JP2005531640A - 組換えタンパク質におけるａｄｐ−リボース−アルギニンに対する機能的置換体としてのトリプトファン - Google Patents

組換えタンパク質におけるａｄｐ−リボース−アルギニンに対する機能的置換体としてのトリプトファン Download PDF

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Publication number
JP2005531640A
JP2005531640A JP2004518082A JP2004518082A JP2005531640A JP 2005531640 A JP2005531640 A JP 2005531640A JP 2004518082 A JP2004518082 A JP 2004518082A JP 2004518082 A JP2004518082 A JP 2004518082A JP 2005531640 A JP2005531640 A JP 2005531640A
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adp
polypeptide
protein
activity
defensin
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Japanese (ja)
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JP2005531640A5 (enExample
Inventor
ジョエル モス
リンダ スティーブンス
クリステル ブアジュアー
リタ ボルテル
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Government of the United States of America
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Government of the United States of America
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Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JP2005531640A publication Critical patent/JP2005531640A/ja
Publication of JP2005531640A5 publication Critical patent/JP2005531640A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004518082A 2002-06-28 2003-06-27 組換えタンパク質におけるａｄｐ−リボース−アルギニンに対する機能的置換体としてのトリプトファン Pending JP2005531640A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39303302P 2002-06-28 2002-06-28
PCT/US2003/020498 WO2004003195A1 (en) 2002-06-28 2003-06-27 Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins

Publications (2)

Publication Number Publication Date
JP2005531640A true JP2005531640A (ja) 2005-10-20
JP2005531640A5 JP2005531640A5 (enExample) 2006-09-28

Family

ID=30000965

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004518082A Pending JP2005531640A (ja) 2002-06-28 2003-06-27 組換えタンパク質におけるａｄｐ−リボース−アルギニンに対する機能的置換体としてのトリプトファン

Country Status (6)

Country Link
US (2) US7541139B2 (enExample)
EP (1) EP1549746A4 (enExample)
JP (1) JP2005531640A (enExample)
AU (1) AU2003247826B2 (enExample)
CA (1) CA2490290A1 (enExample)
WO (1) WO2004003195A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070176A2 (en) 2002-02-19 2003-08-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Modified defensins and their use
EP1549746A4 (en) * 2002-06-28 2006-08-16 Us Gov Health & Human Serv TRYPTOPHAN AS A FUNCTIONAL SPARE FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS
JP2008523068A (ja) * 2004-12-08 2008-07-03 ノバルティス アクチエンゲゼルシャフト 有機化合物の使用
US8828380B2 (en) 2009-09-10 2014-09-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for the treatment of pulmonary disease and method of producing proteins of use therein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965190A (en) * 1986-07-31 1990-10-23 Howard Hughes Medical Institute Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes
US5716816A (en) * 1992-05-22 1998-02-10 The United States Of America As Represented By The Department Of Health And Human Services Clones encoding mammalian ADP-ribosylarginine hydrolases
EP1333093A3 (en) * 1992-11-30 2008-09-10 The Government of the United States of America, as represented by the Secretary Department of Health and Human Services Human muscle nad: arginine adpribosyltransferase
US5386021A (en) * 1993-04-16 1995-01-31 The United States Of America, As Represented By The Department Of Health & Human Services Mammalian guanine nucleotide binding protein with an ADP-rybosylation factor domain
US5459128A (en) * 1993-11-12 1995-10-17 Dana-Farber Cancer Institute Human monocyte chemoattractant protein-1 (MCP-1) derivatives
US6015668A (en) * 1994-09-30 2000-01-18 Life Technologies, Inc. Cloned DNA polymerases from thermotoga and mutants thereof
GB9818938D0 (en) * 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
GB9918155D0 (en) 1999-08-02 1999-10-06 Zeneca Ltd Proteins and peptides
EP1549746A4 (en) * 2002-06-28 2006-08-16 Us Gov Health & Human Serv TRYPTOPHAN AS A FUNCTIONAL SPARE FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS

Also Published As

Publication number Publication date
US20090203878A1 (en) 2009-08-13
AU2003247826B2 (en) 2008-04-24
EP1549746A4 (en) 2006-08-16
US7541139B2 (en) 2009-06-02
EP1549746A1 (en) 2005-07-06
AU2003247826A1 (en) 2004-01-19
US20060074037A1 (en) 2006-04-06
US7923535B2 (en) 2011-04-12
WO2004003195A1 (en) 2004-01-08
CA2490290A1 (en) 2004-01-08

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