JP2005526778A - 免疫調節性非コードｒｎａモチーフを用いて抗体及び主要組織適合性クラスｉ拘束性又はクラスｉｉ拘束性ｔ細胞の応答を開始或いは増強させるための組成物及び方法 - Google Patents
免疫調節性非コードｒｎａモチーフを用いて抗体及び主要組織適合性クラスｉ拘束性又はクラスｉｉ拘束性ｔ細胞の応答を開始或いは増強させるための組成物及び方法 Download PDFInfo
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36449002P | 2002-03-15 | 2002-03-15 | |
| US41221902P | 2002-09-20 | 2002-09-20 | |
| PCT/US2003/007995 WO2003078595A2 (en) | 2002-03-15 | 2003-03-14 | Immunostimulatory double stranded rna and methods of inducing, enhancing or modulating the immune response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526778A true JP2005526778A (ja) | 2005-09-08 |
| JP2005526778A5 JP2005526778A5 (enExample) | 2006-04-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003576589A Pending JP2005526778A (ja) | 2002-03-15 | 2003-03-14 | 免疫調節性非コードｒｎａモチーフを用いて抗体及び主要組織適合性クラスｉ拘束性又はクラスｉｉ拘束性ｔ細胞の応答を開始或いは増強させるための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050222060A1 (enExample) |
| EP (1) | EP1485403A4 (enExample) |
| JP (1) | JP2005526778A (enExample) |
| AU (1) | AU2003218181A1 (enExample) |
| CA (1) | CA2479187A1 (enExample) |
| WO (1) | WO2003078595A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500011A (ja) * | 2006-08-08 | 2010-01-07 | ガンサー ハートマン | ５’リン酸オリゴヌクレオチドの構造および使用 |
| US9399658B2 (en) | 2011-03-28 | 2016-07-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| US10059943B2 (en) | 2012-09-27 | 2018-08-28 | Rheinische Friedrich-Wilhelms-Universität Bonn | RIG-I ligands and methods for producing them |
| KR20200116976A (ko) * | 2018-02-02 | 2020-10-13 | 유니버시티 오브 워싱톤 | 트리파르타이트 모티프 함유 단백질 16(trim16) 신호전달을 유도하기 위한 조성물 및 방법 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258712A3 (en) * | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs |
| CA2520181A1 (en) | 2003-03-26 | 2004-10-14 | Astral Inc. | Selected rna motifs to include cell death and/or apoptosis |
| AU2008266910A1 (en) * | 2007-06-18 | 2008-12-24 | Hemispherx Biopharma, Inc. | Early intervention of viral infections with immune activators |
| CA2708956C (en) | 2007-12-18 | 2018-07-17 | Athera Biotechnologies Ab | Use of annexin a5 for the treatment of vascular disease |
| EP2281043B1 (en) | 2008-04-25 | 2013-03-13 | Innate Pharma | Improved tlr3 agonist compositions |
| HRP20230443T1 (hr) * | 2011-05-24 | 2023-09-15 | BioNTech SE | Individualizirana cjepiva protiv raka |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
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| US3906092A (en) * | 1971-11-26 | 1975-09-16 | Merck & Co Inc | Stimulation of antibody response |
| US5906980A (en) * | 1987-07-17 | 1999-05-25 | Hem Research Inc. | Treatment of hepatitis with mismatched dsRNA |
| US5683986A (en) * | 1987-08-12 | 1997-11-04 | Hemispherx Biopharma Inc. | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment |
| US5593973A (en) * | 1987-09-04 | 1997-01-14 | Hemispherx Biopharma Inc. | Treatment of viral hepatitis with mismatched dsRNA |
| DE69023900T4 (de) * | 1989-02-24 | 1996-10-02 | The Regents Of The University Of California, Berkeley, Calif. | Gentechnologisch veränderte immunglobuline. |
| US5612035A (en) * | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| ZA908037B (en) * | 1989-10-11 | 1991-09-25 | Hem Res Inc | Protection from shock subsequent to injury by double-standed rnas |
| US5998366A (en) * | 1990-09-21 | 1999-12-07 | The Regents Of The University Of California | Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US5696109A (en) * | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| WO1995026204A1 (en) * | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| HU221385B1 (en) * | 1994-07-13 | 2002-09-28 | Chugai Pharmaceutical Co Ltd | Reconstituted human antibody against human interleukin-8 |
