ES2340920T3 - Solucion salina para limpieza de colon. - Google Patents
Solucion salina para limpieza de colon. Download PDFInfo
- Publication number
- ES2340920T3 ES2340920T3 ES03724291T ES03724291T ES2340920T3 ES 2340920 T3 ES2340920 T3 ES 2340920T3 ES 03724291 T ES03724291 T ES 03724291T ES 03724291 T ES03724291 T ES 03724291T ES 2340920 T3 ES2340920 T3 ES 2340920T3
- Authority
- ES
- Spain
- Prior art keywords
- colon
- grams
- solution
- phosphate
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000001072 colon Anatomy 0.000 title claims abstract description 47
- 238000004140 cleaning Methods 0.000 title description 6
- 239000000203 mixture Substances 0.000 claims abstract description 47
- 239000000243 solution Substances 0.000 claims description 69
- 238000010926 purge Methods 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims 6
- 239000007832 Na2SO4 Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 25
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 22
- 239000008141 laxative Substances 0.000 abstract description 18
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract description 6
- 238000002405 diagnostic procedure Methods 0.000 abstract description 5
- 238000001356 surgical procedure Methods 0.000 abstract description 5
- 230000002475 laxative effect Effects 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 3
- 206010014418 Electrolyte imbalance Diseases 0.000 abstract description 2
- 230000000112 colonic effect Effects 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 description 30
- 235000021317 phosphate Nutrition 0.000 description 30
- 239000010452 phosphate Substances 0.000 description 28
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 28
- 239000003792 electrolyte Substances 0.000 description 25
- 238000009472 formulation Methods 0.000 description 21
- 210000002966 serum Anatomy 0.000 description 18
- 239000011734 sodium Substances 0.000 description 17
- 150000003839 salts Chemical class 0.000 description 16
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 16
- 229910052700 potassium Inorganic materials 0.000 description 15
- 239000011575 calcium Substances 0.000 description 14
- 230000037406 food intake Effects 0.000 description 14
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 13
- 239000011591 potassium Substances 0.000 description 13
- 230000001543 purgative effect Effects 0.000 description 11
- 229910052708 sodium Inorganic materials 0.000 description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 10
- 230000002550 fecal effect Effects 0.000 description 10
- 230000002496 gastric effect Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 229940084343 fleet phospho-soda Drugs 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000011777 magnesium Substances 0.000 description 9
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 8
- 229910052791 calcium Inorganic materials 0.000 description 8
- 230000008030 elimination Effects 0.000 description 8
- 238000003379 elimination reaction Methods 0.000 description 8
- 229910052749 magnesium Inorganic materials 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
- 230000004075 alteration Effects 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000001103 potassium chloride Substances 0.000 description 5
- 235000011164 potassium chloride Nutrition 0.000 description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 238000002052 colonoscopy Methods 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 229940125722 laxative agent Drugs 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000001488 sodium phosphate Substances 0.000 description 4
- 235000011008 sodium phosphates Nutrition 0.000 description 4
- 239000013011 aqueous formulation Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- 229940111504 visicol Drugs 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000013038 Hypocalcemia Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229940056944 golytely Drugs 0.000 description 2
- 230000000705 hypocalcaemia Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 201000009868 osmotic diarrhea Diseases 0.000 description 2
