EA200500152A1 - Вторичные аминоанилиновые пиперидины в качестве антагонистов мкг1 и их применение - Google Patents

Вторичные аминоанилиновые пиперидины в качестве антагонистов мкг1 и их применение

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Publication number
EA200500152A1
EA200500152A1 EA200500152A EA200500152A EA200500152A1 EA 200500152 A1 EA200500152 A1 EA 200500152A1 EA 200500152 A EA200500152 A EA 200500152A EA 200500152 A EA200500152 A EA 200500152A EA 200500152 A1 EA200500152 A1 EA 200500152A1
Authority
EA
Eurasian Patent Office
Prior art keywords
subject
compound
present
treating
pharmaceutically acceptable
Prior art date
Application number
EA200500152A
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English (en)
Other versions
EA008826B1 (ru
Inventor
Мохаммад Марзабади
Ю Дзианг
Каи Лу
Чиен-Ан Чен
Джон Делеон
Джон Ветцель
Original Assignee
Х. Лундбекк А/С
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Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200500152A1 publication Critical patent/EA200500152A1/ru
Publication of EA008826B1 publication Critical patent/EA008826B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение направлено на соединения, которые являются селективными антагонистами рецепторов-1 меланинконцентрирующего гормона (МКГ-1). В изобретении предлагается фармацевтическая композиция, включающая терапевтически эффективное количество соединения изобретения и фармацевтически приемлемый носитель. В данном изобретении предлагается фармацевтическая композиция, полученная объединением терапевтически эффективного количества соединения данного изобретения и фармацевтически приемлемого носителя. В данном изобретении дополнительно предлагается способ получения фармацевтической композиции, включающий объединение терапевтически эффективного количества соединений изобретения и фармацевтически приемлемого носителя. В данном изобретении также предлагается способ снижения массы тела у субъекта, который включает введение субъекту количества соединения изобретения, эффективного для снижения массы тела у субъекта. В данном изобретении дополнительно предлагается способ лечения субъекта, страдающего депрессией и/или тревожностью, который включает введение субъекту количества соединения изобретения, эффективного для лечения у субъекта депрессии и/или тревожности. В данном изобретении дополнительно предлагается способ лечения субъекта, страдающего нарушением мочеиспускания.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500152A 2002-07-03 2003-07-03 Вторичные аминоанилиновые пиперидины в качестве антагонистов мкг1 и их применение EA008826B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18914502A 2002-07-03 2002-07-03
PCT/US2003/021391 WO2004005257A1 (en) 2002-07-03 2003-07-03 Secondary amino anilinic piperidines as mch1 antagonists and uses thereof

Publications (2)

Publication Number Publication Date
EA200500152A1 true EA200500152A1 (ru) 2005-06-30
EA008826B1 EA008826B1 (ru) 2007-08-31

Family

ID=30114020

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500152A EA008826B1 (ru) 2002-07-03 2003-07-03 Вторичные аминоанилиновые пиперидины в качестве антагонистов мкг1 и их применение

Country Status (19)

Country Link
US (1) US7473698B2 (ru)
EP (1) EP1556351A4 (ru)
JP (1) JP2005532399A (ru)
KR (1) KR20050034710A (ru)
CN (1) CN1319945C (ru)
AU (1) AU2003259098A1 (ru)
BR (1) BR0312257A (ru)
CA (1) CA2485379A1 (ru)
EA (1) EA008826B1 (ru)
HK (1) HK1080471A1 (ru)
IL (1) IL165730A0 (ru)
IS (1) IS7560A (ru)
MX (1) MXPA04012103A (ru)
NO (1) NO20050113L (ru)
NZ (1) NZ536329A (ru)
PL (1) PL373621A1 (ru)
UA (1) UA77536C2 (ru)
WO (1) WO2004005257A1 (ru)
ZA (1) ZA200409425B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105544B2 (en) 2001-07-05 2006-09-12 Synaptic Pharmaceutical Corporation Substituted alkyl amido piperidines
US7199135B2 (en) 2001-07-05 2007-04-03 H. Lundbeck A/S Substituted alkyl amido piperidines
US20050154022A1 (en) * 2004-01-14 2005-07-14 H. Lundbeck A/S 4-aryl piperidines
US20050154020A1 (en) * 2004-01-14 2005-07-14 Synaptic Pharmaceutical Corporation 4-Aryl piperidines
WO2006015279A1 (en) * 2004-07-28 2006-02-09 Neurogen Corporation Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders
US7329656B2 (en) 2004-10-08 2008-02-12 H. Lundbeck A/S Arylthiobenzylpiperidine derivatives
US20060079683A1 (en) * 2004-10-08 2006-04-13 Marzabadi Mohammad R Arylthiobenzylpiperidine derivatives
US7446204B2 (en) 2004-10-08 2008-11-04 H. Lundbeck A/S Amino substituted aryloxybenzylpiperidine derivatives
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
AU2017234042B2 (en) 2016-03-17 2020-11-19 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of TAAR

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058061T3 (es) 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
FR2744448B1 (fr) 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
ES2157148B1 (es) * 1998-11-18 2002-03-01 Faes Fabrica Espanola De Produ Nuevas piperidinas 4-sustituidas.
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
US20030082623A1 (en) * 1998-12-31 2003-05-01 Beth Borowsky DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
JP2004504303A (ja) * 2000-07-05 2004-02-12 シナプティック・ファーマスーティカル・コーポレーション 選択的メラニン凝集ホルモン−１（ｍｃｈ１）受容体アンタゴニストおよびその使用
AU7320701A (en) * 2000-07-05 2002-01-14 Synaptic Pharmaceutical Corporation DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
US6953801B2 (en) 2001-05-22 2005-10-11 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
EP1411942A4 (en) 2001-07-05 2005-01-26 Synaptic Pharma Corp SUBSTITUTED ANILINE PIPERIDINES AS SELECTIVE MCH ANTAGONISTS

Also Published As

Publication number Publication date
JP2005532399A (ja) 2005-10-27
CN1665786A (zh) 2005-09-07
NZ536329A (en) 2007-06-29
BR0312257A (pt) 2005-04-12
MXPA04012103A (es) 2005-04-19
PL373621A1 (en) 2005-09-05
EP1556351A4 (en) 2007-07-25
WO2004005257A1 (en) 2004-01-15
EP1556351A1 (en) 2005-07-27
US20050245743A1 (en) 2005-11-03
IS7560A (is) 2004-11-26
IL165730A0 (en) 2006-01-15
US7473698B2 (en) 2009-01-06
UA77536C2 (en) 2006-12-15
KR20050034710A (ko) 2005-04-14
CN1319945C (zh) 2007-06-06
HK1080471A1 (en) 2006-04-28
CA2485379A1 (en) 2004-01-15
NO20050113L (no) 2005-01-10
AU2003259098A1 (en) 2004-01-23
EA008826B1 (ru) 2007-08-31
ZA200409425B (en) 2006-04-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU