JP2005525315A5 - - Google Patents
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- Publication number
- JP2005525315A5 JP2005525315A5 JP2003560001A JP2003560001A JP2005525315A5 JP 2005525315 A5 JP2005525315 A5 JP 2005525315A5 JP 2003560001 A JP2003560001 A JP 2003560001A JP 2003560001 A JP2003560001 A JP 2003560001A JP 2005525315 A5 JP2005525315 A5 JP 2005525315A5
- Authority
- JP
- Japan
- Prior art keywords
- moiety
- compound
- aryl
- heteroaryl
- heteroalicyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C1)*1C(*C*1CC1)C(C(C1)C2C(C3)C13C1CCCC1)C2C1*CCC1 Chemical compound *C(C1)*1C(*C*1CC1)C(C(C1)C2C(C3)C13C1CCCC1)C2C1*CCC1 0.000 description 5
- FOQJHZPURACERJ-UHFFFAOYSA-N CB1OC(C)(C)C(C)(C)O1 Chemical compound CB1OC(C)(C)C(C)(C)O1 FOQJHZPURACERJ-UHFFFAOYSA-N 0.000 description 1
- HQDKMMCQUXZGNG-UHFFFAOYSA-N CNNC1Cc2ccccc2CC1 Chemical compound CNNC1Cc2ccccc2CC1 HQDKMMCQUXZGNG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34671102P | 2002-01-08 | 2002-01-08 | |
| US37301102P | 2002-04-16 | 2002-04-16 | |
| PCT/US2003/000390 WO2003059898A2 (en) | 2002-01-08 | 2003-01-08 | Eponemycin and epoxomicin analogs and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525315A JP2005525315A (ja) | 2005-08-25 |
| JP2005525315A5 true JP2005525315A5 (enExample) | 2006-02-23 |
| JP4412586B2 JP4412586B2 (ja) | 2010-02-10 |
Family
ID=26994981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003560001A Expired - Fee Related JP4412586B2 (ja) | 2002-01-08 | 2003-01-08 | エポネマイシンおよびエポキソマイシン類似物およびそれらの用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7524883B2 (enExample) |
| EP (1) | EP1463719A2 (enExample) |
| JP (1) | JP4412586B2 (enExample) |
| AU (1) | AU2003219652A1 (enExample) |
| TW (1) | TW200412349A (enExample) |
| WO (1) | WO2003059898A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7576206B2 (en) † | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
| US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| US8129346B2 (en) | 2004-04-15 | 2012-03-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| PT2030981E (pt) | 2004-05-10 | 2014-10-14 | Onyx Therapeutics Inc | Compostos para inibição da enzima proteassoma |
| CN102847136A (zh) * | 2004-12-07 | 2013-01-02 | 普罗特奥里克斯公司 | 抑制蛋白酶体的组合物 |
| US7468383B2 (en) * | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| BRPI0612607A2 (pt) * | 2005-07-05 | 2010-12-07 | Tufts College | inibidores de alfa proteìna de ativação de fibroblasto |
| KR101434522B1 (ko) | 2005-11-09 | 2014-08-26 | 오닉스 세라퓨틱스, 인크. | 효소 저해를 위한 화합물 |
| CA2641790A1 (en) * | 2006-02-16 | 2007-08-30 | Sma Foundation | Ubiquitin/proteasome inhibitors for the treatment of spinal muscular atrophy |
| RU2450016C2 (ru) * | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| US7642369B2 (en) * | 2006-09-12 | 2010-01-05 | University Of Kentucky Research Foundation | Epoxyketone-based immunoproteasome inhibitors |
| CN101686951A (zh) * | 2006-11-13 | 2010-03-31 | 纽约市哥伦比亚大学托管会 | 治疗糖尿病的选择性蛋白酶体抑制物 |
| US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
| WO2009026579A1 (en) * | 2007-08-23 | 2009-02-26 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
| SI2207791T2 (sl) | 2007-10-04 | 2019-09-30 | Onyx Therapeutics, Inc. | Kristalinični peptidepoksiketonski proteazni inhibitorji in sinteza aminokislinskih ketoepoksidov |
| HUE028502T2 (en) * | 2007-11-06 | 2016-12-28 | Edison Pharmaceuticals Inc | 4- (P-Quinonyl) -2-hydroxybutanamide derivatives for the treatment of mitochondrial diseases |
