JP2005532364A - ガチフロキサシンの新規結晶質形態 - Google Patents
ガチフロキサシンの新規結晶質形態 Download PDFInfo
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- JP2005532364A JP2005532364A JP2004512754A JP2004512754A JP2005532364A JP 2005532364 A JP2005532364 A JP 2005532364A JP 2004512754 A JP2004512754 A JP 2004512754A JP 2004512754 A JP2004512754 A JP 2004512754A JP 2005532364 A JP2005532364 A JP 2005532364A
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- gatifloxacin
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- XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 title claims abstract description 84
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- RMJMZKDEVNTXHE-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;trihydrate Chemical compound O.O.O.FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCNC(C)C1.FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCNC(C)C1 RMJMZKDEVNTXHE-UHFFFAOYSA-N 0.000 claims description 7
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- 239000007790 solid phase Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002076 thermal analysis method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940057977 zinc stearate Drugs 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38909302P | 2002-06-14 | 2002-06-14 | |
| US42333802P | 2002-11-01 | 2002-11-01 | |
| PCT/US2003/019046 WO2003105851A1 (en) | 2002-06-01 | 2003-06-16 | Novel crystalline forms of gatifloxacin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532364A true JP2005532364A (ja) | 2005-10-27 |
| JP2005532364A5 JP2005532364A5 (https=) | 2006-05-11 |
Family
ID=29740100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004512754A Pending JP2005532364A (ja) | 2002-06-14 | 2003-06-16 | ガチフロキサシンの新規結晶質形態 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7411067B2 (https=) |
| EP (1) | EP1471911A1 (https=) |
| JP (1) | JP2005532364A (https=) |
| CN (1) | CN1674902A (https=) |
| AU (1) | AU2003243615A1 (https=) |
| CA (1) | CA2489377A1 (https=) |
| IL (1) | IL165690A0 (https=) |
| WO (1) | WO2003105851A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005118546A1 (en) * | 2004-06-04 | 2005-12-15 | Matrix Laboratories Ltd | Novel crystalline forms of gatifloxacin |
| CA2621616A1 (en) * | 2007-02-19 | 2008-08-19 | Alcon Research, Ltd. | Topical gatifloxacin formulations |
| JP2010522756A (ja) | 2007-03-29 | 2010-07-08 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 結晶形およびその使用 |
| MY180626A (en) | 2013-11-15 | 2020-12-03 | Akebia Therapeutics Inc | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2128601C (en) | 1992-01-31 | 2003-07-15 | Hiroyuki Nagano | Quinolone carboxylic acid derivatives in crystalline hydrate form |
| JP3449658B2 (ja) | 1994-12-21 | 2003-09-22 | 杏林製薬株式会社 | 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法 |
| US6413969B1 (en) | 2000-09-13 | 2002-07-02 | Bristol-Myers Squibb Company | Gatifloxacin pentahydrate |
| US20060142300A1 (en) | 2002-04-08 | 2006-06-29 | Reddy Manne S | Anhydrous crystalline forms of I and II of 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (gatifloxacin) |
-
2003
- 2003-06-16 JP JP2004512754A patent/JP2005532364A/ja active Pending
- 2003-06-16 US US10/462,945 patent/US7411067B2/en not_active Expired - Fee Related
- 2003-06-16 AU AU2003243615A patent/AU2003243615A1/en not_active Abandoned
- 2003-06-16 CA CA002489377A patent/CA2489377A1/en not_active Abandoned
- 2003-06-16 EP EP03760424A patent/EP1471911A1/en not_active Withdrawn
- 2003-06-16 CN CNA038193094A patent/CN1674902A/zh active Pending
- 2003-06-16 WO PCT/US2003/019046 patent/WO2003105851A1/en not_active Ceased
-
2004
- 2004-12-09 IL IL16569004A patent/IL165690A0/xx unknown
-
2008
- 2008-07-01 US US12/217,251 patent/US20080269488A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040038988A1 (en) | 2004-02-26 |
| IL165690A0 (en) | 2006-01-15 |
| EP1471911A1 (en) | 2004-11-03 |
| US20080269488A1 (en) | 2008-10-30 |
| AU2003243615A1 (en) | 2003-12-31 |
| WO2003105851A1 (en) | 2003-12-24 |
| CN1674902A (zh) | 2005-09-28 |
| US7411067B2 (en) | 2008-08-12 |
| CA2489377A1 (en) | 2003-12-24 |
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