JP2005530743A - 結腸の洗浄のための塩溶液 - Google Patents
結腸の洗浄のための塩溶液 Download PDFInfo
- Publication number
- JP2005530743A JP2005530743A JP2004500774A JP2004500774A JP2005530743A JP 2005530743 A JP2005530743 A JP 2005530743A JP 2004500774 A JP2004500774 A JP 2004500774A JP 2004500774 A JP2004500774 A JP 2004500774A JP 2005530743 A JP2005530743 A JP 2005530743A
- Authority
- JP
- Japan
- Prior art keywords
- grams
- composition
- effective amount
- patient
- colonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000001072 colon Anatomy 0.000 title claims abstract description 29
- 239000012266 salt solution Substances 0.000 title description 4
- 238000004140 cleaning Methods 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 68
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims description 66
- 230000000112 colonic effect Effects 0.000 claims description 26
- 239000003792 electrolyte Substances 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 229910052708 sodium Inorganic materials 0.000 claims description 15
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 230000009748 deglutition Effects 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims 11
- 239000008141 laxative Substances 0.000 abstract description 26
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 25
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 22
- 230000002475 laxative effect Effects 0.000 abstract description 17
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract description 11
- 238000001356 surgical procedure Methods 0.000 abstract description 7
- 238000002405 diagnostic procedure Methods 0.000 abstract description 6
- 206010014418 Electrolyte imbalance Diseases 0.000 abstract description 4
- 239000000819 hypertonic solution Substances 0.000 abstract description 4
- 229940021223 hypertonic solution Drugs 0.000 abstract description 4
- 230000000968 intestinal effect Effects 0.000 abstract description 3
- 239000000644 isotonic solution Substances 0.000 abstract description 3
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 abstract description 3
- 238000009472 formulation Methods 0.000 description 36
- 239000010452 phosphate Substances 0.000 description 34
- 229910019142 PO4 Inorganic materials 0.000 description 33
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 33
- 210000002966 serum Anatomy 0.000 description 18
- 239000011734 sodium Substances 0.000 description 17
- 229910052700 potassium Inorganic materials 0.000 description 15
- 235000002639 sodium chloride Nutrition 0.000 description 15
- 239000011575 calcium Substances 0.000 description 14
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 13
- 239000011591 potassium Substances 0.000 description 13
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 13
- 239000012530 fluid Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 10
- 229940084343 fleet phospho-soda Drugs 0.000 description 10
- 230000002550 fecal effect Effects 0.000 description 9
- 229940125722 laxative agent Drugs 0.000 description 9
- 239000011777 magnesium Substances 0.000 description 9
- 230000003204 osmotic effect Effects 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 8
- 229910052791 calcium Inorganic materials 0.000 description 8
- 230000037406 food intake Effects 0.000 description 8
- 230000002496 gastric effect Effects 0.000 description 8
- 229910052749 magnesium Inorganic materials 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 210000002700 urine Anatomy 0.000 description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 210000003608 fece Anatomy 0.000 description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 description 6
- 235000011152 sodium sulphate Nutrition 0.000 description 6
- 239000001103 potassium chloride Substances 0.000 description 5
- 235000011164 potassium chloride Nutrition 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 229910000162 sodium phosphate Inorganic materials 0.000 description 5
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 238000002052 colonoscopy Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000029142 excretion Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000001488 sodium phosphate Substances 0.000 description 4