- 208000028719 osmotic diarrheal disease Diseases 0.000 description 2
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000002579 sigmoidoscopy Methods 0.000 description 2
- ZPFAVCIQZKRBGF-UHFFFAOYSA-N 1,3,2-dioxathiolane 2,2-dioxide Chemical compound O=S1(=O)OCCO1 ZPFAVCIQZKRBGF-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- -1 HCO 3 Inorganic materials 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000012174 carbonated soft drink Nutrition 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229940105597 colyte Drugs 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 229940021013 electrolyte solution Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 201000005991 hyperphosphatemia Diseases 0.000 description 1
- 239000000819 hypertonic solution Substances 0.000 description 1
- 229940021223 hypertonic solution Drugs 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000015122 lemonade Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000020442 loss of weight Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229940118092 nulytely Drugs 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 235000020245 plant milk Nutrition 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 208000024896 potassium deficiency disease Diseases 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
- 238000002609 virtual colonoscopy Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US135857 | 2002-04-30 | ||
| US10/135,857 US6946149B2 (en) | 2002-04-30 | 2002-04-30 | Salt solution for colon cleansing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2340920T3 true ES2340920T3 (es) | 2010-06-11 |
Family
ID=29249548
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03724291T Expired - Lifetime ES2340920T3 (es) | 2002-04-30 | 2003-04-28 | Solucion salina para limpieza de colon. |
| ES10001224T Expired - Lifetime ES2375446T3 (es) | 2002-04-30 | 2003-04-28 | Solución salina para limpieza del colon. |
| ES10182219.5T Expired - Lifetime ES2441890T3 (es) | 2002-04-30 | 2003-04-28 | Solución salina para limpieza del colon |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10001224T Expired - Lifetime ES2375446T3 (es) | 2002-04-30 | 2003-04-28 | Solución salina para limpieza del colon. |
| ES10182219.5T Expired - Lifetime ES2441890T3 (es) | 2002-04-30 | 2003-04-28 | Solución salina para limpieza del colon |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6946149B2 (enExample) |
| EP (3) | EP2292244B1 (enExample) |
| JP (1) | JP2005530743A (enExample) |
| AT (2) | ATE457172T1 (enExample) |
| AU (1) | AU2003231160B2 (enExample) |
| BE (1) | BE2013C049I2 (enExample) |
| CA (1) | CA2484303C (enExample) |
| CY (3) | CY1110011T1 (enExample) |
| DE (1) | DE60331220D1 (enExample) |
| DK (3) | DK2233147T3 (enExample) |
| ES (3) | ES2340920T3 (enExample) |
| FR (1) | FR13C0055I2 (enExample) |
| PT (3) | PT2233147E (enExample) |
| SI (3) | SI1499331T1 (enExample) |
| WO (1) | WO2003092589A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPS088702A0 (en) * | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| GB0224909D0 (en) * | 2002-10-25 | 2002-12-04 | Norgine Europe Bv | Colon cleansing compositions |
| WO2005049049A1 (en) * | 2003-11-17 | 2005-06-02 | Braintree Laboratories, Inc. | Therapeutic peg solution concentrate |
| US7687075B2 (en) * | 2003-11-19 | 2010-03-30 | Salix Pharmaceuticals, Ltd. | Colonic purgative composition with soluble binding agent |
| AU2015221520B2 (en) * | 2003-11-19 | 2017-06-08 | Salix Pharmaceuticals, Inc. | Colonic purgative composition with soluble binding agent |
| US20060051428A1 (en) * | 2004-09-03 | 2006-03-09 | Nelson Ayala | Aspartame and citrate flavored phosphate salt laxative |
| US8557758B2 (en) | 2005-06-07 | 2013-10-15 | S.C. Johnson & Son, Inc. | Devices for applying a colorant to a surface |
| US8061269B2 (en) | 2008-05-14 | 2011-11-22 | S.C. Johnson & Son, Inc. | Multilayer stencils for applying a design to a surface |
| DE102005041711A1 (de) * | 2005-09-01 | 2007-03-08 | Kappstein, Ines, Prof. Dr.med. | Darmspüllösung/Darmspülpulver |
