JP2005525390A5 - - Google Patents
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- Publication number
- JP2005525390A5 JP2005525390A5 JP2003579828A JP2003579828A JP2005525390A5 JP 2005525390 A5 JP2005525390 A5 JP 2005525390A5 JP 2003579828 A JP2003579828 A JP 2003579828A JP 2003579828 A JP2003579828 A JP 2003579828A JP 2005525390 A5 JP2005525390 A5 JP 2005525390A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- amino group
- protected amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 230000001808 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207449.0A GB0207449D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| PCT/EP2003/003339 WO2003082291A1 (en) | 2002-03-28 | 2003-03-27 | N-{´ (2s) -4- (3, 4-difluorobenzyl) morpholin-2yl!methyl} -2-{3-' (methylsulphonyl) amino! phenyl}acetamide as ccr3 antagonist for the treatment of inflammatory conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525390A JP2005525390A (ja) | 2005-08-25 |
| JP2005525390A5 true JP2005525390A5 (US07981874-20110719-C00313.png) | 2006-05-18 |
| JP4490110B2 JP4490110B2 (ja) | 2010-06-23 |
Family
ID=9933998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579828A Expired - Lifetime JP4490110B2 (ja) | 2002-03-28 | 2003-03-27 | 炎症性症状の治療のためのｃｃｒ３拮抗薬としての、ｎ−｛［（２ｓ）−４−（３，４−ジフルオロベンジル）モルホリン−２−イル］メチル｝−２−｛３−［（メチルスルホニル）アミノ］フェニル｝アセトアミド |
Country Status (22)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919356B2 (en) | 2002-09-26 | 2005-07-19 | Bristol Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| JP2009501792A (ja) * | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体のモジュレーターとしてのｎ−ベンジル−モルホリン誘導体 |
| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| EP1931620A1 (en) * | 2005-09-22 | 2008-06-18 | Sanofi-Aventis | Amino-alkyl-amide derivatives as ccr3 receptor liquids |
| HUP0800478A2 (en) * | 2008-07-31 | 2010-03-01 | Sanofi Aventis | Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands |
| CN104203231A (zh) * | 2011-12-01 | 2014-12-10 | 葛兰素集团有限公司 | 治疗和预防眼疾病的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562929A (en) * | 1979-06-21 | 1981-01-13 | Sumitomo Chem Co Ltd | Preparation of optically active cyclopentenolone |
| CZ284687B6 (cs) * | 1986-04-30 | 1999-02-17 | Dainippon Pharmaceutical Co., Ltd. | Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi |
| JPH01117882A (ja) * | 1987-10-30 | 1989-05-10 | Dainippon Pharmaceut Co Ltd | 複素環式カルボン酸アミド誘導体 |
| JPH03291274A (ja) * | 1990-04-09 | 1991-12-20 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| TW223629B (US07981874-20110719-C00313.png) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US6031097A (en) * | 1997-10-27 | 2000-02-29 | Neurogen Corporation | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands |
| AU2056800A (en) * | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
| ATE254620T1 (de) * | 1999-09-14 | 2003-12-15 | Aventis Pharma Inc | Unsubstituierte ethyl- und propylderivate von phenoxythienoisoxazolen als d4 antagonisten |
| PL362984A1 (en) * | 2000-09-29 | 2004-11-15 | Glaxo Group Limited | Compounds useful in the treatment of inflammatory diseases |
| KR20030031198A (ko) * | 2000-09-29 | 2003-04-18 | 글락소 그룹 리미티드 | 염증 질환 치료용 모르폴린-아세트아미드 유도체 |
-
2002
- 2002-03-28 GB GBGB0207449.0A patent/GB0207449D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106782A patent/TW200400823A/zh unknown
- 2003-03-27 AU AU2003216905A patent/AU2003216905A1/en not_active Abandoned
- 2003-03-27 ES ES03712117T patent/ES2339436T3/es not_active Expired - Lifetime
- 2003-03-27 AR ARP030101090A patent/AR039177A1/es unknown
- 2003-03-27 US US10/509,417 patent/US20060058299A1/en not_active Abandoned
- 2003-03-27 BR BR0308719-0A patent/BR0308719A/pt not_active Application Discontinuation
- 2003-03-27 PL PL03372930A patent/PL372930A1/xx not_active Application Discontinuation
- 2003-03-27 IL IL16364803A patent/IL163648A0/xx unknown
- 2003-03-27 MX MXPA04009458A patent/MXPA04009458A/es unknown
- 2003-03-27 RU RU2004126145/04A patent/RU2004126145A/ru not_active Application Discontinuation
- 2003-03-27 AT AT03712117T patent/ATE454892T1/de not_active IP Right Cessation
- 2003-03-27 EP EP03712117A patent/EP1487453B1/en not_active Expired - Lifetime
- 2003-03-27 CN CNA038068656A patent/CN1642553A/zh active Pending
- 2003-03-27 KR KR10-2004-7015447A patent/KR20040095347A/ko not_active Application Discontinuation
- 2003-03-27 JP JP2003579828A patent/JP4490110B2/ja not_active Expired - Lifetime
- 2003-03-27 DE DE60330952T patent/DE60330952D1/de not_active Expired - Lifetime
- 2003-03-27 CA CA002479910A patent/CA2479910A1/en not_active Abandoned
- 2003-03-27 WO PCT/EP2003/003339 patent/WO2003082291A1/en active Application Filing
-
2004
- 2004-08-19 IS IS7415A patent/IS7415A/is unknown
- 2004-09-01 ZA ZA200406990A patent/ZA200406990B/en unknown
- 2004-09-27 NO NO20044098A patent/NO20044098L/no not_active Application Discontinuation
