AU2003247826B2 - Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins - Google Patents

Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins Download PDF

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Publication number
AU2003247826B2
AU2003247826B2 AU2003247826A AU2003247826A AU2003247826B2 AU 2003247826 B2 AU2003247826 B2 AU 2003247826B2 AU 2003247826 A AU2003247826 A AU 2003247826A AU 2003247826 A AU2003247826 A AU 2003247826A AU 2003247826 B2 AU2003247826 B2 AU 2003247826B2
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AU
Australia
Prior art keywords
adp
polypeptide
protein
activity
arginine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003247826A
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English (en)
Other versions
AU2003247826A1 (en
Inventor
Rita Bortell
Christelle Bourgeois
Joel Moss
Linda Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Massachusetts Amherst
US Department of Health and Human Services
Original Assignee
University of Massachusetts Amherst
US Department of Health and Human Services
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Publication date
Application filed by University of Massachusetts Amherst, US Department of Health and Human Services filed Critical University of Massachusetts Amherst
Publication of AU2003247826A1 publication Critical patent/AU2003247826A1/en
Assigned to UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER, THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES reassignment UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER Amend patent request/document other than specification (104) Assignors: Refer to Publication History
Assigned to THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, UNIVERSITY OF MASSACHUSETTS reassignment THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Request for Assignment Assignors: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
Application granted granted Critical
Publication of AU2003247826B2 publication Critical patent/AU2003247826B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723Cationic antimicrobial peptides, e.g. defensins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1077Pentosyltransferases (2.4.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2003247826A 2002-06-28 2003-06-27 Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins Ceased AU2003247826B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39303302P 2002-06-28 2002-06-28
US60/393,033 2002-06-28
PCT/US2003/020498 WO2004003195A1 (en) 2002-06-28 2003-06-27 Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins

Publications (2)

Publication Number Publication Date
AU2003247826A1 AU2003247826A1 (en) 2004-01-19
AU2003247826B2 true AU2003247826B2 (en) 2008-04-24

Family

ID=30000965

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003247826A Ceased AU2003247826B2 (en) 2002-06-28 2003-06-27 Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins

Country Status (6)

Country Link
US (2) US7541139B2 (enExample)
EP (1) EP1549746A4 (enExample)
JP (1) JP2005531640A (enExample)
AU (1) AU2003247826B2 (enExample)
CA (1) CA2490290A1 (enExample)
WO (1) WO2004003195A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070176A2 (en) 2002-02-19 2003-08-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Modified defensins and their use
EP1549746A4 (en) * 2002-06-28 2006-08-16 Us Gov Health & Human Serv TRYPTOPHAN AS A FUNCTIONAL SPARE FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS
JP2008523068A (ja) * 2004-12-08 2008-07-03 ノバルティス アクチエンゲゼルシャフト 有機化合物の使用
US8828380B2 (en) 2009-09-10 2014-09-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for the treatment of pulmonary disease and method of producing proteins of use therein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965190A (en) * 1986-07-31 1990-10-23 Howard Hughes Medical Institute Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes
US5716816A (en) * 1992-05-22 1998-02-10 The United States Of America As Represented By The Department Of Health And Human Services Clones encoding mammalian ADP-ribosylarginine hydrolases
EP1333093A3 (en) * 1992-11-30 2008-09-10 The Government of the United States of America, as represented by the Secretary Department of Health and Human Services Human muscle nad: arginine adpribosyltransferase
US5386021A (en) * 1993-04-16 1995-01-31 The United States Of America, As Represented By The Department Of Health & Human Services Mammalian guanine nucleotide binding protein with an ADP-rybosylation factor domain
US5459128A (en) * 1993-11-12 1995-10-17 Dana-Farber Cancer Institute Human monocyte chemoattractant protein-1 (MCP-1) derivatives
US6015668A (en) * 1994-09-30 2000-01-18 Life Technologies, Inc. Cloned DNA polymerases from thermotoga and mutants thereof
GB9818938D0 (en) * 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
GB9918155D0 (en) 1999-08-02 1999-10-06 Zeneca Ltd Proteins and peptides
EP1549746A4 (en) * 2002-06-28 2006-08-16 Us Gov Health & Human Serv TRYPTOPHAN AS A FUNCTIONAL SPARE FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS

Also Published As

Publication number Publication date
US20090203878A1 (en) 2009-08-13
JP2005531640A (ja) 2005-10-20
EP1549746A4 (en) 2006-08-16
US7541139B2 (en) 2009-06-02
EP1549746A1 (en) 2005-07-06
AU2003247826A1 (en) 2004-01-19
US20060074037A1 (en) 2006-04-06
US7923535B2 (en) 2011-04-12
WO2004003195A1 (en) 2004-01-08
CA2490290A1 (en) 2004-01-08

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Legal Events

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE APPLICANT TO THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES.

PC1 Assignment before grant (sect. 113)

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS

Free format text: FORMER APPLICANT(S): THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARYOF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY O F MASSACHUSETTS MEDICAL CENTER

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired