JP2005526778A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005526778A5 JP2005526778A5 JP2003576589A JP2003576589A JP2005526778A5 JP 2005526778 A5 JP2005526778 A5 JP 2005526778A5 JP 2003576589 A JP2003576589 A JP 2003576589A JP 2003576589 A JP2003576589 A JP 2003576589A JP 2005526778 A5 JP2005526778 A5 JP 2005526778A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- composition
- double
- stranded rna
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 11
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 11
- 208000015181 infectious disease Diseases 0.000 claims 4
- 230000002458 infectious effect Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 1
- 210000000447 Th1 cell Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36449002P | 2002-03-15 | 2002-03-15 | |
| US41221902P | 2002-09-20 | 2002-09-20 | |
| PCT/US2003/007995 WO2003078595A2 (en) | 2002-03-15 | 2003-03-14 | Immunostimulatory double stranded rna and methods of inducing, enhancing or modulating the immune response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526778A JP2005526778A (ja) | 2005-09-08 |
| JP2005526778A5 true JP2005526778A5 (enExample) | 2006-04-27 |
Family
ID=28045408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003576589A Pending JP2005526778A (ja) | 2002-03-15 | 2003-03-14 | 免疫調節性非コードrnaモチーフを用いて抗体及び主要組織適合性クラスi拘束性又はクラスii拘束性t細胞の応答を開始或いは増強させるための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050222060A1 (enExample) |
| EP (1) | EP1485403A4 (enExample) |
| JP (1) | JP2005526778A (enExample) |
| AU (1) | AU2003218181A1 (enExample) |
| CA (1) | CA2479187A1 (enExample) |
| WO (1) | WO2003078595A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258712A3 (en) * | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs |
| CA2520181A1 (en) | 2003-03-26 | 2004-10-14 | Astral Inc. | Selected rna motifs to include cell death and/or apoptosis |
| WO2008017473A2 (en) * | 2006-08-08 | 2008-02-14 | Gunther Hartmann | Structure and use of 5' phosphate oligonucleotides |
| AU2008266910A1 (en) * | 2007-06-18 | 2008-12-24 | Hemispherx Biopharma, Inc. | Early intervention of viral infections with immune activators |
| CA2708956C (en) | 2007-12-18 | 2018-07-17 | Athera Biotechnologies Ab | Use of annexin a5 for the treatment of vascular disease |
| EP2281043B1 (en) | 2008-04-25 | 2013-03-13 | Innate Pharma | Improved tlr3 agonist compositions |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| HRP20230443T1 (hr) * | 2011-05-24 | 2023-09-15 | BioNTech SE | Individualizirana cjepiva protiv raka |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| EP3746088B1 (en) * | 2018-02-02 | 2024-07-10 | University of Washington | Compositions and methods for inducing tripartite motif-containing protein 16 (trim16) signaling |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3906092A (en) * | 1971-11-26 | 1975-09-16 | Merck & Co Inc | Stimulation of antibody response |
| US5906980A (en) * | 1987-07-17 | 1999-05-25 | Hem Research Inc. | Treatment of hepatitis with mismatched dsRNA |
| US5683986A (en) * | 1987-08-12 | 1997-11-04 | Hemispherx Biopharma Inc. | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment |
| US5593973A (en) * | 1987-09-04 | 1997-01-14 | Hemispherx Biopharma Inc. | Treatment of viral hepatitis with mismatched dsRNA |
| DE69023900T4 (de) * | 1989-02-24 | 1996-10-02 | The Regents Of The University Of California, Berkeley, Calif. | Gentechnologisch veränderte immunglobuline. |
| US5612035A (en) * | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| ZA908037B (en) * | 1989-10-11 | 1991-09-25 | Hem Res Inc | Protection from shock subsequent to injury by double-standed rnas |
| US5998366A (en) * | 1990-09-21 | 1999-12-07 | The Regents Of The University Of California | Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US5696109A (en) * | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| WO1995026204A1 (en) * | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| HU221385B1 (en) * | 1994-07-13 | 2002-09-28 | Chugai Pharmaceutical Co Ltd | Reconstituted human antibody against human interleukin-8 |
| ES2366201T3 (es) * | 1994-07-15 | 2011-10-18 | University Of Iowa Research Foundation | Oligonucleótidos inmunmoduladores. |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5698679A (en) * | 1994-09-19 | 1997-12-16 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for targeting an immune response |
| US5736524A (en) * | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| GB9501079D0 (en) * | 1995-01-19 | 1995-03-08 | Bioinvent Int Ab | Activation of T-cells |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| CA2301575C (en) * | 1997-05-20 | 2003-12-23 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| TW589189B (en) * | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| KR20000034847A (ko) * | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| US6514948B1 (en) * | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
| CA2390031A1 (en) * | 1999-11-02 | 2001-05-25 | Chiron Corporation | Double-stranded rna receptor (dsrna-r) and methods relating thereto |
| JP4304900B2 (ja) * | 2000-05-25 | 2009-07-29 | 富士ゼロックス株式会社 | 画像形成方法 |
| US20040052763A1 (en) * | 2000-06-07 | 2004-03-18 | Mond James J. | Immunostimulatory RNA/DNA hybrid molecules |
-
2003
- 2003-03-14 WO PCT/US2003/007995 patent/WO2003078595A2/en not_active Ceased
- 2003-03-14 AU AU2003218181A patent/AU2003218181A1/en not_active Abandoned
- 2003-03-14 CA CA002479187A patent/CA2479187A1/en not_active Abandoned
- 2003-03-14 JP JP2003576589A patent/JP2005526778A/ja active Pending
- 2003-03-14 EP EP03714172A patent/EP1485403A4/en not_active Withdrawn
- 2003-03-14 US US10/507,942 patent/US20050222060A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005526778A5 (enExample) | ||
| NO20015073D0 (no) | Vaksiner | |
| Abou-Alfa et al. | The antiangiogenic ceiling in hepatocellular carcinoma: does it exist and has it been reached? | |
| FI1897548T4 (fi) | T-solujen säätely | |
| WO2006050250A3 (en) | Dose forms comprising vx-950 and their dosage regimen | |
| NZ597915A (en) | Combination therapy for treatment of immune disorders | |
| DE502004005154D1 (de) | Multipartikuläre arzneiform, enthaltend mucoadhaesiv formulierte peptid- oder protein-wirkstoffe, sowie ein verfahren zur herstellung der arzneiform | |
| WO2006041866A3 (en) | Prevention and treatment of hcv infection employing antibodies directed against conformational and linear epitopes | |
| IL276515B1 (en) | PD–L1-specific antibodies and methods of using them | |
| JP2007522094A5 (enExample) | ||
| JP2016040288A5 (enExample) | ||
| JP2002506648A5 (enExample) | ||
| JP2007524613A5 (enExample) | ||
| JP2012504602A5 (enExample) | ||
| JP2019532047A5 (enExample) | ||
| JP2020533302A5 (enExample) | ||
| JP2005511495A5 (enExample) | ||
| Soriano et al. | Treatment of hepatitis delta and HIV infection | |
| JP2013028611A5 (enExample) | ||
| DE60141297D1 (de) | Gegen das menschliche bst2 antigen gerichteter monoklonaler antikörper | |
| WO2003078595B1 (en) | Immunostimulatory double stranded rna and methods of inducing, enhancing or modulating the immune response | |
| AR065765A1 (es) | Composicion de vacuna para el tratamiento de enfermedades infecciosas respiratorias | |
| JP2004523538A5 (enExample) | ||
| Niu et al. | Synergistic and additive effects of cimetidine and levamisole on cellular immune responses to hepatitis B virus DNA vaccine in mice | |
| Kolb et al. | Effective use of tocilizumab for the treatment of steroid‐refractory gastrointestinal acute graft versus host disease in a child with very high levels of serum interleukin‐6 |