- 235000011008 sodium phosphates Nutrition 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- -1 Phospho Chemical class 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 229940111504 visicol Drugs 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000013038 Hypocalcemia Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 229940056944 golytely Drugs 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
- 230000000705 hypocalcaemia Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 235000021056 liquid food Nutrition 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 201000009868 osmotic diarrhea Diseases 0.000 description 2
- 208000028719 osmotic diarrheal disease Diseases 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000015598 salt intake Nutrition 0.000 description 2
- 239000011833 salt mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000019399 Colonic disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 241001274216 Naso Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940105597 colyte Drugs 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- 235000013681 dietary sucrose Nutrition 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000003804 effect on potassium Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000003636 fecal output Effects 0.000 description 1
- 235000021554 flavoured beverage Nutrition 0.000 description 1
- 238000009541 flexible sigmoidoscopy Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 201000005991 hyperphosphatemia Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000015122 lemonade Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000020442 loss of weight Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000010446 mirabilite Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229940118092 nulytely Drugs 0.000 description 1
- 208000024896 potassium deficiency disease Diseases 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001543 purgative effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- 238000002579 sigmoidoscopy Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical group O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000002609 virtual colonoscopy Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/135,857 US6946149B2 (en) | 2002-04-30 | 2002-04-30 | Salt solution for colon cleansing |
| PCT/US2003/013133 WO2003092589A2 (en) | 2002-04-30 | 2003-04-28 | Salt solution for colon cleansing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530743A true JP2005530743A (ja) | 2005-10-13 |
| JP2005530743A5 JP2005530743A5 (enExample) | 2006-06-15 |
Family
ID=29249548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004500774A Withdrawn JP2005530743A (ja) | 2002-04-30 | 2003-04-28 | 結腸の洗浄のための塩溶液 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6946149B2 (enExample) |
| EP (3) | EP1499331B1 (enExample) |
| JP (1) | JP2005530743A (enExample) |
| AT (2) | ATE528011T1 (enExample) |
| AU (1) | AU2003231160B2 (enExample) |
| BE (1) | BE2013C049I2 (enExample) |
| CA (1) | CA2484303C (enExample) |
| CY (3) | CY1110011T1 (enExample) |
| DE (1) | DE60331220D1 (enExample) |
| DK (3) | DK2292244T3 (enExample) |
| ES (3) | ES2441890T3 (enExample) |
| FR (1) | FR13C0055I2 (enExample) |
| PT (3) | PT2233147E (enExample) |
| SI (3) | SI2292244T1 (enExample) |
| WO (1) | WO2003092589A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014513085A (ja) * | 2011-04-15 | 2014-05-29 | ブレーントリー ラボラトリーズ インコーポレーティッド | 通過時間エンハンサーとしての硫酸塩 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPS088702A0 (en) * | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| GB0224909D0 (en) * | 2002-10-25 | 2002-12-04 | Norgine Europe Bv | Colon cleansing compositions |
| JP2007511610A (ja) * | 2003-11-17 | 2007-05-10 | ブレーントリー ラボラトリーズ インコーポレーティッド | 治療用ｐｅｇ溶液濃縮物 |
| AU2015221520B2 (en) * | 2003-11-19 | 2017-06-08 | Salix Pharmaceuticals, Inc. | Colonic purgative composition with soluble binding agent |
| US7687075B2 (en) * | 2003-11-19 | 2010-03-30 | Salix Pharmaceuticals, Ltd. | Colonic purgative composition with soluble binding agent |
| US20060051428A1 (en) * | 2004-09-03 | 2006-03-09 | Nelson Ayala | Aspartame and citrate flavored phosphate salt laxative |
| US8061269B2 (en) | 2008-05-14 | 2011-11-22 | S.C. Johnson & Son, Inc. | Multilayer stencils for applying a design to a surface |
| US8557758B2 (en) | 2005-06-07 | 2013-10-15 | S.C. Johnson & Son, Inc. | Devices for applying a colorant to a surface |
| DE102005041711A1 (de) * | 2005-09-01 | 2007-03-08 | Kappstein, Ines, Prof. Dr.med. | Darmspüllösung/Darmspülpulver |
| ES2278537B1 (es) * | 2006-01-30 | 2008-09-16 | Laboratorios Casen-Fleet, S.L. | Procedimiento de fabricacion de una solucion a base de polietilenglicol con electrolitos, producto obtenido y uso. |
| US7495063B2 (en) * | 2006-02-03 | 2009-02-24 | Dow Global Technologies Inc. | Reduced oligomer concentration in high purity polyalkylene glycols |
| US7985429B2 (en) | 2006-03-03 | 2011-07-26 | C. B. Fleet Company, Inc. | Flavored colonic cleansing system |
| US7998510B2 (en) * | 2006-08-17 | 2011-08-16 | C. B. Fleet Company, Inc. | Low dose colonic cleansing system |
| USD683210S1 (en) | 2007-03-01 | 2013-05-28 | C.B. Fleet Company, Inc. | Container for colonic cleansing kit |
| US20090053304A1 (en) * | 2007-08-23 | 2009-02-26 | Jinling Chen | Composition and method of producing a taste masking formulation of laxatives for bowel cleaning preparation prior to colonoscopy |
| EP2234482B1 (en) * | 2008-01-16 | 2015-08-05 | Braintree Laboratories, Inc. | Sulfate salt prophylaxis and therapies |
| DE102008035542A1 (de) | 2008-07-30 | 2010-02-04 | Siemens Aktiengesellschaft | Verfahren zur Ermittlung von Messdaten aus dem Magen eines Patienten |
| US8778306B2 (en) * | 2009-04-21 | 2014-07-15 | Dale R. Bachwich | Colon lavage system |
| GB0913295D0 (en) | 2009-07-30 | 2009-09-02 | Norgine Bv | Improvements in and relating to pharmaceutical compositions |
| KR20130100323A (ko) * | 2010-10-08 | 2013-09-10 | 아지노모토 가부시키가이샤 | Ｃｔ 콜로노그래피에 사용되는 경구 투여용 액제 및 소화관 조영용 조성물 |
| PL2651415T3 (pl) | 2010-12-13 | 2021-04-19 | Rite-Prep Pty Ltd. | Formulacje dożołądkowe i dookrężnicze oraz sposoby ich wytwarzania i zastosowania |
| CN105963701A (zh) | 2011-01-28 | 2016-09-28 | 布伦特里实验室有限公司 | 用于肠道清洁的方法、组合物以及包装 |
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| WO2013043828A1 (en) | 2011-09-20 | 2013-03-28 | Grain Processing Corporation | Microspheres |
| CN102652759B (zh) * | 2012-05-21 | 2013-05-22 | 四川省川眉芒硝有限责任公司 | 一种含二甲基硅油的医药芒硝口服液制造工艺 |
| NZ704014A (en) | 2012-07-27 | 2017-10-27 | Redhill Biopharma Ltd | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| SG10201702005VA (en) | 2012-09-11 | 2017-04-27 | Norgine Bv | Compositions comprising peg and ascorbate |
| US20140087007A1 (en) * | 2012-09-27 | 2014-03-27 | Braintree Laboratories, Inc. | Bowel cleansing preparations |
| SI2968174T1 (sl) | 2013-03-15 | 2020-02-28 | Braintree Laboratories, Inc. | Dvojna uporaba tablet oralnega farmacevtskega sestavka sulfatnih soli in metode njihove uporabe |
| CN103405640B (zh) * | 2013-08-19 | 2015-08-26 | 姜春杰 | 一种用于晚期妊娠引产术前的清肠颗粒制备方法 |
| KR101659746B1 (ko) | 2014-01-28 | 2016-09-26 | 주식회사한국파마 | 황산염을 함유하는 장관 하제 조성물 및 이의 제조 방법 |
| MX2016014230A (es) | 2014-04-29 | 2017-05-03 | Colonaryconcepts Llc | Alimentos, sistemas, metodos y kits para proporcionar reemplazo de electrolitos. |
| EP3191105A4 (en) * | 2014-09-12 | 2018-05-02 | Braintree Laboratories, Inc. | Sulfate salt solution laxative compositions and methods of use thereof |
| KR102091852B1 (ko) | 2015-03-02 | 2020-03-23 | 코로나리콘셉츠 엘엘씨 | Peg 대사산물 및 peg 분해 생성물 검정을 위한 화합물 및 방법 |
| US10143656B1 (en) | 2017-08-04 | 2018-12-04 | Braintree Laboratories, Inc. | Solid oral sulfate salt formulations for cleaning a colon and methods of using same |
| KR102127003B1 (ko) * | 2017-10-12 | 2020-06-25 | 주식회사 한국팜비오 | 황산염을 포함하는 대장 하제 조성물 |
| KR102111094B1 (ko) * | 2018-06-18 | 2020-05-14 | 주식회사 한국팜비오 | 무수황산나트륨, 황산칼륨, 무수황산마그네슘 및 시메티콘을 포함하는 장관하제 경구투여용 고형제제 조성물 |
| US12239659B2 (en) | 2023-06-15 | 2025-03-04 | Braintree Laboratories, Inc. | Methods of administering safe colon cleansing compositions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86859A (en) * | 1987-07-10 | 1991-12-15 | E Z Em Inc | Aqueous cathartic solution containing inorganic salts |
| JP2596764B2 (ja) * | 1987-11-18 | 1997-04-02 | ルセル森下株式会社 | 腸管洗浄液剤 |
| JPH0816061B2 (ja) * | 1988-07-13 | 1996-02-21 | 森下ルセル株式会社 | 腸管洗浄液用組成物と腸管洗浄液 |
| IT1229568B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Composizione farmaceutica per uso orale adatta all'impiego nel lavaggio gastro intestinale, in particolare per uso diagnostico, oppure come lassativo catartico. |
