JP2005531627A5 - - Google Patents
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- Publication number
- JP2005531627A5 JP2005531627A5 JP2004517093A JP2004517093A JP2005531627A5 JP 2005531627 A5 JP2005531627 A5 JP 2005531627A5 JP 2004517093 A JP2004517093 A JP 2004517093A JP 2004517093 A JP2004517093 A JP 2004517093A JP 2005531627 A5 JP2005531627 A5 JP 2005531627A5
- Authority
- JP
- Japan
- Prior art keywords
- hypertension
- methyl
- pharmaceutically acceptable
- olmesartan
- sildenafil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 7
- 206010020772 Hypertension Diseases 0.000 claims 5
- 229960003310 sildenafil Drugs 0.000 claims 5
- 239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims 4
- 239000005480 Olmesartan Substances 0.000 claims 4
- UQGKUQLKSCSZGY-UHFFFAOYSA-N Olmesartan medoxomil Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229960005117 olmesartan Drugs 0.000 claims 4
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 claims 4
- 229960001199 olmesartan medoxomil Drugs 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 2
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- -1 4-methyl-1-piperazinylsulfonyl Chemical group 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000007530 Essential hypertension Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 201000003099 Renovascular Hypertension Diseases 0.000 claims 1
- 201000004239 Secondary hypertension Diseases 0.000 claims 1
- 206010042957 Systolic hypertension Diseases 0.000 claims 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 229960002639 sildenafil citrate Drugs 0.000 claims 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0214784.1A GB0214784D0 (en) | 2002-06-26 | 2002-06-26 | Novel combination |
| PCT/IB2003/002657 WO2004002461A2 (en) | 2002-06-26 | 2003-06-16 | Combination of pde5 inhibitors with angiotensin ii receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531627A JP2005531627A (ja) | 2005-10-20 |
| JP2005531627A5 true JP2005531627A5 (https=) | 2006-08-10 |
Family
ID=9939342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004517093A Withdrawn JP2005531627A (ja) | 2002-06-26 | 2003-06-16 | 新規混合医薬 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1524996A2 (https=) |
| JP (1) | JP2005531627A (https=) |
| KR (1) | KR20050013156A (https=) |
| CN (1) | CN1662257A (https=) |
| AR (1) | AR040337A1 (https=) |
| AU (1) | AU2003242895A1 (https=) |
| BR (1) | BR0312030A (https=) |
| CA (1) | CA2491002A1 (https=) |
| GB (1) | GB0214784D0 (https=) |
| GT (1) | GT200300124A (https=) |
| MX (1) | MXPA04012569A (https=) |
| NO (1) | NO20050400L (https=) |
| PA (1) | PA8575501A1 (https=) |
| PE (1) | PE20040868A1 (https=) |
| PL (1) | PL375079A1 (https=) |
| RU (1) | RU2004136276A (https=) |
| TW (1) | TW200404546A (https=) |
| UY (1) | UY27863A1 (https=) |
| WO (1) | WO2004002461A2 (https=) |
| ZA (1) | ZA200409532B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7019010B2 (en) | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
| EP2433555A3 (en) * | 2002-07-26 | 2013-01-16 | Olympus Corporation | Image processing system |
| US20060205733A1 (en) * | 2004-08-26 | 2006-09-14 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
| BRPI0502411A (pt) * | 2005-03-31 | 2006-11-28 | Univ Minas Gerais | processo de desenvolvimento de substáncias como inibidores potentes e seletivos de isoformas de fosfodiesterases dos tipos 1 a 5 (pde1,pde2,pde3, pde4, pde5) na base de diocleìna, fluranol ou análogos e suas composições farmacêuticas para o estudo e tratamento de doenças cardiovasculares e produtos associados |
| ES2376628T3 (es) | 2005-06-10 | 2012-03-15 | Dong-A Pharmaceutical Co., Ltd. | Agente para la prevención y el tratamiento de las enfermedades hep�?ticas que contiene un dirivado pirazolopirimidina. |
| WO2007010337A2 (de) * | 2005-07-15 | 2007-01-25 | Proxomed Medizintechnik Gmbh | Verwendung von phosphodiesterase typ 5-hemmern für die prävention und behandlung von adipositas, sowie abgabesysteme für dieselben |
| EP1940389A2 (en) * | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US7858611B2 (en) | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
| AU2007249399A1 (en) * | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| RU2345763C1 (ru) * | 2007-04-26 | 2009-02-10 | ФГУ "Московский научно-исследовательский институт психиатрии Федерального агентства по здравоохранению и социальному развитию" | Способ купирования и предупреждения побочных сердечно-сосудистых явлений при применении ингибиторов фосфодиэстеразы 5-го типа для лечения расстройств эрекции у мужчин |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| US6362178B1 (en) * | 1997-11-12 | 2002-03-26 | Bayer Aktiengesellschaft | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| TWI265925B (en) * | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
| AP2002002455A0 (en) * | 1999-10-11 | 2002-06-30 | Pfizer | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors. |
| WO2002013798A2 (en) * | 2000-08-11 | 2002-02-21 | Pfizer Limited | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
-
2002
- 2002-06-26 GB GBGB0214784.1A patent/GB0214784D0/en not_active Ceased
-
2003
- 2003-06-04 GT GT200300124A patent/GT200300124A/es unknown
- 2003-06-13 PA PA20038575501A patent/PA8575501A1/es unknown
- 2003-06-16 MX MXPA04012569A patent/MXPA04012569A/es unknown
- 2003-06-16 KR KR10-2004-7021041A patent/KR20050013156A/ko not_active Ceased
- 2003-06-16 RU RU2004136276/15A patent/RU2004136276A/ru not_active Application Discontinuation
- 2003-06-16 CN CN03814574XA patent/CN1662257A/zh active Pending
- 2003-06-16 WO PCT/IB2003/002657 patent/WO2004002461A2/en not_active Ceased
- 2003-06-16 JP JP2004517093A patent/JP2005531627A/ja not_active Withdrawn
- 2003-06-16 PL PL03375079A patent/PL375079A1/xx not_active Application Discontinuation
- 2003-06-16 CA CA002491002A patent/CA2491002A1/en not_active Abandoned
- 2003-06-16 BR BR0312030-9A patent/BR0312030A/pt not_active IP Right Cessation
- 2003-06-16 EP EP03761725A patent/EP1524996A2/en not_active Withdrawn
- 2003-06-16 AU AU2003242895A patent/AU2003242895A1/en not_active Abandoned
- 2003-06-20 TW TW092116851A patent/TW200404546A/zh unknown
- 2003-06-24 PE PE2003000636A patent/PE20040868A1/es not_active Application Discontinuation
- 2003-06-24 AR ARP030102252A patent/AR040337A1/es not_active Application Discontinuation
- 2003-06-24 UY UY27863A patent/UY27863A1/es not_active Application Discontinuation
-
2004
- 2004-11-25 ZA ZA200409532A patent/ZA200409532B/en unknown
-
2005
- 2005-01-25 NO NO20050400A patent/NO20050400L/no not_active Application Discontinuation
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