JP2005529098A - 抗コリン作用薬及びｐ３８キナーゼ阻害剤を用いた新規な医薬組成物 - Google Patents

抗コリン作用薬及びｐ３８キナーゼ阻害剤を用いた新規な医薬組成物 Download PDF

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JP2005529098A
JP2005529098A JP2003581779A JP2003581779A JP2005529098A JP 2005529098 A JP2005529098 A JP 2005529098A JP 2003581779 A JP2003581779 A JP 2003581779A JP 2003581779 A JP2003581779 A JP 2003581779A JP 2005529098 A JP2005529098 A JP 2005529098A
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alkyl
carbon atoms
phenyl
substituted
amino
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JP2005529098A5 (enExample
Inventor
ビルギット ユング
ミシェル ペレ
ミヒャエル ピー ピーパー
ハンス クレメンス ライザー
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ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Organic Chemistry (AREA)
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  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2003581779A 2002-04-10 2003-04-08 抗コリン作用薬及びｐ３８キナーゼ阻害剤を用いた新規な医薬組成物 Pending JP2005529098A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37151402P 2002-04-10 2002-04-10
PCT/EP2003/003624 WO2003084539A2 (en) 2002-04-10 2003-04-08 New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2005529098A true JP2005529098A (ja) 2005-09-29
JP2005529098A5 JP2005529098A5 (enExample) 2006-06-01

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US (1) US20030225089A1 (enExample)
EP (1) EP1496900A2 (enExample)
JP (1) JP2005529098A (enExample)
KR (1) KR20050006149A (enExample)
CN (1) CN1658873A (enExample)
AR (1) AR039273A1 (enExample)
AU (1) AU2003224048A1 (enExample)
BR (1) BR0309099A (enExample)
CA (1) CA2479522A1 (enExample)
MX (1) MXPA04009772A (enExample)
PE (1) PE20040325A1 (enExample)
PL (1) PL372620A1 (enExample)
RU (1) RU2004133034A (enExample)
TW (1) TW200307681A (enExample)
UY (1) UY27755A1 (enExample)
WO (1) WO2003084539A2 (enExample)
ZA (1) ZA200407058B (enExample)

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AU2019216351B2 (en) 2018-01-31 2024-07-25 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
CN111818915B (zh) 2018-01-31 2024-05-24 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
TWI878335B (zh) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
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RU2004133034A (ru) 2006-06-20
CN1658873A (zh) 2005-08-24
PL372620A1 (en) 2005-07-25
KR20050006149A (ko) 2005-01-15
MXPA04009772A (es) 2004-12-13
TW200307681A (en) 2003-12-16
AR039273A1 (es) 2005-02-16
WO2003084539A3 (en) 2004-09-02
PE20040325A1 (es) 2004-07-08
EP1496900A2 (en) 2005-01-19
WO2003084539A2 (en) 2003-10-16
CA2479522A1 (en) 2003-10-16
US20030225089A1 (en) 2003-12-04
UY27755A1 (es) 2003-11-28
AU2003224048A1 (en) 2003-10-20

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