *CC(*C1CCNCC1)*O Chemical compound *CC(*C1CCNCC1)*O 0.000 description 5
- UZOFELREXGAFOI-UHFFFAOYSA-N CC1CCNCC1 Chemical compound CC1CCNCC1 UZOFELREXGAFOI-UHFFFAOYSA-N 0.000 description 1
- BJTXBCPCGQESHN-UHFFFAOYSA-N COc1ccccc1CCCCC(Nc(c(F)c1)cc(C2CCNCC2)c1F)=O Chemical compound COc1ccccc1CCCCC(Nc(c(F)c1)cc(C2CCNCC2)c1F)=O BJTXBCPCGQESHN-UHFFFAOYSA-N 0.000 description 1
- AFIFSUXFOSROJQ-UHFFFAOYSA-N COc1ccccc1CCCCC(Nc1cc(C2CCNCC2)ccc1F)=O Chemical compound COc1ccccc1CCCCC(Nc1cc(C2CCNCC2)ccc1F)=O AFIFSUXFOSROJQ-UHFFFAOYSA-N 0.000 description 1
- FAFMDWPGRDIRSZ-UHFFFAOYSA-N O=C(CCCCC(Nc1cc(C2CCNCC2)ccc1)=O)c1ccccc1 Chemical compound O=C(CCCCC(Nc1cc(C2CCNCC2)ccc1)=O)c1ccccc1 FAFMDWPGRDIRSZ-UHFFFAOYSA-N 0.000 description 1
- SDLKTDAJGGCHKG-UHFFFAOYSA-N O=C(CCCCCNc(cc1F)ccc1F)Nc1cccc(C2CCNCC2)c1 Chemical compound O=C(CCCCCNc(cc1F)ccc1F)Nc1cccc(C2CCNCC2)c1 SDLKTDAJGGCHKG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18914502A | 2002-07-03 | 2002-07-03 | |
| PCT/US2003/021391 WO2004005257A1 (en) | 2002-07-03 | 2003-07-03 | Secondary amino anilinic piperidines as mch1 antagonists and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2005532399A true JP2005532399A (ja) | 2005-10-27 |
Family
ID=30114020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520047A Withdrawn JP2005532399A (ja) | 2002-07-03 | 2003-07-03 | Ｍｃｈ１アンタゴニストとしての二級アミノアニリンピペリジン類およびその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7473698B2 (is) |
| EP (1) | EP1556351A4 (is) |
| JP (1) | JP2005532399A (is) |
| KR (1) | KR20050034710A (is) |
| CN (1) | CN1319945C (is) |
| AU (1) | AU2003259098A1 (is) |
| BR (1) | BR0312257A (is) |
| CA (1) | CA2485379A1 (is) |
| EA (1) | EA008826B1 (is) |
| HK (1) | HK1080471A1 (is) |
| IL (1) | IL165730A0 (is) |
| IS (1) | IS7560A (is) |
| MX (1) | MXPA04012103A (is) |
| NO (1) | NO20050113L (is) |
| NZ (1) | NZ536329A (is) |
| PL (1) | PL373621A1 (is) |
| UA (1) | UA77536C2 (is) |
| WO (1) | WO2004005257A1 (is) |
| ZA (1) | ZA200409425B (is) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016041740A (ja) * | 2009-12-22 | 2016-03-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換されたベンズアミド誘導体 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7199135B2 (en) | 2001-07-05 | 2007-04-03 | H. Lundbeck A/S | Substituted alkyl amido piperidines |
| US7105544B2 (en) | 2001-07-05 | 2006-09-12 | Synaptic Pharmaceutical Corporation | Substituted alkyl amido piperidines |
| US20050154020A1 (en) * | 2004-01-14 | 2005-07-14 | Synaptic Pharmaceutical Corporation | 4-Aryl piperidines |
| US20050154022A1 (en) * | 2004-01-14 | 2005-07-14 | H. Lundbeck A/S | 4-aryl piperidines |
| WO2006015279A1 (en) * | 2004-07-28 | 2006-02-09 | Neurogen Corporation | Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders |
| US7446204B2 (en) | 2004-10-08 | 2008-11-04 | H. Lundbeck A/S | Amino substituted aryloxybenzylpiperidine derivatives |
| US20060079683A1 (en) * | 2004-10-08 | 2006-04-13 | Marzabadi Mohammad R | Arylthiobenzylpiperidine derivatives |
| US7329656B2 (en) | 2004-10-08 | 2008-02-12 | H. Lundbeck A/S | Arylthiobenzylpiperidine derivatives |
| BR112018015389B1 (pt) | 2016-03-17 | 2023-12-19 | F. Hoffmann-La Roche Ag | Derivado de 5-etil-4-metil-pirazol-3-carboxamida, seu processo de fabricação, preparação farmacêutica oral e uso |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0223403B1 (en) * | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidine derivative, its preparation, and its use as medicament |
| FR2744448B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| ES2157148B1 (es) * | 1998-11-18 | 2002-03-01 | Faes Fabrica Espanola De Produ | Nuevas piperidinas 4-sustituidas. |