| ES2278537B1 (es) * | 2006-01-30 | 2008-09-16 | Laboratorios Casen-Fleet, S.L. | Procedimiento de fabricacion de una solucion a base de polietilenglicol con electrolitos, producto obtenido y uso. |
| US7495063B2 (en) * | 2006-02-03 | 2009-02-24 | Dow Global Technologies Inc. | Reduced oligomer concentration in high purity polyalkylene glycols |
| US7985429B2 (en) | 2006-03-03 | 2011-07-26 | C. B. Fleet Company, Inc. | Flavored colonic cleansing system |
| US7998510B2 (en) | 2006-08-17 | 2011-08-16 | C. B. Fleet Company, Inc. | Low dose colonic cleansing system |
| USD683210S1 (en) | 2007-03-01 | 2013-05-28 | C.B. Fleet Company, Inc. | Container for colonic cleansing kit |
| US20090053304A1 (en) * | 2007-08-23 | 2009-02-26 | Jinling Chen | Composition and method of producing a taste masking formulation of laxatives for bowel cleaning preparation prior to colonoscopy |
| EP2234482B1 (en) * | 2008-01-16 | 2015-08-05 | Braintree Laboratories, Inc. | Sulfate salt prophylaxis and therapies |
| DE102008035542A1 (de) * | 2008-07-30 | 2010-02-04 | Siemens Aktiengesellschaft | Verfahren zur Ermittlung von Messdaten aus dem Magen eines Patienten |
| WO2010123901A1 (en) * | 2009-04-21 | 2010-10-28 | Bachwich Dale R | Colon lavage system |
| GB0913295D0 (en) | 2009-07-30 | 2009-09-02 | Norgine Bv | Improvements in and relating to pharmaceutical compositions |
| WO2012046847A1 (ja) * | 2010-10-08 | 2012-04-12 | 味の素株式会社 | Ｃｔコロノグラフィに用いられる経口投与用液剤及び消化管造影用組成物 |
| BR112013014827A2 (pt) | 2010-12-13 | 2016-10-04 | Antony Wettstein | formulações gástricas e colônicas e métodos para produzir e usar as mesmas |
| CN103391790B (zh) | 2011-01-28 | 2016-06-15 | 布伦特里实验室有限公司 | 用于肠道清洁的方法、组合物以及包装 |
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| PT2696690T (pt) * | 2011-04-15 | 2017-12-22 | Braintree Laboratories Inc | Sais de sulfato como potenciador de tempo de trânsito |
| US9918942B2 (en) | 2011-09-20 | 2018-03-20 | Grain Processing Corporation | Microspheres |
| CN102652759B (zh) * | 2012-05-21 | 2013-05-22 | 四川省川眉芒硝有限责任公司 | 一种含二甲基硅油的医药芒硝口服液制造工艺 |
| NZ704014A (en) | 2012-07-27 | 2017-10-27 | Redhill Biopharma Ltd | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| BR112015005270B1 (pt) | 2012-09-11 | 2022-11-01 | Norgine Bv | Composição para mistura com água, solução de limpeza de cólon, seus usos e seu kit |
| US20140087007A1 (en) * | 2012-09-27 | 2014-03-27 | Braintree Laboratories, Inc. | Bowel cleansing preparations |
| EA034234B1 (ru) | 2013-03-15 | 2020-01-20 | Брейнтри Лабораторис, Инк. | Пероральные фармацевтические таблетированные композиции двойного применения, содержащие сульфат натрия или его комбинацию с другими сульфатными солями, и способы их получения и применения |
| CN103405640B (zh) * | 2013-08-19 | 2015-08-26 | 姜春杰 | 一种用于晚期妊娠引产术前的清肠颗粒制备方法 |
| KR101659746B1 (ko) | 2014-01-28 | 2016-09-26 | 주식회사한국파마 | 황산염을 함유하는 장관 하제 조성물 및 이의 제조 방법 |
| EP3137167A4 (en) | 2014-04-29 | 2017-12-20 | Colonaryconcepts LLC | Foods, systems, methods, and kits for providing electrolyte replacement |
| EP3191105A4 (en) * | 2014-09-12 | 2018-05-02 | Braintree Laboratories, Inc. | Sulfate salt solution laxative compositions and methods of use thereof |
| HK1247283A1 (zh) | 2015-03-02 | 2018-09-21 | 科罗纳里康赛普茨有限责任公司 | 用於peg代谢物及peg分解产物检测的化合物及方法 |
| US10143656B1 (en) | 2017-08-04 | 2018-12-04 | Braintree Laboratories, Inc. | Solid oral sulfate salt formulations for cleaning a colon and methods of using same |
| KR102127003B1 (ko) * | 2017-10-12 | 2020-06-25 | 주식회사 한국팜비오 | 황산염을 포함하는 대장 하제 조성물 |
| KR102111094B1 (ko) * | 2018-06-18 | 2020-05-14 | 주식회사 한국팜비오 | 무수황산나트륨, 황산칼륨, 무수황산마그네슘 및 시메티콘을 포함하는 장관하제 경구투여용 고형제제 조성물 |
| US12239659B2 (en) | 2023-06-15 | 2025-03-04 | Braintree Laboratories, Inc. | Methods of administering safe colon cleansing compositions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86859A (en) * | 1987-07-10 | 1991-12-15 | E Z Em Inc | Aqueous cathartic solution containing inorganic salts |
| JP2596764B2 (ja) * | 1987-11-18 | 1997-04-02 | ルセル森下株式会社 | 腸管洗浄液剤 |
| JPH0816061B2 (ja) * | 1988-07-13 | 1996-02-21 | 森下ルセル株式会社 | 腸管洗浄液用組成物と腸管洗浄液 |