| EP2088205A1 (en) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
| US20090325903A1 (en) | 2008-06-17 | 2009-12-31 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
| CN101638414B (zh) * | 2008-07-30 | 2014-01-08 | 江苏先声药物研究有限公司 | 肽硼酸及其酯类化合物、制备方法及其用途 |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| EP2796134B1 (en) | 2008-10-21 | 2016-12-07 | Onyx Therapeutics, Inc. | Combination of the peptide epoxyketone proteasome inhibitor carfilzomib with melphalan for use in the treatment of multiple myeloma |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| MX2011012345A (es) | 2009-05-22 | 2012-01-31 | Exelixis Inc | Inhibidores de pi3k/mtor basados en benzoxazepinas contra enfermedades proliferativas. |
| EP2498793B1 (en) | 2009-11-13 | 2019-07-10 | Onyx Therapeutics, Inc. | Oprozomib for use in metastasis suppression |
| WO2011087822A1 (en) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
| AU2011223795B2 (en) | 2010-03-01 | 2015-11-05 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| KR20130094185A (ko) | 2010-04-07 | 2013-08-23 | 오닉스 세라퓨틱스, 인크. | 결정성 펩티드 에폭시케톤 면역프로테아좀 저해제 |
| US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
| US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
| WO2014072985A1 (en) * | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Novel boronic acid derivatives as anti cancer agents |
| WO2015179443A1 (en) | 2014-05-20 | 2015-11-26 | Millennium Pharmaceuticals. Inc. | Boron-containing proteasome inhibitors for use after primary cancer therapy |
| EP3253734B1 (en) * | 2015-02-02 | 2020-12-23 | The Regents of The University of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| CN106588965A (zh) * | 2015-10-15 | 2017-04-26 | 北京大学 | 脲拟肽硼酸化合物及其药物组合物、制备方法和用途 |
| KR102798145B1 (ko) | 2018-04-18 | 2025-04-22 | 콘스텔레이션 파마슈티칼스, 인크. | 메틸 변형 효소 조절제, 이의 조성물 및 용도 |
| CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN110540547A (zh) * | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
| WO2025092827A1 (zh) * | 2023-10-30 | 2025-05-08 | 上海汇伦医药股份有限公司 | 一种环氧类化合物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912133A (en) | 1988-03-07 | 1990-03-27 | Bristol-Myers Company | BU-3862T antitumor antibiotic |
| US4990448A (en) | 1989-08-04 | 1991-02-05 | Bristol-Myers Company | Bu-4061T |
| US5071957A (en) | 1989-08-04 | 1991-12-10 | Bristol-Myers Company | Antibiotic BU-4061T |
| JP3107326B2 (ja) | 1992-04-13 | 2000-11-06 | 日本化薬株式会社 | 生理活性物質ｎｋ−０４０００ｐ、ｎｋ−０４０００ｑ、その製造法及びそれを有効成分として含有する除草剤 |
| US5693617A (en) | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| JP4416501B2 (ja) | 2001-05-30 | 2010-02-17 | ノバルティス アクチエンゲゼルシャフト | ２−｛［ｎ−（２−アミノ−３−（ヘテロアリールまたはアリール）プロピオニル）−アミノアシル］−アミノ｝−アルキルボロン酸誘導体 |
| JPWO2003033506A1 (ja) * | 2001-10-12 | 2005-02-03 | 杏林製薬株式会社 | アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
-
2003
- 2003-01-08 EP EP03715921A patent/EP1463719A2/en not_active Withdrawn
- 2003-01-08 WO PCT/US2003/000390 patent/WO2003059898A2/en not_active Ceased
- 2003-01-08 US US10/501,120 patent/US7524883B2/en not_active Expired - Fee Related
- 2003-01-08 JP JP2003560001A patent/JP4412586B2/ja not_active Expired - Fee Related
- 2003-01-08 AU AU2003219652A patent/AU2003219652A1/en not_active Abandoned
- 2003-05-30 TW TW092114803A patent/TW200412349A/zh unknown
-
2009
- 2009-03-03 US US12/396,849 patent/US20090291998A1/en not_active Abandoned
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