| US5197950A (en) | 1990-07-20 | 1993-03-30 | Clayton Ralph S | Scheduled bowel management system |
| US5710183A (en) | 1995-07-14 | 1998-01-20 | Halow; George M. | Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent |
| DK0858326T3 (da) | 1996-05-08 | 2003-07-07 | Craig A Aronchick | Ikke-vandige colonafføringsmidler |
| CA2221011C (en) | 1996-11-13 | 2003-06-24 | C.B. Fleet Company, Inc. | A coated sodium phosphate bowel cleanser |
| US6162464A (en) | 1997-03-31 | 2000-12-19 | Inkine Pharmaceutical, Inc. | Non-aqueous colonic purgative formulations |
| KR100529512B1 (ko) * | 1997-04-18 | 2005-11-22 | 얀센 파마슈티카 엔.브이. | 장 세척 촉진을 위한 5ｈｔ3 길항제의 용도 |
| JP4092748B2 (ja) * | 1997-09-05 | 2008-05-28 | ニプロ株式会社 | 腸管洗浄液 |
| AU2860500A (en) * | 1999-01-29 | 2000-08-18 | Meri Charmyne Russell | Treatement of colic and gut spasm in horses and other vertebrates |
| AU2002335900A1 (en) * | 2001-10-29 | 2003-05-12 | Shimizu Pharmaceutical Co., Ltd. | Bowel cleansing agent |
-
2002
- 2002-04-30 US US10/135,857 patent/US6946149B2/en not_active Expired - Lifetime
-
2003
- 2003-04-28 EP EP03724291A patent/EP1499331B1/en not_active Expired - Lifetime
- 2003-04-28 EP EP10182219.5A patent/EP2292244B1/en not_active Expired - Lifetime
- 2003-04-28 SI SI200332326T patent/SI2292244T1/sl unknown
- 2003-04-28 CA CA2484303A patent/CA2484303C/en not_active Expired - Lifetime
- 2003-04-28 DE DE60331220T patent/DE60331220D1/de not_active Expired - Lifetime
- 2003-04-28 DK DK10182219.5T patent/DK2292244T3/da active
- 2003-04-28 AT AT10001224T patent/ATE528011T1/de active
- 2003-04-28 ES ES10182219.5T patent/ES2441890T3/es not_active Expired - Lifetime
- 2003-04-28 PT PT10001224T patent/PT2233147E/pt unknown
- 2003-04-28 WO PCT/US2003/013133 patent/WO2003092589A2/en not_active Ceased
- 2003-04-28 DK DK10001224.4T patent/DK2233147T3/da active
- 2003-04-28 ES ES10001224T patent/ES2375446T3/es not_active Expired - Lifetime
- 2003-04-28 PT PT03724291T patent/PT1499331E/pt unknown
- 2003-04-28 JP JP2004500774A patent/JP2005530743A/ja not_active Withdrawn
- 2003-04-28 AU AU2003231160A patent/AU2003231160B2/en not_active Expired
- 2003-04-28 DK DK03724291.4T patent/DK1499331T3/da active
- 2003-04-28 ES ES03724291T patent/ES2340920T3/es not_active Expired - Lifetime
- 2003-04-28 SI SI200331799T patent/SI1499331T1/sl unknown
- 2003-04-28 EP EP10001224A patent/EP2233147B1/en not_active Expired - Lifetime
- 2003-04-28 SI SI200332097T patent/SI2233147T1/sl unknown
- 2003-04-28 AT AT03724291T patent/ATE457172T1/de active
- 2003-04-28 PT PT101822195T patent/PT2292244E/pt unknown
-
2010
- 2010-05-10 CY CY20101100407T patent/CY1110011T1/el unknown
-
2012
- 2012-01-12 CY CY20121100038T patent/CY1112522T1/el unknown
-
2013
- 2013-07-17 BE BE2013C049C patent/BE2013C049I2/fr unknown
- 2013-09-25 FR FR13C0055C patent/FR13C0055I2/fr active Active
-
2014
- 2014-01-07 CY CY20141100004T patent/CY1114745T1/el unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014513085A (ja) * | 2011-04-15 | 2014-05-29 | ブレーントリー ラボラトリーズ インコーポレーティッド | 通過時間エンハンサーとしての硫酸塩 |
| JP2016155833A (ja) * | 2011-04-15 | 2016-09-01 | ブレーントリー ラボラトリーズ インコーポレーティッド | 通過時間エンハンサーとしての硫酸塩 |
| JP2017200948A (ja) * | 2011-04-15 | 2017-11-09 | ブレーントリー ラボラトリーズ インコーポレーティッド | 通過時間エンハンサーとしての硫酸塩 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005530743A (ja) | 結腸の洗浄のための塩溶液 | |
| CN103391790B (zh) | 用于肠道清洁的方法、组合物以及包装 | |
| JP4784770B2 (ja) | 結腸洗浄組成物 | |
| US20110293747A1 (en) | Colon cleansing solution | |
| JP6655391B2 (ja) | Ｐｅｇとアスコルビン酸塩とを含む組成物 | |
| AU2010239378B2 (en) | Colon lavage system | |
| US9149493B2 (en) | Compositions for bowel cleansing and use thereof | |
| CN103237563A (zh) | Ct结肠成像中使用的口服给药用液剂及消化道造影用组合物 | |
| EP2322190B1 (en) | Compositions for bowel cleansing and use thereof | |
| HK1148935B (en) | Salt solution for colon cleansing | |
| HK1154492B (en) | Salt solution for colon cleansing | |
| WO2011049943A1 (en) | Method and kit for gastro-intestinal cleansing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20060426 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060426 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20060426 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20090223 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20090223 |