| US6326381B1 (en) * | 1998-12-17 | 2001-12-04 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates |
| US20030082623A1 (en) * | 1998-12-31 | 2003-05-01 | Beth Borowsky | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof |
| WO2002006245A1 (en) * | 2000-07-05 | 2002-01-24 | Synaptic Pharmarceutical Corporation | Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof |
| CA2384358A1 (en) * | 2000-07-05 | 2002-01-10 | Synaptic Pharmaceutical Corporation | Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof |
| CN1703401A (zh) | 2001-05-22 | 2005-11-30 | 神经原公司 | 黑色素浓集激素受体的配体:取代的1－苄基－4－芳基哌嗪类似物 |
| HUP0401880A2 (hu) | 2001-07-05 | 2005-01-28 | Synaptic Pharmaceutical Corporation | Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
-
2003
- 2003-03-07 UA UA20041210489A patent/UA77536C2/uk unknown
- 2003-07-03 CN CNB038157667A patent/CN1319945C/zh not_active Expired - Fee Related
- 2003-07-03 MX MXPA04012103A patent/MXPA04012103A/es active IP Right Grant
- 2003-07-03 EP EP03763374A patent/EP1556351A4/en not_active Withdrawn
- 2003-07-03 PL PL03373621A patent/PL373621A1/xx not_active Application Discontinuation
- 2003-07-03 NZ NZ536329A patent/NZ536329A/en unknown
- 2003-07-03 KR KR1020057000078A patent/KR20050034710A/ko not_active Application Discontinuation
- 2003-07-03 EA EA200500152A patent/EA008826B1/ru not_active IP Right Cessation
- 2003-07-03 US US10/518,675 patent/US7473698B2/en not_active Expired - Fee Related
- 2003-07-03 BR BR0312257-3A patent/BR0312257A/pt not_active IP Right Cessation
- 2003-07-03 WO PCT/US2003/021391 patent/WO2004005257A1/en active Application Filing
- 2003-07-03 JP JP2004520047A patent/JP2005532399A/ja not_active Withdrawn
- 2003-07-03 IL IL16573003A patent/IL165730A0/xx unknown
- 2003-07-03 CA CA002485379A patent/CA2485379A1/en not_active Abandoned
- 2003-07-03 AU AU2003259098A patent/AU2003259098A1/en not_active Abandoned
-
2004
- 2004-11-23 ZA ZA200409425A patent/ZA200409425B/en unknown
- 2004-11-26 IS IS7560A patent/IS7560A/is unknown
-
2005
- 2005-01-10 NO NO20050113A patent/NO20050113L/no not_active Application Discontinuation
-
2006
- 2006-01-09 HK HK06100334A patent/HK1080471A1/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016041740A (ja) * | 2009-12-22 | 2016-03-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換されたベンズアミド誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1556351A1 (en) | 2005-07-27 |
| EA200500152A1 (ru) | 2005-06-30 |
| CN1319945C (zh) | 2007-06-06 |
| EA008826B1 (ru) | 2007-08-31 |
| UA77536C2 (en) | 2006-12-15 |
| IL165730A0 (en) | 2006-01-15 |
| IS7560A (is) | 2004-11-26 |
| US20050245743A1 (en) | 2005-11-03 |
| NZ536329A (en) | 2007-06-29 |
| MXPA04012103A (es) | 2005-04-19 |
| CA2485379A1 (en) | 2004-01-15 |
| KR20050034710A (ko) | 2005-04-14 |
| NO20050113L (no) | 2005-01-10 |
| ZA200409425B (en) | 2006-04-26 |
| WO2004005257A1 (en) | 2004-01-15 |
| CN1665786A (zh) | 2005-09-07 |
| US7473698B2 (en) | 2009-01-06 |
| BR0312257A (pt) | 2005-04-12 |
| AU2003259098A1 (en) | 2004-01-23 |
| HK1080471A1 (en) | 2006-04-28 |
| EP1556351A4 (en) | 2007-07-25 |
| PL373621A1 (en) | 2005-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1531816B1 (en) | Spirocyclic piperidines as mch1 antagonists and uses thereof | |
| MXPA03011886A (es) | Piperidinias anilinicas sustituidas como antagonistas selectivos de mch. | |
| US7105544B2 (en) | Substituted alkyl amido piperidines | |
| JP2005532399A (ja) | Ｍｃｈ１アンタゴニストとしての二級アミノアニリンピペリジン類およびその使用 | |
| US20050154022A1 (en) | 4-aryl piperidines | |
| US7199135B2 (en) | Substituted alkyl amido piperidines | |
| EP1708704A2 (en) | 4-aryl piperidines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060511 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20090318 |