| ES2366201T3 (es) * | 1994-07-15 | 2011-10-18 | University Of Iowa Research Foundation | Oligonucleótidos inmunmoduladores. |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5698679A (en) * | 1994-09-19 | 1997-12-16 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for targeting an immune response |
| US5736524A (en) * | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| GB9501079D0 (en) * | 1995-01-19 | 1995-03-08 | Bioinvent Int Ab | Activation of T-cells |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| CA2301575C (en) * | 1997-05-20 | 2003-12-23 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| TW589189B (en) * | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| KR20000034847A (ko) * | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| US6514948B1 (en) * | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
| CA2390031A1 (en) * | 1999-11-02 | 2001-05-25 | Chiron Corporation | Double-stranded rna receptor (dsrna-r) and methods relating thereto |
| JP4304900B2 (ja) * | 2000-05-25 | 2009-07-29 | 富士ゼロックス株式会社 | 画像形成方法 |
| US20040052763A1 (en) * | 2000-06-07 | 2004-03-18 | Mond James J. | Immunostimulatory RNA/DNA hybrid molecules |
-
2003
- 2003-03-14 WO PCT/US2003/007995 patent/WO2003078595A2/en not_active Ceased
- 2003-03-14 AU AU2003218181A patent/AU2003218181A1/en not_active Abandoned
- 2003-03-14 CA CA002479187A patent/CA2479187A1/en not_active Abandoned
- 2003-03-14 JP JP2003576589A patent/JP2005526778A/ja active Pending
- 2003-03-14 EP EP03714172A patent/EP1485403A4/en not_active Withdrawn
- 2003-03-14 US US10/507,942 patent/US20050222060A1/en not_active Abandoned
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010500011A (ja) * | 2006-08-08 | 2010-01-07 | ガンサー ハートマン | ５’リン酸オリゴヌクレオチドの構造および使用 |
| JP2014207906A (ja) * | 2006-08-08 | 2014-11-06 | ライニッシュフリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン | ５’リン酸オリゴヌクレオチドの構造および使用 |
| US9381208B2 (en) | 2006-08-08 | 2016-07-05 | Rheinische Friedrich-Wilhelms-Universität | Structure and use of 5′ phosphate oligonucleotides |
| US10238682B2 (en) | 2006-08-08 | 2019-03-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5′ phosphate oligonucleotides |
| US10196638B2 (en) | 2008-05-21 | 2019-02-05 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| US10036021B2 (en) | 2008-05-21 | 2018-07-31 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| US9896689B2 (en) | 2011-03-28 | 2018-02-20 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| US9399658B2 (en) | 2011-03-28 | 2016-07-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| US10059943B2 (en) | 2012-09-27 | 2018-08-28 | Rheinische Friedrich-Wilhelms-Universität Bonn | RIG-I ligands and methods for producing them |
| US10072262B2 (en) | 2012-09-27 | 2018-09-11 | Rheinische Friedrich-Wilhelms-Universität Bonn | RIG-I ligands and methods for producing them |
| US11142763B2 (en) | 2012-09-27 | 2021-10-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | RIG-I ligands and methods for producing them |
| KR20200116976A (ko) * | 2018-02-02 | 2020-10-13 | 유니버시티 오브 워싱톤 | 트리파르타이트 모티프 함유 단백질 16(trim16) 신호전달을 유도하기 위한 조성물 및 방법 |
| KR102828978B1 (ko) | 2018-02-02 | 2025-07-02 | 유니버시티 오브 워싱톤 | 트리파르타이트 모티프 함유 단백질 16(trim16) 신호전달을 유도하기 위한 조성물 및 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003078595B1 (en) | 2004-05-21 |
| CA2479187A1 (en) | 2003-09-25 |
| WO2003078595A2 (en) | 2003-09-25 |
| EP1485403A2 (en) | 2004-12-15 |
| US20050222060A1 (en) | 2005-10-06 |
| EP1485403A4 (en) | 2007-08-08 |
| WO2003078595A3 (en) | 2004-01-22 |
| HK1089773A1 (zh) | 2006-12-08 |
| AU2003218181A1 (en) | 2003-09-29 |
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