CA2490290A1 - Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins - Google Patents
Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins Download PDFInfo
- Publication number
- CA2490290A1 CA2490290A1 CA002490290A CA2490290A CA2490290A1 CA 2490290 A1 CA2490290 A1 CA 2490290A1 CA 002490290 A CA002490290 A CA 002490290A CA 2490290 A CA2490290 A CA 2490290A CA 2490290 A1 CA2490290 A1 CA 2490290A1
- Authority
- CA
- Canada
- Prior art keywords
- adp
- polypeptide
- protein
- activity
- substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39303302P | 2002-06-28 | 2002-06-28 | |
| US60/393,033 | 2002-06-28 | ||
| PCT/US2003/020498 WO2004003195A1 (en) | 2002-06-28 | 2003-06-27 | Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2490290A1 true CA2490290A1 (en) | 2004-01-08 |
Family
ID=30000965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002490290A Abandoned CA2490290A1 (en) | 2002-06-28 | 2003-06-27 | Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7541139B2 (enExample) |
| EP (1) | EP1549746A4 (enExample) |
| JP (1) | JP2005531640A (enExample) |
| AU (1) | AU2003247826B2 (enExample) |
| CA (1) | CA2490290A1 (enExample) |
| WO (1) | WO2004003195A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003070176A2 (en) | 2002-02-19 | 2003-08-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Modified defensins and their use |
| EP1549746A4 (en) * | 2002-06-28 | 2006-08-16 | Us Gov Health & Human Serv | TRYPTOPHAN AS A FUNCTIONAL SPARE FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS |
| JP2008523068A (ja) * | 2004-12-08 | 2008-07-03 | ノバルティス アクチエンゲゼルシャフト | 有機化合物の使用 |
| US8828380B2 (en) | 2009-09-10 | 2014-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for the treatment of pulmonary disease and method of producing proteins of use therein |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965190A (en) * | 1986-07-31 | 1990-10-23 | Howard Hughes Medical Institute | Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes |
| US5716816A (en) * | 1992-05-22 | 1998-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Clones encoding mammalian ADP-ribosylarginine hydrolases |
| EP1333093A3 (en) * | 1992-11-30 | 2008-09-10 | The Government of the United States of America, as represented by the Secretary Department of Health and Human Services | Human muscle nad: arginine adpribosyltransferase |
| US5386021A (en) * | 1993-04-16 | 1995-01-31 | The United States Of America, As Represented By The Department Of Health & Human Services | Mammalian guanine nucleotide binding protein with an ADP-rybosylation factor domain |
| US5459128A (en) * | 1993-11-12 | 1995-10-17 | Dana-Farber Cancer Institute | Human monocyte chemoattractant protein-1 (MCP-1) derivatives |
| US6015668A (en) * | 1994-09-30 | 2000-01-18 | Life Technologies, Inc. | Cloned DNA polymerases from thermotoga and mutants thereof |
| GB9818938D0 (en) * | 1998-08-28 | 1998-10-21 | Alpharma As | Bioactive peptides |
| GB9918155D0 (en) | 1999-08-02 | 1999-10-06 | Zeneca Ltd | Proteins and peptides |
| EP1549746A4 (en) * | 2002-06-28 | 2006-08-16 | Us Gov Health & Human Serv | TRYPTOPHAN AS A FUNCTIONAL SPARE FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS |
-
2003
- 2003-06-27 EP EP03762212A patent/EP1549746A4/en not_active Withdrawn
- 2003-06-27 WO PCT/US2003/020498 patent/WO2004003195A1/en not_active Ceased
- 2003-06-27 JP JP2004518082A patent/JP2005531640A/ja active Pending
- 2003-06-27 AU AU2003247826A patent/AU2003247826B2/en not_active Ceased
- 2003-06-27 US US10/517,565 patent/US7541139B2/en not_active Expired - Lifetime
- 2003-06-27 CA CA002490290A patent/CA2490290A1/en not_active Abandoned
-
2009
- 2009-04-24 US US12/430,023 patent/US7923535B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20090203878A1 (en) | 2009-08-13 |
| JP2005531640A (ja) | 2005-10-20 |
| AU2003247826B2 (en) | 2008-04-24 |
| EP1549746A4 (en) | 2006-08-16 |
| US7541139B2 (en) | 2009-06-02 |
| EP1549746A1 (en) | 2005-07-06 |
| AU2003247826A1 (en) | 2004-01-19 |
| US20060074037A1 (en) | 2006-04-06 |
| US7923535B2 (en) | 2011-04-12 |
| WO2004003195A1 (en) | 2004-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130611 |