| IT1229568B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Composizione farmaceutica per uso orale adatta all'impiego nel lavaggio gastro intestinale, in particolare per uso diagnostico, oppure come lassativo catartico. |
| US5197950A (en) | 1990-07-20 | 1993-03-30 | Clayton Ralph S | Scheduled bowel management system |
| US5710183A (en) | 1995-07-14 | 1998-01-20 | Halow; George M. | Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent |
| ATE235894T1 (de) | 1996-05-08 | 2003-04-15 | Craig A Aronchick | Nichtwässrige abführmittel für den kolon |
| ATE201824T1 (de) | 1996-11-13 | 2001-06-15 | Cb Fleet Co Inc | Darmreiniger auf basis von umhülltem natriumphosphat |
| US6162464A (en) | 1997-03-31 | 2000-12-19 | Inkine Pharmaceutical, Inc. | Non-aqueous colonic purgative formulations |
| AU745361B2 (en) * | 1997-04-18 | 2002-03-21 | Janssen Pharmaceutica N.V. | Use of 5HT3 antagonists for promoting intestinal lavage |
| JP4092748B2 (ja) * | 1997-09-05 | 2008-05-28 | ニプロ株式会社 | 腸管洗浄液 |
| AU2860500A (en) * | 1999-01-29 | 2000-08-18 | Meri Charmyne Russell | Treatement of colic and gut spasm in horses and other vertebrates |
| AU2002335900A1 (en) * | 2001-10-29 | 2003-05-12 | Shimizu Pharmaceutical Co., Ltd. | Bowel cleansing agent |
-
2002
- 2002-04-30 US US10/135,857 patent/US6946149B2/en not_active Expired - Lifetime
-
2003
- 2003-04-28 WO PCT/US2003/013133 patent/WO2003092589A2/en not_active Ceased
- 2003-04-28 PT PT10001224T patent/PT2233147E/pt unknown
- 2003-04-28 SI SI200331799T patent/SI1499331T1/sl unknown
- 2003-04-28 ES ES03724291T patent/ES2340920T3/es not_active Expired - Lifetime
- 2003-04-28 DK DK10001224.4T patent/DK2233147T3/da active
- 2003-04-28 DE DE60331220T patent/DE60331220D1/de not_active Expired - Lifetime
- 2003-04-28 EP EP10182219.5A patent/EP2292244B1/en not_active Expired - Lifetime
- 2003-04-28 AT AT03724291T patent/ATE457172T1/de active
- 2003-04-28 DK DK10182219.5T patent/DK2292244T3/da active
- 2003-04-28 AT AT10001224T patent/ATE528011T1/de active
- 2003-04-28 SI SI200332326T patent/SI2292244T1/sl unknown
- 2003-04-28 PT PT101822195T patent/PT2292244E/pt unknown
- 2003-04-28 DK DK03724291.4T patent/DK1499331T3/da active
- 2003-04-28 ES ES10001224T patent/ES2375446T3/es not_active Expired - Lifetime
- 2003-04-28 AU AU2003231160A patent/AU2003231160B2/en not_active Expired
- 2003-04-28 EP EP03724291A patent/EP1499331B1/en not_active Expired - Lifetime
- 2003-04-28 JP JP2004500774A patent/JP2005530743A/ja not_active Withdrawn
- 2003-04-28 CA CA2484303A patent/CA2484303C/en not_active Expired - Lifetime
- 2003-04-28 ES ES10182219.5T patent/ES2441890T3/es not_active Expired - Lifetime
- 2003-04-28 EP EP10001224A patent/EP2233147B1/en not_active Expired - Lifetime
- 2003-04-28 PT PT03724291T patent/PT1499331E/pt unknown
- 2003-04-28 SI SI200332097T patent/SI2233147T1/sl unknown
-
2010
- 2010-05-10 CY CY20101100407T patent/CY1110011T1/el unknown
-
2012
- 2012-01-12 CY CY20121100038T patent/CY1112522T1/el unknown
-
2013
- 2013-07-17 BE BE2013C049C patent/BE2013C049I2/fr unknown
- 2013-09-25 FR FR13C0055C patent/FR13C0055I2/fr active Active
-
2014
- 2014-01-07 CY CY20141100004T patent/CY1114745T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2375446T3 (es) | Solución salina para limpieza del colon. | |
| JP7277396B2 (ja) | Ｐｅｇとアスコルビン酸塩とを含む組成物 | |
| JP5870119B2 (ja) | 腸洗浄のための、方法、組成物、およびパッケージ | |
| ES2761297T3 (es) | Sistema de lavado de colon | |
| ES2285970T3 (es) | Composiciones de limpieza del colon. | |
| JP6678635B2 (ja) | 大腸内視鏡検査前処置 | |
| US20090258090A1 (en) | Colon cleansing solution | |
| US9149493B2 (en) | Compositions for bowel cleansing and use thereof | |
| ES2409842T3 (es) | Composiciones para la limpieza intestinal y uso de las mismas | |
| CN103237563A (zh) | Ct结肠成像中使用的口服给药用液剂及消化道造影用组合物 | |
| JPH03284620A (ja) | 腸管洗浄用組成物 | |
| ES2928719T3 (es) | Procedimiento de limpieza del colon | |
| HK1148935B (en) | Salt solution for colon cleansing | |
| HK1154492B (en) | Salt solution for colon cleansing | |
| CN121358468A (zh) | 用于肠道清洁产品中的固体形式的盐的漂浮药物递送系统 |